Moderation of Prazosin's Efficacy by Alcohol Withdrawal Symptoms.
CONCLUSIONS: The findings indicate that alcohol withdrawal symptoms are a significant moderator of prazosin treatment response for alcohol use outcomes and for associated symptoms of alcohol craving, anxiety, and mood symptoms. These data support further evaluation of alcohol withdrawal symptoms as a prognostic indicator of prazosin's efficacy in the treatment of AUD. PMID: 33207935 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 19, 2020 Category: Psychiatry Authors: Sinha R, Wemm S, Fogelman N, Milivojevic V, Morgan PM, Angarita GA, Hermes G, Fox HC Tags: Am J Psychiatry Source Type: research

Association of Inflammatory Activity With Larger Neural Responses to Threat and Reward Among Children Living in Poverty.
CONCLUSIONS: These findings suggest that childhood poverty is associated with accentuated neural-immune signaling, consistent with the neuroimmune network hypothesis. PMID: 33207936 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 19, 2020 Category: Psychiatry Authors: Miller GE, White SF, Chen E, Nusslock R Tags: Am J Psychiatry Source Type: research

Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain.
Abstract Adolescence is a peak time for the onset of psychiatric disorders, with anxiety disorders being the most common and affecting as many as 30% of youths. A core feature of anxiety disorders is difficulty regulating fear, with evidence suggesting deficits in extinction learning and corresponding alterations in frontolimbic circuitry. Despite marked changes in this neural circuitry and extinction learning throughout development, interventions for anxious youths are largely based on principles of extinction learning studied in adulthood. Safety signal learning, based on conditioned inhibition of fear in the pr...
Source: The American Journal of Psychiatry - November 10, 2020 Category: Psychiatry Authors: Odriozola P, Gee DG Tags: Am J Psychiatry Source Type: research

Contraception for Women With Psychiatric Disorders.
CONCLUSIONS: Proactive management of mental illness, contraception, and pregnancy improves a woman's capacity to function and optimizes her mental and reproductive health. PMID: 33167674 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 10, 2020 Category: Psychiatry Authors: McCloskey LR, Wisner KL, Cattan MK, Betcher HK, Stika CS, Kiley JW Tags: Am J Psychiatry Source Type: research

Electroconvulsive Therapy in Mania: A Review of 80 Years of Clinical Experience.
Abstract Resistance to pharmacological agents is commonly encountered in the treatment of acute episodes of mania. In contemporary practice guidelines, electroconvulsive therapy (ECT), once a widely used standalone intervention for mania, is no longer considered a first-line treatment. Stigma, logistics, and ethical factors constrain ECT administration in this condition and lead to its underutilization. However, the past three decades have produced promising research regarding the use of ECT in mania. Randomized controlled trials, albeit in limited numbers, the adoption of ultrabrief ECT, examination of the safety...
Source: The American Journal of Psychiatry - November 10, 2020 Category: Psychiatry Authors: Elias A, Thomas N, Sackeim HA Tags: Am J Psychiatry Source Type: research

Understanding the Clinical Effects and Mechanisms of Action of Neurosteroids.
PMID: 33138631 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 3, 2020 Category: Psychiatry Authors: Kleinman RA, Schatzberg AF Tags: Am J Psychiatry Source Type: research

Substance Use Disorders and Addiction: Mechanisms, Trends, and Treatment Implications.
PMID: 33135466 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 1, 2020 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Social Determinants of Health and Smoking Cessation: A Challenge.
PMID: 33135467 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 1, 2020 Category: Psychiatry Authors: Brady KT Tags: Am J Psychiatry Source Type: research

Addiction as a Coping Response: Hyperkatifeia, Deaths of Despair, and COVID-19.
PMID: 33135468 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 1, 2020 Category: Psychiatry Authors: Koob GF, Powell P, White A Tags: Am J Psychiatry Source Type: research

Considering Prenatal Alcohol Exposure in a Developmental Origins of Health and Disease Framework.
PMID: 33135469 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 1, 2020 Category: Psychiatry Authors: McCormack C, Monk C Tags: Am J Psychiatry Source Type: research

