VEGF ‐Trap is a potent modulator of vasoregenerative responses and protects dopaminergic amacrine network integrity in degenerative ischemic neovascular retinopathy
AbstractRetinal hypoxia triggers abnormal vessel growth and microvascular hyper ‐permeability in ischemic retinopathies. Whereas vascular endothelial growth factor A (VEGF‐A) inhibitors significantly hinder disease progression, their benefits to retinal neurons remain poorly understood. Similar to humans, oxygen‐induced retinopathy (OIR) mice exhibit severe retinal microv ascular malformations and profound neuronal dysfunction. OIR mice are thus a phenocopy of human retinopathy of prematurity, and a proxy for investigating advanced stages of proliferative diabetic retinopathy. Hence, the OIR model offers an excellent...
Source: Journal of Neurochemistry - September 23, 2019 Category: Neuroscience Authors: Jes ús E Rojo Arias,
Matina Economopoulou,
David A Juárez López,
Anica Kurzbach,
Kwan H Au Yeung,
Vanessa Englmaier,
Marie Merdausl,
Martin Schaarschmidt,
Marius Ader,
Henning Morawietz,
Richard HW Funk,
József Jászai Tags: Original Article Source Type: research
Confocal Raman spectroscopy: evaluation of a non-invasive technique for the detection of topically applied ketorolac tromethamine in vitro and in vivo
Publication date: Available online 22 August 2019Source: International Journal of PharmaceuticsAuthor(s): Christian J.F. Bertens, Shuo Zhang, Roel J. Erckens, Frank J.H.M. van den Biggelaar, Tos T.J.M. Berendschot, Carroll A.B. Webers, Rudy M.M.A. Nuijts, Marlies GijsAbstractCurrent information about the pharmacokinetics of an ocular drug can only be achieved by invasive sampling. However, confocal Raman spectroscopy bears the potential to quantify drug concentrations non-invasively. In this project, we evaluated the detection and quantification of ocular ketorolac tromethamine levels with confocal Raman spectroscopy after...
Source: International Journal of Pharmaceutics - August 24, 2019 Category: Drugs & Pharmacology Source Type: research
Severe corneal melting following cataract surgery in patients prescribed topical post-operative NSAIDs and a dexamethasone/neomycin combination therapy
Three patients using a post-operative combination of topical Acular ® (ketorolac) and Maxitrol® (dexamethasone and neomycin) were diagnosed with atypical keratopathy soon after routine cataract surgery. An immediate retrospective analysis of patients, who had used this topical drug combination within the hospital in the previous year, identified 10 further patient s who also had significant corneal pathology following uncomplicated cataract surgery. Five of the 13 affected patients had corneal melting and one of these patients suffered corneal perforation and endophthalmitis. (Source: Journal of Cataract and Refractive Surgery)
Source: Journal of Cataract and Refractive Surgery - August 21, 2019 Category: Opthalmology Authors: Emily Cabourne, Nicola Lau, Declan Flanagan, Julie Nott, Jill Bloom, Romesh Angunawela Source Type: research
Population Pharmacokinetics of Periarticular Ketorolac in Adult Patients Undergoing Total Hip or Total Knee Replacement Surgery.
CONCLUSIONS: Our study demonstrates that with periarticular infiltration, S (-) ketorolac was observed to have increased clearance rate and highly variable volume of distribution and lower peak plasma concentration compared to R (+) ketorolac.
PMID: 31425209 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - August 21, 2019 Category: Anesthesiology Authors: Gurunathan U, Parker SL, Maguire R, Ramdath D, Bijoor M, Wallis SC, Roberts JA Tags: Anesth Analg Source Type: research
Sustained release of ketorolac tromethamine from poloxamer 407/cellulose nanofibrils graft nanocollagen based ophthalmic formulations.
Abstract
There has been extensive utilization of poloxamer 407 (PM) for the delivery of various ophthalmic drugs aimed at efficient ophthalmic drug delivery approach for longer precorneal residence time along with acceptable bioavailability of drugs. We have studied the effect of nanocellulose grafted collagen (CGC) on the performance of in situ gels based on PM for the controlled in vitro release of Ketorolac Tromethamine (KT). CGC has shown great influence evident by the reduction in PM critical gelation concentration, increased gel strength, and prolonged the release of loaded drugs compared with the vi...
Source: International Journal of Biological Macromolecules - August 18, 2019 Category: Biochemistry Authors: Orasugh JT, Dutta S, Das D, Pal C, Zaman A, Das S, Dutta K, Banerjee R, Ghosh SK, Chattopadhyay D Tags: Int J Biol Macromol Source Type: research
[ASAP] CdS-Decorated MIL-53(Fe) Microrods with Enhanced Visible Light Photocatalytic Performance for the Degradation of Ketorolac Tromethamine and Mechanism Insight
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.9b04312 (Source: The Journal of Physical Chemistry C)
Source: The Journal of Physical Chemistry C - July 1, 2019 Category: Chemistry Authors: Garima Chaturvedi, Amandeep Kaur, and Sushil Kumar Kansal* Source Type: research
The effect of ketorolac buccal infiltration on postoperative endodontic pain: a prospective, double-blind, randomized, controlled clinical trial
Akhlaghi, Nahid / Azarshab, Mahsa / Akhoundi, Nasrin / Meraji, NaghmehPage 540 - 546Objectives: The aim of the present double-blind, randomized, controlled clinical trial was to evaluate the effect of ketorolac buccal infiltration of on postendodontic pain of patients with symptomatic irreversible pulpitis in mandibular first/second molars.Method and materials: Sixty patients meeting the inclusion criteria were evaluated. After receiving a standard inferior alveolar nerve block (IANB) followed by a buccal infiltration injection with lidocaine, half of the participants randomly received a supplemental buccal infiltration of...
