Effects of atorvastatin on time-dependent change of fast sodium current in simulated acute ischaemic ventricular myocytes.
CONCLUSION: Our results suggest that, in the early stages of ischaemia, changes in INa in ventricular myocytes are time-dependent, showing an initial increase followed by a decrease, while atorvastatin inhibited the transient increase in INa and made the change more gradual. PMID: 31361295 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - July 29, 2019 Category: Cardiology Authors: Li H, Wan Z, Li X, Teng T, Du X, Nie J Tags: Cardiovasc J Afr Source Type: research

OPCAB surgery with an alternative retraction method: a single-centre experience.
This study was a retrospective analysis of OPCAB operations performed between January 2014 and December 2018. Patients were evaluated and operated on by a surgical team led by an experienced OPCAB surgeon with over 200 prior OPCAB surgeries. RESULTS: The study included 606 OPCAB cases, and 21.8% (132) were female and 78.2% (474) were male. Our mortality rate was 1.7% (n = 10) and only two patients suffered a cerebrovascular incident. A statistically significant difference was found between pre-operative and six-month postoperative left ventricular ejection fraction values (p
Source: Cardiovascular Journal of Africa - July 15, 2019 Category: Cardiology Authors: Cetin E, Can T, Unal CS, Keskin A, Kubat E Tags: Cardiovasc J Afr Source Type: research

Plasma phospholipid fatty acid patterns are associated with adiposity and the metabolic syndrome in black South Africans: a cross-sectional study.
CONCLUSION: The n-9 LC-MUFA and n-3 EFA patterns seemed to provide possible protective associations with adiposity and the MetS, whereas the high-Satfat and n-3 VLC-PUFA patterns were associated with adiposity and the MetS in our study participants. The results are reflective of the metabolic difference between overweight and obese compared to lean individuals. PMID: 31361296 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - July 11, 2019 Category: Cardiology Authors: Ojwang AA, Kruger HS, Zec M, Ricci C, Pieters M, Kruger IM, Wentzel-Viljoen E, Smuts CM Tags: Cardiovasc J Afr Source Type: research

Fluorine-18 fluorodeoxyglucose positron emission tomography in assessing myocardial viability in a tertiary academic centre in Johannesburg, South Africa: a pilot study.
CONCLUSION: Our study demonstrated that F18-FDG PET was able to identify 55% of patients with ischaemic heart disease with viability in more than 10% of the total myocardium when using a 17-segment model. PMID: 31194212 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 12, 2019 Category: Cardiology Authors: Mpanya D, Tsabedze N, Libhaber C, Kagodora B, Vangu MD Tags: Cardiovasc J Afr Source Type: research

Clinical outcome of intracoronary versus intravenous high-dose bolus administration of tirofiban in diabetic patients undergoing primary percutaneous coronary intervention.
CONCLUSION: Thirty days post PCI, IC tirofiban was more efficient in ameliorating blood flow in the coronary arteries and myocardial tissue perfusion in DM patients after STEMI despite bleeding events, and MACE rates showed no significant difference between the groups. The IC group showed better improvement in LVEF. PMID: 31194213 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 12, 2019 Category: Cardiology Authors: Ghonim AA, Mostafa A, Emara A, Algazzar AS, Qutub MA Tags: Cardiovasc J Afr Source Type: research

Ellisras Longitudinal Study 2017: Childhood underweight and blood pressure status in a rural black population of South Africa (ELS 26).
CONCLUSIONS: The prevalence of childhood underweight was found to be high in children aged between five and 16 years. To address this problem, well-thought-out intervention systems are need. PMID: 31180114 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 4, 2019 Category: Cardiology Authors: Mphekgwana PM, Makgopa HM, Monyeki KD, Malatji JM, Mabila TE Tags: Cardiovasc J Afr Source Type: research

Atherosclerotic plaque in HIV-positive patients presenting with acute coronary syndromes.
CONCLUSIONS: IVUS and VH demonstrated a high burden of atherosclerosis in the left anterior descending artery and proximal vasculature of HIV-positive patients. The atherosclerotic plaque predominantly comprised non-calcified fibrous and fibro-fatty plaque. PMID: 31180115 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - June 4, 2019 Category: Cardiology Authors: Vachiat A, McCutcheon K, Tsabedze N, Zachariah D, Manga P Tags: Cardiovasc J Afr Source Type: research

