Amitriptyline ’s anticholinergic adverse drug reactions–A systematic multiple-indication review and meta-analysis
DiscussionThe large OR in our analysis shows that ADRs indicative of anticholinergic activities can be attributed to amitriptyline. The low average age of participants in our study may limit the generalizability of the frequency of anticholinergic ADRs in older patients. A lack of dose-dependency may reflect limited reporting of the daily dosage when the ADRs occurred. The exclusion of small studies ( (Source: PLoS One)
Source: PLoS One - April 5, 2023 Category: Biomedical Science Authors: Maria-Sophie Brueckle Source Type: research
Amitriptyline for fibromyalgia: Off ‐label treatment, but non‐inferior to approved medication
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 1, 2023 Category: Rheumatology Authors: Cheng Hsien Hung,
Yung ‐Heng Lee,
James Cheng‐Chung Wei Tags: EDITORIAL Source Type: research
An investigation of the potential effects of amitriptyline on polycystic ovary syndrome induced by estradiol valerate
AbstractPolycystic ovarian syndrome (PCOS) is frequently observed in adolescent women and usually progresses with depression. The aim of this study was to examine the effects of amitriptyline (Ami), a drug used in the treatment of depression, in individuals with PCOS. Forty 12-week-old female Wistar albino rats were randomly divided into five groups: control, sham, PCOS, Ami, and PCOS + Ami. To induce the syndrome in the PCOS groups, a single dose of 4 mg/kg estradiol valerate was administered by intraperitoneal injection; 10 mg/kg Ami was administered by intraperitoneal injection for 30 days in the Ami groups. Aft...
Source: Histochemistry and Cell Biology - March 27, 2023 Category: Biomedical Science Source Type: research
[ASAP] Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.2c00780 (Source: ACS Chemical Neuroscience)
Source: ACS Chemical Neuroscience - March 17, 2023 Category: Neuroscience Authors: Yuying Huang, Hong Chen, Shao-Rui Chen, and Hui-Lin Pan Source Type: research
Sales trends of psychotropic drugs in the COVID-19 pandemic: A national database study in Brazil
Conclusions: The increase in sales, mainly of antidepressants during the COVID-19 pandemic, draws attention to issues related to the mental health of the Brazilian population and on the need for greater monitoring in the dispensing of these drugs. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 17, 2023 Category: Drugs & Pharmacology Source Type: research
Does the addition of electrical stimulation or kinesiotherapy improve outcomes of amitriptyline treatment for women with vulvodynia? A randomized clinical trial
ConclusionKinesiotherapy and electrotherapy additions to amitriptyline administration as well as amitriptyline alone, were effective at improving vestibular pain in women with vulvodynia. Women receiving physical therapy had the greatest improvement in sexual function and frequency of intercourse at post-treatment and follow-up. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - March 16, 2023 Category: OBGYN Source Type: research
Does the addition of electrical stimulation or kinesiotherapy improve outcomes of amitriptyline treatment for women with vulvodynia? A randomized clinical trial
ConclusionKinesiotherapy and electrotherapy additions to amitriptyline administration as well as amitriptyline alone, were effective at improving vestibular pain in women with vulvodynia. Women receiving physical therapy had the greatest improvement in sexual function and frequency of intercourse at post-treatment and follow-up. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - March 16, 2023 Category: OBGYN Source Type: research
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better
Am Fam Physician. 2023 Mar;107(3):316-317.NO ABSTRACTPMID:36920835 (Source: Pain Physician)
Source: Pain Physician - March 15, 2023 Category: Anesthesiology Authors: Henry C Barry Source Type: research
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better
Am Fam Physician. 2023 Mar;107(3):316-317.NO ABSTRACTPMID:36920835 (Source: American Family Physician)
Source: American Family Physician - March 15, 2023 Category: Primary Care Authors: Henry C Barry Source Type: research
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better
Am Fam Physician. 2023 Mar;107(3):316-317.NO ABSTRACTPMID:36920835 (Source: Pain Physician)
Source: Pain Physician - March 15, 2023 Category: Anesthesiology Authors: Henry C Barry Source Type: research
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better
Am Fam Physician. 2023 Mar;107(3):316-317.NO ABSTRACTPMID:36920835 (Source: American Family Physician)
Source: American Family Physician - March 15, 2023 Category: Primary Care Authors: Henry C Barry Source Type: research
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better
Am Fam Physician. 2023 Mar;107(3):316-317.NO ABSTRACTPMID:36920835 (Source: American Family Physician)
Source: American Family Physician - March 15, 2023 Category: Primary Care Authors: Henry C Barry Source Type: research
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better
Am Fam Physician. 2023 Mar;107(3):316-317.NO ABSTRACTPMID:36920835 (Source: American Family Physician)
Source: American Family Physician - March 15, 2023 Category: Primary Care Authors: Henry C Barry Source Type: research
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better
Am Fam Physician. 2023 Mar;107(3):316-317.NO ABSTRACTPMID:36920835 (Source: American Family Physician)
Source: American Family Physician - March 15, 2023 Category: Primary Care Authors: Henry C Barry Source Type: research
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better
Am Fam Physician. 2023 Mar;107(3):316-317.NO ABSTRACTPMID:36920835 (Source: American Family Physician)
Source: American Family Physician - March 15, 2023 Category: Primary Care Authors: Henry C Barry Source Type: research
