Co-aggregation and heritability of organ-specific autoimmunity: a population-based twin study.
Conclusions: Overall, co-aggregation was more pronounced in monozygotic than in dizygotic twins, suggesting that disease overlap is largely attributable to genetic factors. Co-aggregation was common, and twins faced up to a ten-fold risk of developing diseases not present in their co-twin. Our results validate and refine previous heritability estimates based on smaller twin cohorts. PMID: 32229696 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 3, 2020 Category: Endocrinology Authors: Skov J, Eriksson D, Kuja-Halkola R, Höijer J, Gudbjörnsdottir S, Svensson AM, Magnusson PKE, Ludvigsson JF, Kämpe O, Bensing S Tags: Eur J Endocrinol Source Type: research

Maximizing the Calm Before the Storm: Tiered Surgical Response Plan for Novel Coronavirus (COVID-19)
The novel coronavirus (COVID-19) was first diagnosed in Wuhan, China in December 2019 and has now spread throughout the world, being verified by the World Health Organization as a Pandemic on March 11th. This had led to the calling of a national emergency on March 13th in the United States. Many hospitals, healthcare networks, and specifically Departments of Surgery are asking the same questions of how to cope and plan for surge capacity, personnel attrition, novel infrastructure utilization, and resource exhaustion. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - April 3, 2020 Category: Surgery Authors: Samuel Wade Ross, Cynthia W. Lauer, William S. Miles, John M. Green, A Britton Christmas, Addison K. May, Brent D. Matthews Tags: Special Article Source Type: research

Immune checkpoint inhibitor-associated pituitary adverse events: an observational, retrospective, disproportionality study
AbstractPurposeThe aim of this study was to identify and characterize immune checkpoint inhibitors (ICIs)-associated pituitary adverse events (AEs).MethodsThis is a retrospective disproportionality study based on VigiBase, the World Health Organization (WHO) global database of individual case safety reports (ICSRs), with a study period from January 1, 2011 to March 6, 2019. Information component (IC) and reporting odds ratio (ROR) are measures of disproportionate analysis. IC was used to evaluate the association between ICIs and pituitary AEs, while ROR was used to evaluate the differences in reporting of pituitary AEs bet...
Source: Journal of Endocrinological Investigation - April 1, 2020 Category: Endocrinology Source Type: research

Minding the gap between cortisol levels measured with second-generation assays and current diagnostic thresholds for the diagnosis of adrenal insufficiency: a single-center experience.
Authors: Grassi G, Morelli V, Ceriotti F, Polledri E, Fustinoni S, D'Agostino S, Mantovani G, Chiodini I, Arosio M Abstract PURPOSE: The current cut-offs for the diagnosis of adrenal insufficiency (AI) have been established using outdated immunoassays. We compared the cortisol concentrations measured with Roche Cortisol I (R1), the newly available Roche Cortisol II (R2), and liquid chromatography tandem mass spectrometry (LC-MS/MS), the gold standard procedure to measure steroids in patients undergoing the corticotropin (ACTH) test. METHODS: We enrolled 30 patients (age 47 ± 21 years) ...
Source: Hormones - March 31, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Vitamin B 12 deficiency as a cause of severe neurological symptoms in breast fed infant – a case report
ConclusionsVitamin B12 levels should be considered during differential diagnosis of neurological symptoms in exclusively breast-fed infants especially if they co-exist with megaloblastic anemia and psychomotor retardation. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 30, 2020 Category: Pediatrics Source Type: research

Treatment of the adult growth hormone deficiency syndrome with growth hormone: What are the implications for other hormone replacement therapies for hypopituitarism?
Abstract When initiating growth hormone replacement therapy, it is important to consider a patient's other pituitary hormone replacement medications, as adjustments are often necessary. Growth hormone therapy can increase the metabolism of hydrocortisone or endogenous cortisol, unmasking borderline ACTH deficiency and leading to the development of adrenal insufficiency and adrenal crisis. In addition, growth hormone can enhance the metabolism of thyroxine to triiodothyronine, uncovering borderline TSH deficiency. In many patients, thyroid hormone replacement therapy must be started, or the dose of levothyroxine mu...
Source: Growth Hormone and IGF Research - March 23, 2020 Category: Endocrinology Authors: Fierro G, Hoffman AR Tags: Growth Horm IGF Res Source Type: research