Coronary angiographic findings in dilated cardiomyopathy in a sub-Saharan African population.
Abstract AIM: To describe the coronary angiographic aspects observed in patients with dilated cardiomyopathies (DCM) in a sub-Saharan African country in order to improve their management. METHODS: This was a cross-sectional study conducted from 1 January 2010 to 31 March 2016. All patients aged 18 years and older, presenting with DCM and admitted to Abidjan Heart Institute, who underwent coronary angiography were included. One hundred and eight patients were selected. We analysed and compared the coronary angiographic features observed. RESULTS: The median age of our patients was 52 years (46-61). There ...
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: N'Guetta R, Yao H, Ehouman E, Ekou A, Anzouan-Kacou JB, Coulibaly I, Hauhouot-Attoungbre ML, Kramoh E, Yapobi Y, Seka R Tags: Cardiovasc J Afr Source Type: research

Ellisras Longitudinal Study 2017: the association of fat patterning with blood pressure in Polokwane private school children aged five to 15 years (ELS 22).
Abstract BACKGROUND: Obesity is a risk factor for non-communicable diseases and is a global public health concern. OBJECTIVE: The main objectives of this study were to investigate the association of fat patterning and blood pressure among five- to 15-year-old black children attending private schools in Polokwane, South Africa, and to determine the prevalence of obesity and hypertension. METHODS: A total of 1 665 subjects (846 boys and 819 girls), aged five to 15 years and attending three private schools in Polokwane, were included in the study. All anthropometric measurements were taken according to stan...
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Nkwana MR, Monyeki KD, Monyeki SM, Makata TT, Monyeki JM Tags: Cardiovasc J Afr Source Type: research

Effect of time delay of PDA closure on the aortic stiffness index and its relationship with cardiac function.
In this study, we evaluated the effect of time delay of PDA closure on aortic stiffness and its relationship with cardiac function before and after transcatheter closure of the PDA. METHODS: Our study population consisted of 60 children who were scheduled for transcatheter closure of the PDA. They were divided into two groups as follows: group A in whom PDA closure was performed before the age of one year, and group B in whom PDA closure was performed after the age of one year. RESULTS: Before PDA closure, the aortic stiffness index (ASI) was significantly higher in children in group B than in those in group A (p
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Elsaughier SM, Ghaleb R, Mansour H Tags: Cardiovasc J Afr Source Type: research

The Amsterdam Growth and Health Longitudinal Study: how important is physical activity in youth for later health? (ELS 33).
This study followed three birth cohorts (1962, 1963 and 1964) of boys and girls in the Amsterdam region in the Netherlands. The follow-up period was 25 years, with 10 measurements from age 12 to 42 years. The main purpose of the AGAHLS was to detect changes in health and lifestyle over time during the teenage and young adult period. METHODS: In total, 617 subjects were recruited from two secondary schools in Amsterdam and Purmerend. We measured aerobic fitness (VO2 peak), bone mineral density (BMD), obesity from body mass index (BMI) and body fatness from the sum of four skinfolds (S4S). Daily physical activity (DPA) ...
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Kemper HC, Monyeki KD Tags: Cardiovasc J Afr Source Type: research

Natural cocoa inhibits maternal hypercholesterolaemia-induced atherogenesis in rabbit pups.
This study assessed the effect of natural cocoa on atherosclerosis in offspring conceived in maternal hypercholesterolaemia. Female rabbits were fed a cholesterol-enriched diet for two weeks and hypercholesterolaemia was confirmed, after which they were crossed with normocholesterolaemic males. One group of hypercholesterolaemic mothers (HCC) received natural cocoa powder (NCP) in their drinking water, whereas the other group (HC) received only water. Histological analysis of three segments of the aorta (arch, thoracic and abdominal) from offspring of both groups was compared with a control group (NC). Intima-media thickne...
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Blay RM, Adjenti SK, Adutwum-Ofosu KK, Hottor BA, Ahenkorah J, Arko-Boham B, Addai FK Tags: Cardiovasc J Afr Source Type: research

