Dispositional traits help explain individual differences in relationships between a radiographic knee osteoarthritis measure, pain, and physical function
CONCLUSION: Consideration of dispositional traits reduces the variability between radiographic KOA and pain and function. Non-pathological and associated pain-related psychological factors and dispositional traits might serve as parsimonious proxy tools to improve clinical assessments.REGISTRATION: N/A.PMID:38516228 | PMC:PMC10956141 | DOI:10.1177/1759720X241235805 (Source: Adv Data)
Source: Adv Data - March 22, 2024 Category: Epidemiology Authors: Angela M Mickle Roland Staud Cynthia S Garvan Daniel A Kusko Nicola Sambuco Brittany R Addison Kevin R Vincent David T Redden Burel R Goodin Roger B Fillingim Kimberly T Sibille Source Type: research
Immune-related adverse events associated with first-line immune checkpoint inhibitors for metastatic renal cell carcinoma: A systematic review and network meta-analysis
CONCLUSION: The analysis focused on the probability of irAEs occurrence in each system when mRCC patients were treated with different ICI-based therapies, potentially offering significant value for guiding clinical prevention, early diagnosis, and management of irAEs. The limitations of the study included the potential heterogeneity and low certainty of part of the evidence.PMID:38518592 | DOI:10.1016/j.intimp.2024.111884 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 22, 2024 Category: Allergy & Immunology Authors: Shan Wang Hongwei Lv Jing Yu Miao Chen Source Type: research
Dispositional traits help explain individual differences in relationships between a radiographic knee osteoarthritis measure, pain, and physical function
CONCLUSION: Consideration of dispositional traits reduces the variability between radiographic KOA and pain and function. Non-pathological and associated pain-related psychological factors and dispositional traits might serve as parsimonious proxy tools to improve clinical assessments.REGISTRATION: N/A.PMID:38516228 | PMC:PMC10956141 | DOI:10.1177/1759720X241235805 (Source: Adv Data)
Source: Adv Data - March 22, 2024 Category: Epidemiology Authors: Angela M Mickle Roland Staud Cynthia S Garvan Daniel A Kusko Nicola Sambuco Brittany R Addison Kevin R Vincent David T Redden Burel R Goodin Roger B Fillingim Kimberly T Sibille Source Type: research
Immune-related adverse events associated with first-line immune checkpoint inhibitors for metastatic renal cell carcinoma: A systematic review and network meta-analysis
CONCLUSION: The analysis focused on the probability of irAEs occurrence in each system when mRCC patients were treated with different ICI-based therapies, potentially offering significant value for guiding clinical prevention, early diagnosis, and management of irAEs. The limitations of the study included the potential heterogeneity and low certainty of part of the evidence.PMID:38518592 | DOI:10.1016/j.intimp.2024.111884 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 22, 2024 Category: Allergy & Immunology Authors: Shan Wang Hongwei Lv Jing Yu Miao Chen Source Type: research
Immune-Related Adverse Event-Related Adrenal Insufficiency Mediates Immune Checkpoint Inhibitors Efficacy in Cancer Treatment
CONCLUSION: IrAE-related AI was significantly associated with ICI treatment efficacy in patients with cancer, which could be a potentially predictable marker. Due to the destruction of adrenal tissue by T cells with enhanced activity, AI reflects enhanced T cell activity to some extent.PMID:38501053 | PMC:PMC10946443 | DOI:10.2147/CMAR.S444916 (Source: Cancer Control)
Source: Cancer Control - March 19, 2024 Category: Cancer & Oncology Authors: Shasha Zhang Jianhua Wu Yue Zhao Jingjing Zhang Xiaoyun Zhang Chensi Wu Zhidong Zhang Zhanjun Guo Source Type: research
Rare copy number variation in autoimmune Addison ’s disease
In conclusion, rare CNVs do not appear to be a major cause of AAD but further studies are needed to ascertain the potential contribution of rare deletions to the polygenic load of AAD susceptibility. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 18, 2024 Category: Allergy & Immunology Source Type: research
Immune-Related Adverse Event-Related Adrenal Insufficiency Mediates Immune Checkpoint Inhibitors Efficacy in Cancer Treatment
(Source: Cancer Management and Research)
Source: Cancer Management and Research - March 14, 2024 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Application of the integrated threat theory to conservation law enforcement
Conserv Biol. 2024 Mar 13:e14248. doi: 10.1111/cobi.14248. Online ahead of print.ABSTRACTInteractions between law enforcement agents in conservation (e.g., rangers) and illegal resource users (e.g., illegal hunters) can be violent and sometimes fatal, which negatively affects conservation efforts and people's well-being. Models from social psychology, such as integrated threat theory (ITT) (intergroup interactions shape intergroup emotions, prejudices and perceived threats leading to hostile attitudes or behaviors between groups), are useful in addressing such interactions. Conservation approaches relying mainly on law enf...