A Prospect for Environmental Remediation of Perchlorate via Cost-Effective Pinus Leaves and Dandelion Flower Powder-based Layer Double Hydride (LDH) Sorbents
Publication date: Available online 18 March 2020Source: Arabian Journal of ChemistryAuthor(s): Ammara Ahmed, Addison Francis, Na Liu, Ying Ying Liu (Source: Arabian Journal of Chemistry)
Source: Arabian Journal of Chemistry - March 20, 2020 Category: Chemistry Source Type: research

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia.
CONCLUSIONS: There are currently limited trials comparing the efficacy and safety of different glucocorticoid replacement regimens for treating 21-hydroxylase deficiency CAH in children and adults and we were unable to draw any firm conclusions based on the evidence that was presented in the included trials. No trials included long-term outcomes such as quality of life, prevention of adrenal crisis, presence of osteopenia, presence of testicular or ovarian adrenal rest tumours, subfertility and final adult height. There were no trials examining a modified-release formulation of HC or use of 24-hour circadian continuous sub...
Source: Cochrane Database of Systematic Reviews - March 19, 2020 Category: General Medicine Authors: Ng SM, Stepien KM, Krishan A Tags: Cochrane Database Syst Rev Source Type: research

Adrenal failure and orchitis secondary to tuberculosis mimicking metastatic malignancy
Primary adrenal insufficiency, a potentially life-threatening disease, often runs an insidious course mandating a strong clinical suspicion for a prompt diagnosis.1 A 65-year-old farmer presented with a one-month history of fatigue and dizziness reporting episodes of loss of consciousness. On clinical examination, he appeared cachectic, with skin and mucosal hyperpigmentation. Chest computed tomography, subsequent to a chest X-ray showing a “coin” lesion, demonstrated a 2.4 × 2cm nodule of the posterior right upper lobe and small lymph-nodes in the mediastinum. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 18, 2020 Category: General Medicine Authors: Antonios M. Xydakis, Eleftherios Chatzellis, Denise Kolomodi, Gregory A. Kaltsas, Krystallenia I Alexandraki Tags: CLINICAL COMMUNICATION TO THE EDITOR Source Type: research

Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling [Biophysics and Computational Biology]
The CRISPR-Cas9 nuclease has been widely repurposed as a molecular and cell biology tool for its ability to programmably target and cleave DNA. Cas9 recognizes its target site by unwinding the DNA double helix and hybridizing a 20-nucleotide section of its associated guide RNA to one DNA strand, forming an... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - March 17, 2020 Category: Science Authors: Ivan E. Ivanov, Addison V. Wright, Joshua C. Cofsky, Kevin D. Palacio Aris, Jennifer A. Doudna, Zev Bryant Tags: Biological Sciences Source Type: research

Clinical characteristics of adrenal insufficiency as an immune-related adverse event in non-small-cell lung cancer
In conclusion, the incidence of AI among NSCLC patients treated with anti-PD-1 antibodies was similar to previous studies. Corticosteroid replacement improved PS, symptoms, and laboratory data of patients with AI and suspicious of AI. Corticosteroid replacement may contribute to continuation of anti-PD-1 antibodies and survival outcome was preferable in patients with AI and suspicious of AI receiving corticosteroid treatment. (Source: Medical Oncology)
Source: Medical Oncology - March 16, 2020 Category: Cancer & Oncology Source Type: research

Modulation of Post-Traumatic Immune Response Using the IL-1 Receptor Antagonist Anakinra for Improved Visual Outcomes
Journal of Neurotrauma, Ahead of Print. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - March 16, 2020 Category: Neurology Authors: Lucy P. Evans Addison W. Woll Shu Wu Brittany P. Todd Nicole Hehr Adam Hedberg-Buenz Michael G. Anderson Elizabeth A. Newell Polly J. Ferguson Vinit B. Mahajan Matthew M. Harper Alexander G. Bassuk Source Type: research

