Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism
CONCLUSIONS: In middle-aged and older men with hypogonadism and low libido, TRT for two years improved sexual activity, hypogonadal symptoms, and sexual desire, but not erectile function.PMID:37589949 | DOI:10.1210/clinem/dgad484 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 17, 2023 Category: Endocrinology Authors: Karol M Pencina Thomas G Travison Glenn R Cunningham A Michael Lincoff Steven E Nissen Mohit Khera Michael G Miller Panagiotis Flevaris Xue Li Kathleen Wannemuehler Shalender Bhasin Source Type: research
Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism
CONCLUSIONS: In middle-aged and older men with hypogonadism and low libido, TRT for two years improved sexual activity, hypogonadal symptoms, and sexual desire, but not erectile function.PMID:37589949 | DOI:10.1210/clinem/dgad484 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 17, 2023 Category: Endocrinology Authors: Karol M Pencina Thomas G Travison Glenn R Cunningham A Michael Lincoff Steven E Nissen Mohit Khera Michael G Miller Panagiotis Flevaris Xue Li Kathleen Wannemuehler Shalender Bhasin Source Type: research
A new multimodal paradigm for biomarkers longitudinal monitoring: a clinical application to women steroid profiles in urine and blood
Anal Chim Acta. 2023 Aug 1;1267:341389. doi: 10.1016/j.aca.2023.341389. Epub 2023 May 17.ABSTRACTBACKGROUND: Most current state-of-the-art strategies to generate individual adaptive reference ranges are designed to monitor one clinical parameter at a time. An innovative methodology is proposed for the simultaneous longitudinal monitoring of multiple biomarkers. The estimation of individual thresholds is performed by applying a Bayesian modeling strategy to a multivariate score integrating several biomarkers (compound concentration and/or ratio). This multimodal monitoring was applied to data from a clinical study involving...
Source: Analytica Chimica Acta - May 31, 2023 Category: Chemistry Authors: Miguel de Figueiredo Jonas Saugy Martial Saugy Rapha ël Faiss Olivier Salamin Raul Nicoli Tiia Kuuranne Serge Rudaz Francesco Botr è Julien Boccard Source Type: research
A new multimodal paradigm for biomarkers longitudinal monitoring: a clinical application to women steroid profiles in urine and blood
Anal Chim Acta. 2023 Aug 1;1267:341389. doi: 10.1016/j.aca.2023.341389. Epub 2023 May 17.ABSTRACTBACKGROUND: Most current state-of-the-art strategies to generate individual adaptive reference ranges are designed to monitor one clinical parameter at a time. An innovative methodology is proposed for the simultaneous longitudinal monitoring of multiple biomarkers. The estimation of individual thresholds is performed by applying a Bayesian modeling strategy to a multivariate score integrating several biomarkers (compound concentration and/or ratio). This multimodal monitoring was applied to data from a clinical study involving...
Source: Analytica Chimica Acta - May 31, 2023 Category: Chemistry Authors: Miguel de Figueiredo Jonas Saugy Martial Saugy Rapha ël Faiss Olivier Salamin Raul Nicoli Tiia Kuuranne Serge Rudaz Francesco Botr è Julien Boccard Source Type: research
A new multimodal paradigm for biomarkers longitudinal monitoring: a clinical application to women steroid profiles in urine and blood
Anal Chim Acta. 2023 Aug 1;1267:341389. doi: 10.1016/j.aca.2023.341389. Epub 2023 May 17.ABSTRACTBACKGROUND: Most current state-of-the-art strategies to generate individual adaptive reference ranges are designed to monitor one clinical parameter at a time. An innovative methodology is proposed for the simultaneous longitudinal monitoring of multiple biomarkers. The estimation of individual thresholds is performed by applying a Bayesian modeling strategy to a multivariate score integrating several biomarkers (compound concentration and/or ratio). This multimodal monitoring was applied to data from a clinical study involving...