Source: Quintessence International - June 11, 2019 Category: Dentistry Source Type: research
Observation of analgesic effect of dexmedetomidine combined with ketorolac tromethamine in laparoscopic surgery under ERAS.
Authors: Zhang Y, Sun X, Liang J, Wang X, Cao X
Abstract
PMID: 31146517 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - June 2, 2019 Category: General Medicine Tags: Panminerva Med Source Type: research
Current and emerging pharmaceutical interventions for myopia.
Abstract
Myopia is a major cause of visual impairment. Its prevalence is growing steadily, especially in East Asia. Despite the immense disease and economic burden, there are currently no Food and Drug Administration-approved drugs for myopia. This review aims to summarise pharmaceutical interventions of myopia at clinical and preclinical stages in the last decade and discuss challenges for preclinical myopia drugs to progress to clinical trials. Atropine and oral 7-methylxanthine are shown to reduce myopia progression in human studies. The former has been extensively studied and is arguably the most succe...
Source: The British Journal of Ophthalmology - May 15, 2019 Category: Opthalmology Authors: Vutipongsatorn K, Yokoi T, Ohno-Matsui K Tags: Br J Ophthalmol Source Type: research
Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants
The purpose of this study is to extend drug release from ACUVUE Oasys ® and ACUVUE TruEye® silicone hydrogel contact lenses by incorporation of vitamin E in conjunction with a cationic surfactant. In ACUVUE Oasys® and ACUVUE TruEye®, the release of ketorolac tromethamine and flurbiprofen sodium is extended from hours to several days for 11% and 21% vitamin E, (wei ght of vitamin E / weight of dry lens) but with a considerable reduction in the amount of drug released. Cetalkonium chloride and stearylamine increased the drug loading capacity which was otherwise compromised by the addition of vitamin E in the contact lens...
Source: Contact Lens and Anterior Eye - May 10, 2019 Category: Opthalmology Authors: Cesar Torres-Luna, Naiping Hu, Tejaswi Tammareddy, Roman Domszy, Jeffrey Yang, Nam Sun Wang, Arthur Yang Source Type: research
Natamycin niosomes as a promising ocular nanosized delivery system with Ketorolac Tromethamine for dual effects for Treatment of Rabbit Keratitis; In-vitro/In-vivo and histopathological studies.
CONCLUSIONS: This study showed that F8 has the best results from all pharmaceutical in-vitro evaluations and a better cure percent in experimental application and enhancing the prolonged delivery of NAT and penetrating the cornea tissues.
PMID: 30744431 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 14, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Pain management after photorefractive keratectomy
To evaluate the effect of a bandage contact lens soaked in ketorolac ophthalmic 0.45% solution (Acuvail) on pain modulation in patients having transepithelial photorefractive keratectomy (PRK). (Source: Journal of Cataract and Refractive Surgery)
Source: Journal of Cataract and Refractive Surgery - February 1, 2019 Category: Opthalmology Authors: Rohit Shetty, Ritika Dalal, Archana Padmanabhan Nair, Pooja Khamar, Sharon D'Souza, Ravish Vaishnav Source Type: research
Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection and nonsteroidal anti-inflammatory drug use in total knee arthroplasty
Conclusion: Intraoperative periarticular injection with multimodal drugs significantly relieved pain after surgery and reduced the requirements for NSAIDs. This injection also improved patient satisfaction and the range of joint motion with no apparent risks following TKA. (Source: Nigerian Journal of Clinical Practice)
Source: Nigerian Journal of Clinical Practice - August 29, 2018 Category: Rural Health Authors: ZB Shi XQ Dang Source Type: research
Novel in-situ gel for intravesical administration of ketorolac
The objective of the present study was to optimize an in-situ gel formulation of poloxamer and chitosan for intravesical delivery of ketorolac tromethamine. The gelling temperature of the prepared combinations ranged from 20.67 to 25.8 °C. In-vitro release of KT was sustained for up to 7 h using a poloxamer concentration ranging from 17% to 19% and a chitosan concentration ranging from 1% to 2%. Design-Expert® 10 was used to select the optimized formulation (poloxamer/chitosan 17/1.589% w/w) which significantly (p < 0.05) extended the drug release more than each polymer alone. An ex-vivo study showed the abil...
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with chlorphenirmaine maleate
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Marwa A.A. Ragab, Fawzy A. El Yazbi, Ekram M. Hassan, Essam F. Khamis, Mohamed M.A. HamdyAbstractKetorolac tromethamine, KTC and phenylephrine hydrochloride, PHE binary mixture is co-formulated as eye vial, while their ternary mixture with chlorpheniramine maleate is co-formulated as eye drops. The existing work utilizes different spectrophotometric methods which are considered to be simple and rapid for the determination of both mixtures. These methods include: zero-order (D0), first derivative (D1), derivati...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