Robotic Colorectal Surgery.
Abstract The role of robotics in colon and rectal surgery has been established as an important and effective tool for the surgeon. Its inherent technologies have provided for increased visualization and ease of dissection in the minimally invasive approach to surgery. The value of the robot is apparent in the more challenging aspects of colon and rectal procedures, including the intracorporeal anastomosis for right colectomies and the low pelvic dissection for benign and malignant diseases. PMID: 32169183 [PubMed - as supplied by publisher] (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 15, 2020 Category: Cancer & Oncology Authors: Addison P, Agnew JL, Martz J Tags: Surg Clin North Am Source Type: research

Erythema annulare centrifugum and Addison's disease: a casual presentation?
Authors: Giorgio CM, Licata G, Agozzino M, Gambardella A, De Rosa A, Ronchi A, Argenziano G PMID: 32163050 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)
Source: Giornale Italiano di Dermatologia e Venereologia - March 14, 2020 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

Implementing a Learning Collaborative Framework for States Working to Improve Outcomes for Vulnerable Populations: The Opioid Use Disorder, Maternal Outcomes, and Neonatal Abstinence Syndrome Initiative Learning Community
Journal of Women's Health, Ahead of Print. (Source: Journal of Women)
Source: Journal of Women - March 13, 2020 Category: OBGYN Authors: Charlan D. Kroelinger Donna Addison Mirelys Rodriguez Marion E. Rice Meghan T. Frey Hadley R. Hickner Mary Kate Weber Trish Mueller Alisa Velonis Keriann Uesugi Lisa Romero Sanaa Akbarali Natalie Foster Jean Y. Ko Ellen Pliska Christine Mackie Shanna Cox Source Type: research

Cancers, Vol. 12, Pages 639: Recovery of Adrenal Insufficiency Is Frequent After Adjuvant Mitotane Therapy in Patients with Adrenocortical Carcinoma
Isabelle Bourdeau Mitotane is a steroidogenesis inhibitor and adrenolytic drug used for treatment of adrenocortical cancer (ACC). Mitotane therapy causes adrenal insufficiency requiring glucocorticoid replacement in all patients. However, it is unclear whether chronic therapy with mitotane induces complete destruction of zona fasciculata and whether hypothalamic-pituitary-adrenal (HPA) axis can recover after treatment cessation. Our objective was to assess the HPA axis recovery in a cohort of patients after cessation of adjuvant mitotane therapy for ACC. We retrospectively reviewed patient files with stage I-II-III ...
Source: Cancers - March 10, 2020 Category: Cancer & Oncology Authors: Jonathan Poirier Nadia Gagnon Massimo Terzolo Soraya Puglisi Nada El Ghorayeb Anna Calabrese Andr é Lacroix Isabelle Bourdeau Tags: Article Source Type: research

Perioperative glucocorticoids — replacing old ideas
Nature Reviews Endocrinology, Published online: 09 March 2020; doi:10.1038/s41574-020-0342-zCurrent recommendations for perioperative doses of hydrocortisone in patients with adrenal insufficiency undergoing major surgery with general anaesthesia have been examined in a new paper. Compared with current guidelines, lower doses of hydrocortisone, tapered quickly back to baseline levels of glucocorticoids, were found to be effective and safe. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 9, 2020 Category: Endocrinology Authors: Robert J. Weil Source Type: research

Primary antiphospholipid syndrome, Addison disease, and adrenal incidentaloma
We describe an exceptional case of a 23-year-old male patient with APS with persistent high levels of antiphospholipid antibodies (aPL ) from the time of diagnosis, who developed Addison’s disease as a manifestation of APS with atrophy of the adrenal glands, in whom an adrenal incidentaloma was developed later and was corroborated as an aldosterone-producing adenoma. Currently, the patient is asymptomatic and without manifestatio ns of tumor recurrence. The protumoral effect of elevated and persistent aPL is discussed. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 7, 2020 Category: Rheumatology Source Type: research

