Child ’s Oxytocin Response to Mother-Child Interaction: The Contribution of Child Genetics and Maternal Behavior
The oxytocinergic system is a key biological system underlying the need for bonding and protection from threat (Insel, 2010), with recognized associations with social behavior, particularly involving social affiliation (Winslow& Insel, 2002). Indeed, it has been shown to respond to social interactions. For example, Feldman, Gordon, Schneiderman, Weisman, and Zagoory-Sharon (2010) reported that mothers and fathers who provided high levels of tactile contact to their infants evinced increases in salivary oxytocin (OT) following parent –infant interaction. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 16, 2018 Category: Psychiatry Authors: Rita Baiao, Pasco Fearon, Jay Belsky, Joana Baptista, Alexandra Carneiro, Raquel Pinto, Marlene Nogueira, C ésar Oliveira, Isabel Soares, Ana Mesquita Source Type: research

Hair and fingernail cortisol and the onset of acute coronary syndrome in the middle-aged and elderly men
Acute psychosocial stress triggers an activation of the hypothalamic-pituitary-adrenal axis, which causes the adrenal cortex to secrete cortisol. Traditionally, cortisol has been measured in blood and saliva samples, which revealed hormone levels for a short time period. Recently, cortisol has been reportedly measured in hair samples (Russell et al., 2012). Scalp hair grows at an average rate of 1.0  cm/month; 1.0 cm of scalp hair may be used to determine the level of the hormone secreted during a period of 1 month. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 15, 2018 Category: Psychiatry Authors: Shuhei Izawa, Keiichi Miki, Masao Tsuchiya, Haruyo Yamada, Masatoshi Nagayama Source Type: research

Associations of plasma testosterone with clinical manifestations in acute panic disorder
The biological basis of panic disorder (PD) remains largely unknown, despite the significant progress achieved during the last decades regarding this issue (see for a review: Bandelow et al., 2017). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 15, 2018 Category: Psychiatry Authors: Vasilios G. Masdrakis, Charalambos Papageorgiou, Manolis Markianos Source Type: research

Estrogen Administration Improves the Trajectory of Eating Disorder Pathology in Oligo-Amenorrheic Athletes: A Randomized Trial
Disordered eating behavior and attitudes are common in conditions of functional hypothalamic amenorrhea, such as anorexia nervosa (AN) and exercise-induced amenorrhea (Beals and Hill, 2006; Quah et al., 2009), which are also associated with significant psychiatric co-morbidity, including anxiety and depression. Hypogonadism in these conditions has been implicated in psychological morbidity. Estrogen and progesterone receptors are expressed in appetite regulation centers (e.g., the hypothalamus) and regions regulating emotion and cognition (e.g., the amygdala, ventral tegmental area, insula, and hippocampus) (Campolier et a...
Source: Psychoneuroendocrinology - November 15, 2018 Category: Psychiatry Authors: Franziska Plessow, Vibha Singhal, Alexander T. Toth, Nadia Micali, Kamryn T. Eddy, Madhusmita Misra Source Type: research

Hypothalamic-Pituitary-Adrenal Axis Dysregulation in Depressed Adolescents with Non-Suicidal Self-Injury
Non-suicidal self-injury (NSSI) involves the self-directed act of causing harm to one ’s own body without the intent of suicide (Muehlenkamp, 2005). The estimated prevalence of adolescent NSSI is 17% (Swannell et al., 2014) and 40% or higher in clinical samples (Glenn& Klonsky, 2013). Those who self-injure are more prone to self-criticism and negative emotionality (Glassman et al., 2007). Most adolescents engage in NSSI as a method of stress-regulation, with the expectation that it will serve to relieve interpersonal difficulties or reduce negative affect (e.g., Zetterqvist et al., 2013). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 14, 2018 Category: Psychiatry Authors: Bonnie Klimes-Dougan, Erin Begnel, Brandon Almy, Michelle Thai, Melinda Westlund Schreiner, Kathryn Cullen Source Type: research

Beyond the HPA-axis: exploring maternal prenatal influences on birth outcomes and stress reactivity
Mounting evidence indicates that maternal prenatal stress is associated with an increased risk of altered physiological, behavioral, emotional and cognitive outcomes in offspring (Van den Bergh et al., 2017). Maternal depressive or anxiety symptoms have been the most common measures of prenatal stress (e.g. Talge et al., 2007) and findings from many community samples have shown that they might have a detectable impact even at subclinical levels(reviewed in Talge et al., 2007; Van den Bergh et al., 2017; Madigan et al., 2018), thus broadening scientific and public health implications. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 14, 2018 Category: Psychiatry Authors: S. Nazzari, P. Fearon, F. Rice, N. Dottori, F. Ciceri, M. Molteni, A. Frigerio Source Type: research

