A Randomized Controlled Trial of a Novel Formulation of Ketorolac Tromethamine for Continuous Infusion (NTM-001) in Healthy Volunteers
CONCLUSIONS: The PK parameters for NTM-001 and comparator bolus were similar to the modeling targets with no updating of the base model. There were no outliers and little intersubject variability. NTM-001 delivered as a bolus of 12.5 mg IV followed immediately by continuous infusion of 3.5 mg/h using a standard hospital infusion pump may offer an alternative to opioids for acute postoperative pain control.PMID:38070041 | DOI:10.1007/s12325-023-02709-5 (Source: Adv Data)
Source: Adv Data - December 9, 2023 Category: Epidemiology Authors: Joseph V Pergolizzi Amanjot Batra William K Schmidt Source Type: research
A Randomized Controlled Trial of a Novel Formulation of Ketorolac Tromethamine for Continuous Infusion (NTM-001) in Healthy Volunteers
ConclusionsThe PK parameters for NTM-001 and comparator bolus were similar to the modeling targets with no updating of the base model. There were no outliers and little intersubject variability. NTM-001 delivered as a bolus of 12.5 mg IV followed immediately by continuous infusion of 3.5 mg/h using a standard hospital infusion pump may offer an alternative to opioids for acute postoperative pain control. (Source: Advances in Therapy)
Source: Advances in Therapy - December 9, 2023 Category: Drugs & Pharmacology Source Type: research
Preparation of Polycaprolactone and Polymethacrylate Nanofibers for Controlled Ocular Delivery of Ketorolac tromethamine: Pharmacokinetic study in Rabbit's Eye
Eur J Pharm Sci. 2023 Nov 9:106631. doi: 10.1016/j.ejps.2023.106631. Online ahead of print.ABSTRACTOphthalmitis is an inflammation of the eye triggered by various conditions including diseases, allergy, trauma, or surgery. Management of this condition usually includes administration of topical anti-inflammatory eye drops such as nonsteroidal anti-inflammatory drugs. To overcome the challenges of conventional eye drops such as frequent administration and low intraocular bioavailability, nanofibrous inserts of Ketorolac tromethamine (KET) were developed in this study. Polycaprolactone and polymethacrylate containing KET were...
Source: European Journal of Pharmaceutical Sciences - November 11, 2023 Category: Drugs & Pharmacology Authors: Shiva Taghe Shahla Mirzaeei Masood Bagheri Source Type: research
Preparation of Polycaprolactone and Polymethacrylate Nanofibers for Controlled Ocular Delivery of Ketorolac tromethamine: Pharmacokinetic study in Rabbit's Eye
Eur J Pharm Sci. 2023 Nov 9:106631. doi: 10.1016/j.ejps.2023.106631. Online ahead of print.ABSTRACTOphthalmitis is an inflammation of the eye triggered by various conditions including diseases, allergy, trauma, or surgery. Management of this condition usually includes administration of topical anti-inflammatory eye drops such as nonsteroidal anti-inflammatory drugs. To overcome the challenges of conventional eye drops such as frequent administration and low intraocular bioavailability, nanofibrous inserts of Ketorolac tromethamine (KET) were developed in this study. Polycaprolactone and polymethacrylate containing KET were...
Source: European Journal of Pharmaceutical Sciences - November 11, 2023 Category: Drugs & Pharmacology Authors: Shiva Taghe Shahla Mirzaeei Masood Bagheri Source Type: research
Preformulation-Assisted Design of Ketorolac Tromethamine for Effective Ophthalmic Delivery
Journal of Ocular Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - September 7, 2023 Category: Opthalmology Authors: Hamdy Abdelkader Adel Al Fatease Zeinab Fathalla Source Type: research
The effect of topical ketorolac tromethamine on macular thickening after phacoemulsification in diabetic patients
To determine the effect of ketorolac tromethamine 0.5% in preventing post-phacoemulsification macular thickening. This randomized clinical trial. patients randomized 1:1 to receive either topical ketorolac thr... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - July 14, 2023 Category: Opthalmology Authors: Hossein Mohammad-Rabei, Hamideh Sabbaghi, Mehdi Emamverdi, Saeed Karimi, Alireza Ramezani, Homayoun Nikkhah, Bahareh Kheiri, Mehdi Yaseri, Kourosh Sheibani and Razieh Bahreini Tags: Research Source Type: research
Melatonin protects against ketorolac induced gastric mucosal toxic injuries through molecular mechanism associated with the modulation of Arylakylamine N-Acetyltransferase (AANAT) activity
This study aims at exploring the role of gastric endogenous MT level and it's metabolizing enzyme AANAT, at the onset of ketorolac mediated toxicities in the gastric mucosa. Gastric mucosal damage was induced in experimental rats by oral administration of graded doses of KT, where 50 mg/kg b.w. of KT was observed to incur maximum gastric lesions. However, gastric damages were found to be protected in rats, pre-treated with 60 mg/kg b.w. of MT. Post-sacrifice, mean ulcer index, oxidative status, total melatonin levels and enzyme activities associated with MT biosynthesis and catabolism were estimated. The results reveal tha...
