Its a Trap! Aldolase-Prescribed C4 Deoxyradiofluorination Affords Intracellular Trapping and the Tracing of Fructose Metabolism by PET
Conclusion: Our study highlights the significance of aldolase-guided C4 radiodeoxyfluorination of fructose in enabling effective radiotracer trapping, overcoming limitations of C1 and C6 radioanalogs toward a clinically viable tool for imaging fructolysis in highly glycolytic tissues. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Kirby, A., Graf, D., Suchy, M., Calvert, N. D., Charlton, T. A., Ben, R. N., Addison, C. L., Shuhendler, A. Tags: Featured Basic Science Article Source Type: research
Challenges and pitfalls in the management of endocrine toxicities from immune checkpoint inhibitors: a case presentation of synchronous thyrotoxicosis and primary adrenal insufficiency in a melanoma patient
CONCLUSIONS: The simultaneous occurrence of adrenal and thyroid autoimmune diseases, resembling autoimmune polyendocrine syndrome type 2, may occur as a rare but serious side effect of ICI treatment. It often presents with abrupt onset and rapid evolution towards polyglandular insufficiency. Physicians should be aware of the potential association of two or more endocrine disorders and careful monitoring of endocrine function is needed during ICI therapy.PMID:38421588 | DOI:10.1007/s42000-024-00535-0 (Source: Hormones)
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Calogera Claudia Spagnolo Irene Campo Alfredo Campenn ì Davide Cardile Salvatore Cannav ò Nicola Silvestris Mariacarmela Santarpia Rosaria Maddalena Ruggeri Source Type: research
Immune Checkpoint Inhibitors for Kidney and Bladder Cancer: Adrenotoxic Consequences
Adrenal insufficiency (AI) is a described potential treatment toxicity with immune checkpoint inhibitors (ICIs). The presenting symptoms of AI are often non-specific and common symptoms of metastatic cancer. They include fatigue, loss of appetite, weight loss, nausea, abdominal pain, and muscle pain.1 This often leads to a delay in diagnosis until patients are hospitalized with an adrenal crisis.2 Of note, AI may occur due to a primary autoimmune response as well as secondary to pituitary failure or hypophysitis/hypopituitarism. (Source: Urology)
Source: Urology - February 29, 2024 Category: Urology & Nephrology Authors: Kiera Liblik, Jessica Caterini Queen, Naji J. Touma Source Type: research
Multi-omics Investigations in Endocrine Systems and Their Clinical Implications
Adv Exp Med Biol. 2024;1443:187-209. doi: 10.1007/978-3-031-50624-6_10.ABSTRACTInnovative techniques such as the "omics" can be a powerful tool for the understanding of intracellular pathways involved in homeostasis maintenance and identification of new potential therapeutic targets against endocrine-metabolic disorders. Over the last decades, proteomics has been extensively applied in the study of a wide variety of human diseases, including those involving the endocrine system. Among the most endocrine-related disorders investigated by proteomics in humans are diabetes mellitus and thyroid, pituitary, and reproductive sys...
Source: Adv Data - February 27, 2024 Category: Epidemiology Authors: Rodrigo Antonio Peliciari-Garcia Carolina Fonseca de Barros Ayla Secio-Silva Diogo de Barros Peruchetti Renata Marino Romano Paula Bargi-Souza Source Type: research
Neglected Adrenal Hypoplasia Congenita in Two Siblings with Novel Genetic Mutations in NR0B1 Gene and Notable Clinical Course: A Case Report
CONCLUSION: The diagnosis of CAH in case of low levels of 17- OHP, testosterone, and LH, as well as central hypogonadotropic hypogonadism, should be studied, and further investigations are mandatory to evaluate other subtypes of PAI, especially AHC.PMID:38409716 | DOI:10.2174/0118715303285405240202092244 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 27, 2024 Category: Drugs & Pharmacology Authors: Shayesteh Khalili Anahita Zakeri Farzad Hadaegh Seyed Saeed Tamehri Zadeh Source Type: research
Multi-omics Investigations in Endocrine Systems and Their Clinical Implications
Adv Exp Med Biol. 2024;1443:187-209. doi: 10.1007/978-3-031-50624-6_10.ABSTRACTInnovative techniques such as the "omics" can be a powerful tool for the understanding of intracellular pathways involved in homeostasis maintenance and identification of new potential therapeutic targets against endocrine-metabolic disorders. Over the last decades, proteomics has been extensively applied in the study of a wide variety of human diseases, including those involving the endocrine system. Among the most endocrine-related disorders investigated by proteomics in humans are diabetes mellitus and thyroid, pituitary, and reproductive sys...