Long-term glucocorticoid levels measured in hair in patients with depressive and anxiety disorders
Dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis may result in increased or decreased levels of its end-product, cortisol. A disproportionate change in cortisol levels is one of the main hypothesized pathophysiological mechanisms underlying depressive and anxiety disorders (Casper et al., 1988; Elnazer and Baldwin, 2014; Hilbert et al., 2014; Vreeburg et al., 2009, 2010). However, findings have been inconsistent regarding relative hyper- or hypocortisolism in different (subtypes of) disorders. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 14, 2018 Category: Psychiatry Authors: Lotte Gerritsen, Sabine M. Staufenbiel, Brenda W.J.H Penninx, Albert M. van Hemert, Gerard Noppe, Yolanda B. de Rijke, Elisabeth F.C. van Rossum Source Type: research

Foot massage evokes oxytocin release and activation of orbitofrontal cortex and superior temporal sulcus
The neuropeptide oxytocin (OXT) plays an important role in influencing both social bonds and a number of different aspects of social cognition in a variety of different species, including humans (Kendrick et al., 2017). There is increasing evidence across cultures that basal plasma OXT concentrations are reduced in disorders with social dysfunction, such as autism, and by early life social neglect which can also lead to social dysfunction (Green et al., 2001; Oztan et al., 2018; Parker et al., 2014; Zhang et al., 2016). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 14, 2018 Category: Psychiatry Authors: Qin Li, Benjamin Becker, Jennifer Wernicke, Yuanshu Chen, Yingying Zhang, Rui Li, Jiao Le, Juan Kou, Weihua Zhao, Keith M Kendrick Source Type: research

Abnormal postural behavior in patients with functional movement disorders during exposure to stress
Functional (psychogenic) neurological disorders or conversion disorders consist of neurological symptoms that occur in the absence of visible lesions of the nervous system (Espay et al., 2018). Up to 18% of the neurological patients presenting with “unexplained” symptoms are currently diagnosed with functional neurological disorders (Stone et al., 2009b). One of the most common clinical presentations is functional movement disorders (FMD), characterized by motor symptoms such as paralysis or paresis, tremor or dystonia (Stone and Carson, 2 015; Voon et al., 2010). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 14, 2018 Category: Psychiatry Authors: Giuseppe Angelo Zito, Kallia Apazoglou, Anisoara Paraschiv-Ionescu, Kamiar Aminian, Selma Aybek Source Type: research

Hippocampal volume modulates salivary oxytocin level increases after intranasal oxytocin administration
Adverse childhood experiences have protracted neurobiological effects and have been associated with changes in the oxytocinergic system (Meaney, 2001). Research indicates that individuals with a history of childhood adversity show lower oxytocin levels in cerebrospinal fluid (Heim et al., 2009), plasma (Opacka-Juffry& Mohiyeddini, 2012), and saliva (Riem et al., 2017, but see Bhandari et al., 2014), and attenuated sensitivity to intranasal oxytocin administration. For example, stress-reducing effects of intranasal oxytocin, as reflected by cortisol decreases, are impeded in individuals with a history of childhood adver...
Source: Psychoneuroendocrinology - November 12, 2018 Category: Psychiatry Authors: Madelon Riem, Marinus van IJzendoorn, Marian Bakermans-Kranenburg Source Type: research

Low neuroticism and cognitive performance are differently associated to overweight and obesity: a cross-sectional and longitudinal UK Biobank study
Personality traits can be used to identify the appropriate weight loss treatment and management strategies for obese patients (Munro et al., 2011). The outcome of different weight loss interventions in obese people seems to be influenced by their underlying personality traits (Gerlach et al., 2015). For example, obese people with high reward dependence and cooperativeness are more willing to participate in behavioral group therapies (Sullivan et al., 2007). Moreover, patients with lower novelty seeking are more likely to effectively lose gain with this type of intervention (Sullivan et al., 2007). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 12, 2018 Category: Psychiatry Authors: Gaia Olivo, Shaili Gour, Helgi B. Schi öth Source Type: research

Short- and long-term alterations of FKBP5-GR and specific microRNAs in the prefrontal cortex and hippocampus of male rats induced by adolescent stress contribute to depression susceptibility
Depression is a highly prevalent mood disorder with different population risks. Exposure to early life adversities is considered a major risk factor for the onset and development of affective disorders (Heim and Binder, 2012; Heim and Nemeroff, 2001). In particular, adolescence is a critical window of brain development; during this stage, the brain is sensitive to stress reactivity, which heightens vulnerability to psychiatric disorders later in life (Lo Iacono and Carola, 2017; Yohn and Blendy, 2017). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 11, 2018 Category: Psychiatry Authors: Jingjing Xu, Rui Wang, Yuan Liu, Wei Wang, Dexiang Liu, Hong Jiang, Fang Pan Source Type: research

