Cognitive Change in Schizophrenia and Other Psychoses in the Decade Following the First Episode.
CONCLUSIONS: Patients with schizophrenia and other psychoses experience cognitive decline after illness onset, but the magnitude of decline varies across cognitive functions. Distinct mechanisms consequent to the illness and/or psychosocial factors may underlie impairments across different cognitive functions. PMID: 31256609 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Zanelli J, Mollon J, Sandin S, Morgan C, Dazzan P, Pilecka I, Reis Marques T, David AS, Morgan K, Fearon P, Doody GA, Jones PB, Murray RM, Reichenberg A Tags: Am J Psychiatry Source Type: research

Baseline Frontoparietal Task-Related BOLD Activity as a Predictor of Improvement in Clinical Symptoms at 1-Year Follow-Up in Recent-Onset Psychosis.
CONCLUSIONS: These results suggest that frontoparietal activation during cognitive control performance at baseline significantly predicts subsequent symptomatic improvement during early psychosis specialty care. Potential implications for fMRI-based personalized patient treatment are discussed. PMID: 31256610 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Smucny J, Lesh TA, Carter CS Tags: Am J Psychiatry Source Type: research

Identifying Novel Types of Irritability Using a Developmental Genetic Approach.
CONCLUSIONS: The developmental context of irritability may be important in its conceptualization: early-onset persistent irritability may be more neurodevelopmental/ADHD-like and later-onset irritability more depression/mood-like. These findings have implications for treatment as well as nosology. PMID: 31256611 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Riglin L, Eyre O, Thapar AK, Stringaris A, Leibenluft E, Pine DS, Tilling K, Davey Smith G, O'Donovan MC, Thapar A Tags: Am J Psychiatry Source Type: research

Using Neuroimaging to Characterize Brain Alterations Associated With Psychopathology.
PMID: 31256615 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Comment on the Relationship Between Common Variant Schizophrenia Liability and Number of Offspring in the UK Biobank.
e; MR PMID: 31256616 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Lawn RB, Sallis HM, Taylor AE, Wootton RE, Davey Smith G, Davies NM, Hemani G, Fraser A, Penton-Voak IS, Munafò MR Tags: Am J Psychiatry Source Type: research

Cortical Thickness and Connectivity in Schizophrenia.
PMID: 31256617 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Bullmore E Tags: Am J Psychiatry Source Type: research

Smoking and Cognitive Performance: The Chicken and Egg Problem.
PMID: 31256618 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Hajek P, Pruzlj D, Myers Smith K Tags: Am J Psychiatry Source Type: research

The Unhealthy Chicken or the Unhealthy Egg: Quitting Smoking Matters: Response to Hajek et al.
PMID: 31256619 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Vermeulen JM, van den Brink W, de Haan L Tags: Am J Psychiatry Source Type: research

Cerebellar Dysfunction and Schizophrenia: From "Cognitive Dysmetria" to a Potential Therapeutic Target.
Cerebellar Dysfunction and Schizophrenia: From "Cognitive Dysmetria" to a Potential Therapeutic Target. Am J Psychiatry. 2019 Jul 01;176(7):498-500 Authors: Cao H, Cannon TD PMID: 31256620 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Cao H, Cannon TD Tags: Am J Psychiatry Source Type: research

Reports to the Membership.
Authors: Abstract The following are edited/abbreviated versions of the annual reports of the APA Secretary, Treasurer, CEO and Medical Director, Speaker, and Speaker-Elect and the chairpersons of the APA Committee on Bylaws, Membership Committee, Committee of Tellers, and Elections Committee. The full reports were presented at the APA Annual Business Meeting in San Francisco, May 18, 2019. PMID: 31256621 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Books Received.
Authors: PMID: 31256622 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Predicting Risk for Dementia: Is It Ready for the Clinic?
PMID: 31256623 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Johnson SC, Asthana S Tags: Am J Psychiatry Source Type: research