Long-term treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat.
Abstract Synthetic glucocorticoids are widely prescribed for the treatment of numerous inflammatory and autoimmune diseases and they can also affect the way the adrenal gland produces endogenous glucocorticoids. Indeed, patients undergoing synthetic glucocorticoid treatment can develop adrenal insufficiency, a condition characterised by reduced responsiveness of the adrenal to ACTH stimulation or stressors (e.g. surgical or inflammatory stress). To better elucidate the long-term effect of synthetic glucocorticoids treatment and withdrawal on adrenal function, we have investigated the effects of prolonged treatment...
Source: Brain, Behavior, and Immunity - March 7, 2020 Category: Neurology Authors: Spiga F, Zhao Z, Lightman SL Tags: Brain Behav Immun Source Type: research

Icariin reduces LPS-induced acute lung injury in mice undergoing bilateral adrenalectomy by regulating GR α.
In conclusion, ICA reduces ALI in mice undergoing bilateral ADX by regulating GRα, and no inhibitory effect on hypothalamic pituitary adrenal (HPA) axis. PMID: 32147435 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 5, 2020 Category: Drugs & Pharmacology Authors: Sun X, Cheng H, Liu B, Du Y, Dong J, Huang J Tags: Eur J Pharmacol Source Type: research

Calcified Adrenal Lesions: Pattern Recognition Approach on Computed Tomography With Pathologic Correlation
Incidental adrenal lesions are found in 2% to 10% of the population. The presence and pattern of calcifications, in conjunction with other clinical and imaging features, such as soft tissue attenuation, enhancement, and laterality, can aid in narrowing a differential diagnosis, thereby preventing unnecessary biopsies and avoiding delays in management. Calcified adrenal lesions can be categorized under the clinical and laboratory headings of normal adrenal function, hyperfunctioning adrenal tissue, and adrenal insufficiency. In this review, we provide an algorithmic approach to assessing calcified adrenal nodules with corre...
Source: Journal of Computer Assisted Tomography - March 1, 2020 Category: Radiology Tags: Abdominal Imaging Source Type: research

Fatal adrenal crisis due to Addison ’s disease arising in the context of autoimmune polyglandular syndrome type 1
AbstractThe autoimmune polyglandular syndromes (APS) are rare immune-mediated endocrinopathies causing destruction of multiple endocrine and non-endocrine organs. Involvement of adrenal glands associated with any type of APS results in Addison ’s disease. While patients with Addison’s disease often suffer from symptoms of neuroglycopenia, lethal hypotension and hypoglycemia are uncommon. Here, we report a fatal case of APS type 1 with hypotension and profound hypoglycemia in a 24-year-old man who was found unconsciousness at home and progressively evolved into pulseless electrical activity. Although his conditi...
Source: Forensic Science, Medicine, and Pathology - March 1, 2020 Category: Forensic Medicine Source Type: research

Autoimmune polyglandular syndrome type II with co-manifestation of Addison ’s and Graves’ disease in a 15-year-old boy: case report and literature review
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - February 29, 2020 Category: Endocrinology Source Type: research

A 29-year-old patient with adrenoleukodystrophy presenting with Addison's disease.
Authors: Tanaka H, Amano N, Tanaka K, Katsuki T, Adachi T, Shimozawa N, Kawai T Abstract Adrenoleukodystrophy (ALD) is an X-linked disorder caused by a hemizygous mutation of the ABCD1 gene. Patients with ALD show progressive central nervous system demyelination and primary adrenal insufficiency. In Japan, most reported ALD cases were childhood-onset, and only one case of an adult patient with Addison's disease form of ALD has ever been reported. Herein, we present a case of a 29-year-old man with Addison's disease form of ALD. The patient had anorexia, weight loss, and skin pigmentation from 18 years of age. At fi...
Source: Endocrine Journal - February 28, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Hyponatremia and Glucocorticoid Deficiency.
Authors: Garrahy A, Thompson CJ Abstract Hyponatremia is the commonest electrolyte deficiency in clinical practice. Of the many causes of hyponatremia, syndrome of inappropriate antidiuresis (SIAD) is the commonest. Glucocorticoid deficiency, due to central/secondary adrenal insufficiency, is the key differential diagnosis for SIAD, as it presents with a similar biochemical picture of euvolemic hyponatremia and inappropriate urinary concentration. The underlying mechanisms for the development of hyponatremia in glucocorticoid deficiency are: (1) impaired renal water handling in the absence of circulating cortisol a...
Source: Frontiers of Hormone Research - February 26, 2020 Category: Endocrinology Tags: Front Horm Res Source Type: research