Source: Analytica Chimica Acta - May 31, 2023 Category: Chemistry Authors: Miguel de Figueiredo Jonas Saugy Martial Saugy Rapha ël Faiss Olivier Salamin Raul Nicoli Tiia Kuuranne Serge Rudaz Francesco Botr è Julien Boccard Source Type: research
Whole ‐body oxidative stress reduction during testosterone therapy in aging men: A randomized placebo‐controlled trial
ConclusionWhole-body oxidative stress decreased during 24 weeks of testosterone replacement therapy in aging men. (Source: Andrology)
Source: Andrology - May 24, 2023 Category: Urology & Nephrology Authors: Louise Lehmann Christensen,
Henrik Enghusen Poulsen,
Marianne Skovsager Andersen,
Dorte Glintborg Tags: ORIGINAL ARTICLE Source Type: research
Whole ‐body oxidative stress reduction during testosterone therapy in ageing men. A randomized placebo‐controlled trial
ConclusionWhole-body oxidative stress decreased during 24 weeks TRT in ageing men.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - May 13, 2023 Category: Urology & Nephrology Authors: Louise Lehmann Christensen,
Henrik Enghusen Poulsen,
Marianne Skovsager Andersen,
Dorte Glintborg Tags: ORIGINAL ARTICLE Source Type: research
Can testosterone modulate prosocial learning in healthy males? A double-blind, placebo-controlled, testosterone administration study
Biol Psychol. 2023 Feb 16:108524. doi: 10.1016/j.biopsycho.2023.108524. Online ahead of print.ABSTRACTTestosterone is associated with both aggressive and prosocial behavior, which depend on the social context and the trade-off between self- and other-interest. However, little is known about the effects of testosterone on prosocial behavior in a context without such trade-offs. The present study aimed to investigate the effects of exogenous testosterone on prosocial behavior by using a prosocial learning task. Healthy male participants (n =120) received a single dose of testosterone gel in a double-blind, placebo-controlled...
Source: Biological Psychology - February 21, 2023 Category: Psychiatry & Psychology Authors: Xin Wang Jiajun Liao Yu Nan Jie Hu Yin Wu Source Type: research
Novel testosterone gel improves serum testosterone concentrations and aging males' symptoms in patients with late-onset hypogonadism: an active control equivalence, randomized, double-blind, crossover study
Endocr J. 2022 Dec 17. doi: 10.1507/endocrj.EJ22-0497. Online ahead of print.NO ABSTRACTPMID:36529505 | DOI:10.1507/endocrj.EJ22-0497 (Source: Endocrine Journal)
Source: Endocrine Journal - December 18, 2022 Category: Endocrinology Authors: Masato Shirai Akira Tsujimura Kazuhiko Mizushima Takamitsu Tsuru Makoto Kurosawa Akimasa Kure Yuka Uesaka Taiji Nozaki Kazuhiro Kobayashi Shigeo Horie Source Type: research
Platelet aggregation in Klinefelter syndrome is not aggravated by testosterone replacement therapy: A longitudinal follow ‐up study
This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - October 27, 2022 Category: Urology & Nephrology Authors: Simon Chang,
Ole Halfdan Larsen,
Anne ‐Mette Hvas,
Anne Skakkebæk,
Claus Højbjerg Gravholt,
Anna‐Marie Bloch Münster Tags: ORIGINAL ARTICLE Source Type: research
The effect of androgen administration on in vitro fertilization outcome in poor responders undergoing ovarian stimulation with microdose protocol: A randomized clinical trial
CONCLUSION(S): The results of the current study showed that androgen administration in poor responders in in vitro fertilization reduces the total dose of gonadotropin, but it does not improve the pregnancy outcomes.PMID:36272243 | DOI:10.1016/j.ejogrb.2022.09.027 (Source: Reproductive Biology)
Source: Reproductive Biology - October 22, 2022 Category: Reproduction Medicine Authors: Abbas Aflatoonain Lida Saeed Robabe Hosseinisadat Source Type: research
The effect of androgen administration on in vitro fertilization outcome in poor responders undergoing ovarian stimulation with microdose protocol: A randomized clinical trial
CONCLUSION(S): The results of the current study showed that androgen administration in poor responders in in vitro fertilization reduces the total dose of gonadotropin, but it does not improve the pregnancy outcomes.PMID:36272243 | DOI:10.1016/j.ejogrb.2022.09.027 (Source: Reproductive Biology)
Source: Reproductive Biology - October 22, 2022 Category: Reproduction Medicine Authors: Abbas Aflatoonain Lida Saeed Robabe Hosseinisadat Source Type: research
The metabolic effects of hormonal treatment in transgender males: Safety of the testosterone gender-affirming therapy
CONCLUSIONS: Treatment with testosterone is routinely used for the promotion of virilising physical changes in transgender males. However, the likelihood of adverse effects of continuous administration treatment is still unclear. This study contributed to the notion that achieving testosterone levels within the target range is a prerequisite for the safety of the gender-affirming treatment.PMID:35964205 | DOI:10.3233/JRS-200087 (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - August 14, 2022 Category: Drugs & Pharmacology Authors: Charalampos Milionis Ioannis Ilias Evaggelia Venaki Eftychia Koukkou Source Type: research