The effect of perindopril on echocardiographic parameters, NYHA functional class and serum NT-proBNP values in patients with diastolic heart failure.
CONCLUSIONS: Tissue Doppler septal late diastolic velocities and septal systolic myocardial velocities increased in the perindopril group but NT-proBNP levels, and NYHA class was not changed in this study population. PMID: 31140540 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Yuksek U, Cerit L, Eren NK, Ergene O Tags: Cardiovasc J Afr Source Type: research

Effects of cardiopulmonary bypass on pulmonary function in COPD patients undergoing beating heart coronary artery bypass surgery.
CONCLUSIONS: The on-pump beating heart CABG surgery did not affect the postoperative mechanical ventilatory support times in patients with COPD. PMID: 31140541 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Çetin E, Altinay L Tags: Cardiovasc J Afr Source Type: research

Wellens' syndrome: a life-saving diagnosis.
Abstract Wellens' syndrome is a relatively common clinical entity; however, it is often missed, especially in young patients. Without prompt diagnosis and aggressive intervention, patients with Wellens' syndrome may rapidly go on to develop extensive anterior wall myocardial infarction and possibly sudden death. In this case report, we present a 33-year-old male patient with atypical chest pain, and discuss the significance of a prompt recognition of Wellens' syndrome. PMID: 31140542 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Chen YM, Song KX Tags: Cardiovasc J Afr Source Type: research

Factors associated with sub-optimal control of anticoagulation in patients with prosthetic heart valves taking oral anticoagulants in a sub-Saharan African setting.
CONCLUSIONS: Educational level, distance from follow-up facility, number of follow-up visits and source of warfarin supply were found to be significantly associated with sub-optimal control of INR. PMID: 31140545 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Chalachew T, Yadeta D, Tefera E Tags: Cardiovasc J Afr Source Type: research

Unmasking right ventricular dysfunction in chronic rheumatic mitral regurgitation.
Abstract AIMS: Right ventricular (RV) systolic function is an important predictor of mortality but has been poorly studied in chronic rheumatic mitral regurgitation (CRMR). We studied RV systolic function using speckle-tracking echocardiography (STE) in patients with CRMR. METHODS: Seventy-seven patients with CRMR and 40 healthy controls were enrolled in a cross-sectional study at Chris Hani Baragwanath Hospital between January and October 2014. RV peak systolic strain (PSS) and left ventricular (LV) global longitudinal strain (GLS) were measured using Philips Qlab 9 STE software. RESULTS: RVPSS was lowe...
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Meel R, Peters F, Libhaber E, Essop ME Tags: Cardiovasc J Afr Source Type: research

Effects of cardiopulmonary bypass on dialysis-dependent patients.
Abstract BACKGROUND: End-stage renal disease is considered an independent risk factor for early and late survival after coronary artery bypass grafting. METHODS: We retrospectively analysed patients with dialysis-dependent renal insufficiency who had undergone coronary artery bypass surgery between 2010 and 2017. Patients who were operated with the assistance of cardiopulmonary bypass (ONCAB) were in group 1 and those operated with off-pump coronary artery bypass surgery (OPCAB) were in group 2. We compared peri-operative morbidity and mortality rates and short-term results of the two groups. RESULTS: Th...
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Tanrikulu N, Ozbek B Tags: Cardiovasc J Afr Source Type: research

South African Hypertension Society commentary on the American College of Cardiology/American Heart Association hypertension guidelines.
Abstract In late 2017, the publication of the new American College of Cardiology (ACC)/American Heart Association (AHA) hypertension guidelines created considerable controversy. The threshold for hypertension was redefined as> 130/80 mmHg and target blood pressure
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: Rayner B, Jones E, Veriava Y, Seedat YK Tags: Cardiovasc J Afr Source Type: research

The role of echocardiography in acute viral myocarditis.
Abstract The diagnosis of acute viral myocarditis can be very challenging during the initial evaluation, warranting multiple diagnostic tests to be performed, including a full echocardiographic evaluation to exclude other aetiologies that might present similarly. Acute myocarditis may masquerade as acute myocardial infarction in older patients or as any form of cardiomyopathy in young patients. As a result, all these patients need a thorough evaluation and to be managed at a high cardiac-care setting from the very outset. A wide range of diagnostic tests may be warranted, including conventional echocardiography, t...
Source: Cardiovascular Journal of Africa - April 11, 2019 Category: Cardiology Authors: Matshela MR Tags: Cardiovasc J Afr Source Type: research

