Effect of the Hydroethanolic Extract of Bixa orellana Linn (Bixaceae) Leaves on Castor Oil-Induced Diarrhea in Swiss Albino Mice.
Conclusions: The hydroethanolic extract was found to be effective against castor oil-induced diarrhea in experimental mice at 50, 100, and 200 mg/kg bw which provides evidence that could justify its traditional use.
PMID: 31885545 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - December 31, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Norbixin binding to whey protein isolate - alginate electrostatic complexes increases its solubility and stability
Publication date: April 2020Source: Food Hydrocolloids, Volume 101Author(s): Anders Hauer Møller, Wahyu Wijaya, Amita Jahangiri, Bjoern Madsen, Bjarne Joernsgaard, Signe Vaerbak, Marianne Hammershøj, Paul Van der Meeren, Trine Kastrup DalsgaardAbstractNorbixin is a carotenoid extracted from the Annatto plant (Bixa orellana) and widely used as a natural colorant in pharmaceuticals, cosmetics and food. It is water-soluble at neutral and alkaline pH, but below neutral pH, norbixin starts to precipitate limiting the use in acidic food products. As a new approach to enhance the solubility and stability of norbixin in aqueous ...
Source: Food Hydrocolloids - December 7, 2019 Category: Food Science Source Type: research
Molecules, Vol. 24, Pages 4222: Bixa orellana L. (Bixaceae) and Dysphania ambrosioides (L.) Mosyakin & amp; Clemants (Amaranthaceae) Essential Oils Formulated in Nanocochleates against Leishmania amazonensis
Molecules, Vol. 24, Pages 4222: Bixa orellana L. (Bixaceae) and Dysphania ambrosioides (L.) Mosyakin & Clemants (Amaranthaceae) Essential Oils Formulated in Nanocochleates against Leishmania amazonensis
Molecules doi: 10.3390/molecules24234222
Authors:
Laura Machín
Beatriz Tamargo
Abel Piñón
Regla C. Atíes
Ramón Scull
William N. Setzer
Lianet Monzote
Leishmaniasis is a group of neglected tropical diseases caused by protozoan parasites of the Leishmania genus. The absence of effective vaccines and the limitations of current treatments make the search for effective therapies a real need. Diff...
Source: Molecules - November 19, 2019 Category: Chemistry Authors: Laura Mach ín Beatriz Tamargo Abel Pi ñón Regla C. At íes Ram ón Scull William N. Setzer Lianet Monzote Tags: Article Source Type: research
Neuroprotective and Anti-Obesity Effects of Tocotrienols.
Authors: Fukui K
Abstract
Vitamin E is a natural lipophilic vitamin, and the most famous function of vitamin E is an antioxidant activity. Because we have α-tocopherol transfer protein, many vitamin E-related reports are about α-tocopherol. Recently, other vitamin E isoforms, tocotrienols are focusing. Because tocotrienols have unique biological functions such as induction of apoptosis, neuroprotective and anti-obesity effects. Tocotrienols contain in annatto, palm, whole wheat and rice bran. Rice is a typical food in the East Asian countries and Japan. Recently, intake of whole rice is a popular in youn...
