A 12-week evaluation of annatto tocotrienol supplementation for postmenopausal women: safety, quality of life, body composition, physical activity, and nutrient intake
This study was to evaluate the safety of a 12-week supplem... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - June 28, 2018 Category: Complementary Medicine Authors: Chwan-Li Shen, Shu Wang, Shengping Yang, Michael D. Tomison, Mehrnaz Abbasi, Lei Hao, Sheyenne Scott, Md Shahjalal Khan, Amanda W. Romero, Carol K. Felton and Huanbiao Mo Tags: Research article Source Type: research
Identifying Potential Therapeutics for Osteoporosis by Exploiting the Relationship between Mevalonate Pathway and Bone Metabolism.
CONCLUSION: mevalonate pathway can be exploited to develop effective antiosteoporosis agents.
PMID: 29683099 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 25, 2018 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Preparation of aqueous nanodispersions with annatto (Bixa orellana L.) extract using an organic solvent-free and low energy method
Publication date: 15 August 2018 Source:Food Chemistry, Volume 257 Author(s): Antônio P.R. Bitencourt, Jonatas L. Duarte, Anna E.M.F.M. Oliveira, Rodrigo A.S. Cruz, José C.T. Carvalho, Antônio T.A. Gomes, Irlon M. Ferreira, Roseane M. Ribeiro-Costa, José O.C. Silva-Júnior, Caio P. Fernandes The seeds of Bixa orellana L. is widely used in food industry as a natural colorant. A major technological challenge for its utilization on aqueous food products is the low water solubility. Therefore, the present study aimed to obtain aqueous nanodispersions using this natural raw material by using a simple organic sol...
Source: Food Chemistry - March 11, 2018 Category: Food Science Source Type: research
Annatto-entrapped casein-chitosan complexes improve whey color quality after acid coagulation of milk
In this study, casein-chitosan complexes were prepared to deliver annatto preferentially to the curd and reduce the amount of carryover colorant in whey powder. These complexes were relatively spherical, with a mean complex diameter of 8.3 ± 1.9 µm, zeta-potential of +39.4 ± 1.3 mV, and entrapment efficiency of 38.2 ± 3.1%. FT-IR spectroscopy confirmed the electrostatic interaction between casein and chitosan. Complexes and commercial annatto powder were incorporated into homogenized, reduced-fat, and fat-free milk, and subjected to acid coagulation. Whey powder produced from casein-chitosan-complex-tre...
Source: Food Chemistry - February 23, 2018 Category: Food Science Source Type: research
Tocotrienol supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: a 12-week randomized double-blinded placebo-controlled trial
ConclusionsTwelve-week annatto-extracted TT supplementation decreased bone resorption and improved bone turnover rate via suppressing bone remodeling regulators in postmenopausal women with osteopenia. Such osteoprotective TT ’s effects may be, in part, mediated by an inhibition of oxidative stress.Trial registrationClinicalTrials.gov identifier: NCT02058420. Title: Tocotrienols and bone health of postmenopausal women. (Source: Osteoporosis International)
Source: Osteoporosis International - January 12, 2018 Category: Orthopaedics Source Type: research
Stability and Antioxidant Activity of Annatto (Bixa orellana L.) Tocotrienols During Frying and in Fried Tortilla Chips
The objectives were to evaluate their stability during frying, absorption by the fried food, and activity as antioxidants in frying oil and in tortilla chips during storage. AnT3 did not significantly affect the stability of the oil during frying or the sensory profiles of freshly fried chips. The naturally present α‐tocopherol (α‐T) in the oil degraded at a lower rate in the presence of AnT3, resulting in significantly higher α‐T by the end of the frying study. Levels of tocopherols and tocotrienols in the chips mirrored oil levels. AnT3 did not affect the sensory profile of the chips after 1 wk of storage at 50 ...
Source: Journal of Food Science - January 1, 2018 Category: Food Science Authors: Jill K. Winkler ‐Moser, Erica L. Bakota, Hong‐Sik Hwang Tags: Food Chemistry Source Type: research
Combination Effect of δ-Tocotrienol and γ-Tocopherol on Prostate Cancer Cell Growth.
In this study the effect of combined δ-T3 (annatto T3 oil) and γ-Toc (Tmix, γ-Toc-rich oil) therapy was assessed against human androgen-dependent prostate cancer cells (LNCaP). We found that combined treatment of δ-T3 (10 μM) and γ-Toc (5 μM) resulted in reinforced anti-prostate cancer activity. Specifically, cell cycle phase distribution analysis revealed that in addition to G1 arrest caused by the treatment with δ-T3, the combination of δ-T3 with γ-Toc induced G2/M arrest. Enhanced induction of apoptosis by the combined treatment was also observed. These findings indicate that combination of δ-T3 and γ-Toc si...
Source: Journal of Nutritional Science and Vitaminology - December 13, 2017 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research
Effect of UV radiation and its implications on carotenoid pathway in Bixa orellana L.