A Reckoning and Research Agenda for Neuroimaging in Psychiatry.
Abstract Human neuroimaging has been a core component of both research in psychiatry and conceptual models of the brain circuit-level mechanisms underlying psychopathology. Despite landmark neuroimaging research over the past 25 years, we still lack the level of precision and insight needed for bringing neuroimaging tools into clinical care contexts. This brief review examines historical research trends in psychiatric neuroimaging, as well as the basic assumptions underlying current efforts, in order to understand factors that have limited the impact of neuroimaging efforts thus far. These factors include the pitf...
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Etkin A Tags: Am J Psychiatry Source Type: research

The Enigma of Neuroimaging in ADHD.
PMID: 31256625 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Giedd JN Tags: Am J Psychiatry Source Type: research

The Relationship Between Common Variant Schizophrenia Liability and Number of Offspring in the UK Biobank: Response to Lawn et al.
an MC PMID: 31256626 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2019 Category: Psychiatry Authors: Escott-Price V, Pardiñas AF, Santiago E, Walters J, Kirov G, Owen MJ, O'Donovan MC Tags: Am J Psychiatry Source Type: research

Altered Cellular White Matter But Not Extracellular Free Water on Diffusion MRI in Individuals at Clinical High Risk for Psychosis.
CONCLUSIONS: Cellular but not extracellular alterations characterized the clinical high-risk group, especially in those who experienced a decline in functioning. These cellular changes suggest an early deficit that possibly reflects a predisposition to develop attenuated psychotic symptoms. In contrast, extracellular alterations were not observed in this clinical high-risk sample, suggesting that previously reported extracellular abnormalities may reflect an acute response to psychosis, which plays a more prominent role closer to or at onset of psychosis. PMID: 31230461 [PubMed - as supplied by publisher] (Source: The...
Source: The American Journal of Psychiatry - June 24, 2019 Category: Psychiatry Authors: Tang Y, Pasternak O, Kubicki M, Rathi Y, Zhang T, Wang J, Li H, Woodberry KA, Xu L, Qian Z, Zhu A, Whitfield-Gabrieli S, Keshavan MS, Niznikiewicz M, Stone WS, McCarley RW, Shenton ME, Wang J, Seidman LJ Tags: Am J Psychiatry Source Type: research

Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder.
CONCLUSIONS: iTBS appears to be a promising new treatment for PTSD. Most clinical improvements from stimulation occurred early, which suggests a need for further investigation of optimal iTBS time course and duration. Consistent with previous neuroimaging studies of TMS, default mode network connectivity played an important role in response prediction. PMID: 31230462 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 24, 2019 Category: Psychiatry Authors: Philip NS, Barredo J, Aiken E, Larson V, Jones RN, Shea MT, Greenberg BD, van 't Wout-Frank M Tags: Am J Psychiatry Source Type: research

Evidence for Dissociable Linkage of Dimensions of Psychopathology to Brain Structure in Youths.
CONCLUSIONS: The results suggest a dissociable relationship whereby fear is most strongly linked to reduced cortical thickness and overall psychopathology is most strongly linked to global reductions in gray matter volume. Such results have implications for understanding how abnormalities of brain development may be associated with divergent dimensions of psychopathology. PMID: 31230463 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 24, 2019 Category: Psychiatry Authors: Kaczkurkin AN, Park SS, Sotiras A, Moore TM, Calkins ME, Cieslak M, Rosen AFG, Ciric R, Xia CH, Cui Z, Sharma A, Wolf DH, Ruparel K, Pine DS, Shinohara RT, Roalf DR, Gur RC, Davatzikos C, Gur RE, Satterthwaite TD Tags: Am J Psychiatry Source Type: research

A Single Ketamine Infusion Combined With Mindfulness-Based Behavioral Modification to Treat Cocaine Dependence: A Randomized Clinical Trial.
CONCLUSIONS: A single ketamine infusion improved a range of important treatment outcomes in cocaine-dependent adults engaged in mindfulness-based behavioral modification, including promoting abstinence, diminishing craving, and reducing risk of relapse. Further research is needed to replicate these promising results in a larger sample. PMID: 31230464 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 24, 2019 Category: Psychiatry Authors: Dakwar E, Nunes EV, Hart CL, Foltin RW, Mathew SJ, Carpenter KM, Choi CJJ, Basaraba CN, Pavlicova M, Levin FR Tags: Am J Psychiatry Source Type: research