Source: Journal of Nutritional Science and Vitaminology - October 18, 2019 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research
Antinociceptive and Anti-Inflammatory Effects of Bixin, a Carotenoid Extracted from the Seeds of Bixa orellana
This study validates the use of bixin as an anti-inflammatory trough mechanism related to the reduction of neutrophil migration. Furthermore, this is the first report showing the antinociceptive property of bixin, which does not appear to be related to the sedative effect. Further studies are necessary to characterize the mechanisms involved in these effects. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - September 22, 2019 Category: Drugs & Pharmacology Authors: Pacheco, Samanta Daliana Golin Gasparin, Alexia Thamara Jesus, Carlos Henrique Alves Sotomaior, Bruna Bittencourt Ventura, Ana Clara Sans Salom ão Brunow Redivo, Daiany Darlly Belo Cabrini, Daniela de Almeida Gaspari Dias, Josiane de F átima Miguel, Mar Tags: Original Papers Source Type: research
IJERPH, Vol. 16, Pages 3313: The Effects of Tocotrienol on Bone Peptides in a Rat Model of Osteoporosis Induced by Metabolic Syndrome: The Possible Communication between Bone Cells
In conclusion, tocotrienol exerts potential skeletal-promoting benefit by modulating the levels of osteocytes-derived bone-related peptides. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - September 8, 2019 Category: Environmental Health Authors: Sok Kuan Wong Kok-Yong Chin Soelaiman Ima-Nirwana Tags: Article Source Type: research
IJERPH, Vol. 16, Pages 2897: The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate
In conclusion, annatto tocotrienol may potentially retard the progression of osteoarthritis. Future studies to confirm its mechanism of joint protection should be performed. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - August 12, 2019 Category: Environmental Health Authors: Kok-Yong Chin Sok Kuan Wong Fadhlullah Zuhair Japar Sidik Juliana Abdul Hamid Nurul Hafizah Abas Elvy Suhana Mohd Ramli Sabarul Afian Mokhtar Sakthiswary Rajalingham Soelaiman Ima Nirwana Tags: Article Source Type: research
The effects of photodynamic therapy with blue light and papain-based gel associated with Urucum, on collagen and fibroblasts: a spectroscopic and cytotoxicity analysis
AbstractPapacarie Duo ™ is clinically used and has proven effectiveness; however, it is necessary to improve its antimicrobial action. The combined treatment of Papacarie Duo™ with Urucum (Bixa Orellana) could create a potential tool for dental caries treatment; its extract obtained from the seeds ’ pericarp contains a water-soluble primary pigment (cis-bixin) with smaller amounts of other carotenoids. The dicarboxylic acid salts of cis-norbixin and trans-norbixin occur in heated alkaline solutions. To analyze the absorption spectra and cytotoxicity (with human dermal fibroblasts) in differ ent concentrations of Uruc...
Source: Lasers in Medical Science - August 11, 2019 Category: Laser Surgery Source Type: research
Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs
Vitamin E δ-tocotrienol (VEDT), a vitamin E compound isolated from sources such as palm fruit and annatto beans, has been reported to have cancer chemopreventive and therapeutic effects. (Source: Cancer Cell International)
Source: Cancer Cell International - July 22, 2019 Category: Cancer & Oncology Authors: Rony A. Francois, Anying Zhang, Kazim Husain, Chen Wang, Sean Hutchinson, Michael Kongnyuy, Surinder K. Batra, Domenico Coppola, Said M. Sebti and Mokenge P. Malafa Tags: Primary research Source Type: research
Irradiance and light quality affect two annatto (Bixa orellana L.) cultivars with contrasting bixin production
Publication date: Available online 4 July 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Daniele Vidal Faria, Ludmila Nayara de Freitas Correia, Maria Victoria Costa de Souza, Anyela Marcela Ríos Ríos, Camilo Elber Vital, Diego Silva Batista, Marcio Gilberto Cardoso Costa, Wagner Campos OtoniAbstractLight is a key factor influencing growth and development in plants. Specific irradiance and light quality can improve development and production of secondary compounds such as carotenoids during plant tissue culture. Bixin and norbixin, two apocarotenoids obtained from the seeds of Bixa orellana L...
Source: Journal of Photochemistry and Photobiology B: Biology - July 5, 2019 Category: Speech-Language Pathology Source Type: research
Antioxidants from Annatto Seeds as Possible Inhibitory Agents of the Hepatotoxicity Induced by the Antitumor Agent Cisplatin.