Source: Conservation Biology - March 13, 2024 Category: Biology Authors: Mahmood Soofi Benjamin Ghasemi Mohsen Ahmadpour Mobin Soufi Iman Islami Alaina Eckert Mohammad Hossein Gorjian Arabi Ali T Qashqaei Javad Selyari Kamran Nasirahmadi Johannes Kamp Matthias Waltert Jane Addison Chris R Pavey Source Type: research
Application of the integrated threat theory to conservation law enforcement
Conserv Biol. 2024 Mar 13:e14248. doi: 10.1111/cobi.14248. Online ahead of print.ABSTRACTInteractions between law enforcement agents in conservation (e.g., rangers) and illegal resource users (e.g., illegal hunters) can be violent and sometimes fatal, which negatively affects conservation efforts and people's well-being. Models from social psychology, such as integrated threat theory (ITT) (intergroup interactions shape intergroup emotions, prejudices and perceived threats leading to hostile attitudes or behaviors between groups), are useful in addressing such interactions. Conservation approaches relying mainly on law enf...
Source: Conservation Biology - March 13, 2024 Category: Biology Authors: Mahmood Soofi Benjamin Ghasemi Mohsen Ahmadpour Mobin Soufi Iman Islami Alaina Eckert Mohammad Hossein Gorjian Arabi Ali T Qashqaei Javad Selyari Kamran Nasirahmadi Johannes Kamp Matthias Waltert Jane Addison Chris R Pavey Source Type: research
Fertility and sexual activity in patients with Triple A syndrome
ConclusionOur results contribute to still scarce knowledge on fertility in patients with Triple A syndrome and as well represents a foundation for further research on causes of infertility and possible treatment options. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 13, 2024 Category: Endocrinology Source Type: research
Adrenal insufficiency following cerebellar intracranial hemorrhage: a case report
This report presents a case of a previously healthy 58 years-old man who had suffered from persistent weakness and dizziness after a cerebellar intracranial hemorrhage (ICH). Endocrine function tests revealed low levels of plasma cortisol (3.05 μg/dL; normal range: 5–25 μg/dL) and adrenocorticotropic hormone (ACTH) (6.0 pg/mL; normal range: 10–60 pg/mL). The subsequent ACTH stimulation test suggested partial or recent hypopituitarism, resulting in adrenal gland atrophy and a subnormal cortisol response. Ultimately, the dizziness was found to be caused by undiagnosed adrenal insufficiency, which was detected...
Source: Frontiers in Neurology - March 12, 2024 Category: Neurology Source Type: research
Salivary Cortisol Measurement Contamination After Oral
Hydrocortisone: A Randomized Crossover Trial
Horm Metab Res DOI: 10.1055/a-2271-0700The study aimed to evaluate salivary cortisol (SC) contamination and determine
the associated factors in secondary adrenal insufficiency (SAI) patients treated
with hydrocortisone (Hc). A randomized crossover trial involved SAI patients. SC
was measured before the morning Hc dose, then at one, two, and four hours after.
