Diabetes insipidus, bone lesions, and new-onset red-brown papules in a 42-year-old man
A 42-year old Caucasian man was referred to the National Institutes of Health (NIH) for evaluation. His symptoms began approximately 10 years before referral with pituitary dysfunction that manifested as diabetes insipidus, secondary hypogonadism, and hyperprolactinemia, treated with desmopressin and testosterone gel. Eight years later, he began to experience vertigo, dizziness, diplopia, and difficulty focusing and tracking. This was followed by progressive left-sided weakness, poor coordination, and balance difficulties. Magnetic resonance imaging without contrast revealed multiple nonspecific white-matter lesions. Subse...
Source: Journal of the American Academy of Dermatology - March 4, 2013 Category: Dermatology Authors: Rachel I. Kornik, Haley B. Naik, Chyi-Chia Richard Lee, Juvianee Estrada-Veras, William A. Gahl, Edward W. Cowen Tags: Dermatology Grand Rounds at the NIH Source Type: research
Pharmacokinetics of testosterone and estradiol gel preparations in healthy young men
We report here, for the first time, pharmacokinetic data on both high dose testosterone and estradiol gel application in healthy young males. The proposed model will assist in the design of future studies that seek to establish causality between testosterone and estradiol gel administration and behavioral as well as neurophysiological effects. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - January 28, 2013 Category: Psychiatry Authors: Christoph Eisenegger, Arnold von Eckardstein, Ernst Fehr, Sigrid von Eckardstein Tags: Articles Source Type: research
Testosterone Replacement with 1% Testosterone Gel and Priapism: No Definite Risk Relationship
ConclusionsSafety data from the clinical trials for AndroGel 1% did not report any cases of priapism, and its incidence in the postmarketing pharmacovigilance data is extremely low, indicating a minimal risk of inducing priapism. (Source: The Journal of Sexual Medicine)
Source: The Journal of Sexual Medicine - January 24, 2013 Category: Sexual Medicine Authors: Arthur L. Burnett, Natalia KanâDobrosky, Michael G. Miller Tags: ORIGINAL RESEARCH Source Type: research
Spuriously elevated testosterone measurements caused by application of testosterone gel at or near the phlebotomy site.
CONCLUSIONS: The application of testosterone gel at or near the site of venipuncture can markedly increase the measured serum testosterone concentration.
PMID: 23324503 [PubMed - in process] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 1, 2013 Category: Drugs & Pharmacology Authors: Kirk D, Misita C Tags: Ann Pharmacother Source Type: research