Performance of HAS-BLED and CRUSADE risk scores for the prediction of haemorrhagic events in patients with stable coronary artery disease.
Abstract We aimed to compare the power of the HAS-BLED and CRUSADE risk scores in predicting in-hospital bleeding events in patients with stable coronary artery disease undergoing elective coronary angiography. A total of 405 consecutive patients were included in the study. The mean HAS-BLED score was significantly higher (p
Source: Cardiovascular Journal of Africa - March 29, 2019 Category: Cardiology Authors: Yildirim E, Uku O, Bilen MN, Secen O Tags: Cardiovasc J Afr Source Type: research

Remodelling in atrial fibrillation: the impact of amiodarone.
Abstract Atrial fibrillation (AF) is a common heart rhythm disorder with a prevalence of up to 2.9% in the general population. Its mechanism involves a particular electrophysiological profile as well as structural and biohumoral changes that are often irreversible. With the recent advances in pharmacology, amiodarone remains the cornerstone for the treatment of AF. Although it is one of the most controversial anti-arrhythmic agents due to the multitude of side effects, it is further recognised as the most effective drug available for the conversion and maintenance of sinus rhythm in the case of significant left ve...
Source: Cardiovascular Journal of Africa - March 27, 2019 Category: Cardiology Authors: Grosu AI, Radulescu D, Grosu LC, Pop D Tags: Cardiovasc J Afr Source Type: research

Cardiac rehabilitation delivery in Africa.
PMID: 31140544 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - March 27, 2019 Category: Cardiology Authors: Heine M, Turk-Adawi K, Supervia M, Derman W, Lopez-Jimenez F, Naidoo P, Grace SL Tags: Cardiovasc J Afr Source Type: research

Characteristics and 12-month outcome of patients with atrial fibrillation at a tertiary hospital in Botswana.
This study aimed at describing the clinical features and outcome of AF patients at a tertiary hospital in Botswana. METHODS: This prospective study was carried out in the Princess Marina Hospital in Gaborone, Botswana between August 2016 and July 2018. We consecutively enrolled 138 (97.8% black Africans) adult patients with electrocardiographically documented AF. Their baseline clinical and biomedical data were documented, and each patient was followed up for 12 months. The primary study outcome was 12-month all-cause mortality. RESULTS: The mean [standard deviation (SD) ] age of enrolled patients was 66.7 (17.2)...
Source: Cardiovascular Journal of Africa - March 27, 2019 Category: Cardiology Authors: Mwita JC, Ocampo C, Molefe-Baikai OJ, Goepamang M, Botsile E, Tshikuka JG Tags: Cardiovasc J Afr Source Type: research

Change in late sodium current of atrial myocytes in spontaneously hypertensive rats with allocryptopine treatment.
CONCLUSIONS: The results clearly show that an increase in INa,Late in SHR atrial myocytes was inhibited by All derived from Chinese herbal medicine. PMID: 30882133 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - March 14, 2019 Category: Cardiology Authors: Dong Y, Huang Y, Wu HL, Ke J, Yin YL, Zhu C, Li B, Li J, Gao L, Xue Q, Zhang JC, Li Y Tags: Cardiovasc J Afr Source Type: research

Effects of acute hypoxic provocation on the autonomic nervous system in 'healthy' young smokers, measured by heart rate variability.
CONCLUSIONS: Smoking probably impairs autonomic regulation in healthy young males and may lead to decreased HRV, even before subjective clinical signs and symptoms appear. PMID: 30778498 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - February 14, 2019 Category: Cardiology Authors: Taralov ZZ, Dimov PK, Terziyski KV, Marinov BI, Topolov MK, Kostianev SS Tags: Cardiovasc J Afr Source Type: research

Beta-blocker target dosing and tolerability in a dedicated heart failure clinic in Johannesburg.
CONCLUSIONS: In a dedicated heart failure clinic in South Africa, beta-blockers were well-tolerated in the treatment of HFrEF. The potential role of specific heart rate-lowering therapy in patients treated adequately with heart failure medication and proper up-titration of beta-blockers is relatively small. PMID: 30740613 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - February 11, 2019 Category: Cardiology Authors: Bolon J, McCutcheon K, Klug E, Smith D, Manga P Tags: Cardiovasc J Afr Source Type: research