Telehealth During COVID-19-Does Everyone Have Equal Access?
PMID: 33135470 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 1, 2020 Category: Psychiatry Authors: Nadkarni A, Hasler V, AhnAllen CG, Amonoo HL, Green DW, Levy-Carrick NC, Mittal L Tags: Am J Psychiatry Source Type: research

Why Timing Matters in Alcohol Use Disorder Recovery.
PMID: 33135471 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 1, 2020 Category: Psychiatry Authors: Sullivan EV Tags: Am J Psychiatry Source Type: research

Neuromelanin MRI: Dark Substance Shines a Light on Dopamine Dysfunction and Cocaine Use.
PMID: 33135472 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 1, 2020 Category: Psychiatry Authors: Bradberry CW Tags: Am J Psychiatry Source Type: research

Quality of Outpatient Depression Treatment in Patients With Comorbid Substance Use Disorder.
CONCLUSIONS: Despite the availability of effective treatments for depression, patients with co-occurring substance use disorders are less likely to receive guideline-concordant depression treatment. Efforts to improve the provision of care to those with co-occurring substance use disorders should focus on clinician-based interventions and use of integrated care models to improve the quality of depression treatment. PMID: 33115247 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 29, 2020 Category: Psychiatry Authors: Coughlin LN, Pfeiffer P, Ganoczy D, Lin LA Tags: Am J Psychiatry Source Type: research

Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder.
CONCLUSIONS: Schizophrenia and bipolar disorder do not appear to share similar mitochondrial alterations in the DLPFC. The selective and coordinated down-regulation of energy production genes in schizophrenia is consistent with the effects of chronic reductions in pyramidal neuron firing, and enhancement of this activity may serve as a therapeutic target. PMID: 33115248 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 29, 2020 Category: Psychiatry Authors: Glausier JR, Enwright JF, Lewis DA Tags: Am J Psychiatry Source Type: research

The Prehistory of Psychiatric Genetics: 1780-1910.
Abstract While psychiatric genetics has emerged as one of our most dynamic research fields, the historical context in which we view these developments is limited. To provide such a perspective, the author reviews 48 representative texts, published from 1780 to 1910, examining the inheritance of insanity. Six main conclusions emerge. First, most authors viewed heredity as among the strongest risk factors for insanity. Second, most writers concluded that a predisposition to illness rather than the illness itself was transmitted in families. Third, the probabilistic nature of the transmission was noted, as insanity o...
Source: The American Journal of Psychiatry - October 15, 2020 Category: Psychiatry Authors: Kendler KS Tags: Am J Psychiatry Source Type: research

The Overlapping Neurobiology of Induced and Pathological Anxiety: A Meta-Analysis of Functional Neural Activation.
CONCLUSIONS: This meta-analysis indicates a consistent pattern of activation across induced and pathological anxiety, supporting the proposition that some neurobiological mechanisms overlap and that the former may be used as a model for the latter. Induced anxiety might nevertheless be a better model for some anxiety disorders than others. PMID: 33054384 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 15, 2020 Category: Psychiatry Authors: Chavanne AV, Robinson OJ Tags: Am J Psychiatry Source Type: research

Correction to Dwyer et al.
Authors: PMID: 32998544 [PubMed] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Highlights From Residents' Journal: September 2020.
Authors: PMID: 32998545 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Insights Into Suicide and Depression.
PMID: 32998546 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Is Testosterone an Effective Hormonal Therapy for Women With Antidepressant-Resistant Major Depression?
PMID: 32998547 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Authors: Mathew SJ Tags: Am J Psychiatry Source Type: research

Toward Preventive Psychiatry: The Role of Advanced Epidemiological Methods.
PMID: 32998548 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Authors: Firth J, Wootton RE, Carvalho AF Tags: Am J Psychiatry Source Type: research

APA Council Reports.
Authors: Abstract At the 2020 virtual fall component meetings of the American Psychiatric Association, the APA councils heard reports from their components. Following are summaries of the activities of the councils and their components. PMID: 32998549 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

