Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication
CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017 (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 7, 2023 Category: Cardiology Authors: Veysel Özgür Barış Esra Gedikli Adnan Berk Din çsoy Ay şen Erdem Source Type: research
Medication Overuse Headache: an Updated Review and Clinical Recommendations on Management
AbstractOverviewMedication overuse headache (MOH) is highly prevalent among individuals with primary headache disorders.Purpose of Review(1) Provide an update on epidemiology, risk factors, and treatment strategies of MOH and (2) provide recommendations on the management of MOH.Recent FindingsThe prevalence of MOH ranges from 0.5 to 7.2%. Risk factors for MOH include female sex, lower socioeconomic status, some psychiatric conditions, and substance use disorders, among others. Recent large clinical trials support preventative therapy as an integral component of MOH management. Emerging clinical trial evidence supports anti...
Source: Current Neurology and Neuroscience Reports - June 5, 2023 Category: Neuroscience Source Type: research
Basic micro-pollutants in sludge from municipal wastewater treatment plants in the Northwest Spain: Occurrence and risk assessment of sludge disposal
Chemosphere. 2023 May 31:139094. doi: 10.1016/j.chemosphere.2023.139094. Online ahead of print.ABSTRACTSludge is one of the most problematic residues generated during wastewater treatment. Herein, we validate a single-step, sensitive procedure for the determination of a selection of 46 basic micro-pollutants, either used as pharmaceuticals or pesticides, in sludge from municipal sewage treatment plants (STPs), using liquid chromatography tandem mass spectrometry as determination technique. The proposed method permitted to achieve accurate recoveries (values from 70% to 120%, for samples spiked at different concentration le...
Source: Chemosphere - June 2, 2023 Category: Chemistry Authors: V Fern ández-Fernández M Ramil I Rodr íguez Source Type: research
Basic micro-pollutants in sludge from municipal wastewater treatment plants in the Northwest Spain: Occurrence and risk assessment of sludge disposal
Chemosphere. 2023 May 31:139094. doi: 10.1016/j.chemosphere.2023.139094. Online ahead of print.ABSTRACTSludge is one of the most problematic residues generated during wastewater treatment. Herein, we validate a single-step, sensitive procedure for the determination of a selection of 46 basic micro-pollutants, either used as pharmaceuticals or pesticides, in sludge from municipal sewage treatment plants (STPs), using liquid chromatography tandem mass spectrometry as determination technique. The proposed method permitted to achieve accurate recoveries (values from 70% to 120%, for samples spiked at different concentration le...
Source: Chemosphere - June 2, 2023 Category: Chemistry Authors: V Fern ández-Fernández M Ramil I Rodr íguez Source Type: research
Combined exposure to microplastics and amitriptyline caused intestinal damage, oxidative stress and gut microbiota dysbiosis in zebrafish (Danio rerio)
Aquat Toxicol. 2023 May 24;260:106589. doi: 10.1016/j.aquatox.2023.106589. Online ahead of print.ABSTRACTThe potential toxicity of microplastics (MPs) and hydrophilic pharmaceuticals to aquatic organisms has recently raised great public concern, yet their combined effects on aquatic organisms remain largely unknown. Herein, the combined effects of MPs and the commonly prescribed amitriptyline hydrochloride (AMI) on the intestinal tissue and gut microbiota of zebrafish (Danio rerio) were investigated. Adult zebrafish were exposed to microplastics (polystyrene, PS, 440 µg/L), AMI (2.5 µg/L), PS+AMI (440 µg/L PS + 2.5 µg/...
Source: Aquatic Toxicology - May 28, 2023 Category: Toxicology Authors: Yanhong Shi Chen Chen Ziming Han Kun Chen Xiangyang Wu Xuchun Qiu Source Type: research
Combined exposure to microplastics and amitriptyline caused intestinal damage, oxidative stress and gut microbiota dysbiosis in zebrafish (Danio rerio)
Aquat Toxicol. 2023 May 24;260:106589. doi: 10.1016/j.aquatox.2023.106589. Online ahead of print.ABSTRACTThe potential toxicity of microplastics (MPs) and hydrophilic pharmaceuticals to aquatic organisms has recently raised great public concern, yet their combined effects on aquatic organisms remain largely unknown. Herein, the combined effects of MPs and the commonly prescribed amitriptyline hydrochloride (AMI) on the intestinal tissue and gut microbiota of zebrafish (Danio rerio) were investigated. Adult zebrafish were exposed to microplastics (polystyrene, PS, 440 µg/L), AMI (2.5 µg/L), PS+AMI (440 µg/L PS + 2.5 µg/...
Source: Aquatic Toxicology - May 28, 2023 Category: Toxicology Authors: Yanhong Shi Chen Chen Ziming Han Kun Chen Xiangyang Wu Xuchun Qiu Source Type: research
The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis
Conclusions(CGRP(r)mAbs) have the best safety and efficacy profile of all drugs for migraine prophylaxis, followed closely by gepants. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 19, 2023 Category: Neurology Source Type: research
Effect of CYP2D6 pharmacogenetic phenotype and phenoconversion on serum concentrations of antidepressants and antipsychotics: a retrospective cohort study
ConclusionThe data stress the relevance of PC-informed PGx in psychopharmacological treatment and suggest that PC should be included in PGx result interpretation when PGx is implemented in routine clinical care, especially before initiating amitriptyline- or risperidone-treatment, to start with a dose adequate to the respective CYP2D6 functional enzyme status. Moreover, PGx and therapeutic drug monitoring should be used complementary but not alternatively. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - May 11, 2023 Category: Drugs & Pharmacology Source Type: research
Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low- and middle-income countries
CONCLUSIONS: In LMICs there is low-certainty evidence supporting the efficacy of combined psychosocial and pharmacologic interventions on reducing harmful alcohol use relative to psychosocial interventions alone. There is insufficient evidence to determine the efficacy of pharmacologic or psychosocial interventions on reducing harmful alcohol use largely due to the substantial heterogeneity in outcomes, comparisons, and interventions that precluded pooling of these data in meta-analyses. The majority of studies are brief interventions, primarily among men, and using measures that have not been validated in the target popul...
Source: Cochrane Database of Systematic Reviews - May 9, 2023 Category: General Medicine Authors: M Claire Greene Jeremy Kane Michelle Alto Ali Giusto Kathryn Lovero Melissa Stockton Jasmine McClendon Terriann Nicholson Milton L Wainberg Renee M Johnson Wietse Anton Tol Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: Am J Physiol Cell Ph... - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