The endogenous oxytocin system in depressive disorders: A systematic review and meta-analysis
Depressive disorders are characterized by affective symptoms such as depressed mood, loss of interest and enjoyment, reduced energy, increased fatiguability, and diminished activity (American Psychiatric Association, 2013). They are complex disorders, as they comprise various subtypes, characterized by co-occuring symptoms and chronicity, and are often accompanied by comorbidities. Furthermore, depressive disorders are influenced by multiple psychological, social and biological factors (Kendler et al., 2006, 2002) which has implications for their treatment. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 11, 2018 Category: Psychiatry Authors: Sinha Engel, Sebastian Laufer, Christine Knaevelsrud, Sarah Schumacher Source Type: research

Chronic Histamine 3 Receptor Antagonism Alleviates Depression like Conditions in mice via Modulation of Brain-Derived Neurotrophic Factor and Hypothalamus-Pituitary Adrenal Axis
Modulation of histaminergic activity has been shown to be involved in several physiological functions, such as circadian rhythm, energy homeostasis, sensory and motor functions, cognition, and attention, which are affected in several central nervous system(CNS) disorders (Haas and Panula, 2003; Leurs et al., 2005). All actions of histamine (HA) are orchestrated by four HA receptors, H1-H4R, which are members of the G-protein-coupled receptor (GPCR) family (Haas and Panula, 2003). Out of four HA receptors, H3R is of particular interest concerning CNS functions. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 11, 2018 Category: Psychiatry Authors: Ajeet Kumar, Shalini Dogra, Chandan Sona, Deepmala Umrao, Mamunur Rashid, Sandeep K Singh, Muhammad Wahajuddin, Prem N Yadav Source Type: research

Basal testosterone ’s relationship with dictator game decision-making depends on cortisol reactivity to acute stress: A dual-hormone perspective on dominant behavior during resource allocation
As a species, we have evolved in social hierarchies, and the stratification of individuals within human groups helps organize us and maintain social order (Anderson et al., 2015; Ellis, 1994; Sapolsky, 2000). Within a social hierarchy, having higher status - respect or deference that is based on an individual ’s perceived social value (Anderson et al., 2015; Magee and Galinsky, 2008) - grants several benefits, such as access to limited resources and social influence over others (Cheng et al., 2013; Sapolsky, 2000). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 10, 2018 Category: Psychiatry Authors: Smrithi Prasad, Erik L. Knight, Pranjal H. Mehta Source Type: research

Epigenetics of the Molecular Clock and Bacterial Diversity in Bipolar Disorder
Bipolar Disorder (BD) is a mood disorder, which is characterized by recurrent manic, depressive or mixed episodes. Even though many potential pathomechanisms of BD have been identified over the last decades, it is still largely unknown how these disease mechanisms interact with each other. Neurotransmitter dysbalances, neurotrophic factor imbalances, chronic inflammation, oxidative stress and disturbed circadian rhythms have been put forward as putative underlying mechanisms (Boland et al., 2012; Andreazza et al., 2008; Berk et al., 2011; Bengesser and Reininghaus, 2013; Tsai et al., 2012; Soczynska et al., 2011; Kapczinsk...
Source: Psychoneuroendocrinology - November 10, 2018 Category: Psychiatry Authors: S.A. Bengesser, S. M örkl, A. Painold, N. Dalkner, A. Birner, F.T. Fellendorf, M. Platzer, R. Queissner, C. Hamm, A. Maget, R. Pilz, A. Rieger, J. Wagner-Skacel, B. Reininghaus, H.P. Kapfhammer, E. Petek, K. Kashofer, B. Halwachs, P. Holzer, A. Waha, E.Z Source Type: research

Virtually Stressed? A refined virtual reality adaptation of the Trier Social Stress Test (TSST) induces robust endocrine responses
Over the last decades a number of highly standardized laboratory stressors have been developed to induce psychosocial stress in the laboratory (e.g. the Socially-Evaluated Cold Pressor Test, SECPT, (Schwabe et al., 2013); Maastricht Acute Stress Test, MAST, (Smeets et al., 2012). Among these protocols, the Trier Social Stress Test (TSST; Kirschbaum et al., 1993) has become widely used in psychobiological stress research as it has been proven to evoke robust endocrine and cardiovascular responses in the majority of participants. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 10, 2018 Category: Psychiatry Authors: Patrick Zimmer, Benjamin Buttlar, Georg Halbeisen, Eva Walther, Gregor Domes Source Type: research

Editorial Board
(Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 9, 2018 Category: Psychiatry Source Type: research

Increased frequency of mind wandering in healthy women using oral contraceptives
Oral contraceptives (OC) are the most common type of contraceptive method used in industrialized countries (Daniels et al., 2015). It is estimated that 26% of women who are of reproductive age currently use OC and 82% of women report using it at some point in their lives (Daniels and Mosher, 2013). Around 10% of OC users report experiencing mood side effects (e.g., depressive symptoms, irritability (Kelly et al., 2010), which are common reasons for OC cessation (Rosenberg and Waugh, 1998; Westhoff et al., 2007). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 8, 2018 Category: Psychiatry Authors: Catherine Raymond, Marie-France Marin, Robert-Paul Juster, Sarah Leclaire, Olivier Bourdon, Sophia Cayer-Falardeau, Sonia J. Lupien Source Type: research

