Pre-Emptive Topical Ketorolac Tromethamine 0.5% for Panretinal Photocoagulation
Journal of Ocular Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - April 1, 2021 Category: Opthalmology Authors: Joanne Shalini Chewa Raja Sujaya Singh Fazliana Ismail Source Type: research

Drugs for Allergic Rhinitis and Allergic Conjunctivitis
Date: April 19, 2021 Issue #:  1622Summary:  The choice of drugs for treatment of allergic rhinitis depends on the severity of symptoms and whether they are are intermittent or persistent (see Table 1). (Source: The Medical Letter)
Source: The Medical Letter - March 24, 2021 Category: Drugs & Pharmacology Authors: admin Tags: Acular Aerius Afrin Alavert Alaway Alcaftadine Allegra Allergic rhinitis Alocril Alomide Antihistamines Avamys azelastine azelastine/fluticasone propionate Beclomethasone dipropionate Beconase AQ Benadryl Bepotastine Be Source Type: research

Application of Nalbuphine in Trigeminal Ganglion Pulse Radiofrequency Surgery in Patients with Postherpetic Neuralgia
In conclusion, intramuscular injection of nalbuphine 30 min before trigeminal ganglion pulse radiofrequency surgery can be conducive to pain relief and improve the postoperative comfort of patients, providing an effective alternative for the alleviation of PHN in clinic.PMID:33747319 | PMC:PMC7943312 | DOI:10.1155/2021/6623112 (Source: Pain Research and Management)
Source: Pain Research and Management - March 22, 2021 Category: Anesthesiology Authors: Song Wen Qiu-Xia Xiao Zhao-Qiong Zhu Li Chen Ying Li Qi-Hua Ran Song Cao Liu-Lin Xiong Source Type: research

Application of Nalbuphine in Trigeminal Ganglion Pulse Radiofrequency Surgery in Patients with Postherpetic Neuralgia
In conclusion, intramuscular injection of nalbuphine 30 min before trigeminal ganglion pulse radiofrequency surgery can be conducive to pain relief and improve the postoperative comfort of patients, providing an effective alternative for the alleviation of PHN in clinic.PMID:33747319 | PMC:PMC7943312 | DOI:10.1155/2021/6623112 (Source: Pain Research and Management)
Source: Pain Research and Management - March 22, 2021 Category: Anesthesiology Authors: Song Wen Qiu-Xia Xiao Zhao-Qiong Zhu Li Chen Ying Li Qi-Hua Ran Song Cao Liu-Lin Xiong Source Type: research

Application of Nalbuphine in Trigeminal Ganglion Pulse Radiofrequency Surgery in Patients with Postherpetic Neuralgia
In conclusion, intramuscular injection of nalbuphine 30 min before trigeminal ganglion pulse radiofrequency surgery can be conducive to pain relief and improve the postoperative comfort of patients, providing an effective alternative for the alleviation of PHN in clinic.PMID:33747319 | PMC:PMC7943312 | DOI:10.1155/2021/6623112 (Source: Pain Research and Management)
Source: Pain Research and Management - March 22, 2021 Category: Anesthesiology Authors: Song Wen Qiu-Xia Xiao Zhao-Qiong Zhu Li Chen Ying Li Qi-Hua Ran Song Cao Liu-Lin Xiong Source Type: research

Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - February 15, 2021 Category: Nanotechnology Authors: Mireia Mallandrich Ana C Calpena Beatriz Clares Alexander Parra Mar ía L García Jos é L. Soriano Francisco Fern ández-Campos Source Type: research

Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders
Nanomedicine, Ahead of Print. (Source: Future Medicine: Nanomedicine)
Source: Future Medicine: Nanomedicine - February 15, 2021 Category: Nanotechnology Authors: Mireia Mallandrich Ana C Calpena Beatriz Clares Alexander Parra Mar ía L García Jos é L. Soriano Francisco Fern ández-Campos Source Type: research

Effects of topical instillation of 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, and 0.03% flurbiprofen sodium on corneal sensitivity in ophthalmologically normal cats.
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that neither short-term nor prolonged topical instillation of 3 NSAID ophthalmic solutions had any effect on the CS of healthy cats. Given potential differences in cyclooxygenase expression between healthy and diseased eyes, further investigation of the effects of topical NSAID instillation in the eyes of cats with ocular surface inflammation is warranted. PMID: 33369491 [PubMed - as supplied by publisher] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - December 29, 2020 Category: Veterinary Research Authors: Roberts JK, Meekins JM, Roush JK, Rankin AJ Tags: Am J Vet Res Source Type: research

