Annatto hypersensitivity after oral ingestion confirmed by placebo-controlled oral challenge

Natural dyes, in contrast to synthetic ones, can be a source of protein, so their consumption may be associated with immunoglobulin E (IgE) –dependent allergic reactions. Among natural dyes, symptoms were most often observed after carmine ingestion1 and only occasionally after annatto and concerned the skin, respiratory system, or even anaphylaxis. Annatto (E-160b) is a natural yellow-orange dye obtained from the seeds of the tropical tree Bixa orenella coming from the Americas.2 It is found as a colorant in many foods, such as cheese, margarine, breakfast cereals, grilled chicken, dressings, coffee creamers, mustard, colored rice, popcorn, ice cream, crackers, yogurts, cakes, jelly, and medicines.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research