Stress reactivity in preschool-aged children: Evaluation of a social stress paradigm and investigation of the impact of prenatal maternal stress
In animals and humans, prenatal maternal stress (PS) has impact on birth outcomes, development and stress regulation as well as disease in the offspring (e.g., Stein et al., 2014; Van den Bergh et al., 2017). The intrauterine environment contributes to long-term consequences particularly via epigenetic modifications —a process referred to as prenatal programming (Sosnowski et al., 2018). While the importance of PS is well-established, its precise mechanisms and the timing of its effects are still within the scope of current research. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 5, 2018 Category: Psychiatry Authors: T.S. Send, S. Bardtke, M. Gilles, I.A.C. Wolf, M.W. S ütterlin, C. Kirschbaum, M. Laucht, S.H. Witt, M. Rietschel, F. Streit, M. Deuschle Source Type: research

Withdrawal of plasma estradiol is associated with increased anxiety reported by women in the first 12 hours after delivery
Transient mood changes, also known as postpartum blues, occur in 15 to 85% of women in the immediate puerperium (Henshaw, 2003) and are usually described as predictors of postpartum depression (DPP) (Reck et al., 2009). DPP is a severe condition affecting around 10 to 22% of the mothers (Gaynes et al., 2005). In recent reviews investigating predictors of postpartum depression, besides the role of postpartum blues and environmental stressors, hormonal changes were addressed as possible important biomarkers for this period (Garcia-Leal et al., 2017; Guintivano et al., 2018). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 2, 2018 Category: Psychiatry Authors: Marcos Gon çalves de Rezende, Cybele Garcia-Leal, Marcos Felipe Silva de Sá, Ricardo de Carvalho Cavalli, Cristina Marta Del-Ben Tags: Short Communication Source Type: research

Low vagal tone in two rat models of psychopathology involving high or low corticosterone stress responses
One of the current challenges in mental health research is the identification of risk factors and mechanisms related to individual vulnerability to develop psychopathologies (Weger and Sandi, 2018). Given the well-known impact of stress in triggering and exacerbating psychopathologies (de Kloet et al., 2016; McEwen et al., 2012), a great deal of research is concentrating on understanding the role of the major physiological stress systems [i.e., the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenocortical (HPA) axis] in this context (Carnevali et al., 2018; de Kloet et al., 2005; Pruessner et al., 1997; ...
Source: Psychoneuroendocrinology - November 2, 2018 Category: Psychiatry Authors: Damien Huzard, Sriparna Ghosal, Jocelyn Grosse, Luca Carnevali, Andrea Sgoifo, Carmen Sandi Source Type: research

Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder
Major depressive disorder (MDD) is one of the most prevalent and disabling psychiatric illness, with a high lifetime prevalence ranging from 10-15% (Kessler et al., 2005, 2013a). Cognitive dysfunction is a core diagnostic feature of MDD and is likely to cause considerable interference and functional impairment in patients' daily life function (Mcintyre et al., 2013), but effective alleviation of the cognitive deficits is difficult to achieve with current antidepressant therapies (Amado-Boccara et al., 1995). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 2, 2018 Category: Psychiatry Authors: Yanling Zhou, Wei Zheng, Weijian Liu, Chengyu Wang, Yanni Zhan, Hanqiu Li, Lijian Chen, Yuping Ning Source Type: research

Poor night ’s sleep predicts following day’s salivary alpha-amylase under high but not low stress
Poor sleep predicts next day ’s salivary alpha-amylase profile under stressThe salivary alpha-amylase profile is unrelated to following night’s sleepDiurnal salivary alpha-amylase profile is not sensitive to everyday occurring sleep variationsSalivary alpha-amylase profiles indicate autonomic nervous system dysregulation (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 29, 2018 Category: Psychiatry Authors: Kristina Klaus, Johanna M. Doerr, Jana Strahler, Nadine Skoluda, Alexandra Linnemann, Urs M. Nater Source Type: research

Memories of and influenced by the Trier Social Stress Test
Stress has obtained a rather bad reputation nowadays. It is often related to impaired cognitive performance and when occurring chronically it is commonly associated with physical and mental health problems. However, research has illustrated that the impact of stress on cognitive functions such as learning and memory are far more complex than initially assumed. Stress may enhance or impair memory depending on several key modulators and mediators. Both quantitative and qualitative shifts take place (Schwabe& Wolf, 2013). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 29, 2018 Category: Psychiatry Authors: Oliver T. Wolf Source Type: research

