Subcortical Signatures of Hemizygosity and Psychosis in 22q11.2 Deletion Syndrome: Finding Common Ground in Rare Genetic Variation.
PMID: 32605438 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Eisenberg DP, Gregory MD, Berman KF Tags: Am J Psychiatry Source Type: research

Comment on Limbic Hyperactivity in Response to Emotionally Neutral Stimuli in Schizophrenia: A Neuroimaging Meta-Analysis of the Hypervigilant Mind.
PMID: 32605439 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Rasetti R, Chen Q, Weinberger DR Tags: Am J Psychiatry Source Type: research

COVID-19, Substance Use, Anorexia Nervosa, 22q11.2 Deletion Syndrome, and Stress.
PMID: 32605440 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Correction to Dwyer et al.
Authors: PMID: 32605441 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Rapid Implementation of Telehealth in Hospital Psychiatry in Response to COVID-19.
PMID: 32605442 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Kalin ML, Garlow SJ, Thertus K, Peterson MJ Tags: Am J Psychiatry Source Type: research

The Mental Health Effects of COVID-19 on Health Care Providers in China.
PMID: 32605443 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Lin K, Yang BX, Luo D, Liu Q, Ma S, Huang R, Lu W, Majeed A, Lee Y, Lui LMW, Mansur RB, Nasri F, Subramaniapillai M, Rosenblat JD, Liu Z, McIntyre RS Tags: Am J Psychiatry Source Type: research

Limbic Hyperactivity in Response to Emotionally Neutral Stimuli in Schizophrenia: Response to Rasetti et al.
vin S PMID: 32605444 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Dugré JR, Dumais A, Potvin S Tags: Am J Psychiatry Source Type: research

A Reckoning to Keep Doing What We Are Already Doing With PET and SPECT Functional Neuroimaging.
PMID: 32605445 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Henderson TA, Cohen P, van Lierop M, Thornton J, McLean MK, Uszler JM, Siow YH, Cardaci G Tags: Am J Psychiatry Source Type: research

Neural Insensitivity to the Effects of Hunger: A Potential Mechanism Underlying Persistent Dietary Restriction in Anorexia Nervosa?
PMID: 32605446 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Javaras KN, Pizzagalli DA Tags: Am J Psychiatry Source Type: research

Correction to Hurd et al.
Authors: PMID: 32605447 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

A Reckoning and Research Agenda for Neuroimaging in Psychiatry: Response to Henderson et al.
PMID: 32605448 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Etkin A Tags: Am J Psychiatry Source Type: research

Alcohol Use Disorder and Suicide Risk: A Fresh and Closer Look.
PMID: 32605449 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Hasin DS Tags: Am J Psychiatry Source Type: research

Medical Marijuana: Putting the Cart Before the Horse.
PMID: 32605450 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Brady KT Tags: Am J Psychiatry Source Type: research

COVID-19, Medication-Assisted Treatment, and Increased Risk for Further Respiratory Depression.
PMID: 32605451 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2020 Category: Psychiatry Authors: Boyer J Tags: Am J Psychiatry Source Type: research

From Rare Copy Number Variants to Biological Processes in ADHD.
CONCLUSIONS: Integration of a stringent filtering procedure in CNV studies with suitable bioinformatics approaches can identify ADHD candidate genes at increased levels of credibility. The authors' analytic pipeline provides additional insight into the molecular mechanisms underlying ADHD and allows prioritization of genes for functional validation in validated model organisms. PMID: 32600152 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 30, 2020 Category: Psychiatry Authors: Harich B, van der Voet M, Klein M, Čížek P, Fenckova M, Schenck A, Franke B Tags: Am J Psychiatry Source Type: research

Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology.
CONCLUSIONS: A pattern of pervasively reduced neocortical thickness appears to be common across all forms of mental disorders and may represent a transdiagnostic feature of general psychopathology. As has been documented with regard to symptoms and diagnoses, the underlying brain structural correlates of mental disorders may not exhibit specificity, and the continued pursuit of such specific correlates may limit progress toward more effective strategies for etiological understanding, prevention, and intervention. PMID: 32600153 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 30, 2020 Category: Psychiatry Authors: Romer AL, Elliott ML, Knodt AR, Sison ML, Ireland D, Houts R, Ramrakha S, Poulton R, Keenan R, Melzer TR, Moffitt TE, Caspi A, Hariri AR Tags: Am J Psychiatry Source Type: research

Diagnostic Classification for Human Autism and Obsessive-Compulsive Disorder Based on Machine Learning From a Primate Genetic Model.
CONCLUSIONS: The identified core regions may serve as a basis for building markers for ASD and OCD diagnoses, as well as measures of symptom severity. These findings may inform future development of machine-learning models for psychiatric disorders and may improve the accuracy and speed of clinical assessments. PMID: 32539526 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 16, 2020 Category: Psychiatry Authors: Zhan Y, Wei J, Liang J, Xu X, He R, Robbins TW, Wang Z Tags: Am J Psychiatry Source Type: research

Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups.
CONCLUSIONS: The study findings suggest robust but subtle differences across different age groups among ADHD, ASD, and OCD. ADHD-specific intracranial volume and hippocampal differences in children and adolescents, and ASD-specific cortical thickness differences in the frontal cortex in adults, support previous work emphasizing structural brain differences in these disorders. PMID: 32539527 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 16, 2020 Category: Psychiatry Authors: Boedhoe PSW, van Rooij D, Hoogman M, Twisk JWR, Schmaal L, Abe Y, Alonso P, Ameis SH, Anikin A, Anticevic A, Arango C, Arnold PD, Asherson P, Assogna F, Auzias G, Banaschewski T, Baranov A, Batistuzzo MC, Baumeister S, Baur-Streubel R, Behrmann M, Bellgro Tags: Am J Psychiatry Source Type: research

Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity.
CONCLUSIONS: These findings provide strong evidence for striatal CINs as a critical cellular target that may contribute to pathophysiology in children with rapid-onset OCD symptoms, and perhaps in other conditions. PMID: 32539528 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 16, 2020 Category: Psychiatry Authors: Xu J, Liu RJ, Fahey S, Frick L, Leckman J, Vaccarino F, Duman RS, Williams K, Swedo S, Pittenger C Tags: Am J Psychiatry Source Type: research

Callous-Unemotional Traits and Risk of Gun Carrying and Use During Crime.
CONCLUSIONS: This study demonstrates the importance of considering callous-unemotional traits in gun violence research both because callous-unemotional traits increase gun carrying and use in adolescents and because the traits may moderate other key risk factors. Notably, the influence of peer gun carrying and ownership may have been underestimated in past research for the majority of adolescents by not considering the moderating influence of callous-unemotional traits. PMID: 32539529 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 16, 2020 Category: Psychiatry Authors: Robertson EL, Frick PJ, Walker TM, Kemp EC, Ray JV, Thornton LC, Wall Myers TD, Steinberg L, Cauffman E Tags: Am J Psychiatry Source Type: research

Correction to Lenze et al.
Authors: PMID: 32475135 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2020 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Do Benzodiazepines Cause Alzheimer's Disease?
PMID: 32475136 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2020 Category: Psychiatry Authors: Salzman C Tags: Am J Psychiatry Source Type: research

Can Pharmacological Augmentation of Cognitive Training Remediate Age-Related Cognitive Decline?
PMID: 32475137 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2020 Category: Psychiatry Authors: Smucny J, Carter CS Tags: Am J Psychiatry Source Type: research

Benzodiazepines: A Perspective.
PMID: 32475138 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2020 Category: Psychiatry Authors: Rosenbaum JF Tags: Am J Psychiatry Source Type: research

Small Flies Meet Big Data: Genetic Convergence of Neurodevelopmental Disorders Modeled in Drosophila.
PMID: 32475139 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2020 Category: Psychiatry Authors: Karam CS, Coie LA, Javitch JA Tags: Am J Psychiatry Source Type: research

