Osteoprotective Effects in Postmenopausal Osteoporosis Rat Model: Oral Tocotrienol vs. Intraosseous Injection of Tocotrienol-Poly Lactic-Co-Glycolic Acid Combination
In conclusion, daily oral tocotrienol and one-time intraosseous injection of tocotrienol–PLGA combination were equally effective in offering protection against ovariectomy-induced bone changes. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 18, 2021 Category: Drugs & Pharmacology Source Type: research
Bixin protects mice against bronchial asthma though modulating PI3K/Akt pathway
Int Immunopharmacol. 2021 Oct 20;101(Pt B):108266. doi: 10.1016/j.intimp.2021.108266. Online ahead of print.ABSTRACTAccumulating evidence has implicated the potential of natural compounds in treatment of asthma. Bixin is a natural food coloring isolated from the seeds of Bixa Orellana, which possesses anti-tumor, anti-inflammatory and antioxidative properties. Nevertheless, its therapeutic effect in asthma has not been elucidated. Our present study demonstrated that administration of Bixin suppressed allergic airway inflammation and reversed glucocorticoids resistance, as well as alleviated airway remodeling and airway hyp...
Source: International Immunopharmacology - October 22, 2021 Category: Allergy & Immunology Authors: Yingjie Zhu Dong Sun Han Liu Linzi Sun Jing Jie Jingjing Luo Liping Peng Lei Song Source Type: research
Bixasteroid, a new compound from the fruits of < em > Bixa orellana < /em > and its anti-inflammatory activity
Nat Prod Res. 2021 Sep 10:1-7. doi: 10.1080/14786419.2021.1974436. Online ahead of print.ABSTRACTBixasteroid (1), one new steroid together with five known compounds (2-6), were isolated from the ethyl acetate fraction of ethanol extract of Bixa orellana fruits. All of these known compounds were isolated from the plant for the first time. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configuration of compound 1 was determined by X-ray crystallographic data analysis as well as by the quantum chemical ECD calculations. All the isolated compounds were tested for their anti-inflammato...
Source: Natural Product Research - September 11, 2021 Category: Biochemistry Authors: Yi-Min Chen Tian-Qi Xu Xiao-Qi Zhang Chun-Lin Fan Wen-Cai Ye Wei Xu Guang-Xiong Zhou Source Type: research
Bixasteroid, a new compound from the fruits of < em > Bixa orellana < /em > and its anti-inflammatory activity
Nat Prod Res. 2021 Sep 10:1-7. doi: 10.1080/14786419.2021.1974436. Online ahead of print.ABSTRACTBixasteroid (1), one new steroid together with five known compounds (2-6), were isolated from the ethyl acetate fraction of ethanol extract of Bixa orellana fruits. All of these known compounds were isolated from the plant for the first time. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configuration of compound 1 was determined by X-ray crystallographic data analysis as well as by the quantum chemical ECD calculations. All the isolated compounds were tested for their anti-inflammato...
Source: Natural Product Research - September 11, 2021 Category: Biochemistry Authors: Yi-Min Chen Tian-Qi Xu Xiao-Qi Zhang Chun-Lin Fan Wen-Cai Ye Wei Xu Guang-Xiong Zhou Source Type: research
Spent mushroom substrate is capable of physisorption-chemisorption of CO < sub > 2 < /sub >
Environ Res. 2021 Aug 30;204(Pt A):111945. doi: 10.1016/j.envres.2021.111945. Online ahead of print.ABSTRACTNo in-depth investigation exists on the feasibility of integrating hydrothermal carbonization (HTC) and pelletization into the process of making spent mushroom substrate (SMS), an agro-food residue from the commercial mushroom industry, into an adsorbent for post-combustion CO2 removal. Therefore, this study analyzed if it could be possible for systematically converting low-pressure hydrochars of various SMSs into carbon-adsorbing mini-capsules. Sources of SMS included paddy straw and achiote capsule shell from Pleur...