A patient with anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA syndrome) and 13 live births.
Abstract Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) or Bland-White-Garland syndrome is a rarely seen congenital anomaly. Adult and infantile types are defined according to the degree of collateral development between the left coronary artery (LCA) and right coronary artery (RCA). If left untreated, ALCAPA has a 90% mortality rate in the first year of life, primarily due to myocardial ischaemia and heart failure. The degree of collateral development and the related LCA perfusion in ALCAPA syndrome determine the occurrence of symptoms. Herein, we present a case of a female patien...
Source: Cardiovascular Journal of Africa - February 6, 2019 Category: Cardiology Authors: Yolcu M, Bilal MS, Avsar MK, Yildirim O Tags: Cardiovasc J Afr Source Type: research

Second recurrence of familial atrial myxomas: mother and daughter simultaneously.
We report on two cases of recurrent cardiac myxoma, a mother and daughter, who concurrently presented with a second recurrence of atrial myxomas. The time interval between the first and second recurrence following surgery was four years in both. The possibility of repeat recurrence of cardiac myxomas demonstrates the importance of regular echocardiography to detect recurrence and to prevent the potential complications associated with cardiac myxomas. Family screening should be recommended for familial myxomas. PMID: 30729976 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - February 6, 2019 Category: Cardiology Authors: Bayramoglu Z, Oral K, Ezelsoy M, Akpinar B Tags: Cardiovasc J Afr Source Type: research

Cardiovascular risk factors among people living with HIV in rural Kenya: a clinic-based study.
CONCLUSIONS: An elevated prevalence of undiagnosed cardiovascular risk factors such as hypertension and raised total cholesterol levels was found among people living with HIV. There was an association between raised total cholesterol and nucleoside reverse-transcriptase inhibitor (NRTI) -based ART regimens. Our findings provide further rationale for integrating routine cardiovascular risk-factor screening into HIV-care services. PMID: 30720846 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - January 24, 2019 Category: Cardiology Authors: Juma K, Nyabera R, Mbugua S, Odinya G, Jowi J, Ngunga M, Zakus D, Yonga G Tags: Cardiovasc J Afr Source Type: research

Assessment of adherence to medication for cardiovascular diseases: measurement tools.
Abstract The effectiveness of treatment and prevention of chronic illnesses can be optimised with adherence to medication treatment. This is very often assessed by means of a self-report. However, the challenge here is to choose the most suitable questionnaire or the one that is best overall in a given situation. The aim of this systematic review was to assess existing self-reported medication adherence scales, which measure adherence to treatment for cardiovascular disease. The review demonstrated that relatively few disease-specific adherence scales exist. Generic questionnaires and those specific to adherence t...
Source: Cardiovascular Journal of Africa - January 23, 2019 Category: Cardiology Authors: Uchmanowicz B, Szymańska-Chabowska A, Jankowska-Polańska B Tags: Cardiovasc J Afr Source Type: research

Blood pressure measurement in pregnancy and in hypertensive disorders of pregnancy: devices, techniques and challenges.
Abstract Measurement of blood pressure is essential for clinical management of patients. To obtain an accurate blood pressure reading, the use of a validated device and an appropriate technique are required. This is of particular importance in pregnancy where the physiological changes affect vessel wall compliance. Moreover, currently it is difficult to predict in early pregnancy (prior to 20 weeks of gestation) which women would develop hypertension or pre-eclampsia. For this reason, blood pressure devices require validation in pregnancy and in hypertensive disorders of pregnancy to ensure that accurate readings ...
Source: Cardiovascular Journal of Africa - January 23, 2019 Category: Cardiology Authors: Ngene NC, Moodley J Tags: Cardiovasc J Afr Source Type: research

