Effects of Transdermal Testosterone Gel or an Aromatase Inhibitor on serum concentration and pulsatility of Growth Hormone in older men with age-related low Testosterone
Growth hormone is the major regulator of growth and body composition. Pulsatile GH secretion declines exponentially with age. Testosterone replacement is being increasingly offered to older men with age-related low testosterone. Testosterone administration has been shown to stimulate GH secretion. However, little is known about the effect of testosterone aromatization to estradiol on GH pulsatility and its impact on IGF-1 in older men. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 18, 2017 Category: Biomedical Science Authors: Jenny Pena Dias, Johannes D. Veldhuis, Olga Carlson, Michelle Shardell, Chee W. Chia, Denise Melvin, Josephine M. Egan, Shehzad Basaria Source Type: research
Transdermal testosterone gel for induction and continuation of puberty in adolescent boys with hepatic dysfunction
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - December 21, 2016 Category: Endocrinology Source Type: research
Transdermal testosterone gel for induction and continuation of puberty in adolescent boys with hepatic dysfunction
Journal Name: Journal of Pediatric Endocrinology and Metabolism Volume: 30 Issue: 1 Pages: 105-109 (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - December 19, 2016 Category: Endocrinology Source Type: research
Effects of Testosterone Replacement on Electrocardiographic Parameters in Men: Findings from Two Randomized Trials.
CONCLUSION: Testosterone replacement attenuated the age-related increase in QTcF duration in men. The clinical implications of these findings require further investigation.
PMID: 27992261 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 18, 2016 Category: Endocrinology Authors: Gagliano-Jucá T, İçli TB, Pencina KM, Li Z, Tapper J, Huang G, Travison TG, Tsitouras P, Harman SM, Storer TW, Bhasin S, Basaria S Tags: J Clin Endocrinol Metab Source Type: research
Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men.
CONCLUSIONS: Short-term sex steroid withdrawal in healthy men causes adverse changes in body composition. These findings support the role of estradiol as a determinant of adiposity in men.
PMID: 27482750 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 1, 2016 Category: Endocrinology Authors: Chao J, Rubinow KB, Kratz M, Amory JK, Matsumoto AM, Page ST Tags: J Clin Endocrinol Metab Source Type: research
Effect of testosterone on insulin sensitivity, oxidative metabolism and body composition in aging men with type 2 diabetes on metformin monotherapy
Conclusion
TRT in aging men with lowered BioT levels and T2D controlled on metformin monotherapy improved body composition; however, glycaemic control, peripheral insulin sensitivity, EGP and substrate metabolism were unchanged. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - July 11, 2016 Category: Endocrinology Authors: Line V. Magnussen, Dorte Glintborg, Pernille Hermann, David M. Hougaard, Kurt Højlund, Marianne Andersen Tags: ORIGINAL ARTICLE Source Type: research
Effects of long-term testosterone administration on cognition in older men with low or low-to-normal testosterone concentrations: a prespecified secondary analysis of data from the randomised, double-blind, placebo-controlled TEAAM trial
Publication date: Available online 1 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Grace Huang, Whitney Wharton, Shalender Bhasin, S Mitchell Harman, Karol M Pencina, Panayiotis Tsitouras, Zhuoying Li, Kathleen A Hally, Sanjay Asthana, Thomas W Storer, Shehzad Basaria Background The effects of testosterone on cognitive function in older men are incompletely understood. We aimed to establish the effects of long-term testosterone administration on multiple domains of cognitive function in older men with low or low-to-normal testosterone concentrations. Methods We did the ...
Source: The Lancet Diabetes and Endocrinology - July 1, 2016 Category: Endocrinology Source Type: research
Effects of testosterone and estradiol deficiency on vasomotor symptoms in hypogonadal men.
CONCLUSIONS: Estradiol deficiency is the key mediator of VMS in hypogonadal men. At high levels, testosterone may have a suppressive effect.