Source: Environmental Research - September 2, 2021 Category: Environmental Health Authors: Lucas da Silva Alves Bruno Rafael de Almeida Moreira Ronaldo da Silva Viana Eust áquio Souza Dias Danny Lee Rinker Arturo Pardo-Gimenez Diego Cunha Zied Source Type: research
Molecules, Vol. 26, Pages 4720: Co-Treatment of Purified Annatto Oil (Bixa orellana L.) and Its Granules (Chronic ®) Improves the Blood Lipid Profile and Bone Protective Effects of Testosterone in the Orchiectomy-Induced Osteoporosis in Wistar Rats
This study aimed to evaluate and compare the effects of co-treatment with purified annatto oil (PAO) or its granules (GRA, Chronic®) with that of testosterone on the orchiectomy-induced osteoporosis in Wistar rats. After surgery, rats were treated from day 7 until day 45 with testosterone only (TES, 7 mg/kg, IM) or TES + PAO or GRA (200 mg/kg, p.o.). The following parameters were evaluated: food/water intake, weight, HDL, LDL, glucose, triglycerides (TG), total cholesterol (TC), alkaline phosphatase levels, blood phosphorus and calcium contents, femur weight, structure (through scanning electron microscopy), and calcium c...
Source: Molecules - August 4, 2021 Category: Chemistry Authors: Arlindo C ésar Matias Pereira Helison de Oliveira Carvalho Danna Emanuelle Santos Gon çalves Karyny Roberta Tavares Pican ço Abrah ão Victor Tavares de Lima Teixeira dos dos Santos Heitor Ribeiro da da Silva Francinaldo Sarges Braga Roberto Messias Be Tags: Article Source Type: research
Annatto hypersensitivity after oral ingestion confirmed by placebo-controlled oral challenge
Natural dyes, in contrast to synthetic ones, can be a source of protein, so their consumption may be associated with immunoglobulin E (IgE) –dependent allergic reactions. Among natural dyes, symptoms were most often observed after carmine ingestion1 and only occasionally after annatto and concerned the skin, respiratory system, or even anaphylaxis. Annatto (E-160b) is a natural yellow-orange dye obtained from the seeds of the tropical tree Bixa orenella coming from the Americas.2 It is found as a colorant in many foods, such as cheese, margarine, breakfast cereals, grilled chicken, dressings, coffee creamers, mustard, co...
Source: Annals of Allergy, Asthma and Immunology - July 25, 2021 Category: Allergy & Immunology Authors: Beata Sadowska, Marlena Sztormowska, Marta Che łmińska Tags: Letters Source Type: research
Annato hypersensitivity after oral ingestion confirmed by placebo-controlled, oral challenge.
Natural dyes, in contrast to synthetic ones, can be a source of protein, so their consumption may be associated with IgE-dependent allergic reactions. Among natural dyes, symptoms were most often observed after carmine ingestion1 and only occasionally after annatto and concerned the skin, respiratory system or even anaphylaxis. Annato (E-160b) is a natural yellow-orange dye obtained from the seeds of the tropical tree Bixa orenella, coming from Americas.2 It is found as a colorant in many foods, such as cheese, margarine, breakfast cereals, grilled chicken, dressings, coffee creamers, mustard, colored rice, popcorn, ice cr...
Source: Annals of Allergy, Asthma and Immunology - July 25, 2021 Category: Allergy & Immunology Authors: Beata Sadowska, Marlena Sztormowska, Marta Che łmińska Tags: Letters Source Type: research
A Toxicological Evaluation of Geranylgeraniol
Regul Toxicol Pharmacol. 2021 Jun 15:104975. doi: 10.1016/j.yrtph.2021.104975. Online ahead of print.ABSTRACTGeranylgeraniol (GGOH) is an isoprenoid compound found in annatto seeds and an intermediate of the mevalonate pathway found within organisms serving various functions. Toxicological studies on its safety profile are not readily available. To assess the safety of GGOH, a molecularly distilled, food grade annatto oil, consisting of approximately 80% trans-GGOH, was subjected to a bacterial reverse mutation test, an in vitro mammalian chromosomal aberration test, and an in vivo mammalian micronucleus test in order to i...