Swallowed Steroids and Adrenal Insufficiency in Eosinophilic Esophagitis: Should We Screen and How to Screen
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - February 22, 2020 Category: Gastroenterology Tags: Invited Commentaries Source Type: research

Adrenal Insufficiency in Children With Eosinophilic Esophagitis Treated With Topical Corticosteroids
Objectives: The aim of the study was to identify practices of gastroenterologists screening for adrenal insufficiency (AI) and report prevalence of AI in children with eosinophilic esophagitis (EoE) treated with topical corticosteroids (TCS); compare serum dehydroepiandrosterone sulfate (DHEA-S) levels to morning serum cortisol (MSC) levels as screening tool for AI. Methods: A multipart study was conducted. In part 1, a survey about screening practices for AI in children with EoE on TCS was sent to gastroenterologists belonging to a PedsGI listserv and to EoE consortia. In part 2, children with EoE on TCS for ≥6 mo...
Source: Journal of Pediatric Gastroenterology and Nutrition - February 22, 2020 Category: Gastroenterology Tags: Original Article: Gastroenterology: Eosinophilic GI Disease Source Type: research

Grass pollen as a trigger of emergency department presentations and hospital admissions for respiratory conditions in the subtropics: A systematic review.
CONCLUSION: Exposure to airborne grass pollen appears to have a small and inconsistent increase on asthma ED presentations and hospital admissions in the subtropics. These findings are comparable to reported observations from studies undertaken in temperate regions. PMID: 32069762 [PubMed - in process] (Source: Environmental Research)
Source: Environmental Research - February 20, 2020 Category: Environmental Health Authors: Simunovic M, Dwarakanath D, Addison-Smith B, Susanto NH, Erbas B, Baker P, Davies JM Tags: Environ Res Source Type: research

Glycolipid-Mediated Basophil Activation in Alpha-Gal Allergy
Alpha-gal-containing glycolipids activate basophils sensitized with plasma from alpha-gal allergic subjects in an IgE-dependent manner suggesting a role for glycolipid in the effector phase of IgE-mediated food allergy. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 20, 2020 Category: Allergy & Immunology Authors: Onyinye I. Iweala, Shailesh K. Choudhary, Claire T. Addison, Cole J. Batty, Camille M. Kapita, Claire Amelio, Alexander J. Schuyler, Shenglou Deng, Eric M. Bachelder, Kristy M. Ainslie, Paul B. Savage, Patrick J. Brennan, Scott P. Commins Source Type: research

Clinical and biochemical factors to predict biochemical adrenal insufficiency in hospitalized patients with indeterminate cortisol levels: a retrospective study
Adrenal insufficiency (AI) in hospitalized patients is a fatal condition if left undiagnosed. Most patients may require an adrenocorticotropic hormone (ACTH) stimulation test to facilitate AI diagnosis. We aim... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - February 19, 2020 Category: Endocrinology Authors: Worapaka Manosroi, Natapong Kosachunhanan and Pichitchai Atthakomol Tags: Research article Source Type: research

Robotic Colorectal Surgery
The role of robotics in colon and rectal surgery has been established as an important and effective tool for the surgeon. Its inherent technologies have provided for increased visualization and ease of dissection in the minimally invasive approach to surgery. The value of the robot is apparent in the more challenging aspects of colon and rectal procedures, including the intracorporeal anastomosis for right colectomies and the low pelvic dissection for benign and malignant diseases. (Source: Surgical Clinics of North America)
Source: Surgical Clinics of North America - February 18, 2020 Category: Surgery Authors: Poppy Addison, Jennifer L. Agnew, Joseph Martz Source Type: research

Autoimmune Addison's disease
Publication date: Available online 30 January 2020Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Serena Saverino, Alberto FalorniPrimary adrenal insufficiency (PAI) occurs in 1/5000–1/7000 individuals in the general population. Autoimmune Addison's disease (AAD) is the major cause of PAI and is a major component of autoimmune polyendocrine syndrome type 1 (APS1) and type 2 (APS2). Presence of 21-hydroxylase autoantibodies (21OHAb) identifies subjects with ongoing clinical or pre-clinical adrenal autoimmunity. AAD requires life-long substitutive therapy with two-three daily dose...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - February 15, 2020 Category: Endocrinology Source Type: research

