Longitudinal evaluation of multiple biomarkers for the detection of testosterone gel administration in women with normal menstrual cycle
In this study, the sensitivity of the current urinary and haematological markers of the Athlete Biological Passport (ABP), as well as serum steroid biomarkers, was investigated for the monitoring of a 28 ‐day T gel treatment combined with endogenous fluctuation of the menstrual cycle in 14 healthy female subjects. Additionally, the analysis of urinary target compounds was performed on a subset of samples for endogenous/exogenous origin via isotope ratio mass spectrometry (IRMS). In serum, concentr ations of T and dihydrotestosterone (DHT) increased significantly during the treatment, whereas in urine matrix the most affe...
Source: Drug Testing and Analysis - April 14, 2021 Category: Drugs & Pharmacology Authors: Olivier Salamin,
Raul Nicoli,
Tobias Langer,
Julien Boccard,
Carine Schweizer Grundisch,
Cheng Xu,
Serge Rudaz,
Tiia Kuuranne,
Nelly Pitteloud,
Martial Saugy Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research
Longitudinal evaluation of multiple biomarkers for the detection of testosterone gel administration in women with normal menstrual cycle
In this study, the sensitivity of the current urinary and haematological markers of the Athlete Biological Passport (ABP), as well as serum steroid biomarkers was investigated for the monitoring of a 28 ‐days T gel treatment combined with endogenous fluctuation of the menstrual cycle in 14 healthy female subjects. Additionally, the analysis of urinary target compounds was performed on a subset of samples for endogenous/exogenous origin via isotope ratio mass spectrometry (IRMS). In serum, concent rations of T and dihydrotestosterone (DHT) increased significantly during the treatment, whereas in urine matrix the most affe...
Source: Drug Testing and Analysis - April 5, 2021 Category: Drugs & Pharmacology Authors: Olivier Salamin,
Raul Nicoli,
Tobias Langer,
Julien Boccard,
Carine Schweizer Grundisch,
Cheng Xu,
Serge Rudaz,
Tiia Kuuranne,
Nelly Pitteloud,
Martial Saugy Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research
A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102
ConclusionThe doses of testosterone supplementation used in this study did not significantly improve AIMSS.Trial registrationClinicalTrials.gov Identifier: NCT01573442 (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - November 25, 2020 Category: Cancer & Oncology Source Type: research
Onset of vitiligo in a patient with acquired secondary hypogonadism under treatment with testosterone gel 2%: inside the pathogenesis,
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
A cross-sectional comparison of secondary polycythemia in testosterone-deficient men treated with nasal testosterone gel vs. intramuscular testosterone cypionate.
CONCLUSIONS: The prevalence of polycythemia in men treated with Natesto was markedly lower compared to the men who received TC therapy.
PMID: 32744998 [PubMed - as supplied by publisher] (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - July 26, 2020 Category: Urology & Nephrology Authors: Best JC, Gonzalez D, Masterson TA, Blachman-Braun R, Pai R, Ramasamy R Tags: Can Urol Assoc J Source Type: research
New testosterone 2% gel using Ferring Advanced Skin Technology (FAST), for the treatment of testosterone deficiency in men, with a novel applicator.
Authors: Kirby M, Kalhan A, Hackett G
Abstract
INTRODUCTION: Testosterone deficiency (TD) is an increasing problem that can affect a man's physical and psychological health, and quality of life. Testosterone replacement therapy (TRT), combined with weight reduction, lifestyle advice, and the treatment of co-morbidities, is the treatment of choice in men who are not concerned about fertility. However, there remains an unmet need in this therapeutic area, relating to factors such as inconvenient or painful administration, fluctuations in testosterone levels, supra-physiologic testosterone levels, poor tolera...
Source: Expert Review of Endocrinology and Metabolism - June 21, 2020 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Development and validation of a fast gas chromatography combustion isotope ratio mass spectrometry method for the detection of epiandrosterone sulfate in urine
AbstractIn doping control, to confirm the exogenous origin of exogenously administered anabolic androgenic steroids (AAS), a gas chromatography combustion isotope ratio mass spectrometry (GC ‐C‐IRMS) analysis is performed. Recently published work suggests epiandrosterone sulfate (EpiAS) as a promising IRMS target compound for the detection of AAS, capable of prolonging the detection window. However, EpiAS is only excreted in urine in its sulfoconjugated form while all other IRMS tar get compounds are excreted glucuronidated, meaning that EpiAS cannot be incorporated in the existing IRMS methods. A separate extensive sa...
Source: Drug Testing and Analysis - April 7, 2020 Category: Drugs & Pharmacology Authors: Laurie De Wilde,
Pieter Van Renterghem,
Peter Van Eenoo,
Micha ël Polet Tags: RESEARCH ARTICLE Source Type: research
The role of testosterone in menopausal hormone treatment. What is the evidence?
