Sensitivity of doping biomarkers after administration of a single dose testosterone gel
Drug Testing and Analysis, EarlyView. (Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - December 28, 2017 Category: Drugs & Pharmacology Authors: JennyMullen
,
AnnicaB örjesson
,
OscarHopcraft
,
Jenny J.Schulze
,
MagnusEricsson
,
AndersRane
,
MikaelLehtihet
,
LenaEkström Source Type: research
The Effect of Testosterone on Cardiovacular Biomarkers in the Testosterone Trials.
Conclusions and Relevance: Testosterone treatment for one year of older men with low testosterone was associated with small reductions in cholesterol and insulin but not with other glucose markers or markers of inflammation or fibrinolysis or with troponin. The clinical importance of these findings is unclear and requires a larger trial of clinical outcomes.
PMID: 29253154 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 14, 2017 Category: Endocrinology Authors: Mohler ER, Ellenberg SS, Lewis CE, Wenger NK, Budoff MJ, Lewis MR, Barrett-Connor E, Swerdloff RS, Stephens-Shields A, Bhasin S, Cauley JA, Crandall JP, Cunningham GR, Ensrud KE, Gill TM, Matsumoto AM, Molitch ME, Pahor M, Preston PE, Hou X, Cifelli D, Sn Tags: J Clin Endocrinol Metab Source Type: research
Sensitivity of doping biomarkers after administration of a single dose testosterone gel
In this study, we investigated the detectability of a single dose of 100 mg T gel in 8 healthy male subjects. We also studied which biomarkers were most sensitive to T gel administration, including blood biomarkers. The ABP successfully detected T gel administration in all 8 subjects. The most sensitive ratio was 5αAdiol/E, however, also T/E and 5αAdiol/5βAdiol showed atypical findings. IRMS was performed on 5 subjects and only two met all the criteria for a positive test according to the rules set by WADA. The other three showed inconclusive results. Other markers that were affected by T gel administration, not used fo...
Source: Drug Testing and Analysis - November 18, 2017 Category: Drugs & Pharmacology Authors: Jenny Mullen, Annica B örjesson, Oscar Hopcraft, Jenny J. Schulze, Magnus Ericsson, Anders Rane, Mikael Lehtihet, Lena Ekström Tags: RESEARCH ARTICLE Source Type: research
Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men
Male hypogonadism results in changes in body composition characterized by increases in fat mass. Resident immune cells influence energy metabolism in adipose tissue and could promote increased adiposity through paracrine effects. We hypothesized that manipulation of circulating sex steroid levels in healthy men would alter adipose tissue immune cell populations. Subjects (n = 44 men, 19–55 yr of age) received 4 wk of treatment with the gonadotropin-releasing hormone receptor antagonist acyline with daily administration of 1) placebo gel, 2) 1.25 g testosterone gel (1.62%), 3) 5 g testosterone gel, or 4) 5 g testoster...
Source: AJP: Endocrinology and Metabolism - November 1, 2017 Category: Endocrinology Authors: Rubinow, K. B., Chao, J. H., Hagman, D., Kratz, M., Van Yserloo, B., Gaikwad, N. W., Amory, J. K., Page, S. T. Tags: Research Article Source Type: research
Testosterone therapy preserves muscle strength and power in aging men with type 2 diabetes —a randomized controlled trial
Summary
The purpose of the study was to evaluate whether testosterone replacement therapy improves muscle mechanical and physical function in addition to increasing lean leg mass and total lean body mass in aging men with type 2 diabetes and lowered bio‐available testosterone (BioT) levels. Thirty‐nine men aged 50–70 years with type 2 diabetes and BioT levels <7.3 nmol/L were included from an academic tertiary‐care medical center. Patients were randomized to testosterone gel (testosterone replacement therapy, n = 20) or placebo (n = 19) for 24 weeks, applying a double‐blinded design. Muscle mechanical f...
Source: Andrology - September 15, 2017 Category: Urology & Nephrology Authors: L. V. Magnussen, L. G. Hvid, A. P. Hermann, D. M. Hougaard, B. Gram, P. Caserotti, M. S. Andersen Tags: Original Article Source Type: research
Circulating Sex Steroids Co-regulate Adipose Tissue Immune Cell Populations in Healthy Men.
Abstract
Male hypogonadism results in changes in body composition characterized by increases in fat mass. Resident immune cells influence energy metabolism in adipose tissue and could promote increased adiposity through paracrine effects. We hypothesized that manipulation of circulating sex steroid levels in healthy men would alter adipose tissue immune cell populations. Subjects (n=44 men, 19-55 years of age) received 4 weeks of treatment with the GnRH receptor antagonist acyline with daily administration of 1) placebo gel, 2) 1.25g testosterone gel (1.62%), 3) 5g testosterone gel, or 4) 5g testosterone g...