Distinct Patterns of Neural Habituation and Generalization in Children and Adolescents With Autism With Low and High Sensory Overresponsivity.
CONCLUSIONS: The results suggest that all children with autism have atypical brain responses to sensory stimuli, but whether they express atypical behavioral responses depends on top-down regulatory mechanisms. Results are discussed in terms of targeted intervention approaches. PMID: 31230465 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 24, 2019 Category: Psychiatry Authors: Green SA, Hernandez L, Lawrence KE, Liu J, Tsang T, Yeargin J, Cummings K, Laugeson E, Dapretto M, Bookheimer SY Tags: Am J Psychiatry Source Type: research

Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia.
CONCLUSIONS: Brain network architecture can explain the irregular topographic distribution of cortical thickness reductions in schizophrenia. This finding, replicated in three distinct schizophrenia cohorts, suggests that the effect is robust and independent of illness stage. PMID: 31164006 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 5, 2019 Category: Psychiatry Authors: Wannan CMJ, Cropley VL, Chakravarty MM, Bousman C, Ganella EP, Bruggemann JM, Weickert TW, Weickert CS, Everall I, McGorry P, Velakoulis D, Wood SJ, Bartholomeusz CF, Pantelis C, Zalesky A Tags: Am J Psychiatry Source Type: research

Association of Choroid Plexus Enlargement With Cognitive, Inflammatory, and Structural Phenotypes Across the Psychosis Spectrum.
CONCLUSIONS: These findings suggest the involvement of the choroid plexus across the psychosis spectrum with a potential pathophysiological mechanism involving the neuroimmune axis, which functions in maintaining brain homeostasis and interacting with the peripheral immune and inflammatory system. The choroid plexus may be an important target in future research. PMID: 31164007 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 5, 2019 Category: Psychiatry Authors: Lizano P, Lutz O, Ling G, Lee AM, Eum S, Bishop JR, Kelly S, Pasternak O, Clementz B, Pearlson G, Sweeney JA, Gershon E, Tamminga C, Keshavan M Tags: Am J Psychiatry Source Type: research

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.
CONCLUSIONS: This study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt. PMID: 31164008 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 5, 2019 Category: Psychiatry Authors: Mullins N, Bigdeli TB, Børglum AD, Coleman JRI, Demontis D, Mehta D, Power RA, Ripke S, Stahl EA, Starnawska A, Anjorin A, M.R.C.Psych, Corvin A, Sanders AR, Forstner AJ, Reif A, Koller AC, Świątkowska B, Baune BT, Müller-Myhsok B, Penninx BWJH, Pato Tags: Am J Psychiatry Source Type: research

From Neurobiology to Novel Medications: A Principled Approach to Translation.
PMID: 31154816 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Authors: Gordon JA Tags: Am J Psychiatry Source Type: research

How Long Does Antidepressant Withdrawal Typically Last?
PMID: 31154817 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Authors: Hengartner MP, Davies J, Read J Tags: Am J Psychiatry Source Type: research

Correction to Attia et al.
Authors: PMID: 31154818 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Developing Novel Psychopharmacological Strategies and Therapeutics.
PMID: 31154819 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Correction to Kwako et al.
Authors: PMID: 31154820 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Addressing Clinical Challenges of Antidepressant Discontinuation.
PMID: 31154821 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Authors: Fava GA, Cosci F Tags: Am J Psychiatry Source Type: research

When Discontinuing SSRI Antidepressants Is a Challenge: A Response to Letters to the Editor.
PMID: 31154822 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Authors: Jha MK, Trivedi MH Tags: Am J Psychiatry Source Type: research

A Word to the Wise About Intranasal Esketamine.
PMID: 31109197 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 21, 2019 Category: Psychiatry Authors: Schatzberg AF Tags: Am J Psychiatry Source Type: research

Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial.
CONCLUSIONS: CBD's potential to reduce cue-induced craving and anxiety provides a strong basis for further investigation of this phytocannabinoid as a treatment option for opioid use disorder. PMID: 31109198 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 21, 2019 Category: Psychiatry Authors: Hurd YL, Spriggs S, Alishayev J, Winkel G, Gurgov K, Kudrich C, Oprescu AM, Salsitz E Tags: Am J Psychiatry Source Type: research

Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: A Prospective Multicenter Randomized Double-Blind Placebo-Controlled Trial.
CONCLUSIONS: High-frequency dTMS over the medial prefrontal cortex and anterior cingulate cortex significantly improved OCD symptoms and may be considered as a potential intervention for patients who do not respond adequately to pharmacological and psychological interventions. PMID: 31109199 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 21, 2019 Category: Psychiatry Authors: Carmi L, Tendler A, Bystritsky A, Hollander E, Blumberger DM, Daskalakis J, Ward H, Lapidus K, Goodman W, Casuto L, Feifel D, Barnea-Ygael N, Roth Y, Zangen A, Zohar J Tags: Am J Psychiatry Source Type: research

Continued Benefits of Methylphenidate in ADHD After 2 Years in Clinical Practice: A Randomized Placebo-Controlled Discontinuation Study.
CONCLUSIONS: Continued treatment with methylphenidate remains effective after long-term use. Some individual patients may, however, be withdrawn from methylphenidate without deterioration. This finding supports guideline recommendations that patients be assessed periodically to determine whether there is a continued need for methylphenidate treatment. PMID: 31109200 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 21, 2019 Category: Psychiatry Authors: Matthijssen AM, Dietrich A, Bierens M, Kleine Deters R, van de Loo-Neus GHH, van den Hoofdakker BJ, Buitelaar JK, Hoekstra PJ Tags: Am J Psychiatry Source Type: research

Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study.
CONCLUSIONS: Current treatment options for treatment-resistant depression have considerable limitations in terms of efficacy and patient acceptability. Esketamine is expected to address an unmet medical need in this population through its novel mechanism of action and rapid onset of antidepressant efficacy. The study supports the efficacy and safety of esketamine nasal spray as a rapidly acting antidepressant for patients with treatment-resistant depression. PMID: 31109201 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 21, 2019 Category: Psychiatry Authors: Popova V, Daly EJ, Trivedi M, Cooper K, Lane R, Lim P, Mazzucco C, Hough D, Thase ME, Shelton RC, Molero P, Vieta E, Bajbouj M, Manji H, Drevets WC, Singh JB Tags: Am J Psychiatry Source Type: research

Prediction of Onset of Substance-Induced Psychotic Disorder and Its Progression to Schizophrenia in a Swedish National Sample.
CONCLUSIONS: Substance-induced psychotic disorder appears to result from substantial drug exposure in individuals at high familial risk for substance abuse and moderately elevated familial risk for psychosis. Familial risk for psychosis, but not substance abuse, predicts progression from substance-induced psychosis to schizophrenia. Schizophrenia following substance-induced psychosis is likely a drug-precipitated disorder in highly vulnerable individuals, not a syndrome predominantly caused by drug exposure. PMID: 31055966 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 6, 2019 Category: Psychiatry Authors: Kendler KS, Ohlsson H, Sundquist J, Sundquist K Tags: Am J Psychiatry Source Type: research

Exposure to Maternal Depressive Symptoms in Fetal Life or Childhood and Offspring Brain Development: A Population-Based Imaging Study.
CONCLUSIONS: Perinatal maternal depressive symptoms were consistently associated with child brain development assessed 10 years later. These results suggest that the postnatal period is a window of vulnerability for adversities such as maternal depressive symptoms. PMID: 31055967 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 6, 2019 Category: Psychiatry Authors: Zou R, Tiemeier H, van der Ende J, Verhulst FC, Muetzel RL, White T, Hillegers M, El Marroun H Tags: Am J Psychiatry Source Type: research

Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [11C]NOP-1A.
CONCLUSIONS: Increased NOP in cocaine use disorder suggests an adaptive response to decreased N/OFQ, or increased CRF transmission, or both. Future studies should examine the interactions between CRF and NOP to elucidate their role in negative reinforcement and relapse. NOP agonist medications to enhance N/OFQ should be explored as a therapeutic to treat cocaine use disorder. PMID: 31055968 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 6, 2019 Category: Psychiatry Authors: Narendran R, Tollefson S, Himes ML, Paris J, Lopresti B, Ciccocioppo R, Mason NS Tags: Am J Psychiatry Source Type: research