Source: Advances in Experimental Medicine and Biology - February 27, 2024 Category: Research Authors: Rodrigo Antonio Peliciari-Garcia Carolina Fonseca de Barros Ayla Secio-Silva Diogo de Barros Peruchetti Renata Marino Romano Paula Bargi-Souza Source Type: research
Neglected Adrenal Hypoplasia Congenita in Two Siblings with Novel Genetic Mutations in NR0B1 Gene and Notable Clinical Course: A Case Report
CONCLUSION: The diagnosis of CAH in case of low levels of 17- OHP, testosterone, and LH, as well as central hypogonadotropic hypogonadism, should be studied, and further investigations are mandatory to evaluate other subtypes of PAI, especially AHC.PMID:38409716 | DOI:10.2174/0118715303285405240202092244 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 27, 2024 Category: Endocrinology Authors: Shayesteh Khalili Anahita Zakeri Farzad Hadaegh Seyed Saeed Tamehri Zadeh Source Type: research
Chimpanzees demonstrate a behavioural signature of human joint action
Cognition. 2024 Feb 26;246:105747. doi: 10.1016/j.cognition.2024.105747. Online ahead of print.ABSTRACTThe strength of human society can largely be attributed to the tendency to work together to achieve outcomes that are not possible alone. Effective social coordination benefits from mentally representing a partner's actions. Specifically, humans optimize social coordination by forming internal action models adapted to joint rather than individual task demands. To what extent do humans share the cognitive mechanisms that support optimal human coordination and collaboration with other species? An ecologically inspired joint...
Source: Cognition - February 27, 2024 Category: Neurology Authors: Merryn D Constable Emma Suvi McEwen G ünther Knoblich Callum Gibson Amanda Addison Sophia Nestor Josep Call Source Type: research
Neglected Adrenal Hypoplasia Congenita in Two Siblings with Novel Genetic Mutations in NR0B1 Gene and Notable Clinical Course: A Case Report
CONCLUSION: The diagnosis of CAH in case of low levels of 17- OHP, testosterone, and LH, as well as central hypogonadotropic hypogonadism, should be studied, and further investigations are mandatory to evaluate other subtypes of PAI, especially AHC.PMID:38409716 | DOI:10.2174/0118715303285405240202092244 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 27, 2024 Category: Drugs & Pharmacology Authors: Shayesteh Khalili Anahita Zakeri Farzad Hadaegh Seyed Saeed Tamehri Zadeh Source Type: research
Multi-omics Investigations in Endocrine Systems and Their Clinical Implications
Adv Exp Med Biol. 2024;1443:187-209. doi: 10.1007/978-3-031-50624-6_10.ABSTRACTInnovative techniques such as the "omics" can be a powerful tool for the understanding of intracellular pathways involved in homeostasis maintenance and identification of new potential therapeutic targets against endocrine-metabolic disorders. Over the last decades, proteomics has been extensively applied in the study of a wide variety of human diseases, including those involving the endocrine system. Among the most endocrine-related disorders investigated by proteomics in humans are diabetes mellitus and thyroid, pituitary, and reproductive sys...
Source: Adv Data - February 27, 2024 Category: Epidemiology Authors: Rodrigo Antonio Peliciari-Garcia Carolina Fonseca de Barros Ayla Secio-Silva Diogo de Barros Peruchetti Renata Marino Romano Paula Bargi-Souza Source Type: research
Multi-omics Investigations in Endocrine Systems and Their Clinical Implications
Adv Exp Med Biol. 2024;1443:187-209. doi: 10.1007/978-3-031-50624-6_10.ABSTRACTInnovative techniques such as the "omics" can be a powerful tool for the understanding of intracellular pathways involved in homeostasis maintenance and identification of new potential therapeutic targets against endocrine-metabolic disorders. Over the last decades, proteomics has been extensively applied in the study of a wide variety of human diseases, including those involving the endocrine system. Among the most endocrine-related disorders investigated by proteomics in humans are diabetes mellitus and thyroid, pituitary, and reproductive sys...
Source: Advances in Experimental Medicine and Biology - February 27, 2024 Category: Research Authors: Rodrigo Antonio Peliciari-Garcia Carolina Fonseca de Barros Ayla Secio-Silva Diogo de Barros Peruchetti Renata Marino Romano Paula Bargi-Souza Source Type: research
Diagnosis and management of secondary adrenal crisis
Rev Endocr Metab Disord. 2024 Feb 27. doi: 10.1007/s11154-024-09877-x. Online ahead of print.ABSTRACTAdrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventiv...
Source: ENDOCR REV - February 27, 2024 Category: Endocrinology Authors: Luciana Martel-Duguech Jonathan Poirier Isabelle Bourdeau Andr é Lacroix Source Type: research
