Annato hypersensitivity after oral ingestion confirmed by placebo-controlled, oral challenge.

Natural dyes, in contrast to synthetic ones, can be a source of protein, so their consumption may be associated with IgE-dependent allergic reactions. Among natural dyes, symptoms were most often observed after carmine ingestion1 and only occasionally after annatto and concerned the skin, respiratory system or even anaphylaxis. Annato (E-160b) is a natural yellow-orange dye obtained from the seeds of the tropical tree Bixa orenella, coming from Americas.2 It is found as a colorant in many foods, such as cheese, margarine, breakfast cereals, grilled chicken, dressings, coffee creamers, mustard, colored rice, popcorn, ice cream, crackers, yoghurts, cakes, jelly and medicines.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research