Comparison of clinical characteristics of a pediatric cohort with combined pituitary hormone deficiency caused by mutation of the PROP1 gene or of other origins
CONCLUSION: Patients with the PROP1 mutations present a clinical picture significantly different from that of other forms of congenital hypopituitarism. Certain specific clinical results may lead to the successful identification of children requiring diagnostics for the PROP1 gene mutation.PMID:38147295 | DOI:10.1007/s42000-023-00510-1 (Source: Hormones)
Source: Hormones - December 26, 2023 Category: Endocrinology Authors: Agata Zygmunt-G órska Ma łgorzata Wójcik None AleksandraGilis-Januszewska Anna Starmach Miros ław Bik-Multanowski Jerzy B Starzyk Source Type: research
Perioperative growth hormone levels as an early predictor of new-onset secondary adrenal insufficiency following transsphenoidal pituitary tumor resection
CONCLUSION: Early morning GH level on POD1 can predict NOSAI with fair accuracy when perioperative stress dose glucocorticoid is administered. Prediction accuracy can be improved by considering CSF leakage, DI, and perioperative changes in GH and PRL in the final regression model.PMID:38148260 | DOI:10.1016/j.asjsur.2023.12.120 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - December 26, 2023 Category: Surgery Authors: Fon-Yih Tsuang Shyang-Rong Shih Ham-Min Tseng Huan-Chih Wang Source Type: research
Comparison of clinical characteristics of a pediatric cohort with combined pituitary hormone deficiency caused by mutation of the PROP1 gene or of other origins
CONCLUSION: Patients with the PROP1 mutations present a clinical picture significantly different from that of other forms of congenital hypopituitarism. Certain specific clinical results may lead to the successful identification of children requiring diagnostics for the PROP1 gene mutation.PMID:38147295 | DOI:10.1007/s42000-023-00510-1 (Source: Hormones)
Source: Hormones - December 26, 2023 Category: Endocrinology Authors: Agata Zygmunt-G órska Ma łgorzata Wójcik None AleksandraGilis-Januszewska Anna Starmach Miros ław Bik-Multanowski Jerzy B Starzyk Source Type: research
Perioperative growth hormone levels as an early predictor of new-onset secondary adrenal insufficiency following transsphenoidal pituitary tumor resection
CONCLUSION: Early morning GH level on POD1 can predict NOSAI with fair accuracy when perioperative stress dose glucocorticoid is administered. Prediction accuracy can be improved by considering CSF leakage, DI, and perioperative changes in GH and PRL in the final regression model.PMID:38148260 | DOI:10.1016/j.asjsur.2023.12.120 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - December 26, 2023 Category: Surgery Authors: Fon-Yih Tsuang Shyang-Rong Shih Ham-Min Tseng Huan-Chih Wang Source Type: research
Detecting the interferences in adrenocorticotropic hormone measurement - three cases reinforcing the efficiency of the complementary clinical and laboratory audit
Biochem Med (Zagreb). 2024 Feb 15;34(1):010802. doi: 10.11613/BM.2024.010802. Epub 2023 Dec 15.ABSTRACTAccurate measurement of adrenocorticotropic hormone (ACTH) is crucial in the evaluation of pituitary and adrenal disorders. Although great progress has been achieved in ACTH measurement with immunometric assays, interference may occur and adversely affect the clinical management. The report contributes to compiling the evidence on the clinical challenges with the management of the interferences in the ACTH measurement by presenting three cases: two with clinically overt hypercortisolism and discrepant ACTH concentrations ...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Tugba Barlas Mehmet Muhittin Yalcin Zakir Osmanov Ozlem Gulbahar Alev Eroglu Altinova Mujde Akturk Mehmet Ayhan Karakoc Ilhan Yetkin Fusun Balos Toruner Source Type: research
Confinement primes cells for faster migration by polarizing active mitochondria
Nanoscale Adv. 2023 Nov 22;6(1):209-220. doi: 10.1039/d3na00478c. eCollection 2023 Dec 19.ABSTRACTMechanical cues in the tumor microenvironment interplay with internal cellular processes to control cancer cell migration. Microscale pores present in tumor tissue confer varying degrees of confinement on migrating cells, increasing matrix contact and inducing cytoskeletal rearrangement. Previously, we observed that increased collagen matrix contact significantly increased cell migration speed and cell-induced strains within the matrix. However, the effects of this confinement on future cell migration are not fully understood....