Aldosterone and renin in relation to surrogate measures of sympathetic activity: the SABPA study.
Abstract INTRODUCTION: Hypertension, particularly in black populations, is often accompanied by augmented sympathetic nervous system activity and suppressed renin activity, indicative of possible blood pressure (BP) dysregulation. The potential role of the interrelationship between the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system in the context of low-renin conditions is unclear. We therefore explored whether surrogate measures of sympathetic activity [noradrenaline, 24-hour heart rate (HR) and percentage (%) dipping of night-time HR] relate to renin, aldosterone and aldosterone-...
Source: Cardiovascular Journal of Africa - January 22, 2019 Category: Cardiology Authors: Gafane-Matemane LF, van Rooyen JM, Schutte R, Schutte AE Tags: Cardiovasc J Afr Source Type: research

Laron syndrome related to homozygous growth hormone receptor c.784 > C mutation in a patient with hypoplastic pulmonary arteries.
In this report, we present a 10-year-and-5-month-old girl with severe peripheral-type pulmonary artery hypoplasia and Laron syndrome related to homozygous GHR c.784>C mutation. PMID: 30720842 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - January 22, 2019 Category: Cardiology Authors: Akinci A, Karakurt C, Hwa V, Dündar I, Çamtosun E Tags: Cardiovasc J Afr Source Type: research

The pattern of risk-factor profile in Egyptian patients with acute coronary syndrome: phase II of the Egyptian cross-sectional CardioRisk project.
S, Beshay M, Shawky A, Yusef M, Abd El-Ghany M, Gamal A, Baghdady Y, Mostafa T, Zahran M, El Rabat K, Bendary A, El Shorbagy A Abstract BACKGROUND: Egypt is the most populous country in the Middle East and North Africa and has more than 15% of the cardiovascular deaths in the region, but little is known about the prevalence of traditional risk factors and treatment strategies in acute coronary syndrome (ACS) patients across Egypt. METHODS: From November 2015 to August 2017, data were collected from 1 681 patients with ACS in 30 coronary care centres, covering 11 governorates across Egypt, spanning the Medite...
Source: Cardiovascular Journal of Africa - January 16, 2019 Category: Cardiology Authors: Reda A, Ashraf M, Soliman M, Ragy H, El Kersh A, Abdou W, Mostafa T, Hassan M, Farag E, Khamis H, Wadie M, Elbahry A, Salama S, Kazamel G, Sadaka M, Mostafa M, Abd El-Bary A, Sanad O, Rafla S, Abd El-Hady Y, Selim M, Farag N, El-Ghawaby H, El-Araby H, Emi Tags: Cardiovasc J Afr Source Type: research

Management of low-density lipoprotein cholesterol levels in South Africa: the International ChoLesterol management Practice Study (ICLPS).
Abstract The International Cholesterol Management Practice Study (ICLPS) South Africa investigated achievement of European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guideline low-density lipoprotein cholesterol (LDL-C) targets in real-world clinical practice. Demographic data, clinical characteristics, cardiovascular risk factors, lipid-modifying medications, lipid values and investigator's assessment of cardiovascular risk were recorded for 396 patients on stable lipid-modifying therapy. Most (98.7%) patients received statins; 25.1% of statin-treated patients were receiving high-intensity...
Source: Cardiovascular Journal of Africa - January 16, 2019 Category: Cardiology Authors: Blom DJ, Raal F, Amod A, Naidoo P, Lai YE, ICLPS SA study group Tags: Cardiovasc J Afr Source Type: research

Long-segment patchplasty of diffuse left anterior descending artery disease on the beating heart.
CONCLUSIONS: Bypass grafting of the LAD with long-segment LITA onlay patchplasty can safely be performed in patients with multisegment LAD disease, with acceptable early-term results. In this procedure, proximal and distal segments of the diseased LAD are revascularised with LITA grafts, which may improve long-term survival and quality of life. PMID: 30720843 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - January 7, 2019 Category: Cardiology Authors: Kaya E, Isik O Tags: Cardiovasc J Afr Source Type: research

Outcomes in patients with acute coronary syndrome in a referral hospital in sub-Saharan Africa.
CONCLUSIONS: In our series, the in-hospital, 30-day and one-year mortality rates following ACS remain high, particularly for STEMI patients. Delayed presentation to hospital following symptom onset is a major concern. PMID: 30534849 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - December 4, 2018 Category: Cardiology Authors: Varwani MH, Jeilan M, Ngunga M, Barasa A Tags: Cardiovasc J Afr Source Type: research

