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Study Compares Clinical Outcomes of Older Adults Prescribed 10 Common Antidepressants
Older adults with depression may be least likely to discontinue or switch treatment when prescribed sertraline for the first time compared with other antidepressants, suggests areport inThe American Journal of Psychiatry. The study compared one-year outcomes in 93,000 Danish residents with depression who for the first time filled a prescription for one of 10 antidepressants. The research was funded in part by the Health Research Foundation of the Central Denmark Region.“Although clinical trials are considered the gold standard in drug effectiveness research, their experimental conditions often do not represent complex, r...
Source: Psychiatr News - October 23, 2023 Category: Psychiatry Tags: antidepressants cardiovascular problems death depression falls older adults sertraline The American Journal of Psychiatry treatment discontinuation Source Type: research

Utilizing a Microfluidic Platform to Investigate Drug-Eluting Beads: Binding and Release of Amphiphilic Antidepressants
Int J Pharm. 2023 Oct 21:123517. doi: 10.1016/j.ijpharm.2023.123517. Online ahead of print.ABSTRACTDrug-eluting beads made of responsive polyelectrolyte networks are used in the treatment of liver cancer. Aggregates of loaded drugs in complex with the networks dissolve upon release, causing swelling of the network. According to a recent mechanism the release and swelling rates are controlled by the mass transport of drug through a depletion layer created in the microgel. We hypothesise that the mechanism, in which the stability of the drug aggregates and the swelling properties of the network play crucial roles, offers mea...
Source: Cancer Control - October 23, 2023 Category: Cancer & Oncology Authors: Marcus Wanselius Yassir Al-Tikriti Per Hansson Source Type: research

Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research

Differential targeting of lysophosphatidic acid LPA 1 , LPA 2 , and LPA 3 receptor signalling by tricyclic and tetracyclic antidepressants
Eur J Pharmacol. 2023 Sep 25:176064. doi: 10.1016/j.ejphar.2023.176064. Online ahead of print.ABSTRACTWe previously reported that in different cell types antidepressant drugs activate lysophosphatidic acid (LPA) LPA1 receptor to induce proliferative and prosurvival responses. Here, we further characterize this unique action of antidepressants by examining their effects on two additional LPA receptor family members, LPA2 and LPA3. Human LPA1-3 receptors were stably expressed in HEK-293 cells (HEK-LPA1, -LPA2 and -LPA3 cells) and their functional activity was determined by Western blot and immunofluorescence. LPA effectively...
Source: European Journal of Pharmacology - September 27, 2023 Category: Drugs & Pharmacology Authors: Maria C Olianas Simona Dedoni Pierluigi Onali Source Type: research