The role of the endothelium in the hyperemic response to passive leg movement: looking beyond nitric oxide.
Abstract Passive leg movement (PLM) evokes a robust and predominantly nitric oxide (NO)-mediated increase in blood flow that declines with age and disease. Consequently, PLM is becoming increasingly accepted as a sensitive assessment of endothelium-mediated vascular function. However, a substantial PLM-induced hyperemic response is still evoked despite NO synthase (NOS) inhibition. Therefore, in 9 young healthy men (25±4 yrs), this investigation aimed to determine if the combination of two potent endothelium-dependent vasodilators, specifically prostaglandin (PG) and endothelium-derived hyperpolarizing fact...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 11, 2020 Category: Physiology Authors: Trinity JD, Kwon OS, Broxterman RM, Gifford JR, Kithas AC, Hydren JR, Jarrett CL, Shields KL, Bisconti AV, Park SH, Craig JC, Nelson AD, Morgan DE, Jessop JE, Bledsoe AD, Richardson RS Tags: Am J Physiol Heart Circ Physiol Source Type: research

Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial.
Authors: Martins-de-Barros AV, Barros AM, Siqueira AK, Lucena EE, Sette de Souza PH, Araújo FA Abstract BACKGROUND: The preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the potential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare the efficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and trismus after mandibular third molar removal. MATERIAL AND METHODS: The researches implemented a triple-blind, randomized clinical trial. The study was conducted with ASA I individuals aging between 18 and 35...
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - November 29, 2020 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research

Ketorolac tromethamine pretreatment suppresses sufentanil-induced cough during general anesthesia induction: a prospective randomized controlled trial
To observe the effect of pretreatment with ketorolac tromethamine on sufentanil-induced cough in general anesthesia patients. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - August 17, 2020 Category: Anesthesiology Authors: Zhen Tian, Bei Hu, Min Miao, Lulu Zhang, Lin Wang and Bin Chen Tags: Research article Source Type: research

Cetirizine Ophthalmic Solution (Zerviate) for Allergic Conjunctivitis
Date: June 1, 2020 Issue #:  1599Summary:  A 0.24% ophthalmic solution of the second-generation H1-antihistamine cetirizine (Zerviate– Eyevance) is now available by prescription for treatment of ocular itching associated with allergic conjunctivitis in patients ≥2 years old. Oral cetirizine (Zyrtec, and others), which is used for treatment of allergic conjunctivitis and rhinitis, has been available over the counter (OTC) for years. (Source: The Medical Letter)
Source: The Medical Letter - April 29, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Acular Alaway Alcaftadine Allergic rhinitis Alocril Alomide nedocromil Antihistamines azelastine Bepotastine Bepreve cetirizine Clear Eyes Conjunctivitis corticosteroids Cromolyn Epinastine Ketorolac Ketotifen Lastacaft Source Type: research

Effective mamagement of acute postoperative pain using intravenous emulsions of novel ketorolac prodrugs: in vitro and in vivo evaluations.
EFFECTIVE MAMAGEMENT OF ACUTE POSTOPERATIVE PAIN USING INTRAVENOUS EMULSIONS OF NOVEL KETOROLAC PRODRUGS: IN VITRO AND IN VIVO EVALUATIONS. Eur J Pharm Sci. 2020 Apr 17;:105344 Authors: Niu B, Yin Z, Qiu N, Yu Y, Huang Q, Zhu Q, Zhuang X, Chen Y Abstract The aim was to prepare intravenous fat emulsions (IFEs) of ketorolac (KTL) ester prodrugs and to investigate the pharmacokinetics and pharmacodynamics of these formulations. Three prodrugs of KTL (KTL-IS, KTL-AX and KTL-BT) were synthesized as a means to increase the lipid solubility of KTL. All KTL prodrugs with higher Log P values presented increase...
Source: European Journal of Pharmaceutical Sciences - April 16, 2020 Category: Drugs & Pharmacology Authors: Niu B, Yin Z, Qiu N, Yu Y, Huang Q, Zhu Q, Zhuang X, Chen Y Tags: Eur J Pharm Sci Source Type: research