Source: Cancer Control - December 21, 2023 Category: Cancer & Oncology Authors: Jenna A Mosier Emily D Fabiano Catherine M Ludolph Addison E White Cynthia A Reinhart-King Source Type: research
Incidence and Risk Factors for Adrenal Crisis in Pediatric-onset Adrenal Insufficiency: A Prospective Study
CONCLUSION: A substantial proportion of patients with pediatric-onset AI experience AC. Younger age and an increased number of infections are independent risk factors for developing AC in these patients.PMID:38128002 | DOI:10.1210/clinem/dgad753 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 21, 2023 Category: Endocrinology Authors: Mayumi Hosokawa Yosuke Ichihashi Yasunori Sato Nao Shibata Keisuke Nagasaki Kento Ikegawa Yukihiro Hasegawa Takashi Hamajima Fusa Nagamatsu Shigeru Suzuki Chikahiko Numakura Naoko Amano Goro Sasaki Keiko Nagahara Shun Soneda Daisuke Ariyasu Miwako Maeda H Source Type: research
Confinement primes cells for faster migration by polarizing active mitochondria
Nanoscale Adv. 2023 Nov 22;6(1):209-220. doi: 10.1039/d3na00478c. eCollection 2023 Dec 19.ABSTRACTMechanical cues in the tumor microenvironment interplay with internal cellular processes to control cancer cell migration. Microscale pores present in tumor tissue confer varying degrees of confinement on migrating cells, increasing matrix contact and inducing cytoskeletal rearrangement. Previously, we observed that increased collagen matrix contact significantly increased cell migration speed and cell-induced strains within the matrix. However, the effects of this confinement on future cell migration are not fully understood....
Source: Adv Data - December 21, 2023 Category: Epidemiology Authors: Jenna A Mosier Emily D Fabiano Catherine M Ludolph Addison E White Cynthia A Reinhart-King Source Type: research
Detecting the interferences in adrenocorticotropic hormone measurement - three cases reinforcing the efficiency of the complementary clinical and laboratory audit
Biochem Med (Zagreb). 2024 Feb 15;34(1):010802. doi: 10.11613/BM.2024.010802. Epub 2023 Dec 15.ABSTRACTAccurate measurement of adrenocorticotropic hormone (ACTH) is crucial in the evaluation of pituitary and adrenal disorders. Although great progress has been achieved in ACTH measurement with immunometric assays, interference may occur and adversely affect the clinical management. The report contributes to compiling the evidence on the clinical challenges with the management of the interferences in the ACTH measurement by presenting three cases: two with clinically overt hypercortisolism and discrepant ACTH concentrations ...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Tugba Barlas Mehmet Muhittin Yalcin Zakir Osmanov Ozlem Gulbahar Alev Eroglu Altinova Mujde Akturk Mehmet Ayhan Karakoc Ilhan Yetkin Fusun Balos Toruner Source Type: research
Incidence and Risk Factors for Adrenal Crisis in Pediatric-onset Adrenal Insufficiency: A Prospective Study
CONCLUSION: A substantial proportion of patients with pediatric-onset AI experience AC. Younger age and an increased number of infections are independent risk factors for developing AC in these patients.PMID:38128002 | DOI:10.1210/clinem/dgad753 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 21, 2023 Category: Endocrinology Authors: Mayumi Hosokawa Yosuke Ichihashi Yasunori Sato Nao Shibata Keisuke Nagasaki Kento Ikegawa Yukihiro Hasegawa Takashi Hamajima Fusa Nagamatsu Shigeru Suzuki Chikahiko Numakura Naoko Amano Goro Sasaki Keiko Nagahara Shun Soneda Daisuke Ariyasu Miwako Maeda H Source Type: research
Detecting the interferences in adrenocorticotropic hormone measurement - three cases reinforcing the efficiency of the complementary clinical and laboratory audit
Biochem Med (Zagreb). 2024 Feb 15;34(1):010802. doi: 10.11613/BM.2024.010802. Epub 2023 Dec 15.ABSTRACTAccurate measurement of adrenocorticotropic hormone (ACTH) is crucial in the evaluation of pituitary and adrenal disorders. Although great progress has been achieved in ACTH measurement with immunometric assays, interference may occur and adversely affect the clinical management. The report contributes to compiling the evidence on the clinical challenges with the management of the interferences in the ACTH measurement by presenting three cases: two with clinically overt hypercortisolism and discrepant ACTH concentrations ...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Tugba Barlas Mehmet Muhittin Yalcin Zakir Osmanov Ozlem Gulbahar Alev Eroglu Altinova Mujde Akturk Mehmet Ayhan Karakoc Ilhan Yetkin Fusun Balos Toruner Source Type: research