Operational and Management Structure of the Jackson Heart Study Community Outreach Center.
This report provides an overview of the practice and infrastructure. PMID: 32037312 [PubMed - in process] (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - February 12, 2020 Category: International Medicine & Public Health Authors: Addison C, Jenkins BC, White M, Wilson G, Fortenberry M, Thigpen D, Young L, Woodberry C, McCoy P, Antoine-LaVigne D Tags: J Health Care Poor Underserved Source Type: research

Acute Statin Administration Reduces Levels of Steroid Hormone Precursors
Horm Metab Res DOI: 10.1055/a-1099-9556Cholesterol-lowering statin drugs are used by approximately 25% of US adults 45 years of age and older and frequency of use is even higher among the elderly. Cholesterol provides the substrate for steroid hormone synthesis and its intracellular concentrations are tightly regulated. Our aim was to evaluate whether statin use acutely changes the circulating levels of cortisol, other glucocorticoid precursor molecules and their metabolites. Fourteen subjects not taking statins were administered a single oral dose (2 mg) of pitavastatin. Bl...
Source: Hormone and Metabolic Research - February 10, 2020 Category: Endocrinology Authors: London, Edra Tatsi, Christina Soldin, Steven J. Wassif, Christopher A. Backlund, Peter Ng, David Biesecker, Leslie G. Stratakis, Constantine A. Tags: Endocrine Research Source Type: research

Acute Statin Administration Reduces Levels of Steroid Hormone Precursors
Horm Metab Res DOI: 10.1055/a-1099-9556Cholesterol-lowering statin drugs are used by approximately 25% of US adults 45 years of age and older and frequency of use is even higher among the elderly. Cholesterol provides the substrate for steroid hormone synthesis and its intracellular concentrations are tightly regulated. Our aim was to evaluate whether statin use acutely changes the circulating levels of cortisol, other glucocorticoid precursor molecules and their metabolites. Fourteen subjects not taking statins were administered a single oral dose (2 mg) of pitavastatin. Blood samples collected at baseline and 24&t...
Source: Hormone and Metabolic Research - February 10, 2020 Category: Endocrinology Authors: London, Edra Tatsi, Christina Soldin, Steven J. Wassif, Christopher A. Backlund, Peter Ng, David Biesecker, Leslie G. Stratakis, Constantine A. Tags: Endocrine Research Source Type: research

Adrenal insufficiency: physiology, clinical presentation and diagnostic challenges
Publication date: Available online 7 February 2020Source: Clinica Chimica ActaAuthor(s): Julie Martin-Grace, Rosemary Dineen, Mark Sherlock, Christopher J ThompsonAbstractAdrenal insufficiency (AI) is a serious condition, which can arise from pathology affecting the adrenal gland itself (primary adrenal insufficiency, PAI), hypothalamic or pituitary pathology (secondary adrenal insufficiency, SAI), or as a result of suppression of the hypothalamic-pituitary-adrenal (HPA) axis by exogenous glucocorticoid therapy (tertiary adrenal insufficiency, TAI). AI is associated with an increase in morbidity and mortality and a reducti...
Source: Clinica Chimica Acta - February 7, 2020 Category: Laboratory Medicine Source Type: research

Contemporary Trends and Outcomes of Percutaneous and Surgical Mitral Valve Replacement or Repair in Patients with Cancer
In the era of emerging options for mitral valvular intervention, we sought to characterize the relative utilization, outcomes, and post-hospital dispositions of patients referred for transcatheter mitral valve repair (TMVRepair) and surgical mitral valve procedures (SMVP), by cancer-status. Leveraging the National Inpatient Sample, a representative national dataset, ICD-9 codes for all adults>18 years with comorbid mitral regurgitation, and cancer without metastatic disease admitted from 2003-2015 were queried. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 7, 2020 Category: Cardiology Authors: Avirup Guha, Amit Kumar Dey, Shuab Omer, William T. Abraham, Guilherme Attizzani, Hani Jneid, Daniel Addison Source Type: research