Authors: Souza LF, Medeiros NDS, Dos Santos PCP, Pagno CH, Nora CD, de Jong EV, de Oliveira Rios A
Abstract
The effects of annatto seeds and of bixin on the oxidative damage induced by cisplatin in male Wistar rats was evaluated in the present study by way of lipid peroxidation, weight gain, the food efficiency coefficient, fat deposits in the hepatocytes and dosing of the enzymes in this organ. The animals were divided into four groups: control group (CG), cisplatin group (CPG), bixin+cisplatin group (CBG) and annatto+cisplatin group (CUG). Cisplatin (5 mg/kg body weight) was injected intraperitoneally 48...
Source: Natural Product Communications - June 9, 2019 Category: Biochemistry Tags: Nat Prod Commun Source Type: research
Selective extraction of bioactive compounds from annatto seeds by sequential supercritical CO2 process
Publication date: Available online 23 April 2019Source: The Journal of Supercritical FluidsAuthor(s): Renata Vardanega, Gislaine C. Nogueira, Carla D.O. Nascimento, Adelia F. Faria-Machado, M. Angela A. MeirelesAbstractThe present work proposed a two-step sequential scCO2 extraction process to selectively extract the main bioactive compounds from annatto seeds, geranylgeraniol and tocols, aiming to diversify and to improve the added-value of annatto seeds products. Firstly, pressure (10, 17, 24 and 31 MPa) and temperature (40 and 60 °C) conditions resulting CO2 densities ranging from 290 kg/m3 to 915 kg/m3 were in...
Source: The Journal of Supercritical Fluids - April 25, 2019 Category: Chemistry Source Type: research
Biodegradable antioxidant chitosan films useful as an anti-aging skin mask.
Abstract
Cosmetics, personal care and biomedical products obtained by bio-based polymers and natural bioactive compounds are a new growing market. The ecological awareness is changing consumers' demands, causing consumers to look for more sustainable options, with a reduced environmental impact. The innovation of this work was to develop a natural polymer matrix (chitosan) entrapping antioxidant actives compounds such as annatto (Bixa Orellana L.) and vitamin C with potential application as sustainable anti-aging skin mask treatment. Films of chitosan (Ch) and reacetylated chitosan (RCh), exhibiting differ...
Source: International Journal of Biological Macromolecules - April 9, 2019 Category: Biochemistry Authors: Afonso CR, Hirano RS, Gaspar AL, Chagas EGL, Carvalho RA, Silva FV, Leonardi GR, Lopes PS, Silva CF, Yoshida CMP Tags: Int J Biol Macromol Source Type: research
Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu2+-Induced Oxidation Ex Vivo.
Authors: Conte L, Somacal S, Nichelle SM, Rampelotto C, Robalo SS, Roehrs M, Emanuelli T
Abstract
Lycopene-based medications and supplements have been developed to prevent atherosclerosis, primarily because of their ability to decrease low-density lipoprotein (LDL) oxidation. Bixin and norbixin are carotenoids found in the seeds of annatto (Bixa orellana) and are colorants widely used by the food industry. Some studies have already demonstrated that these compounds have antioxidant and antiatherogenic potential in vitro and in animal models, but there is no evidence supporting the effects of their long-ter...
Source: Journal of Nutrition and Metabolism - April 6, 2019 Category: Nutrition Tags: J Nutr Metab Source Type: research
Annatto (Bixa orellana) δ-TCT supplementation protected against embryonic DNA damages through alterations in PI3K/ Akt-Cyclin D1 pathway.
Authors: Syairah Mohd Mutalip S, Hamim Rajikin M, Ab Rahim S, Mohamed Noor Khan N
Abstract
Protective action by annatto-derived delta-tocotrienol (δ-TCT) and soy-derived alpha-tocopherol (α-TOC) through the regulation of PI3K/Akt-Cyclin D1 pathway against the nicotine-induced DNA damages is the focus of the present study. Nicotine, which has been widely reported to have numerous adverse effects on the reproductive system, was used as reproductive toxicant. 48 female balb/c mice (6-8 weeks) (23-25 g) were randomly divided into 8 groups (G1-G8; n = 6) and treated with either nicotine or/and annatto δ-TCT/...
Source: International Journal for Vitamin and Nutrition Research - March 27, 2019 Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
