The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Tetrahedron Lett. 2023 Oct 25;130:154748. doi: 10.1016/j.tetlet.2023.154748. Epub 2023 Sep 9.ABSTRACTFluorogenic probes for imaging enable visualization and analysis of difficult-to-reach cells and organelles. However, there are limited efficient examples of tuning these fluorescent molecules to higher wavelengths. This is vital since different tissues are sensitive to varying wavelength emissions. To address this need, we report the discovery, tuning, structure-photophysical property relationships (SPPR), and time-dependent DFT (TD-DFT) computations of 400-700+ nm fluorescent pyrido[2',1':2,3]imidazo[4,5-c]isoquinolines a...
Source: Tetrahedron Letters - February 19, 2024 Category: Chemistry Authors: Nathan Bedard Addison G Coen Scott Pekarske Andrew Sennett Garrett J Davis Timothy Chavez Dennis L Lichtenberger Christopher Hulme Source Type: research