New Findings Related to Cognition, Intellectual Disability, Dementia, and Autism.
PMID: 32475140 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2020 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Antidepressants, Pregnancy, and Autism: Setting the Record(s) Straight.
PMID: 32475141 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2020 Category: Psychiatry Authors: Maloney SE, Rogers CE, Constantino JN Tags: Am J Psychiatry Source Type: research

An Array of Studies Addressing Cognition and Cognitively Defined Neuropsychiatric Conditions: Many More Connections Than You Might Think.
Abstract Six articles in the June 2020 issue of the American Journal of Psychiatry address the overall construct of cognition. These articles have a broad connection to cognition, which is itself a broad concept. From the experimental psychology perspective, cognition is the set of processes associated with attending, learning, knowing, and remembering. From the clinical perspective, a number of neuropsychiatric conditions are defined by the presence of cognitive impairment, with onset ranging from childhood, such as attention deficit hyperactivity disorder and intellectual disability, to later life, such as demen...
Source: The American Journal of Psychiatry - June 1, 2020 Category: Psychiatry Authors: Harvey PD Tags: Am J Psychiatry Source Type: research

Association Between the Use of Cannabis and Physical Violence in Youths: A Meta-Analytical Investigation.
;, Dumais A Abstract OBJECTIVE: The aim of this meta-analysis was to investigate the extent to which cannabis use among youths is associated with the risk of perpetrating physical violence. METHODS: Searches were conducted in PubMed, PsycINFO, Web of Science, and Google Scholar for articles published from the inception of each database to July 2019. All studies that examined both cannabis use and the perpetration of physical violence in a sample of youths and young adults
Source: The American Journal of Psychiatry - May 27, 2020 Category: Psychiatry Authors: Dellazizzo L, Potvin S, Dou BY, Beaudoin M, Luigi M, Giguère CÉ, Dumais A Tags: Am J Psychiatry Source Type: research

Hormonal Treatments for Major Depressive Disorder: State of the Art.
Abstract Major depressive disorder is a common psychiatric disorder associated with marked suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030, major depression will be the leading cause of disease burden worldwide. While numerous treatments for major depression exist, many patients do not respond adequately to traditional antidepressants. Thus, more effective treatments for major depression are needed, and targeting certain hormonal systems is a conceptually based approach that has shown promise in the treatment of this disorder. A number of hormones and hormone-manipula...
Source: The American Journal of Psychiatry - May 27, 2020 Category: Psychiatry Authors: Dwyer JB, Aftab A, Widge A, Rodriguez CI, Carpenter LL, Nemeroff CB, Kalin NH, APA Council of Research Task Force on Novel Biomarkers and Treatments Tags: Am J Psychiatry Source Type: research

Parietal-Prefrontal Feedforward Connectivity in Association With Schizophrenia Genetic Risk and Delusions.
CONCLUSIONS: These computationally derived observations support a role for feedforward parietal-prefrontal information processing deficits in delusional psychopathology and in genetic risk for schizophrenia. PMID: 32456505 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 27, 2020 Category: Psychiatry Authors: Greenman DLB, La MAN, Shah S, Chen Q, Berman KF, Weinberger DR, Tan HY Tags: Am J Psychiatry Source Type: research

Neural Correlates of the Dual-Pathway Model for ADHD in Adolescents.
CONCLUSIONS: The dual-pathway model has both shared and separable neuroanatomical correlates, and the shared correlate in the occipital cortex has the potential to serve as an imaging trait marker of ADHD, especially the inattention symptom domain. PMID: 32375536 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 7, 2020 Category: Psychiatry Authors: Shen C, Luo Q, Jia T, Zhao Q, Desrivières S, Quinlan EB, Banaschewski T, Millenet S, Bokde ALW, Büchel C, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Paillère-Martinot ML, Nees F, Papadopoulos Orfanos D, Paus T Tags: Am J Psychiatry Source Type: research

