Exploring the impact of antibiotics, microplastics, nanoparticles, and pesticides on zebrafish gut microbiomes: Insights into composition, interactions, and health implications
Chemosphere. 2023 Dec 2:140867. doi: 10.1016/j.chemosphere.2023.140867. Online ahead of print.ABSTRACTThis reviewdu addresses the impact of various chemical entities like pesticides, antibiotics, nanoparticles and microplastic on gut microbiota of zebrafish. Gut microbiota plays a vital role in metabolic regulation in every organism. As majority of metabolic pathways coordinated by microbiota, small alterations associated with mild to serious outcomes. Because of their unstoppable usage in day-to-day life, the present-day research on gut microbiota is mostly comprising aforementioned chemicals. It is better to understand h...
Source: Chemosphere - December 4, 2023 Category: Chemistry Authors: Rajesh Pamanji T N Kumareshan Lakshmi Priya S Gisha Sivan Joseph Selvin Source Type: research
Exploring the impact of antibiotics, microplastics, nanoparticles, and pesticides on zebrafish gut microbiomes: Insights into composition, interactions, and health implications
Chemosphere. 2023 Dec 2:140867. doi: 10.1016/j.chemosphere.2023.140867. Online ahead of print.ABSTRACTThis reviewdu addresses the impact of various chemical entities like pesticides, antibiotics, nanoparticles and microplastic on gut microbiota of zebrafish. Gut microbiota plays a vital role in metabolic regulation in every organism. As majority of metabolic pathways coordinated by microbiota, small alterations associated with mild to serious outcomes. Because of their unstoppable usage in day-to-day life, the present-day research on gut microbiota is mostly comprising aforementioned chemicals. It is better to understand h...
Source: Chemosphere - December 4, 2023 Category: Chemistry Authors: Rajesh Pamanji T N Kumareshan Lakshmi Priya S Gisha Sivan Joseph Selvin Source Type: research
Exploring the impact of antibiotics, microplastics, nanoparticles, and pesticides on zebrafish gut microbiomes: Insights into composition, interactions, and health implications
Chemosphere. 2023 Dec 2:140867. doi: 10.1016/j.chemosphere.2023.140867. Online ahead of print.ABSTRACTThis reviewdu addresses the impact of various chemical entities like pesticides, antibiotics, nanoparticles and microplastic on gut microbiota of zebrafish. Gut microbiota plays a vital role in metabolic regulation in every organism. As majority of metabolic pathways coordinated by microbiota, small alterations associated with mild to serious outcomes. Because of their unstoppable usage in day-to-day life, the present-day research on gut microbiota is mostly comprising aforementioned chemicals. It is better to understand h...
Source: Chemosphere - December 4, 2023 Category: Chemistry Authors: Rajesh Pamanji T N Kumareshan Lakshmi Priya S Gisha Sivan Joseph Selvin Source Type: research
Exploring the impact of antibiotics, microplastics, nanoparticles, and pesticides on zebrafish gut microbiomes: Insights into composition, interactions, and health implications
Chemosphere. 2023 Dec 2:140867. doi: 10.1016/j.chemosphere.2023.140867. Online ahead of print.ABSTRACTThis reviewdu addresses the impact of various chemical entities like pesticides, antibiotics, nanoparticles and microplastic on gut microbiota of zebrafish. Gut microbiota plays a vital role in metabolic regulation in every organism. As majority of metabolic pathways coordinated by microbiota, small alterations associated with mild to serious outcomes. Because of their unstoppable usage in day-to-day life, the present-day research on gut microbiota is mostly comprising aforementioned chemicals. It is better to understand h...
Source: Chemosphere - December 4, 2023 Category: Chemistry Authors: Rajesh Pamanji T N Kumareshan Lakshmi Priya S Gisha Sivan Joseph Selvin Source Type: research
Amitriptyline as second-line treatment for IBS in primary care settings
Nature Reviews Gastroenterology & Hepatology, Published online: 21 November 2023; doi:10.1038/s41575-023-00873-1Amitriptyline as second-line treatment for IBS in primary care settings (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - November 21, 2023 Category: Gastroenterology Authors: Katrina Ray Source Type: research
Medication economic burden of antidepressant non-adherence in Spain
Conclusion: Reducing non-adherence to antidepressants is critical to improving clinical and economic outcomes. The implementation of interventions and standardized measures, including early detection indicators, is urgently needed. Antidepressants differ with regard to non-adherence and their cost, and this should be considered when prescribing this medication. The Medication Possession Ratio could be used by the healthcare provider and clinician to identify non-adherent patients for monitoring, and to take necessary corrective actions. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Source Type: research
Catchment area, fate, and environmental risks investigation of micropollutants in Danish wastewater
This study aimed to investigate the spatial distribution of micropollutants in wastewater related to catchment area, and their environmental risks and fate. About 24-h flow proportional effluent (n = 26) wastewater samples were collected from eight WWTPs across Denmark. From five of these WWTPs corresponding influent samples (n = 20) were collected. Samples were enriched by multi-layer solid phase and analysed by liquid chromatography-high-resolution mass spectrometry and comprehensive two-dimensional gas chromatography with high-resolution mass spectrometry detection. We detected and quantified 79 micropollutants from a l...