Publication date: Available online 2 October 2017 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): M. Sankari, H. Hridya, P. Sneha, C. George Priya Doss, Siva Ramamoorthy The current study was undertaken to analyse the effect of short-term UV-B and UV-C radiations in provoking carotenoid biosynthesis in Bixa orellana. Seeds of B. orellana were germinated and exposed to the short term UV pre-treatment under controlled environmental condition for 5days. The UV treated young seedlings response in pigment contents; antioxidant enzyme activity and mRNA gene expression level were analysed. The pigme...
Source: Journal of Photochemistry and Photobiology B: Biology - October 3, 2017 Category: Speech-Language Pathology Source Type: research
Supplementation with tocotrienols from Bixa orellana improves the in vivo efficacy of daptomycin against methicillin-resistant Staphylococcus aureus in a mouse model of infected wound
Conclusion These data suggest that treatment with T3s may be useful for the management of infected wounds as immune adjuvants in combination with DAP. (Source: Phytomedicine)
Source: Phytomedicine - September 28, 2017 Category: Drugs & Pharmacology Source Type: research
Phase behaviour and mathematical modelling for the system annatto seed oil in compressed carbon dioxide+ethanol as co-solvent
Publication date: December 2017 Source:The Journal of Supercritical Fluids, Volume 130 Author(s): Renata Vardanega, Irede A. Dalmolin, Gislaine C. Nogueira, Tahmasb Hatami, M. Angela A. Meireles This work reports phase equilibrium experimental data (cloud points) for the system annatto seed oil in compressed carbon dioxide+ethanol as co-solvent. The oil was obtained by supercritical fluid extraction at 40°C and 20MPa using carbon dioxide as solvent. The synthetic static method was employed for the measurements, which were carried out in a temperature range from 25 to 60°C and up to 19.32MPa. The experiments were c...
Source: The Journal of Supercritical Fluids - August 5, 2017 Category: Chemistry Source Type: research
Obtaining bixin from semi-defatted annatto seeds by a mechanical method and solvent extraction: Process integration and economic evaluation
Publication date: September 2017 Source:Food Research International, Volume 99, Part 1 Author(s): Sylvia C. Alcázar-Alay, J. Felipe Osorio-Tobón, Tânia Forster-Carneiro, M. Angela A. Meireles This work involves the application of physical separation methods to concentrate the pigment of semi-defatted annatto seeds, a noble vegetal biomass rich in bixin pigments. Semi-defatted annatto seeds are the residue produced after the extraction of the lipid fraction from annatto seeds using supercritical fluid extraction (SFE). Semi-defatted annatto seeds are use in this work due to three important reasons: i) previous lipi...
Source: Food Research International - August 5, 2017 Category: Food Science Source Type: research
Annatto carotenoids attenuate oxidative stress and inflammatory response after high-calorie meal in healthy subjects
Publication date: Available online 3 August 2017 Source:Food Research International Author(s): Miguel Roehrs, Lisiane Conte, Dariane Trivisiol da Silva, Thiago Duarte, Luana Haselein Maurer, José Antonio Mainardi, Rafael Noal Moresco, Sabrina Somacal, Tatiana Emanuelli The aim of this study was to evaluate the effect of annatto carotenoids intake associated to a single high-calorie meal (high fat and high carbohydrate) in postprandial biochemical, inflammatory and oxidative stress markers. Twelve healthy subjects (6 men, 6 women) were included in this randomised, controlled crossover study. Baseline blood sampl...
Source: Food Research International - August 3, 2017 Category: Food Science Source Type: research
Cover Image, Volume 118, Number 9, September 2017
Cover: The cover image, by R. Priya et al., is based on the Article Molecular Modeling and Dynamic Simulation of Arabidopsis Thaliana Carotenoid Cleavage Dioxygenase Gene: A Comparison with Bixa orellana and Crocus Sativus, DOI: 10.1002/jcb.25919. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - July 13, 2017 Category: Biochemistry Authors: R. Priya, P. Sneha, Renata Rivera Madrid, C.George Priya Doss, Pooja Singh, Ramamoorthy Siva Tags: Cover Source Type: research
Bixin ameliorates high fat diet-induced cardiac injury in mice through inflammation and oxidative stress suppression.
Abstract
Diabetic cardiomyopathy is known as an essential complication of diabetes, a main reason leading to mortality for diabetic patients, and novel therapeutic strategies for treatment are urgently required. Bixin (BX), isolated from the seeds of Bixa orellana, is a carotenoid, possessing anti-inflammatory, anti-tumor and anti-oxidant activities. In our study, we attempted to calculate the role of bixin in cardiac injury progression, and reveal the possible molecular mechanism. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) ge...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 10, 2017 Category: Drugs & Pharmacology Authors: Xu Z, Kong XQ Tags: Biomed Pharmacother Source Type: research
Molecular Modeling and Dynamic Simulation of Arabidopsis thaliana Carotenoid Cleavage Dioxygenase Gene: A Comparison with Bixa orellana and Crocus sativus
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - February 1, 2017 Category: Biochemistry Authors: Priya R, Sneha P, Renata Rivera Madrid, George Priya Doss C, Pooja Singh, Siva Ramamoorthy Tags: Article Source Type: research