The procedure was performed twice on two days of a week: one day while taking Hc
in tablet form (tablet set) and one day while taking Hc in capsule form (capsule
set). Area under the curve (AUC) of SC levels o...
Source: Hormone and Metabolic Research - March 6, 2024 Category: Endocrinology Authors: Chihaoui, Melika Mouelhi, Yasmine Hammami, Bessem Oueslati, Ibtissem Khessairi, Nadia Chaker, Fatma Yazidi, Meriem Feki, Moncef Tags: Original Article: Endocrine Care Source Type: research
Cardiovascular Disease Incidence and Cardiovascular Health Among Diverse Women With Breast and Gynecologic Cancers
Oncol Nurs Forum. 2024 Feb 19;51(2):113-125. doi: 10.1188/24.ONF.113-125.ABSTRACTOBJECTIVES: To examine if racial differences in cardiovascular health (CVH) are associated with cardiovascular disease (CVD) disparities among women with breast and gynecologic cancers.SAMPLE & SETTING: The sample consisted of 252 Black women and 93 White women without a self-reported history of cancer or CVD who developed a breast or gynecologic malignancy. Women who developed CVD before their cancer diagnosis were excluded.METHODS & VARIABLES: CVH was classified using metrics of the American Heart Association's Life's Simple 7 framew...
Source: Oncology Nursing Forum - March 5, 2024 Category: Nursing Authors: Timiya S Nolan Jennifer A Sinnott Jessica L Krok-Schoen Elizabeth K Arthur Emily Ridgway-Limle Darrell M Gray Ii Daniel Addison Sakima Smith Karen Patricia Williams Darryl B Hood Joshua J Joseph Ashley Felix Source Type: research
Cardiovascular Disease Incidence and Cardiovascular Health Among Diverse Women With Breast and Gynecologic Cancers
Oncol Nurs Forum. 2024 Feb 19;51(2):113-125. doi: 10.1188/24.ONF.113-125.ABSTRACTOBJECTIVES: To examine if racial differences in cardiovascular health (CVH) are associated with cardiovascular disease (CVD) disparities among women with breast and gynecologic cancers.SAMPLE & SETTING: The sample consisted of 252 Black women and 93 White women without a self-reported history of cancer or CVD who developed a breast or gynecologic malignancy. Women who developed CVD before their cancer diagnosis were excluded.METHODS & VARIABLES: CVH was classified using metrics of the American Heart Association's Life's Simple 7 framew...
Source: Oncology Nursing Forum - March 5, 2024 Category: Nursing Authors: Timiya S Nolan Jennifer A Sinnott Jessica L Krok-Schoen Elizabeth K Arthur Emily Ridgway-Limle Darrell M Gray Ii Daniel Addison Sakima Smith Karen Patricia Williams Darryl B Hood Joshua J Joseph Ashley Felix Source Type: research
Cardiovascular Disease Incidence and Cardiovascular Health Among Diverse Women With Breast and Gynecologic Cancers
Oncol Nurs Forum. 2024 Feb 19;51(2):113-125. doi: 10.1188/24.ONF.113-125.ABSTRACTOBJECTIVES: To examine if racial differences in cardiovascular health (CVH) are associated with cardiovascular disease (CVD) disparities among women with breast and gynecologic cancers.SAMPLE & SETTING: The sample consisted of 252 Black women and 93 White women without a self-reported history of cancer or CVD who developed a breast or gynecologic malignancy. Women who developed CVD before their cancer diagnosis were excluded.METHODS & VARIABLES: CVH was classified using metrics of the American Heart Association's Life's Simple 7 framew...
Source: Oncology Nursing Forum - March 5, 2024 Category: Nursing Authors: Timiya S Nolan Jennifer A Sinnott Jessica L Krok-Schoen Elizabeth K Arthur Emily Ridgway-Limle Darrell M Gray Ii Daniel Addison Sakima Smith Karen Patricia Williams Darryl B Hood Joshua J Joseph Ashley Felix Source Type: research