Source: Regulatory Toxicology and Pharmacology : RTP - June 18, 2021 Category: Toxicology Authors: Kayla Preece R óbert Glávits John R Foster Timothy Murbach John R Endres G ábor Hirka Ad él Vértesi Erzs ébet Béres Ilona Pasics Szakonyin é Source Type: research
Bixin attenuates mechanical allodynia, anxious and depressive-like behaviors associated with experimental diabetes counteracting oxidative stress and glycated hemoglobin
Brain Res. 2021 Jun 6:147557. doi: 10.1016/j.brainres.2021.147557. Online ahead of print.ABSTRACTNeuropathic pain, depression, and anxiety are common comorbidities in diabetic patients, whose pathophysiology involves hyperglycemia-induced increased oxidative stress. Bixin (BIX), an apocarotenoid extracted from the seeds of Bixa orellana, has been used in traditional medicine to treat diabetes and has been recognized by its antioxidant profile. We aimed to investigate the effect of the BIX over the mechanical allodynia, depressive, and anxious-like behaviors associated with experimental diabetes, along with its involved mec...
Source: Brain Research - June 9, 2021 Category: Neurology Authors: Alexia Thamara Gasparin Evelize Stacoviaki Rosa Carlos Henrique Alves Jesus Izonete Cristina Guiloski Helena Cristina da Silva de Assis Olair Carlos Beltrame Ros ângela Locatelli Dittrich Samanta Daliana Golin Pacheco Janaina Menezes Zanoveli Joice Maria Source Type: research
IJERPH, Vol. 18, Pages 5538: Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens, Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial
lia Guadalupe-Grau
Recreational running (RR) is becoming a popular way to increase physical activity for improving health, together with a higher incidence of knee injuries. The aim was to analyze the effect of a four-week supplementation with a mixture of Harpagophytum procumbens, Zingiber officinale and Bixa orellana on males, middle-aged, RR with an undiagnosed knee discomfort. A randomized triple-blind placebo-control trial was conducted among male RR aged 40–60 years suffering from self-declared knee discomfort after training. Participants were assigned to supplementation (2 g/day in 6 doses; n = 13; inter...
Source: International Journal of Environmental Research and Public Health - May 22, 2021 Category: Environmental Health Authors: Marcela Gonz ález-Gross Carlos Quesada-Gonz ález Javier Rueda Manuel Sillero-Quintana Nicolas Issaly Angel Enrique D íaz Eva Gesteiro David Escobar-Toledo Rafael Torres-Peralta Marc Roller Amelia Guadalupe-Grau Tags: Article Source Type: research
Fabrication of natural colorimetric indicators for monitoring freshness of ready ‐to‐cook idli batter
Natural colorimetric indicator for monitoring freshness of RTC idli batter stored at normal temperature distribution supply chain. Natural colorimetric indicators have been fabricated using annatto and pomegranate extract powder and compared with chemical colorimetric indicator fabricated using bromophenol blue (BPB) to monitor the freshness of ready ‐to‐cook (RTC) idli batter. The fabricated colorimetric indicator labels work on increasing headspace carbon dioxide (CO2) concentration and decreasing pH of stored batter, where indicators showed visible color change from lightest to darkest for spoiled samples. The heads...
Source: Packaging Technology and Science - March 3, 2021 Category: Food Science Authors: Pratik S. Gaikwad,
Binod K. Yadav,
Anandakumar Sugumar Tags: RESEARCH ARTICLE Source Type: research
Therapeutic potential of annatto tocotrienol with self-emulsifying drug delivery system in a rat model of postmenopausal bone loss
Publication date: May 2021Source: Biomedicine & Pharmacotherapy, Volume 137Author(s): Nur-Vaizura Mohamad, Soelaiman Ima-Nirwana, Kok-Yong Chin (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 12, 2021 Category: Drugs & Pharmacology Source Type: research