Source: American Journal of Physiology. Endocrinology and Metabolism - July 11, 2017 Category: Physiology Authors: Rubinow KB, Chao J, Hagman D, Kratz M, Van Yserloo B, Gaikwad NW, Amory JK, Page ST Tags: Am J Physiol Endocrinol Metab Source Type: research
Use of testosterone gel compared to intramuscular formulation for puberty induction in males with constitutional delay of growth and puberty: a preliminary study
ConclusionsTo our knowledge this is the first study on use of TTG for pubertal activation on CDGP population. Our preliminary data confirm the efficacy of short-term Testosterone gel treatment to induce puberty compared to conventional treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 10, 2017 Category: Endocrinology Source Type: research
The effectiveness of transdermal testosterone gel 1% (androgel) for poor responders undergoing in vitro fertilization
. (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - May 31, 2017 Category: Endocrinology Authors: Hang Thi Doan Lam Hoang Quan Tung Thanh Nguyen Source Type: research
Effects of testosterone therapy on BMI, blood pressure, and laboratory profile of transgender men: a systematic review
In conclusion, exogenous testosterone administration to transgender men was associated with modest increases in BMI, hemoglobin/hematocrit, and LDL‐cholesterol, and with decreases in HDL‐cholesterol. Long‐term studies are needed to assess the long‐term risks of testosterone therapy, particularly as they relate to cardiometabolic risks such as diabetes, dyslipidemia and the metabolic syndrome. (Source: Andrology)
Source: Andrology - May 1, 2017 Category: Urology & Nephrology Authors: I. Velho, T. M. Fighera, P. K. Ziegelmann, P. M. Spritzer Tags: Original Article Source Type: research
Dose ‐response effects of sex hormone concentrations on body composition and adipokines in medically castrated healthy men administered graded doses of testosterone gel
ConclusionsIn healthy men higher serum concentrations of T, DHT and E2 were associated with greater increases in lean mass and decreases in fat mass but not with changes in serum glucose, insulin, or adipokinesThis article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - March 30, 2017 Category: Endocrinology Authors: Arthi Thirumalai, Katya B. Rubinow, Lori A. Cooper, John K. Amory, Brett T. Marck, Alvin M. Matsumoto, Stephanie T. Page Tags: Original Article Source Type: research
Efficacy and safety of testosterone replacement gel for treating hypogonadism in men: Phase III open ‐label studies
Summary
Efficacy and safety of testosterone gel 2% (TG) were evaluated in two phase 3, open‐labelled, single‐arm, multicentre studies (000023 and extension study 000077). Hypogonadal men having serum testosterone levels <300 ng/dl at two consecutive measurements were included. Study duration was 9 months (000023: 3 months; 000077: 6 months). Starting dose of TG (46 mg) was applied on upper arm/shoulder. The primary endpoint (000023) was responder rate (subjects with average 24‐hour serum testosterone concentration 300‐1050 ng/dl on Day 90). Study 000077 evaluated the safety of TG in patients rolling over f...
Source: Andrologia - March 9, 2017 Category: Urology & Nephrology Authors: L. Belkoff, G. Brock, D. Carrara, A. Neijber, M. Ando, J. Mitchel Tags: ORIGINAL ARTICLE Source Type: research
Erectile dysfunction in patients with chronic pain treated with opioids.
CONCLUSIONS: Erectile function and quality of sexual life, as well as anxiety, improved in patients treated chronically with opioids after administering andrological treatment. The management of patients with pain should include a review of their sexual health history given the significant emotional impact posed to the patient, the impact on their overall quality of life and its good clinical response to an interdisciplinary treatment.
PMID: 28236471 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - February 27, 2017 Category: Journals (General) Tags: Med Clin (Barc) Source Type: research
Testosterone Treatment and Cognitive Function in Men With Memory Impairment
This randomized trial compares the effects of testosterone gel vs placebo for 12 months on verbal memory and other cognitive functions in older men with low testosterone and age-associated memory impairment. (Source: JAMA)
Source: JAMA - February 21, 2017 Category: Journals (General) Source Type: research
Testosterone Treatment and Coronary Artery Plaque Volume in Men With Low Testosterone
This clinical trial compares the effects of testosterone gel vs placebo for 12 months on noncalcified coronary artery plaque volume in older men with low testosterone. (Source: JAMA)
Source: JAMA - February 21, 2017 Category: Journals (General) Source Type: research