Increased Protein Insolubility in Brains From a Subset of Patients With Schizophrenia.
CONCLUSIONS: This study suggests a pathological process related to protein insolubility for a subset of patients with schizophrenia. Determining the molecular mechanism of this subtype of schizophrenia could lead to a better understanding of the pathways underlying the clinical phenotype in some patients with major mental illness as well as to improved nosology and identification of novel therapeutic targets. PMID: 31055969 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 6, 2019 Category: Psychiatry Authors: Nucifora LG, MacDonald ML, Lee BJ, Peters ME, Norris AL, Orsburn BC, Yang K, Gleason K, Margolis RL, Pevsner J, Tamminga CA, Sweet RA, Ross CA, Sawa A, Nucifora FC Tags: Am J Psychiatry Source Type: research

Rigorous Translational Models Are Key to Studying Ketamine's Antidepressant Mechanism: Response to Wang and Kaplin.
PMID: 31039633 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Heifets BD, Williams NR, Blasey C, Sudheimer K, Rodriguez CI, Schatzberg AF Tags: Am J Psychiatry Source Type: research

Heterogeneity in Major Depressive Disorder: Lessons From Developmental Research on Irritability.
PMID: 31039634 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Pine DS Tags: Am J Psychiatry Source Type: research

Consumer Warning for Genetic Tests Claiming to Predict Response to Medications: Implications for Psychiatry.
PMID: 31039635 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Rosenblat JD, Goldberg JF, McIntyre RS Tags: Am J Psychiatry Source Type: research

New Insights Into the Mechanisms of Ketamine's Antidepressant Effects: Understanding the Role of VEGF in Mediating Plasticity Processes.
PMID: 31039637 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Kenwood MM, Roseboom PH, Oler JA, Kalin NH Tags: Am J Psychiatry Source Type: research

Opportunities for Improving Access to Evidence-Based Treatments of Depression.
PMID: 31039638 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Weissman MM, Wainberg ML, Olfson M Tags: Am J Psychiatry Source Type: research

Explaining Naltrexone's Interference With Ketamine's Antidepressant Effect.
PMID: 31039639 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Wang M, Kaplin A Tags: Am J Psychiatry Source Type: research

The Concept of Mania in Traditional Andean Culture.
PMID: 31039640 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Uscamayta Ayvar MJ, Sanchez Garrafa R, Escobar JI, de Erausquin GA Tags: Am J Psychiatry Source Type: research

Improving the Lives of Patients With Major Depression by Focusing on New Treatment Approaches.
PMID: 31039641 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Vladimir Horowitz (1903-1989).
PMID: 31039642 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Hart AR, Kellner CH Tags: Am J Psychiatry Source Type: research

Scientific Issues Relevant to Improving the Diagnosis, Risk Assessment, and Treatment of Major Depression.
Abstract Over the past two decades, research in the biology and treatment of major depression has led to advances in our understanding of the biology of the disorder and to the development of novel treatments. While progress has been made, a number of key issues have emerged regarding diagnosis of the disorder and how we develop and test new therapies. Among these are the potential need to include new dimensions in the diagnostic criteria, the limited utility of clinical predictors of response, the moving away from traditional blinded trials in major depression, and whether preclinical models tell us much about no...
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Schatzberg AF Tags: Am J Psychiatry Source Type: research

Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples.
CONCLUSIONS: Subtle differences in cortical surface area are widespread in children but not adolescents and adults with ADHD, confirming involvement of the frontal cortex and highlighting regions deserving further attention. Notably, the alterations behave like endophenotypes in families and are linked to ADHD symptoms in the population, extending evidence that ADHD behaves as a continuous trait in the population. Future longitudinal studies should clarify individual lifespan trajectories that lead to nonsignificant findings in adolescent and adult groups despite the presence of an ADHD diagnosis. PMID: 31014101 [PubM...
Source: The American Journal of Psychiatry - April 24, 2019 Category: Psychiatry Authors: Hoogman M, Muetzel R, Guimaraes JP, Shumskaya E, Mennes M, Zwiers MP, Jahanshad N, Sudre G, Wolfers T, Earl EA, Soliva Vila JC, Vives-Gilabert Y, Khadka S, Novotny SE, Hartman CA, Heslenfeld DJ, Schweren LJS, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avanc Tags: Am J Psychiatry Source Type: research