Hpa axis responses to psychological challenge linking stress and disease: what do we know on sources of intra- and interindividual variability?
Chronic stress is a major risk factor for several disorders, including highly prevalent diseases such as depression, anxiety disorders, cardiovascular diseases, and the metabolic syndrome (see 3.8 and 3.9). Since the finding of a disinhibited hypothalamic-pituitary-adrenal (HPA) axis in depressed patients (Carroll et al., 1980), it was assumed that alterations in the activity of this system may be a close correlate of stress-related pathology. The HPA axis is a core component of the neuroendocrine stress response. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 29, 2018 Category: Psychiatry Authors: Sandra Z änkert, Silja Bellingrath, Stefan Wüst, Brigitte M. Kudielka Source Type: research

Women's fertility cues affect cooperative behavior: Evidence for the role of the human putative chemosignal estratetraenol
Human body odors have been shown to convey social signals of many kinds. In the animal kingdom, many mammalian species use odorous cues to communicate periods of reproduction readiness among females. Specifically, female body odor and other body secretions take on an attractive character around the ovulation period (Doty, 1986). In rodents for example, females' body odors are known to stimulate males' reproductive systems, causing an increase in males' testosterone levels (Brown& Macdonald, 1985). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 29, 2018 Category: Psychiatry Authors: Chen Oren, Simone G. Shamay-Tsoory Source Type: research

Methylation of the glucocorticoid receptor gene associated with depression in patients with acute coronary syndrome
Because acute coronary syndrome (ACS) is a leading cause of death, increased effort has been made toward improving its treatment outcomes and prognosis (Benjamin et al., 2018). Depression is a common comorbidity in ACS patients and is associated with poor prognoses with increased morbidity and mortality (Lichtman et al., 2014). These phenomena may be due to common biological mechanisms shared by ACS and depression. Because depression can be treated, a clearer understanding of the pathophysiology of depression in ACS patients could improve its prognosis. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 29, 2018 Category: Psychiatry Authors: Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Hye-Ran Kim, Myung-Geun Shin, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Jin-Sang Yoon, Jae-Min Kim Source Type: research

Assay Validation of Hair Androgens Across the Menstrual Cycle
Noninvasive measurement of androgens like testosterone and dehydroepiandrosterone (DHEA) in salivary samples has been widely used as an index of hypothalamic-pituitary-gonadal (HPG) axis responses to stress and daily experiences (Kirschbaum& Hellhammer, 1994; Meyer et al., 2014; Karlamangla et al., 2013) and applied to multiple professional fields such as human development, psychobiology and mental health (Adam, 2006; Knorr et al., 2010; Shirtcliff et al., 2009). The popularity of salivary biomarkers research is largely due to its feasibility, noninvasive ease of sampling, point-of-care collection and repeated sampling...
Source: Psychoneuroendocrinology - October 28, 2018 Category: Psychiatry Authors: Wen Wang, Shannin N. Moody, Jeff Kiesner, Anna T. Appiani, Olivia C. Robertson, Elizabeth A. Shirtcliff Source Type: research

Altered Cellular Immune Reactivity in Traumatized Women with and without Major Depressive Disorder
Alterations of the hypothalamic-pituitary-adrenal (HPA) axis such as altered glucocorticoid receptor sensitivity and increased immune reactivity might contribute to the pathogenesis of major depressive disorder (MDD) (Pariante, 2017). Exposure to adverse childhood experiences (ACE) enhances the risk to develop MDD later in life and is itself associated with changes in HPA axis function (Mandelli et al., 2015; Anacker et al., 2014). Indeed, a growing body of evidence suggests a close interplay among ACE, inflammation and altered HPA axis signaling in the pathogenesis of later life mental disorders (Nusslock and Miller, 2016...
Source: Psychoneuroendocrinology - October 28, 2018 Category: Psychiatry Authors: Julian Hellmann-Regen, Carsten Spitzer, Linn K. Kuehl, Katharina Schultebraucks, Christian Otte, Katja Wingenfeld Tags: Short Communication Source Type: research

Human chemosignals modulate emotional perception of biological motion in a sex-specific manner
Pheromones, secreted to the outside by an individual and received by a second individual of the same species, are ubiquitously used in the animal kingdom and mediate a wide range of social interactions (Karlson and Luscher, 1959; Wyatt, 2003). A well-studied class of pheromones is called sex pheromones, which regulate behaviors related to mate choice and reproduction. Their influence on the recipients take many forms, from priming the reproductive system (Keller-Costa et al., 2014), inducing preference, searching behavior, and the adoption of a mating stance in the opposite sex (Dorries et al., 1997; Li et al., 2002), to f...
Source: Psychoneuroendocrinology - October 27, 2018 Category: Psychiatry Authors: Yuting Ye, Yuan Zhuang, Monique A.M. Smeets, Wen Zhou Source Type: research

Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice
There are clinically important reciprocal interactions between androgens and the brain (Pack et al., 2011; Taub øll et al., 2015). Androgens can affect functions of the central nervous system (CNS) and play an important role in the pathophysiology of various neural disorders, including epilepsy (Verrotti et al., 2007, Reddy, 2013; Taubøll et al., 2015) while epilepsy and/or antiepileptic drugs can alter and rogen levels to promote the development of reproductive hormonal disorders (Herzog and Fowler, 2005; Røste et al., 2005). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 27, 2018 Category: Psychiatry Authors: Piotr Tutka, Katarzyna Mr óz, Tomasz Mróz, Grzegorz Buszewicz, David Aebisher, Dorota Bartusik-Aebisher, Patrycjusz Kołodziejczyk, Jarogniew J. Łuszczki Source Type: research

Salivary cortisone, as a biomarker for psychosocial stress, is associated with state anxiety and heart rate
An adaptive response to a stressor (i.e., a demand or threat) comprises activation in the central nervous system, the autonomic nervous system (ANS), and the endocrine system (Chrousos and Gold, 1992). The brain orchestrates the stress response and is central for the adaptation to current and future stressors (Ulrich-Lai and Herman, 2009). ANS stimulation is marked by a rapid increase of heart rate (Allen et al., 2014), the release of plasma catecholamines and salivary alpha-amylase (Granger et al., 2007; Rohleder and Nater, 2009). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 27, 2018 Category: Psychiatry Authors: Yoon Ju Bae, Janis Reinelt, Jeffrey Netto, Marie Uhlig, Anja Willenberg, Uta Ceglarek, Arno Villringer, Joachim Thiery, Michael Gaebler, Juergen Kratzsch Source Type: research

Salivary Uric Acid: Associations with Resting and Reactive Blood Pressure Response To Social Evaluative Stress in Healthy African Americans
In the United States, cardiovascular disease (CVD) disproportionately burdens African Americans (Association A.H., 2013). In addition to socioeconomic variables such as education and poverty and decreased access to preventive care, psychosocial variables, such as discrimination, are viewed as key determinants of CVD disparities (Adler, 2013; Ladwig et al., 2014). One particularly important precursor to CVD and disparity is psychobiological stress (Dimsdale, 2008). In tandem, African Americans have higher rates of many stress-related CVD risk factors (Blankstein et al., 2011; Flegal et al., 2010). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 26, 2018 Category: Psychiatry Authors: Jacqueline Woerner, Todd Lucas, Jennifer Pierce, Jenna L. Riis, Douglas A. Granger Source Type: research

Hypothalamic-pituitary-adrenal axis feedback sensitivity in different states of back pain
The transition from acute to chronic pain has been associated with a number of peripheral and central physiological, psychological and psychosocial predictors, among them prominently also stress experience and stress reactivity (e.g., Flor, 2017; Vachon-Presseau, 2018). The activation of the hypothalamic-pituitary-adrenal (HPA) axis plays an important mediating role in the relationship between stress and pain (e.g., McEwen and Kalia, 2010). In acute pain, higher baseline cortisol levels are associated with lower pain reports (Al ’Absi et al., 2002). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 26, 2018 Category: Psychiatry Authors: Frauke Nees, Martin L öffler, Katrin Usai, Herta Flor Source Type: research

Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women
Major depressive episodes occur twice as frequent in women compared to men (Kessler et al., 2005), and women also tend to exhibit greater symptom severity and higher rates of co-morbid disorders (Marcus et al., 2008). A recent nationwide Danish cohort study of trends in depression replicated the women to men risk ratio of 2 to 1, and further replicated an even higher risk ratio for adolescent girls from expected time of puberty onset (age 12-19) with a girls to boys risk ratio of 2.7 to 1 (Skovlund et al., 2017). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 26, 2018 Category: Psychiatry Authors: DS Stenb æk, E Budtz-Jørgensen, Pinborg A, PS Jensen, VG Frokjaer Source Type: research

Editorial Board
(Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 25, 2018 Category: Psychiatry Source Type: research

Reduced plasma ghrelin concentrations are associated with decreased brain reactivity to food cues after laparoscopic sleeve gastrectomy
Laparoscopic sleeve gastrectomy (LSG) is a surgical procedure that leads to the removal of the gastric fundus. It is currently one of the most effective treatments for morbid obesity (Diamantis et al., 2014). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 25, 2018 Category: Psychiatry Authors: Guanya Li, Gang Ji, Yang Hu, Li Liu, Qingchao Jin, Wenchao Zhang, Lei Liu, Yuanyuan Wang, Jizheng Zhao, Karen M. von Deneen, Antao Chen, Guangbin Cui, Yu Han, Huaning Wang, Qingchuan Zhao, Kaichun Wu, Corinde E. Wiers, Dardo Tomasi, Lorenzo Leggio, Nora D Source Type: research

