Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication

CONCLUSION: In this study, we determined that empagliflozin significantly ameliorated amitriptyline-induced QT and QTc prolongation. This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.PMID:37285169 | DOI:10.5830/CVJA-2023-017
Source: Cardiovascular Journal of Africa - Category: Cardiology Authors: Source Type: research