Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia
Conclusion: This report summarizes the clinical significance of macrolide-resistant and refractory MP pneumonia and discusses the efficacy and safety of alternative drugs, with a stepwise approach to the management of MP pneumonia recommended from the viewpoint of clinical practice.What is Known:•Although MP pneumonia is usually a benign self-limited infection with response macrolides as first line therapy,severe life-threatening cases may develop if additional treatment strategies are not effectively implemented.•Macrolide-resistant and refractory MP pneumonia are two conditions that may complicate the clinical cour...
Source: European Journal of Pediatrics - April 18, 2024 Category: Pediatrics Source Type: research
Occipital dermal sinus associated with infectious teratoma in an adult patient affected by Klippel-Feil syndrome: Rare case report and literature review
CONCLUSION: The association between KFS, cerebellar teratoma, and DS has not yet been described in the literature, with only the association of the first two being extremely rare.PMID:38628535 | PMC:PMC11021108 | DOI:10.25259/SNI_1024_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Breno Nery Victoria Rodrigues Durand Rafael De Almeida Rabello Anna Carolyne Mendes De Oliveira Eduardo Quaggio Manoela Marques Ortega Bruno Camporezi Jos é Alencar De Sousa Segundo Source Type: research
Endoscopic closure techniques of bariatric surgery complications: a meta-analysis
ConclusionObservational reports show that patients managed with OTSC were more likely to experience healing of their defect than those managed with endoscopic suturing. Larger controlled studies comparing different closure devices for bariatric leaks should be carried out to better understand the ideal endoscopic approach to these complications. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 17, 2024 Category: Surgery Source Type: research
Sepsis and case fatality rates and associations with deprivation, ethnicity, and clinical characteristics: population-based case –control study with linked primary care and hospital data in England
ConclusionGiven the variety of predictors and their level of associations for developing sepsis, there is a need for prediction models for risk of developing sepsis that can help to target preventative antibiotic therapy. (Source: Infection)
Source: Infection - April 16, 2024 Category: Infectious Diseases Source Type: research
Mycotic aortic aneurysms: characteristic macroscopic findings in a case series
We report 10 patients with MAAs in whom macroscopically, similar coined-sized lesions of the inner aortic wall were seen in all cases. When a coin-sized lesion in the inner aortic wall is seen during open surgical repair of an aortic aneurysm, the surgeon should consider an infectious cause. Microbiological tissue samples should be collected, and additional targeted antibiotic therapy should be started.PMID:38616531 | DOI:10.1080/14017431.2024.2341696 (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - April 15, 2024 Category: Cardiology Authors: Tim Somers Hedwig M J M Nies Ilse J E Kouijzer Pui Yuen Lee Wim J Morshuis Guillaume S C Geuzebroek Source Type: research
Indwelling pleural catheter infection and colonisation: a clinical practice review
J Thorac Dis. 2024 Mar 29;16(3):2196-2204. doi: 10.21037/jtd-23-1761. Epub 2024 Mar 27.ABSTRACTIndwelling pleural catheters (IPCs) are used in the management of malignant pleural effusions, but they can become infected in 5.7% of cases. This review aims to provide a summary of the development of IPC infections and their microbiology, diagnosis and management. IPC infections can be deep, involving the pleural space, or superficial. The former are of greater clinical concern. Deep infection is associated with biofilm formation on the IPC surface and require longer courses of antibiotic treatment. Mortality from infections is...
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Dheeraj K Sethi Mark A Webber Eleanor K Mishra Source Type: research
Mycotic aortic aneurysms: characteristic macroscopic findings in a case series
We report 10 patients with MAAs in whom macroscopically, similar coined-sized lesions of the inner aortic wall were seen in all cases. When a coin-sized lesion in the inner aortic wall is seen during open surgical repair of an aortic aneurysm, the surgeon should consider an infectious cause. Microbiological tissue samples should be collected, and additional targeted antibiotic therapy should be started.PMID:38616531 | DOI:10.1080/14017431.2024.2341696 (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - April 15, 2024 Category: Cardiology Authors: Tim Somers Hedwig M J M Nies Ilse J E Kouijzer Pui Yuen Lee Wim J Morshuis Guillaume S C Geuzebroek Source Type: research
Indwelling pleural catheter infection and colonisation: a clinical practice review
J Thorac Dis. 2024 Mar 29;16(3):2196-2204. doi: 10.21037/jtd-23-1761. Epub 2024 Mar 27.ABSTRACTIndwelling pleural catheters (IPCs) are used in the management of malignant pleural effusions, but they can become infected in 5.7% of cases. This review aims to provide a summary of the development of IPC infections and their microbiology, diagnosis and management. IPC infections can be deep, involving the pleural space, or superficial. The former are of greater clinical concern. Deep infection is associated with biofilm formation on the IPC surface and require longer courses of antibiotic treatment. Mortality from infections is...
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Dheeraj K Sethi Mark A Webber Eleanor K Mishra Source Type: research
Expert opinion on antimicrobial therapies: is there enough scientific evidence to state that targeted therapies outperform non-targeted ones?
. (Source: Expert Opinion on Drug Delivery)
Source: Expert Opinion on Drug Delivery - April 15, 2024 Category: Drugs & Pharmacology Authors: Cristina YusEnrique G ámezManuel Arrueboa Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza, Spainb Department of Chemical and Environmental Engineering, University of Zaragoza, Zaragoza, Spainc Aragon Health Source Type: research
Antibiotic prescribing patterns in the placement of dental implants in Europe: A systematic review of survey-based studies
CONCLUSIONS: The most commonly prescribed antibiotic both pre- and postoperatively is amoxicillin and, in allergic patients, clindamycin. In Europe, more doses of PAT are being prescribed than suggested by current recommendations. For this reason, more PAT education is needed in educational curricula to promote a more rational use of antibiotics to reduce the occurrence of antimicrobial resistance.PMID:38615255 | DOI:10.4317/medoral.26450 (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - April 14, 2024 Category: ENT & OMF Authors: Á-O Salgado-Peralvo N Kewalramani A P érez-Jardón M P érez-Sayáns M-V Mateos-Moreno L Arriba-Fuente Source Type: research
Emerging threats of high biofilm formation and antibiotic resistance in clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from Pakistan
CONCLUSIONS: Clinical MRSA strains exhibit a substantial potential for biofilm formation, contributing to a resistant phenotype. Routine antibiotic testing in clinical settings that overlook the biofilm aspect may lead to the failure of empiric antibiotic therapy.PMID:38614413 | DOI:10.1016/j.meegid.2024.105592 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 13, 2024 Category: Genetics & Stem Cells Authors: Asad Ali Saba Riaz Source Type: research
Emerging threats of high biofilm formation and antibiotic resistance in clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from Pakistan
CONCLUSIONS: Clinical MRSA strains exhibit a substantial potential for biofilm formation, contributing to a resistant phenotype. Routine antibiotic testing in clinical settings that overlook the biofilm aspect may lead to the failure of empiric antibiotic therapy.PMID:38614413 | DOI:10.1016/j.meegid.2024.105592 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 13, 2024 Category: Genetics & Stem Cells Authors: Asad Ali Saba Riaz Source Type: research