Associations of Cord Blood Leptin and Adiponectin with Children ’s Cognitive Abilities
Leptin and adiponectin are peptide hormones secreted by adipose tissue and the placenta that play a role in metabolism and possibly neurodevelopment (Masuzaki et al., 1997; Chen et al., 2006; Arnoldussen et al., 2014). Leptin receptors are distributed throughout the brain, and leptin acts in multiple brain regions that are important for cognition (Funahashi et al., 2003; Farr et al., 2006; Oomura et al., 2006; Morrison, 2009). In mice, short-term leptin infusions improved memory and learning (Farr et al., 2006; Oomura et al., 2006). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 25, 2018 Category: Psychiatry Authors: Nan Li, Tye E Arbuckle, Gina Muckle, Bruce P Lanphear, Michel Boivin, Aimin Chen, Linda Dodds, William D Fraser, Emmanuel Ouellet, Jean R S éguin, Maria P Velez, Kimberly Yolton, Joseph M Braun Source Type: research

Stress and immunosenescence: The role of telomerase
Chronic stress is a major contributor to the development and progression of a range of physical and mental disorders such as cardiovascular disease, type 2 diabetes, metabolic syndrome, autoimmune disease and depression (Cohen et al., 2007). Several lines of evidence converge to suggest that these pathophysiological effects of stress on health and disease risk are mediated in large part by rate of accelerated aging of the immune system (immunosenescence). This process is characterized by the inability to mount an appropriate and effective immune response to challenge, and it is associated with a low-grade chronic pro-infla...
Source: Psychoneuroendocrinology - October 23, 2018 Category: Psychiatry Authors: Karin de Punder, Christine Heim, Pathik D. Wadhwa, Sonja Entringer Source Type: research

Major depression and atrial natriuretic peptide: the role of adverse childhood experiences
Neuroendocrine peptides have been increasingly acknowledged in psychiatric research due to their actions in the central nervous system (CNS) (Bandelow et al., 2017). Atrial natriuretic peptide (ANP) is a 28 amino acid peptide, which is synthesised in cardiomyocytes and acts in the context of blood pressure regulation. Reduced basal ANP levels have been associated with cardiovascular disease, overweight, hypertension, and insulin resistance (Wis én et al., 2011). In the CNS, ANP is expressed in the hypothalamus, brainstem, cerebellum, and cerebral cortex (Meyer and Herrmann-Lingen, 2018). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 23, 2018 Category: Psychiatry Authors: M. Kaczmarczyk, C. Otte, K. Wiedemann, L.K. Kuehl, K. Schultebraucks, C. Spitzer, K. Wingenfeld Tags: Short Communication Source Type: research

Higher trait reappraisal predicts stronger HPA axis habituation to repeated stress
Psychosocial stress is a common occurrence in daily life, consisting of various challenges, threats, loss, and harm (Lazarus, 1966). Undergoing stress can be advantageous when it leads to adaptation and growth. Conversely, the inability to adapt to repeated stress is linked with declines in cognitive functioning, systemic inflammation, premature aging, immune system dysfunction, and higher likelihood of suffering from metabolic disorders such as diabetes and cardiovascular disease (Cohen et al., 2012; Graham et al., 2006; Glaser& Kiecolt-Glaser, 2005; Tamashiro et al., 2011). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 23, 2018 Category: Psychiatry Authors: Lydia G. Roos, Johanna Janson, Sarah C. Sturmbauer, Jeanette M. Bennett, Nicolas Rohleder Source Type: research

PTSD psychotherapy improves blood pressure but leaves HPA axis feedback sensitivity stable and unaffected: first evidence from a pre-post treatment study
Although key to development of tailored drugs for augmentation treatment of psychotherapy for posttraumatic stress disorder (PTSD), the biological correlates of PTSD remission are still unknown, probably because pre-post treatment studies searching for them are rare. Not even the feedback sensitivity of the otherwise well-studied hypothalamic-pituitary-adrenal (HPA) axis nor arterial blood pressure (BP), which was previously reported to be elevated in PTSD patients, have so far been analyzed during PTSD treatment. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 21, 2018 Category: Psychiatry Authors: Christine F. Schubert, Monika Schreckenbach, Thomas Kirmeier, Dominique J. Gall-Kleebach, Bastian Wollweber, Dominik R. Buell, Uhr M, Rita Rosner, Ulrike Schmidt Source Type: research

Over-expression of TGF- β1 gene in medication free Schizophrenia
Immunological pathways play a crucial role in developing and precipitating neuropsychiatric disorders. Although the exact pathogenesis of schizophrenia is unknown, the possible role of genetic and biomarker involvement of the immune system is gaining attention. Here we quantified the mRNA expression of cytokines as a key role player of the immune system from the peripheral blood mononuclear cells of patients with schizophrenia and healthy controls to identify the differentially expressed genes. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 20, 2018 Category: Psychiatry Authors: Mahsa M. Amoli, Fatemeh Khatami, Seyed Masoud Arzaghi, Samaneh Enayati, Ali-Akbar Nejatisafa Source Type: research