A Brain-Centric Model of Suicidal Behavior.
PMID: 32998550 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Authors: Mann JJ, Rizk MM Tags: Am J Psychiatry Source Type: research

Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents.
Abstract OBJECTIVE: Death by suicide is a highly preventable yet growing worldwide health crisis. To date, there has been a lack of adequately powered genomic studies of suicide, with no sizable suicide death cohorts available for analysis. To address this limitation, the authors conducted the first comprehensive genomic analysis of suicide death using previously unpublished genotype data from a large population-ascertained cohort. METHODS: The analysis sample comprised 3,413 population-ascertained case subjects of European ancestry and 14,810 ancestrally matched control subjects. Analytical methods included ...
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Authors: Docherty AR, Shabalin AA, DiBlasi E, Monson E, Mullins N, Adkins DE, Bacanu SA, Bakian AV, Crowell S, Chen D, Darlington TM, Callor WB, Christensen ED, Gray D, Keeshin B, Klein M, Anderson JS, Jerominski L, Hayward C, Porteous DJ, McIntosh A, Li Q, Coon H Tags: Am J Psychiatry Source Type: research

Predicting Suicide.
PMID: 32998552 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Authors: Goldman D Tags: Am J Psychiatry Source Type: research

In Need of a Quorum: From Microbes to Mood Via the Immune System.
PMID: 32998553 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Authors: Cruz-Pereira JS, Cryan JF Tags: Am J Psychiatry Source Type: research

Using Genetics to Increase Specificity of Outcome Prediction in Psychiatric Disorders: Prospects for Progression.
PMID: 32998554 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 30, 2020 Category: Psychiatry Authors: Holmans PA Tags: Am J Psychiatry Source Type: research

Association of Prenatal Alcohol Exposure With Psychological, Behavioral, and Neurodevelopmental Outcomes in Children From the Adolescent Brain Cognitive Development Study.
CONCLUSIONS: Any alcohol use during pregnancy is associated with subtle yet significant psychological and behavioral effects in children. Women should continue to be advised to abstain from alcohol consumption from conception throughout pregnancy. PMID: 32972200 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 24, 2020 Category: Psychiatry Authors: Lees B, Mewton L, Jacobus J, Valadez EA, Stapinski LA, Teesson M, Tapert SF, Squeglia LM Tags: Am J Psychiatry Source Type: research

Large-Scale Functional Brain Network Architecture Changes Associated With Trauma-Related Dissociation.
CONCLUSIONS: Trauma-related dissociative symptoms, distinct from PTSD and childhood trauma, can be estimated on the basis of network connectivity. Furthermore, between-network brain connectivity may provide an unbiased estimate of symptom severity, paving the way for more objective, clinically useful biomarkers of dissociation and advancing our understanding of its neural mechanisms. PMID: 32972201 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 24, 2020 Category: Psychiatry Authors: Lebois LAM, Li M, Baker JT, Wolff JD, Wang D, Lambros AM, Grinspoon E, Winternitz S, Ren J, Gönenç A, Gruber SA, Ressler KJ, Liu H, Kaufman ML Tags: Am J Psychiatry Source Type: research

Psychotherapy at a Distance.
This article briefly reviews the limited clinical evidence supporting different modes of telepsychotherapy, then focuses on how remote therapy affects clinicians and their patients. PMID: 32972202 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 24, 2020 Category: Psychiatry Authors: Markowitz JC, Milrod B, Heckman TG, Bergman M, Amsalem D, Zalman H, Ballas T, Neria Y Tags: Am J Psychiatry Source Type: research

Thalamic Nuclei Volumes in Psychotic Disorders and in Youths With Psychosis Spectrum Symptoms.
CONCLUSIONS: The study findings demonstrate that smaller thalamic association nuclei represent a neurodevelopmental abnormality associated with psychosis, risk for psychosis in youths, and cognitive impairment. Identifying specific thalamic nuclei abnormalities in psychosis has implications for early detection of psychosis risk and treatment of cognitive impairment in psychosis. PMID: 32911995 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 10, 2020 Category: Psychiatry Authors: Huang AS, Rogers BP, Sheffield JM, Jalbrzikowski ME, Anticevic A, Blackford JU, Heckers S, Woodward ND Tags: Am J Psychiatry Source Type: research