Spontaneous fertility and variable spectrum of reproductive phenotype in a family with adult-onset X-linked adrenal insufficiency harboring a novel DAX-1/NR0B1 mutation
Adrenal hypoplasia congenita (AHC) is an X-linked disorder that affects the adrenal cortex and hypothalamus-pituitary-gonadal axis (HPG), leading to primary adrenocortical insufficiency (PAI) and hypogonadotro... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - February 6, 2020 Category: Endocrinology Authors: Michelle Cerutti C. Vargas, Felipe Scipi ão Moura, Cecília P. Elias, Sara R. Carvalho, Nelson Rassi, Ilda S. Kunii, Magnus R. Dias-da-Silva and Flavia Amanda Costa-Barbosa Tags: Case report Source Type: research

Adrenal insufficiency: physiology, clinical presentation and diagnostic challenges.
Abstract Adrenal insufficiency (AI) is a serious condition, which can arise from pathology affecting the adrenal gland itself (primary adrenal insufficiency, PAI), hypothalamic or pituitary pathology (secondary adrenal insufficiency, SAI), or as a result of suppression of the hypothalamic-pituitary-adrenal (HPA) axis by exogenous glucocorticoid therapy (tertiary adrenal insufficiency, TAI). AI is associated with an increase in morbidity and mortality and a reduction in quality of life. In addition, the most common cause of PAI, autoimmune adrenalitis, may be associated with a variety of other autoimmune disorders....
Source: International Journal of Clinical Chemistry - February 6, 2020 Category: Chemistry Authors: Martin-Grace J, Dineen R, Sherlock M, Thompson CJ Tags: Clin Chim Acta Source Type: research

The effect of catheter ‐directed thrombolytic use on readmission rates and in‐hospital outcomes among cancer patients with venous thromboembolism in the United States
AbstractBackgroundCancer inducing a hypercoagulable state, venous thromboembolism (VTE) remains a leading cause of morbidity and mortality globally. We assessed the impacts of cancer on the likelihood for readmission after a VTE ‐targeted procedure.MethodsWe created a new cohort using discharge ‐level data from all hospitalizations from State Inpatient Databases of geographically dispersed participating states (18‐27 states).ResultsIn those presenting with VTE during index ‐admission (619 241), 2.4% patients underwent catheter directed thrombolytic therapy (CDL) on index admission and among those 20.3% had c...
Source: Journal of Cardiac Surgery - February 4, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Avirup Guha, Grant McKinley, Amit K. Dey, Rebecca Carter, P. Elliott Miller, Abhishek J. Deshmukh, Raja Zaghlol, Ana Barac, Nihar R. Desai, Daniel Addison Tags: ORIGINAL ARTICLE Source Type: research

A Novel Homozygous Mutation in CYP11A1 Gene is Associated with Severe Adrenal Insufficiency in 46, XX Patient.
Conclusion: Different types of inheritance patterns have been observed in CYP11A1-related adrenal insufficiency cases. We consider our case is an due to an autosomal recessive inheritance. PMID: 32000563 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - February 2, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Autoimmune polyglandular syndrome type III associated with antineutrophil cytoplasmic autoantibody-mediated crescentic glomerulonephritis: A case report and literature review
We report a patient with Hashimoto thyroiditis, adult-onset Still disease, alopecia, vasculitis, ANCA-mediated crescentic glomerulonephritis, and hyperparathyroidism, which is a very rare combination. We present this case as evidence for the coexistence of several different immune-mediated diseases in the clinical context of a PAS IIIc. (Source: Medicine)
Source: Medicine - February 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Detection of Adrenal Insufficiency in Moderate to Severe Asthma
Systemic corticosteroid(CS) is necessary for control of asthma in moderate to severe asthma though they often result in adrenal insufficiency(AI) that need hydrocortone replacement therapy.We attempted to describe characteristics of those with possible AI in order to detect those who might need replacement therapy. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Michiko Haida, Akihiko Hashiguchi, Takahiro Inoue Source Type: research