A diagnostic algorithm for pulmonary hypertension due to left heart disease in resource-limited settings: can busy clinicians adopt a simple, practical approach?
Abstract Pulmonary hypertension (PH) has progressively moved from an orphan disease to a significant global health problem with a major disease burden in limited7hyphen;resource countries, where over 97% of patients live. The aetiologies of PH differ between high- and low-income nations, but PH due to left heart disease is credited to be the most frequent contemporary form. Although a straightforward diagnosis of PH requires the use of right heart catheterisation (RHC), access to equipment for RHC is a deterrent. Furthermore, the risk associated with RHC limits its uptake to a selection of specialised centres. Mor...
Source: Cardiovascular Journal of Africa - November 30, 2018 Category: Cardiology Authors: Dzudie A, Kengne AP, Lamont K, Dzekem BS, Aminde LN, Abanda MH, Thienemann F, Sliwa K Tags: Cardiovasc J Afr Source Type: research

Association between coronary tortuosity and mitral annular calcification.
This study was conducted with the aim of evaluating the association between CorT and MAC. METHODS: The medical records of consecutive patients who underwent coronary angiography were retrospectively reviewed. The study group consisted of 2 736 patients. Taking into consideration the inclusion criteria, 392 patients with MAC and 687 patients without MAC (control group) were included in the study. Biochemical, clinical and echocardiographic parameters and CorT were evaluated in all patients. CorT was defined as three fixed bends during both systole and diastole, with the angle of each bend 45° or more. RESULTS:...
Source: Cardiovascular Journal of Africa - November 30, 2018 Category: Cardiology Authors: Cerit L, Cerit Z Tags: Cardiovasc J Afr Source Type: research

A retrospective review of right-sided hearts at a South African tertiary hospital.
CONCLUSIONS: A RSH is an unusual occurrence. Dextrocardia, the most common cause, is frequently associated with ACM and extra-cardiac abnormalities. It is therefore important to timeously elucidate the cause of a RSH. PMID: 30462143 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - November 21, 2018 Category: Cardiology Authors: Beringer N, Cilliers A Tags: Cardiovasc J Afr Source Type: research

Pulmonary thromboendarterectomy in a combined thrombophilia patient.
We report on a 50-year-old female patient with combined inherited thrombophilia, including protein C and protein S deficiencies, who was diagnosed with CTEPH and was successfully treated with pulmonary thromboendarterectomy. PMID: 30460973 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - November 20, 2018 Category: Cardiology Authors: Akbayrak H, Tekumit H Tags: Cardiovasc J Afr Source Type: research

Intracoronary or intravenous abciximab after aspiration thrombectomy in patients with STEMI undergoing primary percutaneous coronary intervention.
CONCLUSIONS: IC versus IV abciximab did not enhance myocardial reperfusion in non-selected patients with STEMI undergoing primary PCI after aspiration thrombectomy had successfully been performed. PMID: 30460974 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - November 20, 2018 Category: Cardiology Authors: Bedjaoui A, Allal K, Lounes MS, Belhadi CE, Mekarnia A, Sediki S, Kara M, Azaza A, Monsuez JJ, Benkhedda S Tags: Cardiovasc J Afr Source Type: research

Audit of transfusion of blood products in paediatric congenital heart surgery on cardiopulmonary bypass.
Abstract BACKGROUND: Cardiac surgery is associated with peri-operative bleeding, which may result in the need for blood transfusion, particularly in paediatric congenital cardiac surgery on cardiopulmonary bypass (CPB). There is a necessity for regular auditing in order to improve practices. METHODS: Retrospective, contextual, descriptive data of 105 patients were collected for the period January to December 2014. RESULTS: The median age of patients was four (1-6) years, weight was 13 (8.4-20) kg, and mean lowest CPB haemoglobin level was 8.3 (1.5) g/dl. There was a statistically significant difference i...
Source: Cardiovascular Journal of Africa - November 6, 2018 Category: Cardiology Authors: Bayebaye CT, Motshabi-Chakane P, Muteba MK Tags: Cardiovasc J Afr Source Type: research

