Multi-omics Investigations in Endocrine Systems and Their Clinical Implications
Adv Exp Med Biol. 2024;1443:187-209. doi: 10.1007/978-3-031-50624-6_10.ABSTRACTInnovative techniques such as the "omics" can be a powerful tool for the understanding of intracellular pathways involved in homeostasis maintenance and identification of new potential therapeutic targets against endocrine-metabolic disorders. Over the last decades, proteomics has been extensively applied in the study of a wide variety of human diseases, including those involving the endocrine system. Among the most endocrine-related disorders investigated by proteomics in humans are diabetes mellitus and thyroid, pituitary, and reproductive sys...
Source: Advances in Experimental Medicine and Biology - February 27, 2024 Category: Research Authors: Rodrigo Antonio Peliciari-Garcia Carolina Fonseca de Barros Ayla Secio-Silva Diogo de Barros Peruchetti Renata Marino Romano Paula Bargi-Souza Source Type: research
Neglected Adrenal Hypoplasia Congenita in Two Siblings with Novel Genetic Mutations in NR0B1 Gene and Notable Clinical Course: A Case Report
CONCLUSION: The diagnosis of CAH in case of low levels of 17- OHP, testosterone, and LH, as well as central hypogonadotropic hypogonadism, should be studied, and further investigations are mandatory to evaluate other subtypes of PAI, especially AHC.PMID:38409716 | DOI:10.2174/0118715303285405240202092244 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 27, 2024 Category: Endocrinology Authors: Shayesteh Khalili Anahita Zakeri Farzad Hadaegh Seyed Saeed Tamehri Zadeh Source Type: research
Chimpanzees demonstrate a behavioural signature of human joint action
Cognition. 2024 Feb 26;246:105747. doi: 10.1016/j.cognition.2024.105747. Online ahead of print.ABSTRACTThe strength of human society can largely be attributed to the tendency to work together to achieve outcomes that are not possible alone. Effective social coordination benefits from mentally representing a partner's actions. Specifically, humans optimize social coordination by forming internal action models adapted to joint rather than individual task demands. To what extent do humans share the cognitive mechanisms that support optimal human coordination and collaboration with other species? An ecologically inspired joint...
Source: Cognition - February 27, 2024 Category: Neurology Authors: Merryn D Constable Emma Suvi McEwen G ünther Knoblich Callum Gibson Amanda Addison Sophia Nestor Josep Call Source Type: research
Neglected Adrenal Hypoplasia Congenita in Two Siblings with Novel Genetic Mutations in NR0B1 Gene and Notable Clinical Course: A Case Report
CONCLUSION: The diagnosis of CAH in case of low levels of 17- OHP, testosterone, and LH, as well as central hypogonadotropic hypogonadism, should be studied, and further investigations are mandatory to evaluate other subtypes of PAI, especially AHC.PMID:38409716 | DOI:10.2174/0118715303285405240202092244 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 27, 2024 Category: Drugs & Pharmacology Authors: Shayesteh Khalili Anahita Zakeri Farzad Hadaegh Seyed Saeed Tamehri Zadeh Source Type: research
Multi-omics Investigations in Endocrine Systems and Their Clinical Implications
Adv Exp Med Biol. 2024;1443:187-209. doi: 10.1007/978-3-031-50624-6_10.ABSTRACTInnovative techniques such as the "omics" can be a powerful tool for the understanding of intracellular pathways involved in homeostasis maintenance and identification of new potential therapeutic targets against endocrine-metabolic disorders. Over the last decades, proteomics has been extensively applied in the study of a wide variety of human diseases, including those involving the endocrine system. Among the most endocrine-related disorders investigated by proteomics in humans are diabetes mellitus and thyroid, pituitary, and reproductive sys...
Source: Adv Data - February 27, 2024 Category: Epidemiology Authors: Rodrigo Antonio Peliciari-Garcia Carolina Fonseca de Barros Ayla Secio-Silva Diogo de Barros Peruchetti Renata Marino Romano Paula Bargi-Souza Source Type: research
Multi-omics Investigations in Endocrine Systems and Their Clinical Implications
Adv Exp Med Biol. 2024;1443:187-209. doi: 10.1007/978-3-031-50624-6_10.ABSTRACTInnovative techniques such as the "omics" can be a powerful tool for the understanding of intracellular pathways involved in homeostasis maintenance and identification of new potential therapeutic targets against endocrine-metabolic disorders. Over the last decades, proteomics has been extensively applied in the study of a wide variety of human diseases, including those involving the endocrine system. Among the most endocrine-related disorders investigated by proteomics in humans are diabetes mellitus and thyroid, pituitary, and reproductive sys...
Source: Advances in Experimental Medicine and Biology - February 27, 2024 Category: Research Authors: Rodrigo Antonio Peliciari-Garcia Carolina Fonseca de Barros Ayla Secio-Silva Diogo de Barros Peruchetti Renata Marino Romano Paula Bargi-Souza Source Type: research
Diagnosis and management of secondary adrenal crisis
Rev Endocr Metab Disord. 2024 Feb 27. doi: 10.1007/s11154-024-09877-x. Online ahead of print.ABSTRACTAdrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventiv...