Source: Environmental Science and Pollution Research International - November 10, 2023 Category: Environmental Health Authors: Kristoffer Kilpinen Jason Devers Mafalda Castro Selina Tisler Mathias B J ørgensen Peter Mortensen Jan H Christensen Source Type: research
Cost-minimization analysis of escitalopram, fluoxetine, and amitriptyline in the treatment of depression
CONCLUSION: The choice of an antidepressant depends on multiple aspects, among which the cost of treatment plays a crucial role. Among the drugs compared, fluoxetine seems to offer greater value for money. The study emphasizes that selective serotonin reuptake inhibitors are the most commonly prescribed antidepressants not only because of their favorable pharmacological profile but also because of their affordability. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 2, 2023 Category: Drugs & Pharmacology Authors: Harshit Hemant Salian MV Raghav Vikram Singh Rawat A Divakar Source Type: research
Trial Confirms Antidepressant Improves IBS in Primary Care
People who received low-dose amitriptyline, a tricyclic antidepressant, for irritable bowel syndrome (IBS) symptoms that persisted despite dietary changes and first-line treatments such as analgesics experienced an improvement in IBS severity and symptoms compared with those who received a placebo. More people discontinued the placebo than amitriptyline due to adverse events, according to results from a phase 3 randomized clinical trial involving 463 participants from 55 primary care practices in the UK. In addition, there was no difference between the groups in anxiety, depression, or ability to work after 6 months. (Sour...
Source: JAMA - Journal of the American Medical Association - November 1, 2023 Category: General Medicine Source Type: research
Gabapentin and oral antidepressants for chronic pruritus: a prospective cohort study evaluating efficacy and side effects in daily dermatological practice
CONCLUSION: Treatment with gabapentin and antidepressants should be considered in patients with chronic pruritus unresponsive to conventional treatment.PMID:37905412 | DOI:10.1080/09546634.2023.2274291 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - October 31, 2023 Category: Dermatology Authors: T A Kouwenhoven P C M van de Kerkhof M Kamsteeg Source Type: research
Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways
The standard therapy for bronchial asthma consists of combinations of acute (short-acting ß2-sympathomimetics) and, depending on the severity of disease, additional long-term treatment (including inhaled glucocor... (Source: Respiratory Research)
Source: Respiratory Research - October 31, 2023 Category: Respiratory Medicine Authors: Paulina Hempel, Virag Klein, Anna Michely, Svenja B öll, Annette D. Rieg, Jan Spillner, Till Braunschweig, Saskia von Stillfried, Norbert Wagner, Christian Martin, Klaus Tenbrock and Eva Verjans Tags: Research Source Type: research
A new MAS-related G protein-coupled receptor X2 cell membrane chromatography analysis model based on HALO-tag technology and its applications
Talanta. 2023 Oct 18;268(Pt 1):125317. doi: 10.1016/j.talanta.2023.125317. Online ahead of print.ABSTRACTCell membrane chromatography (CMC) is an effective method for studying receptors with multiple transmembrane structure such as MAS-related G protein-coupled receptor X2 (MrgX2). CMC relies on the maintenance of the complete biological structure of a membrane receptor; however, it needs to be further improved to obtain a more convenient and stable CMC model. In the present study, the haloalkane dehalogenase protein tag (HALO-tag) technology was used to construct a new MrgX2/CMC model. The fusion receptors of MrgX2 with H...
Source: Talanta - October 25, 2023 Category: Chemistry Authors: Qianqian Jia Yanni Lv Chenyang Miao Jingting Feng Yifan Ding Tongpei Zhou Shengli Han Langchong He Source Type: research
A new MAS-related G protein-coupled receptor X2 cell membrane chromatography analysis model based on HALO-tag technology and its applications
Talanta. 2023 Oct 18;268(Pt 1):125317. doi: 10.1016/j.talanta.2023.125317. Online ahead of print.ABSTRACTCell membrane chromatography (CMC) is an effective method for studying receptors with multiple transmembrane structure such as MAS-related G protein-coupled receptor X2 (MrgX2). CMC relies on the maintenance of the complete biological structure of a membrane receptor; however, it needs to be further improved to obtain a more convenient and stable CMC model. In the present study, the haloalkane dehalogenase protein tag (HALO-tag) technology was used to construct a new MrgX2/CMC model. The fusion receptors of MrgX2 with H...
Source: Talanta - October 25, 2023 Category: Chemistry Authors: Qianqian Jia Yanni Lv Chenyang Miao Jingting Feng Yifan Ding Tongpei Zhou Shengli Han Langchong He Source Type: research