A Prehistory of the Diathesis-Stress Model: Predisposing and Exciting Causes of Insanity in the 19th Century.
Abstract Histories of the diathesis-stress model trace its origins to the 1950s. However, of 26 psychiatric texts published between 1800 and 1910, 17 noted that causes of insanity could be usefully divided into those that predispose to illness and those that excite onset. In this "predisposition-excitation framework" (PEF) for the etiology of insanity, hereditary or constitutional factors were critical predisposing causes, but education, occupation, sex, and marital status were typically included as well. Psychological traumas were key exciting causes, but so were somatic diseases, pregnancy, and substan...
Source: The American Journal of Psychiatry - May 7, 2020 Category: Psychiatry Authors: Kendler KS Tags: Am J Psychiatry Source Type: research

Sleep Onset Problems and Subcortical Development in Infants Later Diagnosed With Autism Spectrum Disorder.
CONCLUSIONS: These findings provide initial evidence that sleep onset problems in the first year of life precede ASD diagnosis and are associated with altered neurodevelopmental trajectories in infants at high familial risk who go on to develop ASD. If replicated, these findings could provide new insights into a potential role of sleep difficulties in the development of ASD. PMID: 32375538 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 7, 2020 Category: Psychiatry Authors: MacDuffie KE, Shen MD, Dager SR, Styner MA, Kim SH, Paterson S, Pandey J, St John T, Elison JT, Wolff JJ, Swanson MR, Botteron KN, Zwaigenbaum L, Piven J, Estes AM Tags: Am J Psychiatry Source Type: research

Implementation of Advanced Methods for Reproductive Pharmacovigilance in Autism: A Meta-Analysis of the Effects of Prenatal Antidepressant Exposure.
CONCLUSIONS: In this meta-analysis, neither psychiatric control nor discordant-sibling designs supported an association between prenatal antidepressant exposure and autism. Discordant-sibling designs effectively addressed surveillance bias in pharmacovigilance reports derived from national registries and other large databases. PMID: 32375539 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 7, 2020 Category: Psychiatry Authors: Vega ML, Newport GC, Bozhdaraj D, Saltz SB, Nemeroff CB, Newport DJ Tags: Am J Psychiatry Source Type: research

Mental Health Response to the COVID-19 Outbreak in China.
PMID: 32375540 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 7, 2020 Category: Psychiatry Authors: Zhou J, Liu L, Xue P, Yang X, Tang X Tags: Am J Psychiatry Source Type: research

Developmental Differences in Neural Responding to Threat and Safety: Implications for Treating Youths With Anxiety.
PMID: 32354263 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2020 Category: Psychiatry Authors: Gee DG, Kribakaran S Tags: Am J Psychiatry Source Type: research

Mapping Symptom Clusters to Circuits: Toward Personalizing TMS Targets to Improve Treatment Outcomes in Depression.
PMID: 32354264 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2020 Category: Psychiatry Authors: Nestor SM, Blumberger DM Tags: Am J Psychiatry Source Type: research

Toward Circuit Mechanisms of Pathophysiology in Depression.
Abstract The search for more effective treatments for depression is a long-standing primary objective in both psychiatry and translational neuroscience. From initial models centered on neurochemical deficits, such as the monoamine hypothesis, research toward this goal has shifted toward a focus on network and circuit models to explain how key nodes in the limbic system and beyond interact to produce persistent shifts in affective states. To build these models, researchers have turned to two complementary approaches: neuroimaging studies in human patients (and their healthy counterparts) and neurophysiology studies...
Source: The American Journal of Psychiatry - May 1, 2020 Category: Psychiatry Authors: Spellman T, Liston C Tags: Am J Psychiatry Source Type: research

Examining the Reach of Smartphone Apps for Depression and Anxiety.
PMID: 32354266 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2020 Category: Psychiatry Authors: Wasil AR, Gillespie S, Shingleton R, Wilks CR, Weisz JR Tags: Am J Psychiatry Source Type: research

