Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling
Multiple sclerosis (MS), an autoimmune and degenerative disease, is characterized by demyelination and chronic neuroinflammation. Bixin is a carotenoid isolated from the seeds of Bixa orellana that exhibits various potent pharmacological activities, including antioxidant, anti-inflammatory, and anti-tumor properties. However, the effects of bixin on MS have not yet been examined. To evaluate the effects and underlying molecular mechanisms of bixin on MS, experimental autoimmune encephalomyelitis (EAE) was established in C57BL/6 mice, which were treated via intragastric administration of bixin solutions. To evaluate the mol...
Source: Frontiers in Immunology - December 9, 2020 Category: Allergy & Immunology Source Type: research
Fabrication of natural colorimetric indicators for monitoring freshness of ready ‐to‐cook idli batter
Natural colorimetric indicator for monitoring freshness of RTC idli batter stored at normal temperature distribution supply chain. Natural colorimetric indicators have been fabricated using annatto and pomegranate extract powder and compared with chemical colorimetric indicator fabricated using bromophenol blue (BPB) to monitor the freshness of ready ‐to‐cook (RTC) idli batter. The fabricated colorimetric indicator labels work on increasing headspace carbon dioxide (CO2) concentration and decreasing pH of stored batter, where indicators showed visible color change from lightest to darkest for spoiled samples. The heads...
Source: Packaging Technology and Science - December 6, 2020 Category: Food Science Authors: Pratik S. Gaikwad,
Binod K. Yadav,
Anandakumar Sugumar Tags: RESEARCH ARTICLE Source Type: research
Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR- γ/TGF-β1/Smad3 pathway.
Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-γ/TGF-β1/Smad3 pathway.
Int Immunopharmacol. 2020 Nov 06;:107117
Authors: Ma JQ, Zhang YJ, Tian ZK, Liu CM
Abstract
Bixin, an natural carotenoid extracted from the seeds of the Bixa orellana has been shown to possess numerous important pharmacological activities. The present study was aimed to investigate the mechanisms of Bixin on carbon tetrachloride (CCl4)-induced kidney inflammation, fibrosis and oxidative stress in mice. Our results ...
Source: International Immunopharmacology - November 6, 2020 Category: Allergy & Immunology Authors: Ma JQ, Zhang YJ, Tian ZK, Liu CM Tags: Int Immunopharmacol Source Type: research
Intercalation of Apocarotenoids from Annatto (Bixa orellana L.) into Layered Double Hydroxides
Synthetic conditions were evaluated to intercalate norbixin into layered double hydroxides (LDH). Norbixin was isolated from a hydrosoluble commercial annatto extract. LDH samples comprising M2+/Al3+ (M = Mg, Zn) were synthesized by coprecipitation and characterized by X-ray diffraction, thermal analysis coupled to mass spectrometry, vibrational spectroscopies, and solid-state 13C nuclear magnetic resonance. Radical scavenging activity of LDH hybrids was monitored by electron paramagnetic resonance towards the stable radical DPPH (1,1-diphenyl-2-picrylhydrazyl). LDH hosts presented more than 50 wt.% of norbixin and d-spaci...
Source: Journal of the Brazilian Chemical Society - October 30, 2020 Category: Chemistry Source Type: research
Achiote (Bixa orellana) Lipophilic Extract, Bixin, and δ-tocotrienol Effects on Lifespan and Stress Resistance in Caenorhabditis elegans
This study could provide insights for further research on a new beneficial use of this important crop in health and nutraceutical applications beyond its use as a source of natural pigments. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - October 29, 2020 Category: Drugs & Pharmacology Authors: G ómez-Linton, Darío R. Alavez, Silvestre Navarro-Oca ña, Arturo Rom án-Guerrero, Angélica Pinz ón-López, Luis P érez-Flores, Laura J. Tags: Original Papers Source Type: research
Bixa orellana L. by-products' fractions from an industrial process: antiproliferative activity on tumor cells and chemical profile.
In conclusion, this by-product becomes of great value, being a potential candidate for development of new anti-tumor ingredients.
