Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: American Journal of Physiology. Cell Physiology - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: Am J Physiol Cell Ph... - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: American Journal of Physiology. Cell Physiology - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: Am J Physiol Cell Ph... - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: American Journal of Physiology. Cell Physiology - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: Am J Physiol Cell Ph... - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: American Journal of Physiology. Cell Physiology - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: Am J Physiol Cell Ph... - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: American Journal of Physiology. Cell Physiology - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: Am J Physiol Cell Ph... - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand
Am J Physiol Cell Physiol. 2023 May 8. doi: 10.1152/ajpcell.00535.2022. Online ahead of print.ABSTRACTTraditionally prescribed for mood disorders, tricyclic antidepressants (TCAs) have shown promising therapeutic effects on chronic neuralgia and irritable bowel syndrome. However, the mechanism by which these atypical effects manifest is unclear. Among the proposed mechanisms is the well-known pain-related inhibitory G-protein coupled receptor (GiPCR), namely, the opioid receptor (OR). Here, we confirmed that TCA indeed stimulates OR and regulates the gating of TRPC4, a downstream signaling of the Gi-pathway. In an ELISA to...
Source: American Journal of Physiology. Cell Physiology - May 8, 2023 Category: Cytology Authors: Byeongseok Jeong Young Pyo Song Ji Yeon Chung Ki Chul Park Jin Hyeong Kim Insuk So Chansik Hong Source Type: research
Levator Ani Syndrome Presenting with Vaginal Pain
BMJ Case Rep. 2023 May 4;16(5):e255190. doi: 10.1136/bcr-2023-255190.ABSTRACTLevator ani syndrome (LAS), also known as levator ani spasm, puborectalis syndrome, chronic proctalgia, pyriformis syndrome and pelvic tension myalgia, produces chronic anal pain. The levator ani muscle is susceptible to the development of myofascial pain syndrome, and trigger points may be elicited on physical examination. The pathophysiology remains to be fully delineated. The diagnosis of LAS is suggested primarily by the clinical history, physical examination and the exclusion of organic disease that can produce recurrent or chronic proctalgia...
Source: Pain Physician - May 4, 2023 Category: Anesthesiology Authors: Louise Dunphy Frances Wood Emad Saleem Mubarak Lynda Coughlin Source Type: research
Amitriptyline efficacy in decreasing implant ‐induced foreign body reaction
AbstractBeyond its actions on the nervous system, amitriptyline (AM) has been shown to lower inflammatory, angiogenic, and fibrogenic markers in a few pathological conditions in human and in experimental animal models. However, its effects on foreign body reaction (FBR), a complex adverse healing process, after biomedical material implantation are not known. We have evaluated the effects of AM on the angiogenic and fibrogenic components on a model of implant-induced FBR. Sponge disks were implanted subcutaneously in C57BL/6 mice, that were treated daily with oral administration of AM (5 mg/kg) for seven consecutive days...
Source: IUBMB Life - April 22, 2023 Category: Research Authors: Karina Scheuermann,
Celso Tarso Rodrigues Viana,
Diego Carlos Reis,
Marcela Guimar ães Takahashi Lazari,
Laura Alejandra Ariza Orellano,
Clara Tolentino Machado,
Leticia Cristine Cardoso Santos,
Henning Ulrich,
Luciano Santos Aggum Capettini,
Si Tags: RESEARCH ARTICLE Source Type: research
Guidelines for the management of chronic cough in adults
We present herein the second-line tests that might be considered in patients whose coughing has persisted, notwithstanding initial management. The experts have also put forward a definition of unexplained or refractory chronic cough (URCC), the objective being to more precisely identify those patients whose cough persists despite optimal management. Lastly, these guidelines indicate the pharmacological and non-pharmacological interventions of use in URCC. Amitriptyline, pregabalin, gabapentin or morphine combined with speech and/or physical therapy are mainstays in treatment strategies. Other treatment options, such as P2X...
Source: Revue des Maladies Respiratoires - April 20, 2023 Category: Respiratory Medicine Authors: L Guilleminault S Demoulin-Alexikova L de Gabory S Bruley des Varannes D Brouqui ères M Balaguer A Chapron S Grassin Delyle M Poussel N Guibert G Reychler W Trzepizur V Woisard S Crestani Source Type: research