Some Comments on Psychedelic Research.
PMID: 32354267 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2020 Category: Psychiatry Authors: Schatzberg AF Tags: Am J Psychiatry Source Type: research

Comment on Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder.
PMID: 32354268 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2020 Category: Psychiatry Authors: Syed T, Smith EG Tags: Am J Psychiatry Source Type: research

What Does It Mean to Be Transdiagnostic and How Would We Know?
PMID: 32354269 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2020 Category: Psychiatry Authors: Barch DM Tags: Am J Psychiatry Source Type: research

The Critical Relationship Between Anxiety and Depression.
PMID: 32354270 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2020 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Informing Further Research in the Use of Brain Stimulation in Psychiatric Disorders: Response to Syed and Smith.
PMID: 32354271 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2020 Category: Psychiatry Authors: Philip NS, Barredo J, Aiken E, Larson V, Jones RN, Shea MT, Greenberg BD, van 't Wout-Frank M Tags: Am J Psychiatry Source Type: research

Is Depression Nature or Nurture? Yes.
PMID: 32340465 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 28, 2020 Category: Psychiatry Authors: Weissman MM Tags: Am J Psychiatry Source Type: research

The Rearing Environment and Risk for Major Depression: A Swedish National High-Risk Home-Reared and Adopted-Away Co-Sibling Control Study.
CONCLUSIONS: In matched full and half sibships at high risk for major depression, compared with individuals raised in their home environment, those reared in adoptive homes (homes selected in Sweden for their high-quality rearing environment) had a significantly reduced risk for major depression. This protective effect disappeared if an adoptive parent had major depression or if the adoptive home experienced parental death or divorce during childhood/adolescence. The rearing environment has a meaningful impact on risk for major depression, and this effect is likely mediated both by parental depression and the continuity or...
Source: The American Journal of Psychiatry - April 28, 2020 Category: Psychiatry Authors: Kendler KS, Ohlsson H, Sundquist J, Sundquist K Tags: Am J Psychiatry Source Type: research

Association Between Ambient Air Pollution and Daily Hospital Admissions for Depression in 75 Chinese Cities.
CONCLUSIONS: The study results suggest that short-term exposure to ambient air pollution is associated with an increased risk of daily hospital admission for depression in the general urban population in China, which may have important implications for improving mental wellness among the public. PMID: 32312109 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 21, 2020 Category: Psychiatry Authors: Gu X, Guo T, Si Y, Wang J, Zhang W, Deng F, Chen L, Wei C, Lin S, Guo X, Wu S Tags: Am J Psychiatry Source Type: research

Intergenerational Effects of Maternal Holocaust Exposure on FKBP5 Methylation.
CONCLUSIONS: This study replicates and extends the previously observed decrement in FKBP5 intron 7, site 6 methylation in Holocaust offspring. The predominance of this effect in offspring of mothers exposed during childhood implicates maternal developmental programming as a putative mechanism. PMID: 32312110 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 21, 2020 Category: Psychiatry Authors: Bierer LM, Bader HN, Daskalakis NP, Lehrner A, Provençal N, Wiechmann T, Klengel T, Makotkine I, Binder EB, Yehuda R Tags: Am J Psychiatry Source Type: research

20-Year Trends in the Pharmacologic Treatment of Bipolar Disorder by Psychiatrists in Outpatient Care Settings.
CONCLUSIONS: Substantial changes have occurred in the treatment of bipolar disorder over the past 20 years, with second-generation antipsychotics in large measure supplanting traditional mood stabilizers. Antidepressant prescriptions persisted despite a lack of evidence for their efficacy in bipolar disorder and concerns about increasing the risk of mania. Research is needed to compare the real-world effectiveness and tolerability of newer antipsychotics with those of traditional mood stabilizers. PMID: 32312111 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 21, 2020 Category: Psychiatry Authors: Rhee TG, Olfson M, Nierenberg AA, Wilkinson ST Tags: Am J Psychiatry Source Type: research