Source: Chemico-Biological Interactions - June 22, 2023 Category: Molecular Biology Authors: Romit Majumder Madhuri Datta Adrita Banerjee Debasish Bandyopadhyay Aindrila Chattopadhyay Source Type: research
Melatonin protects against ketorolac induced gastric mucosal toxic injuries through molecular mechanism associated with the modulation of Arylakylamine N-Acetyltransferase (AANAT) activity
This study aims at exploring the role of gastric endogenous MT level and it's metabolizing enzyme AANAT, at the onset of ketorolac mediated toxicities in the gastric mucosa. Gastric mucosal damage was induced in experimental rats by oral administration of graded doses of KT, where 50 mg/kg b.w. of KT was observed to incur maximum gastric lesions. However, gastric damages were found to be protected in rats, pre-treated with 60 mg/kg b.w. of MT. Post-sacrifice, mean ulcer index, oxidative status, total melatonin levels and enzyme activities associated with MT biosynthesis and catabolism were estimated. The results reveal tha...
Source: Chemico-Biological Interactions - June 22, 2023 Category: Molecular Biology Authors: Romit Majumder Madhuri Datta Adrita Banerjee Debasish Bandyopadhyay Aindrila Chattopadhyay Source Type: research
Effect of Ketorolac Tromethamine Combined With Remifentanil on Reducing Complications During the General Anesthesia Emergence
CONCLUSIONS: Ketorolac tromethamine combined with remifentanil can effectively relieve pain and sedation during general anesthesia recovery and reduce the incidence of complications related to general anesthesia recovery. At the same time, the application of ketorolac tromethamine can reduce the dosage of remifentanil and inhibit the occurrence of adverse reactions when used alone.PMID:37245134 | DOI:10.1016/j.jopan.2023.01.004 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - May 28, 2023 Category: Nursing Authors: Xi Zhang Jie Chang Ran Ran Yun Xiao Hong Cao Yuqi Wang Source Type: research
Effect of Ketorolac Tromethamine Combined With Remifentanil on Reducing Complications During the General Anesthesia Emergence
CONCLUSIONS: Ketorolac tromethamine combined with remifentanil can effectively relieve pain and sedation during general anesthesia recovery and reduce the incidence of complications related to general anesthesia recovery. At the same time, the application of ketorolac tromethamine can reduce the dosage of remifentanil and inhibit the occurrence of adverse reactions when used alone.PMID:37245134 | DOI:10.1016/j.jopan.2023.01.004 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - May 28, 2023 Category: Nursing Authors: Xi Zhang Jie Chang Ran Ran Yun Xiao Hong Cao Yuqi Wang Source Type: research
Effect of Ketorolac Tromethamine Combined With Remifentanil on Reducing Complications During the General Anesthesia Emergence
CONCLUSIONS: Ketorolac tromethamine combined with remifentanil can effectively relieve pain and sedation during general anesthesia recovery and reduce the incidence of complications related to general anesthesia recovery. At the same time, the application of ketorolac tromethamine can reduce the dosage of remifentanil and inhibit the occurrence of adverse reactions when used alone.PMID:37245134 | DOI:10.1016/j.jopan.2023.01.004 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - May 28, 2023 Category: Nursing Authors: Xi Zhang Jie Chang Ran Ran Yun Xiao Hong Cao Yuqi Wang Source Type: research
Effect of Ketorolac Tromethamine Combined With Remifentanil on Reducing Complications During the General Anesthesia Emergence
CONCLUSIONS: Ketorolac tromethamine combined with remifentanil can effectively relieve pain and sedation during general anesthesia recovery and reduce the incidence of complications related to general anesthesia recovery. At the same time, the application of ketorolac tromethamine can reduce the dosage of remifentanil and inhibit the occurrence of adverse reactions when used alone.PMID:37245134 | DOI:10.1016/j.jopan.2023.01.004 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - May 28, 2023 Category: Nursing Authors: Xi Zhang Jie Chang Ran Ran Yun Xiao Hong Cao Yuqi Wang Source Type: research
Effect of Ketorolac Tromethamine Combined With Remifentanil on Reducing Complications During the General Anesthesia Emergence
CONCLUSIONS: Ketorolac tromethamine combined with remifentanil can effectively relieve pain and sedation during general anesthesia recovery and reduce the incidence of complications related to general anesthesia recovery. At the same time, the application of ketorolac tromethamine can reduce the dosage of remifentanil and inhibit the occurrence of adverse reactions when used alone.PMID:37245134 | DOI:10.1016/j.jopan.2023.01.004 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - May 28, 2023 Category: Nursing Authors: Xi Zhang Jie Chang Ran Ran Yun Xiao Hong Cao Yuqi Wang Source Type: research
Effect of Ketorolac Tromethamine Combined With Remifentanil on Reducing Complications During the General Anesthesia Emergence
To observe the effect of ketorolac tromethamine combined with remifentanil in sedation and analgesia during general anesthesia emergence and reducing general anesthesia complications. (Source: Journal of PeriAnesthesia Nursing)
Source: Journal of PeriAnesthesia Nursing - May 27, 2023 Category: Nursing Authors: Xi Zhang, Jie Chang, Ran Ran, Yun Xiao, Hong Cao, Yuqi Wang Tags: Research Source Type: research
Ketorolac Tromethamine Loaded Nano-Spray Dried Nanoparticles: Preparation, Characterization, Cell Viability, COL1A1 Gene Simulation and Determination of Anti-inflammatory Activity by In Vivo HET-CAM Assay
CONCLUSION: With the obtained cell viability, gene expression, and HET-CAM results, it has the hope of a successful nano-topical formulation, especially in both wound healing and anti-inflammatory treatment.PMID:36698231 | DOI:10.2174/1567201820666230125144133 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 26, 2023 Category: Drugs & Pharmacology Authors: A A Lper Öztürk Tilbe Çevikelli Elif Kaya Tilki Umay Merve G üven H Tuba K ıyan Source Type: research