Source: ENDOCR REV - February 27, 2024 Category: Endocrinology Authors: Luciana Martel-Duguech Jonathan Poirier Isabelle Bourdeau Andr é Lacroix Source Type: research
Chimpanzees demonstrate a behavioural signature of human joint action
Cognition. 2024 Feb 26;246:105747. doi: 10.1016/j.cognition.2024.105747. Online ahead of print.ABSTRACTThe strength of human society can largely be attributed to the tendency to work together to achieve outcomes that are not possible alone. Effective social coordination benefits from mentally representing a partner's actions. Specifically, humans optimize social coordination by forming internal action models adapted to joint rather than individual task demands. To what extent do humans share the cognitive mechanisms that support optimal human coordination and collaboration with other species? An ecologically inspired joint...
Source: Cognition - February 27, 2024 Category: Neurology Authors: Merryn D Constable Emma Suvi McEwen G ünther Knoblich Callum Gibson Amanda Addison Sophia Nestor Josep Call Source Type: research
Diagnosis and management of secondary adrenal crisis
Rev Endocr Metab Disord. 2024 Feb 27. doi: 10.1007/s11154-024-09877-x. Online ahead of print.ABSTRACTAdrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventiv...
Source: ENDOCR REV - February 27, 2024 Category: Endocrinology Authors: Luciana Martel-Duguech Jonathan Poirier Isabelle Bourdeau Andr é Lacroix Source Type: research
Chimpanzees demonstrate a behavioural signature of human joint action
Cognition. 2024 Feb 26;246:105747. doi: 10.1016/j.cognition.2024.105747. Online ahead of print.ABSTRACTThe strength of human society can largely be attributed to the tendency to work together to achieve outcomes that are not possible alone. Effective social coordination benefits from mentally representing a partner's actions. Specifically, humans optimize social coordination by forming internal action models adapted to joint rather than individual task demands. To what extent do humans share the cognitive mechanisms that support optimal human coordination and collaboration with other species? An ecologically inspired joint...
Source: Cognition - February 27, 2024 Category: Neurology Authors: Merryn D Constable Emma Suvi McEwen G ünther Knoblich Callum Gibson Amanda Addison Sophia Nestor Josep Call Source Type: research
Chimpanzees demonstrate a behavioural signature of human joint action
Cognition. 2024 Feb 26;246:105747. doi: 10.1016/j.cognition.2024.105747. Online ahead of print.ABSTRACTThe strength of human society can largely be attributed to the tendency to work together to achieve outcomes that are not possible alone. Effective social coordination benefits from mentally representing a partner's actions. Specifically, humans optimize social coordination by forming internal action models adapted to joint rather than individual task demands. To what extent do humans share the cognitive mechanisms that support optimal human coordination and collaboration with other species? An ecologically inspired joint...
Source: Cognition - February 27, 2024 Category: Neurology Authors: Merryn D Constable Emma Suvi McEwen G ünther Knoblich Callum Gibson Amanda Addison Sophia Nestor Josep Call Source Type: research
Opioid-induced adrenal insufficiency: diagnostic and management considerations
The dramatic rise in opioid use over the last two decades has led to a surge in their harmful health effects. Lesser known among clinicians is the impact of opioids on the endocrine system, especially with regard to cortisol. Opioids can suppress the hypothalamus-pituitary-adrenal (HPA) axis and may result in clinically significant adrenal insufficiency, especially in those treated at higher doses and for a longer time. A high clinical suspicion is necessary in this population for early diagnosis of opioid-induced adrenal insufficiency (OAI). Diagnosis of OAI is challenging, as the symptoms are often vague and overlap with...
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research
Diagnosis and management of secondary adrenal crisis
AbstractAdrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventive strategies, its prevalence is increasing in patients with SAI, TAI and IAI due to more freq...
Source: Reviews in Endocrine and Metabolic Disorders - February 27, 2024 Category: Endocrinology Source Type: research
Radiation Therapy Physics Quality Assurance and Management Practices in Low- and Middle-Income Countries: An Initial Pilot Survey in Six Countries and Validation Through a Site Visit
CONCLUSIONS: The preliminary study showed a direct correlation between QA needs and the development index of a country, and the follow-up survey examines operational and physics QA practices in the RT clinics in Ghana, one of the initial countries surveyed. This will form the basis of a planned continent-wide survey in Africa intended to spotlight QA practices in low- and middle-income countries, the challenges faced, and lessons learned to help understand the gaps and needs to support local physics QA and management programs. Audits during the site visit show education and training remain the most important needs in opera...
Source: Adv Data - February 26, 2024 Category: Epidemiology Authors: Afua A Yorke Vonetta M Williams Shekinah Elmore Kellie Alleyne-Mike Eric Addison Philip Oppong Kyeremeh Samuel Nii Adu Tagoe Christoph Jon Trauernicht Graeme L Lazarus Eric C Ford Source Type: research