Transradial versus transfemoral intervention in non-ST-segment elevation acute coronary syndrome patients undergoing percutaneous coronary intervention: the Korean transradial intervention registry of 1 285 patients.
CONCLUSIONS: In patients with NSTE-ACS, TRI was associated with favourable one-year clinical outcomes and lower bleeding complications compared to TFI. Independent predictors of MACE were clinical and angiographic profiles (CKD, MVD) rather than vascular access sites. PMID: 30398512 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - November 6, 2018 Category: Cardiology Authors: Lee MH, Bang DW, Park BW, Cho BR, Rha SW, Jeong MH, Yoon J, Suh J, Han KR, Hyon MS Tags: Cardiovasc J Afr Source Type: research

Delayed left ventricular pseudo-aneurysm after postinfarction repair of ventricular septal defect.
We report on surgical management for a left ventricular pseudo-aneurysm that developed four years after surgery for ventricular septal defect in a patient with acute myocardial infarction. PMID: 30398513 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - November 6, 2018 Category: Cardiology Authors: Song YS, Seol SH, Kim SH, Kim DK, Kim KH, Kim DI, Jun HJ Tags: Cardiovasc J Afr Source Type: research

Clinical and echocardiographic correlates of pulmonary hypertension among heart failure patients in Lagos, south-western Nigeria.
Abstract BACKGROUND: Pulmonary hypertension (PH) is very prevalent among heart failure (HF) subjects and is now recognised as an independent predictor of poor prognosis. There is a paucity of data in our environment about the frequency and correlates of PH in HF. We aimed to determine the frequency of PH in HF patients in an academic hospital and assess its correlates using echocardiography. METHODS: A total of 219 heart failure patients in NYHA functional class II to IV, and without co-morbidities that could cause PH, were consecutively recruited. Demographic, clinical and echocardiographic data were obtaine...
Source: Cardiovascular Journal of Africa - November 5, 2018 Category: Cardiology Authors: Kushimo OA, Mbakwem AC, Ajuluchukwu JN, Amadi CE Tags: Cardiovasc J Afr Source Type: research

Ellisras Longitudinal Study 2017: The relationship between waist circumference, waist-to-hip ratio, skinfolds and blood pressure among young adults in Ellisras, South Africa (ELS 14).
This study examined the relationship between anthropometric parameters and blood pressure (BP) among young adults in the Ellisras rural area of South Africa. METHODS: A total of 742 (365 females and 377 males) young adults aged 22 to 30 years, who were part of the Ellisras Longitudinal Study (ELS), participated in the research. Anthropometric and BP measurements were taken using the protocol of the International Society for the Advancement of Kinanthropometry (ISAK). Linear regression was used to determine the relationship between anthropometric parameters and BP. The risk of developing hypertension among young Elisra...
Source: Cardiovascular Journal of Africa - November 5, 2018 Category: Cardiology Authors: Sebati RB, Monyeki KD, Monyeki MS, Motloutsi B, Toriola AL, Monyeki MJ Tags: Cardiovasc J Afr Source Type: research

Ellisras Longitudinal Study conference 2017.
CONCLUSIONS: There was a high prevalence of overweight and obesity among rural Ellisras females. Moreover, increasing cholesterol intake was associated with overweight and obesityin the overall sample. PMID: 30371723 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - October 24, 2018 Category: Cardiology Authors: Mashiane JT, Monyeki KD, Kengne AP, Rosina NM, Monyeki MS Tags: Cardiovasc J Afr Source Type: research

The Pan-African Society of Cardiology position paper on reproductive healthcare for women with rheumatic heart disease.
Abstract This position paper summarises the current knowledge on the epidemiology, diagnosis and management of women of childbearing age with rheumatic heart disease (RHD) in Africa, as well as the available data on their use of reproductive health services. The aim is to provide guidance to health professionals on aspects of sexual and reproductive health in women with RHD. It reviews the diagnosis, management and counselling of women with RHD throughout their reproductive life. Additionally, this publication discusses potential ways of integrating obstetric and cardiovascular care at peripheral levels of the hea...
Source: Cardiovascular Journal of Africa - September 18, 2018 Category: Cardiology Authors: Mocumbi AO, Jamal KK, Mbakwem A, Shung-King M, Sliwa K Tags: Cardiovasc J Afr Source Type: research