PMID: 33016138 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - October 3, 2020 Category: Biochemistry Authors: Basting RT, Abreu PMB, Sousa IMO, de Carvalho JE, Carvalho PRN, Foglio MA Tags: Nat Prod Res Source Type: research
Direct microencapsulation of an annatto extract by precipitation of psyllium husk mucilage polysaccharides
Publication date: Available online 13 September 2020Source: Food HydrocolloidsAuthor(s): André Álvares Monge Neto, Larissa Fonseca Tomazini, Amanda Gouveia Mizuta, Rúbia Carvalho Gomes Corrêa, Grasiele Scaramal Madrona, Flávio Faria de Moraes, Rosane Marina Peralta (Source: Food Hydrocolloids)
Source: Food Hydrocolloids - September 13, 2020 Category: Food Science Source Type: research
Cellulose acetate nanofibers loaded with crude annatto extract: Preparation, characterization, and in vivo evaluation for potential wound healing applications
Publication date: January 2021Source: Materials Science and Engineering: C, Volume 118Author(s): Ana Elisa Antunes dos Santos, Francisco Vieira dos Santos, Kátia Michelle Freitas, Lúcia Pinheiro Santos Pimenta, Luciana de Oliveira Andrade, Tamires Amorim Marinho, Gleide Fernandes de Avelar, Aline Bruna da Silva, Roberta Viana Ferreira (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - September 12, 2020 Category: Materials Science Source Type: research
Effect of a Blend of Zingiber officinale Roscoe and Bixa orellana L. Herbal Supplement on the Recovery of Delayed-Onset Muscle Soreness Induced by Unaccustomed Eccentric Resistance Training: A Randomized, Triple-Blind, Placebo-Controlled Trial
ConclusionThe herbal supplement maintained the maximum power of the lower limbs and attenuated muscle pain.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT03961022. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - July 20, 2020 Category: Physiology Source Type: research
Butein inhibits lipogenesis in Caenorhabditis elegans
AbstractButein, a flavonoid found in annatto seeds and lacquer trees, may be used for many health benefits, including the prevention of obesity. However, its anti ‐obesity effects are not completely understood; in particular, the effects of butein on the regulation of lipid metabolism have not been explained. Thus, the goal of the current study was to determine the effects of butein on lipid metabolism inCaenorhabditis elegans, which is a multi ‐organ nematode used as an animal model in obesity research. Butein at 70 μM reduced triglyceride content by 27% compared to the control without altering food intake and ener...
Source: BioFactors - July 13, 2020 Category: Biochemistry Authors: Renalison Farias ‐Pereira,
Zhenyu Zhang,
Cheon‐Seok Park,
Daeyoung Kim,
Kee‐Hong Kim,
Yeonhwa Park Tags: Research Communication Source Type: research
Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.
Abstract
Atrophic A\age-related macular degeneration (AMD) and Stargardt disease (STGD) are major blinding diseases affecting millions of patients worldwide, but no treatment is available. In dry AMD and STGD oxidative stress and subretinal accumulation of N-retinylidene-N-retinylethanolamine (A2E), a toxic by-product of the visual cycle, causes retinal pigment epithelium (RPE) and photoreceptor degeneration leading to visual impairment. Acute and chronic retinal degeneration following blue light damage (BLD) in BALB/c mice and aging of Abca4-/- Rdh8-/- mice, respectively, reproduce features of AMD and STG...
Source: Aging - April 6, 2020 Category: Biomedical Science Authors: Fontaine V, Monteiro E, Fournié M, Brazhnikova E, Boumedine T, Vidal C, Balducci C, Guibout L, Latil M, Dilda PJ, Veillet S, Sahel JA, Lafont R, Camelo S Tags: Aging (Albany NY) Source Type: research
Molecules, Vol. 25, Pages 1536: A DyP-Type Peroxidase of Pleurotus sapidus with Alkene Cleaving Activity
Ersoy
Alkene cleavage is a possibility to generate aldehydes with olfactory properties for the fragrance and flavor industry. A dye-decolorizing peroxidase (DyP) of the basidiomycete Pleurotus sapidus (PsaPOX) cleaved the aryl alkene trans-anethole. The PsaPOX was semi-purified from the mycelium via FPLC, and the corresponding gene was identified. The amino acid sequence as well as the predicted tertiary structure showed typical characteristics of DyPs as well as a non-canonical Mn2+-oxidation site on its surface. The gene was expressed in Komagataella pfaffii GS115 yielding activities up to 142 U/L using 2,2&l...
Source: Molecules - March 26, 2020 Category: Chemistry Authors: Nina-Katharina Krahe Ralf G. Berger Franziska Ersoy Tags: Article Source Type: research
Portable Near-Infrared spectroscopy for rapid authentication of adulterated paprika powder
In conclusion, results showed that NIR spectroscopy is a useful screening technique for identification and quantification of adulteration in paprika. (Source: Journal of Food Composition and Analysis)
Source: Journal of Food Composition and Analysis - January 4, 2020 Category: Food Science Source Type: research