PMID: 27300575 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - June 13, 2016 Category: Endocrinology Authors: Taylor AP, Lee H, Webb ML, Joffe H, Finkelstein JS Tags: J Clin Endocrinol Metab Source Type: research
Effect of testosterone on insulin sensitivity, oxidative metabolism, and body‐composition in aging men with type 2 diabetes on metformin monotherapy
ConclusionTRT of aging men with lowered BioT‐levels and T2D controlled on metformin monotherapy improved body‐composition; however glycemic control, peripheral insulin‐sensitivity, EGP and substrate metabolism were unchanged.Clinical trial registration number: NCT01560546, www.clinicaltrials.gov (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - May 31, 2016 Category: Endocrinology Authors: L.V. Magnussen, D. Glintborg, P. Hermann, D.M. Hougaard, K. Højlund, M. Andersen Tags: ORIGINAL ARTICLE Source Type: research
Testosterone gel improved sexual function, but not walk distance or fatigue, in older men with low testosterone.
PMID: 27182922 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - May 16, 2016 Category: Internal Medicine Authors: Hamidi O, Montori VM Tags: Ann Intern Med Source Type: research
Transdermal testosterone pretreatment in poor responders undergoing ICSI: a randomized clinical trial
STUDY QUESTION
Does pretreatment with transdermal testosterone increase the number of cumulus-oocyte complexes (COCs) retrieved by more than 1.5 in poor responders undergoing intracytoplasmic sperm injection (ICSI), using recombinant follicle stimulating hormone (FSH) and gonadotrophin releasing hormone agonists (GnRHa)?
SUMMARY ANSWER
Testosterone pretreatment failed to increase the number of COCs by more than 1.5 as compared with no pretreatment in poor responders undergoing ICSI (difference between medians: 0.0, 95% CI: –1.0 to +1.0).
WHAT IS KNOWN ALREADY
Androgens are thought to play an important role in early...
Source: Human Reproduction - April 20, 2016 Category: Reproduction Medicine Authors: Bosdou, J. K., Venetis, C. A., Dafopoulos, K., Zepiridis, L., Chatzimeletiou, K., Anifandis, G., Mitsoli, A., Makedos, A., Messinis, I. E., Tarlatzis, B. C., Kolibianakis, E. M. Tags: Endocrinology Source Type: research
Testosterone Attenuates Age-Related Fall in Aerobic Function in Mobility Limited Older Men with Low Testosterone.
CONCLUSION: Testosterone supplementation in mobility-limited older men increased hemoglobin and attenuated the age-related declines in and θ. Long-term intervention studies are needed to determine the durability of this effect.
PMID: 27050869 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 5, 2016 Category: Endocrinology Authors: Storer TW, Bhasin S, Travison TG, Pencina K, Miciek R, McKinnon J, Basaria S Tags: J Clin Endocrinol Metab Source Type: research
Effects of testosterone replacement on metabolic and inflammatory markers in men with opioid ‐induced androgen deficiency
ConclusionIn this 14‐week trial, testosterone administration in men with opioid‐induced androgen deficiency was not associated with worsening of metabolic and inflammatory markers. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - April 3, 2016 Category: Endocrinology Authors: Grace Huang, Thomas Travison, Marcello Maggio, Robert R. Edwards, Shehzad Basaria Tags: Original Article Source Type: research
Effects of testosterone replacement on metabolic and inflammatory markers in men with opioid‐induced androgen deficiency
ConclusionIn this 14‐week trial, testosterone administration in men with opioid‐induced androgen deficiency was not associated with worsening of metabolic and inflammatory markers. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - April 3, 2016 Category: Endocrinology Authors: Grace Huang, Thomas Travison, Marcello Maggio, Robert R. Edwards, Shehzad Basaria Tags: Original Article Source Type: research
Pd07-08 changes in testicular volume and function after testosterone replacement vs. restoration: analysis of a randomized, double blind, placebo-controlled trial of enclomiphene citrate vs. androgel™ 1.62% in men with secondary hypogonadism
Testicular volume (TV) loss and impaired spermatogenesis are frequently observed after exogenous testosterone (T) replacement. For that reason, selective estrogen receptor modulators (SERM) are used to treat hypogonadal infertile men. The TV changes with SERM or exogenous T replacement have not been prospectively studied. Our objective was to investigate changes in testicular volume, male hormones and seminal parameters in men receiving testosterone gel (Androgel 1.62%, AG) vs. a novel SERM (Enclomiphene citrate, EC) vs. (Source: The Journal of Urology)
Source: The Journal of Urology - March 28, 2016 Category: Urology & Nephrology Authors: Igor Sorokin, Charles Welliver, Paul Feustel, Adam Parker, Jaye Thompson, Greg Fontenot, Ronald Wiehle, Andrew McCullough Tags: Infertility: Therapy II Source Type: research