Maternal Psychological Resilience During Pregnancy and Newborn Telomere Length: A Prospective Study.
CONCLUSIONS: The results indicate that maternal psychological resilience may exert a salubrious effect on offspring telomere biology and highlight the importance of enhancing maternal mental health and well-being during pregnancy. PMID: 32911996 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 10, 2020 Category: Psychiatry Authors: Verner G, Epel E, Lahti-Pulkkinen M, Kajantie E, Buss C, Lin J, Blackburn E, Räikkönen K, Wadhwa PD, Entringer S Tags: Am J Psychiatry Source Type: research

Alcohol, Tobacco, and Comorbid Psychiatric Disorders and Associations With Sexual Identity and Stress-Related Correlates.
CONCLUSIONS: This research suggests that integrated substance use and mental health prevention and treatment programs are needed, particularly for individuals who identify as sexual minorities. The increased stressors experienced by sexual minority individuals may be important drivers of these high levels of comorbidities. PMID: 32911997 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 10, 2020 Category: Psychiatry Authors: Evans-Polce RJ, Kcomt L, Veliz PT, Boyd CJ, McCabe SE Tags: Am J Psychiatry Source Type: research

Effect Sizes of Deletions and Duplications on Autism Risk Across the Genome.
CONCLUSIONS: Autism risk conferred by duplications is less influenced by IQ compared with deletions. The model applied in this study, trained on CNVs encompassing>4,500 genes, suggests highly polygenic properties of gene dosage with respect to autism risk and IQ loss. These models will help to interpret CNVs identified in the clinic. PMID: 32911998 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 10, 2020 Category: Psychiatry Authors: Douard E, Zeribi A, Schramm C, Tamer P, Loum MA, Nowak S, Saci Z, Lord MP, Rodríguez-Herreros B, Jean-Louis M, Moreau C, Loth E, Schumann G, Pausova Z, Elsabbagh M, Almasy L, Glahn DC, Bourgeron T, Labbe A, Paus T, Mottron L, Greenwood CMT, Huguet G, Jac Tags: Am J Psychiatry Source Type: research

Early Detection and Preventive Treatment in Bipolar Disorder.
PMID: 32880471 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Authors: Post RM Tags: Am J Psychiatry Source Type: research

Childhood and Adolescent Neurodevelopmental Disorders.
PMID: 32867515 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia.
PMID: 32867516 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Authors: Keepers GA, Fochtmann LJ, Anzia JM, Benjamin S, Lyness JM, Mojtabai R, Servis M, Walaszek A, Buckley P, Lenzenweger MF, Young AS, Degenhardt A, Hong SH, (Systematic Review) Tags: Am J Psychiatry Source Type: research

Shared or Distinct Alterations in Brain Structure in Disorders Across the Impulsivity-Compulsivity Spectrum: What Can We Learn From Cross-Disorder Comparisons of ADHD, ASD, and OCD?
PMID: 32867517 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Authors: Fairchild G Tags: Am J Psychiatry Source Type: research

ADHD: Progressing From Genetic Discoveries to Biological Insights.
PMID: 32867518 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Authors: Thapar A Tags: Am J Psychiatry Source Type: research

The American Journal of Psychiatry's Commitment to Combat Racism, Social Injustice, and Health Care Inequities.
PMID: 32867519 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Authors: Kalin NH, Binder E, Brady KT, Lewis DA, Pine DS, Rodriguez C, Trivedi MH Tags: Am J Psychiatry Source Type: research

Callous-Unemotional Traits and Gun Violence.
PMID: 32867520 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Authors: Blair RJR Tags: Am J Psychiatry Source Type: research

"Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth": National Academies Report Calling for a Decade of Children and Youth.
"Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth": National Academies Report Calling for a Decade of Children and Youth. Am J Psychiatry. 2020 Sep 01;177(9):808-810 Authors: Muñoz RF, Weissman MM PMID: 32867521 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Authors: Muñoz RF, Weissman MM Tags: Am J Psychiatry Source Type: research

Correction to Boedhoe et al.
Authors: PMID: 32867522 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Disruptive Behavior Disorders: The Challenge of Delineating Mechanisms in the Face of Heterogeneity.
Abstract Causal pathways to disruptive behavior disorders, even within the same diagnostic category, are varied. Both equifinality and multifinality pose considerable challenges to uncovering underlying mechanisms and understanding varied developmental trajectories associated with disruptive behavior disorders. Uncovering genetic causes requires improved granularity in how we operationalize presentation and developmental trajectories associated with disruptive behavior disorders. If we want to integrate the study of genetic, environmental, and neurocognitive factors within a longitudinal framework, we need to impr...
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Authors: Viding E, McCrory E Tags: Am J Psychiatry Source Type: research

Early Childhood Nurturance and the Sculpting of Neurodevelopment.
PMID: 32867524 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 31, 2020 Category: Psychiatry Authors: Luby JL Tags: Am J Psychiatry Source Type: research

The Impact of COVID-19 on Individuals With Intellectual and Developmental Disabilities: Clinical and Scientific Priorities.
PMID: 32854530 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 27, 2020 Category: Psychiatry Authors: Constantino JN, Sahin M, Piven J, Rodgers R, Tschida J Tags: Am J Psychiatry Source Type: research

Evidence for Dopamine Abnormalities in the Substantia Nigra in Cocaine Addiction Revealed by Neuromelanin-Sensitive MRI.
CONCLUSIONS: Given that previous imaging studies show decreased dopamine signaling in the striatum, the finding of increased NM-MRI signal in the substantia nigra provides additional insight into the pathophysiology of cocaine use disorder. One interpretation is that cocaine use disorder is associated with a redistribution of dopamine between cytosolic and vesicular pools, leading to increased accumulation of neuromelanin. The study findings thus suggest that NM-MRI can serve as a practical imaging tool for interrogating the dopamine system in addiction. PMID: 32854531 [PubMed - as supplied by publisher] (Source: The ...
Source: The American Journal of Psychiatry - August 27, 2020 Category: Psychiatry Authors: Cassidy CM, Carpenter KM, Konova AB, Cheung V, Grassetti A, Zecca L, Abi-Dargham A, Martinez D, Horga G Tags: Am J Psychiatry Source Type: research

The Sources of Parent-Child Transmission of Risk for Suicide Attempt and Deaths by Suicide in Swedish National Samples.
CONCLUSIONS: The transmission of suicide attempt across generations is moderately strong and arises equally from genetic and rearing effects. Parental psychiatric illness explains almost half of the genetic transmission of suicide attempt but none of the rearing effect. Suicide death is modestly transmitted across generations, probably via genetic effects, although rearing may play a role. While suicide attempt and suicide death share a substantial proportion of their hereditary risk, they do not, from a genetic perspective, simply reflect milder and more severe forms of the same diathesis. PMID: 32854532 [PubMed - as...
Source: The American Journal of Psychiatry - August 27, 2020 Category: Psychiatry Authors: Kendler KS, Ohlsson H, Sundquist J, Sundquist K, Edwards AC Tags: Am J Psychiatry Source Type: research

Treatment-Specific Associations Between Brain Activation and Symptom Reduction in OCD Following CBT: A Randomized fMRI Trial.
CONCLUSIONS: The study findings demonstrate that associations between brain activation and treatment response were treatment specific to CBT relative to a control psychotherapy and that these associations were stable from adolescence to mature adulthood. Such treatment-specific associations are important for the development of biomarkers to personalize treatment in OCD. PMID: 32854533 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 27, 2020 Category: Psychiatry Authors: Norman LJ, Mannella KA, Yang H, Angstadt M, Abelson JL, Himle JA, Fitzgerald KD, Taylor SF Tags: Am J Psychiatry Source Type: research