Cushing’s syndrome – Disease monitoring: Recurrence, surveillance with biomarkers or imaging studies
Publication date: Available online 30 January 2020Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Oskar RagnarssonAbstractPituitary surgery is the first-line treatment for patients with Cushing’s disease. For patients who are not considered candidates for pituitary surgery, pituitary radiation and bilateral adrenalectomy are further treatment alternatives. Not all patients are cured with pituitary surgery, and a substantial number of patients develop recurrence, sometimes many years after an apparently successful treatment. The same applies to patients treated with radiotherapy....
Source: Best Practice and Research Clinical Endocrinology and Metabolism - January 31, 2020 Category: Endocrinology Source Type: research

Autoimmune Addison’s Disease
Publication date: Available online 30 January 2020Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Serena Saverino, Alberto FalorniAbstractPrimary adrenal insufficiency (PAI) occurs in 1/5,000-1/7,000 individuals in the general population. Autoimmune Addison’s disease (AAD) is the major cause of PAI and is a major component of autoimmune polyendocrine syndrome type 1 (APS1) and type 2 (APS2). Presence of 21-hydroxylase autoantibodies (21OHAb) identifies subjects with ongoing clinical or pre-clinical adrenal autoimmunity. AAD requires life-long substitutive therapy with two-three ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - January 31, 2020 Category: Endocrinology Source Type: research

Evolution and evolving resolution of controversy over existence and prevalence of cerebral/renal salt wasting
Purpose of review The topic of hyponatremia is in a state of flux. We review a new approach to diagnosis that is superior to previous methods. It simplifies identifying the causes of hyponatremia, the most important issue being the differentiation of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) from cerebral/renal salt wasting (RSW). We also report on the high prevalence of RSW without cerebral disease in the general wards of the hospital. Recent findings We applied our new approach to hyponatremia by utilizing sound pathophysiologic criteria in 62 hyponatremic patients. Seventeen (27%) had ...
Source: Current Opinion in Nephrology and Hypertension - January 30, 2020 Category: Urology & Nephrology Tags: CLINICAL NEPHROLOGY: Edited by David S. Goldfarb Source Type: research

Blood pressure evaluated by 24  h ambulatory blood pressure monitoring in Ramadan-fasting patients with corticotrope deficiency
ConclusionsFasting was not associated with an increased risk for hypotension in patients with known and treated corticotrope deficiency. (Source: Endocrine)
Source: Endocrine - January 29, 2020 Category: Endocrinology Source Type: research

Containment and care? A qualitative interview study exploring police custody staff views about delivering brief alcohol interventions to heavy drinking arrestees
. (Source: Drugs: Education, Prevention, and Policy)
Source: Drugs: Education, Prevention, and Policy - January 28, 2020 Category: Addiction Authors: Ruth McGovern Lisa Crowe Michelle Addison Matthew Hickman Judi Kidger Elaine McColl Dot Newbury-Birch Eileen Kaner Source Type: research

Safety and Efficacy of Using Nuts to Improve Bowel Health in Hemodialysis Patients
Constipation is common in patients with end-stage kidney disease. Nondrug strategies to manage constipation are challenging because of dietary potassium, phosphate, and fluid restrictions. Nuts are a high-fiber food but are excluded from the diet because of the high potassium and phosphate content. The aim of this study was to examine the safety and efficacy of using nuts to improve constipation in adults undertaking hemodialysis (HD). (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - January 27, 2020 Category: Urology & Nephrology Authors: Kelly Lambert, Luke Bird, Addison C. Borst, Andrew Fuller, Yanan Wang, Geraint B. Rogers, Jordan Stanford, Martina L. Sanderson-Smith, Jonathan G. Williams, Brett C. McWhinney, Elizabeth P. Neale, Yasmine Probst, Maureen Lonergan Tags: Original Research Source Type: research

Autoimmune Gastritis in Pediatrics: A Review of 3 Cases
Conclusion: Although AIG is rare in children, pediatric gastroenterologists and pathologists should have a heightened suspicion for this entity in those patients with a history of autoimmune disorders and/or pernicious anemia. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - January 24, 2020 Category: Gastroenterology Tags: Short Communications: Gastroenterology Source Type: research