AbstractAbout 40% of postmenopausal women have decreased sexual desire causing distress. Estrogen therapy attenuates vaginal complaints, but has no effect on sexual desire. Although sexual function has been linked to testosterone, there is no clear relation between sexual desire and circulating levels of testosterone. Nevertheless, treatment with transdermal (patch) testosterone improved sexual function in several randomized controlled trials. Women with hypoactive sexual desire disorder who were treated with testosterone reported more satisfying sexual episodes and sexual desire compared with the placebo group. Adverse ef...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Nora Johansen,
Angelica Lind én Hirschberg,
Mette Haase Moen Tags: COMMENTARY Source Type: research
Single dose testosterone administration increases impulsivity in the intertemporal choice task among healthy males.
Abstract
Circulating levels of testosterone have been positively associated with impulsivity. The present study investigates the effect of testosterone administration on impulsivity in an intertemporal choice task, where participants are given a choice between smaller-sooner rewards and larger-later rewards. Healthy young male participants (n = 111) received a single-dose of 150 mg testosterone gel in a double-blind, placebo-controlled, between-subjects design. At 180 min post-administration, participants performed the decision-making task. Both model-free (i.e., higher indifference point) and mode...
Source: Hormones and Behavior - November 21, 2019 Category: Endocrinology Authors: Wu Y, Shen B, Liao J, Li Y, Zilioli S, Li H Tags: Horm Behav Source Type: research
Effects of transdermal administration of testosterone gel on the urinary steroid profile in hypogonadal men: implications in antidoping analysis
Publication date: Available online 6 September 2019Source: SteroidsAuthor(s): Michele Iannone, Amelia Palermo, Xavier de la Torre, Francesco Romanelli, Andrea Sansone, Massimiliano Sansone, Andrea Lenzi, Francesco BotrèAbstractTestosterone is one of the most abused pseudo-endogenous anabolic steroids in sport doping. The current method adopted to detect the abuse of testosterone and other pseudo-endogenous steroids (endogenous steroids when administered exogenously) is first based on the longitudinal monitoring of several urinary biomarkers, which constitute the so called “steroidal module” of the Athlete Biological P...
Source: Steroids - September 7, 2019 Category: Drugs & Pharmacology Source Type: research
Open-label phase IV clinical trial to evaluate the effect of nasal testosterone gel on reproductive hormones and semen parameters in hypogonadal men
Low testosterone (low T) affects around 12% of men under age of 40 and prescriptions for testosterone replacement therapy (TRT) to men of reproductive age are increasing. Unfortunately, most commonly prescribed TRT as gels, patches, injections and pellets are long-acting and can cause azoospermia in up to 65% of men. Therefore, it is imperative to identify an option for increasing T while minimizing effects on semen parameters. Natesto ® (125 uL/nostril, 11.0 mg testosterone/dose, three times a day (TID)) is a short-acting, FDA approved nasal TRT available since 2015. (Source: Fertility and Sterility)
Source: Fertility and Sterility - August 31, 2019 Category: Reproduction Medicine Authors: Thomas A. Masterson, Joshua N. Bitran, Manuel Molina, Emad Ibrahim, Ursula Kaiser, Ranjith Ramasamy Tags: Late-Breaking 1 Source Type: research
The effectiveness of transdermal testosterone gel 1% (androgel) for poor responders undergoing in vitro fertilization
To investigate the effectiveness of treatment with transdermal testosterone gel(TTG) 1%(androgel) before ovarian stimulation (COS) using GnRH antagonist in low responders undergoing IVF/intracytoplasmic sperm injection (ICCSI)s. (Source: Fertility and Sterility)
Source: Fertility and Sterility - August 31, 2019 Category: Reproduction Medicine Authors: Anjali Chaudhary Tags: Poster session Source Type: research
Individualization of custom compounded hormone therapy in a patient with chemotherapy induced premature ovarian insufficiency and impaired liver function - case report.
In conclusion, custom compound HT has the possibility of tailoring and adjusting therapy to the individual need, which has been the everlasting goal in menopause medicine and should be a good option for special clinical cases.
PMID: 31363339 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - August 2, 2019 Category: General Medicine Tags: Acta Clin Croat Source Type: research
Monitoring testosterone replacement therapy with transdermal gel: when and how?
ConclusionAssessment of TRT with transdermal gels at its peak and at its minimum could be useful in providing a finely tailored treatment for hypogonadal men, both preventing supra-physiological levels and maintaining adequate concentrations through the day. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 1, 2019 Category: Endocrinology Source Type: research
