A network medicine-based approach to explore the relationship between depression and inflammation
ConclusionNeuroimmune signaling pathways play an important role in the pathogenesis of depression, and many classes of antidepressants exhibiting anti-inflammatory properties. The pathogenesis of depression is closely related to inflammation. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - July 10, 2023 Category: Psychiatry Source Type: research
Synergistic combination of carvedilol, amlodipine, amitriptyline, and antibiotics as an alternative treatment approach for the susceptible and multidrug-resistant A. baumannii infections via drug repurposing
AbstractWe evaluated in vitro activity of 13 drugs used in the treatment of some non-communicable diseases via repurposing to determine their potential use in the treatment ofAcinetobacter baumannii infections caused by susceptible and multidrug-resistant strains.A. baumannii is a multidrug-resistant Gram-negative bacteria causing nosocomial infections, especially in intensive care units. It has been identified in the WHO critical pathogen list and this emphasises urgent need for new treatment options. As the development of new therapeutics is expensive and time consuming, finding new uses of existing drugs via drug reposi...
Source: European Journal of Clinical Microbiology and Infectious Diseases - July 10, 2023 Category: Microbiology Source Type: research
A Brief Review on the Novel Therapies for Painful Diabetic Neuropathy
AbstractPurpose of ReviewAlmost half of people diagnosed with diabetes mellitus will develop painful diabetic neuropathy (PDN), a condition greatly impacting quality of life with complicated pathology. While there are different FDA approved forms of treatment, many of the existing options are difficult to manage with comorbities and are associated with unwanted side effects. Here, we summarize the current and novel treatments for PDN.Recent FindingsCurrent research is exploring alternative pain management treatments from the first line options of pregabalin, gabapentin, duloxetine, and amitriptyline which often have side e...
Source: Current Pain and Headache Reports - July 1, 2023 Category: Neurology Source Type: research
Experimental Study of Antidepressant Properties of Afobazole
We studied the effects of oral administration of Afobazole in a dose of 10 mg/kg for 5 days on depressive-like behavior of male C57BL/6 mice in the tail suspension test in comparison with amitriptyline (10 mg/kg) or fluoxetine (20 mg/kg) treatment. Afobazole produced an antidepressant effect similar to amitriptyline, but inferior to fluoxetine. The σ1 receptor antagonist BD-1047 in a dose of 5 mg/kg blocked the antidepressant effect of Afobazole, which indicates the involvement of σ1 receptors in the antidepressant effect of the drug. (Source: Bulletin of Experimental Biology and Medicine)
Source: Bulletin of Experimental Biology and Medicine - June 20, 2023 Category: Biology Source Type: research
Developing an Artificial Intelligence-Guided Signal Detection in the Food and Drug Administration Adverse Event Reporting System (FAERS): A Proof-of-Concept Study Using Galcanezumab and Simulated Data
ConclusionAI could significantly ease some of the most time-consuming and labor-intensive steps of signal detection and validation. The AI-based approach showed promising results, however, future work is needed to validate the framework. (Source: Drug Safety)
Source: Drug Safety - June 10, 2023 Category: Drugs & Pharmacology Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