Cortisol, dehydroepiandrosterone sulfate, fatty acids and their relation in recurrent depression
The overwhelming burden of major depressive disorder (MDD) is mainly due to its recurrent nature (Charlson et al., 2011). Suggested mechanisms underlying the recurrent course of MDD include alterations in endocrinology and metabolism. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 19, 2018 Category: Psychiatry Authors: D.M. ter Horst, A.H. Schene, C.A. Figueroa, J. Assies, A. Lok, C.L.H. Bockting, H.G. Ruh é, R.J.T. Mocking Source Type: research

BDNF Val66Met Polymorphism and Posttraumatic Stress Symptoms in U.S. Military Veterans: Protective Effect of Physical Exercise
Posttraumatic stress disorder (PTSD) is a psychiatric disorder characterized by intrusive symptoms, avoidance of trauma reminders, negative thoughts and mood, and alterations in arousal and reactivity that affects approximately 8% of U.S. military veterans in their lifetimes (Wisco et al., 2016). There is increasing interest in identifying genetic markers for PTSD, and understanding how these markers may be moderated by environmental and psychosocial risk and protective factors (e.g., Mota et al., 2018). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 17, 2018 Category: Psychiatry Authors: Barbara L. Pitts, Julia M. Whealin, Ilan Harpaz-Rotem, Ronald S. Duman, John H. Krystal, Steven M. Southwick, Robert H. Pietrzak Tags: Short Communication Source Type: research

Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study
In recent years, the role of intestinal microbiota, as a component of the microbiota-gut-brain axis, has become an important player in neuroscience and psychiatric research. Animal and human studies point out the role of those bacteria in maintaining the psycho-neuro-immunological balance through various actions, such as the modulation of the immune and the neuroendocrine systems e.g. hypothalamic-pituitary adrenal axis (HPA), changes of the TRP metabolism in the serotonin (5-HT) and the kynurenine axes, regulation of the neurogenesis and improvement of intestinal permeability. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 16, 2018 Category: Psychiatry Authors: Leszek Rudzki, Lucyna Ostrowska, Dariusz Pawlak, Aleksandra Ma łus, Krystyna Pawlak, Napoleon Waszkiewicz, Agata Szulc Source Type: research

Social stability influences the association between adrenal responsiveness and hair cortisol concentrations in rhesus macaques
The concentration of cortisol in hair is increasingly being used in a wide variety of species as a biomarker of chronic stress. Taxa examined so far include domesticated pets and livestock (Accorsi et al., 2008; Comin et al., 2011; Keckeis et al., 2012), mammalian wildlife (Ashley et al., 2011; Bechsh øft et al., 2011; Koren et al., 2008; Martin and Réale, 2008), non-human primates (Davenport et al., 2006; Dettmer et al., 2014; Hamel et al., 2011; Laudenslager et al., 2011), and humans (e.g. D'Anna-Hernandez et al., 2011; Dettenborn et al., 2010; Sauvé et al., 2007; Van Uum et al., 2008). (Source: Psyc...
Source: Psychoneuroendocrinology - October 12, 2018 Category: Psychiatry Authors: J. Vandeleest, J.P. Capitanio, A. Hamel, J. Meyer, M. Novak, S.P. Mendoza, B. McCowan Source Type: research

The dual nature of hypothalamic-pituitary-adrenal axis regulation in dyads of very preterm infants and their mothers
The mother-infant dyad is meant to be an open, non-linear dynamic system in which mothers and infants reciprocally regulate their states in order to adjust to challenging and stressful conditions (Provenzi et al., 2015a,b; Tronick& Beeghly, 2011). The emergence of patterns of behavioral and biological rhythms co-regulation is key to this dyadic self-regulating system (Feldman, 2006; Welch, 2016). At the behavioral level, mother-infant coordination has been widely investigated (Provenzi et al., 2018) and conceptualized as a coupling of behavioral and affective states in a given moment (e.g., dyadic matching; Weinberg et...
Source: Psychoneuroendocrinology - October 12, 2018 Category: Psychiatry Authors: Livio Provenzi, Lorenzo Giusti, Monica Fumagalli, Susanna Frigerio, Francesco Morandi, Renato Borgatti, Fabio Mosca, Rosario Montirosso Source Type: research

Grief, Depressive Symptoms, and Inflammation in the Spousally Bereaved
The loss of a spouse is an extremely stressful life event that puts people at risk for mental and physical health problems (Stahl et al., 2016). Bereavement is linked with an increased risk of cardiovascular disease (CVD), and premature mortality (Moon et al., 2013). Even after adjusting for established risk factors, the death of a spouse is associated with an increased rate of mortality from cardiovascular events (Hart et al., 2007). The first 3 months after the loss of a spouse puts people at the greatest risk for cardiovascular events (Shor et al., 2012). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - October 11, 2018 Category: Psychiatry Authors: Christopher Fagundes, Ryan L. Brown, Michelle A. Chen, Kyle W. Murdock, Levi Saucedo, Angie LeRoy, E. Lydia Wu, Luz M. Garcini, Anoushka D. Shahane, Faiza Baameur, Cobi Heijnen Source Type: research