Randomized, Double-Blind, Placebo-Controlled Study to Compare the Efficacy of Combination of Lidocaine with Ketorolac or Triamcinolone versus Lidocaine Alone for Soft Tissue Injuries
Publication date: Available online 28 January 2020Source: Journal of OrthopaedicsAuthor(s): Bura Sindhupakorn, Darawan Jomkoh, Theeranit NamkunteeAbstractBackgroundCorticosteroid and Ketorolac tromethamine is a pain reducing.ObjectiveThe primary objective was pain intensity scores (VAS) in 10, 30, 60 minutes, 2, 6 hours, 1, and 7 days.Method120 patients were randomized. The placebo group (normal saline) and experimental groups (ketorolac 30 mg, 60 mg, triamcinolone 10 mg, 20 mg., and 40 mg, respectively) were compared.ResultVAS at 60 min, 2, 6 hours, 1 and 7 days was significantly different (P
Source: Journal of Orthopaedics - January 28, 2020 Category: Orthopaedics Source Type: research

VEGF ‐Trap is a potent modulator of vasoregenerative responses and protects dopaminergic amacrine network integrity in degenerative ischemic neovascular retinopathy
AbstractRetinal hypoxia triggers abnormal vessel growth and microvascular hyper ‐permeability in ischemic retinopathies. Whereas vascular endothelial growth factor A (VEGF‐A) inhibitors significantly hinder disease progression, their benefits to retinal neurons remain poorly understood. Similar to humans, oxygen‐induced retinopathy (OIR) mice exhibit severe retinal microv ascular malformations and profound neuronal dysfunction. OIR mice are thus a phenocopy of human retinopathy of prematurity, and a proxy for investigating advanced stages of proliferative diabetic retinopathy. Hence, the OIR model offers an excellent...
Source: Journal of Neurochemistry - September 23, 2019 Category: Neuroscience Authors: Jes ús E Rojo Arias, Matina Economopoulou, David A Juárez López, Anica Kurzbach, Kwan H Au Yeung, Vanessa Englmaier, Marie Merdausl, Martin Schaarschmidt, Marius Ader, Henning Morawietz, Richard HW Funk, József Jászai Tags: Original Article Source Type: research

Confocal Raman spectroscopy: evaluation of a non-invasive technique for the detection of topically applied ketorolac tromethamine in vitro and in vivo
Publication date: Available online 22 August 2019Source: International Journal of PharmaceuticsAuthor(s): Christian J.F. Bertens, Shuo Zhang, Roel J. Erckens, Frank J.H.M. van den Biggelaar, Tos T.J.M. Berendschot, Carroll A.B. Webers, Rudy M.M.A. Nuijts, Marlies GijsAbstractCurrent information about the pharmacokinetics of an ocular drug can only be achieved by invasive sampling. However, confocal Raman spectroscopy bears the potential to quantify drug concentrations non-invasively. In this project, we evaluated the detection and quantification of ocular ketorolac tromethamine levels with confocal Raman spectroscopy after...
Source: International Journal of Pharmaceutics - August 24, 2019 Category: Drugs & Pharmacology Source Type: research

Severe corneal melting following cataract surgery in patients prescribed topical post-operative NSAIDs and a dexamethasone/neomycin combination therapy
Three patients using a post-operative combination of topical Acular ® (ketorolac) and Maxitrol® (dexamethasone and neomycin) were diagnosed with atypical keratopathy soon after routine cataract surgery. An immediate retrospective analysis of patients, who had used this topical drug combination within the hospital in the previous year, identified 10 further patient s who also had significant corneal pathology following uncomplicated cataract surgery. Five of the 13 affected patients had corneal melting and one of these patients suffered corneal perforation and endophthalmitis. (Source: Journal of Cataract and Refractive Surgery)
Source: Journal of Cataract and Refractive Surgery - August 21, 2019 Category: Opthalmology Authors: Emily Cabourne, Nicola Lau, Declan Flanagan, Julie Nott, Jill Bloom, Romesh Angunawela Source Type: research

Population Pharmacokinetics of Periarticular Ketorolac in Adult Patients Undergoing Total Hip or Total Knee Replacement Surgery.
CONCLUSIONS: Our study demonstrates that with periarticular infiltration, S (-) ketorolac was observed to have increased clearance rate and highly variable volume of distribution and lower peak plasma concentration compared to R (+) ketorolac. PMID: 31425209 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - August 21, 2019 Category: Anesthesiology Authors: Gurunathan U, Parker SL, Maguire R, Ramdath D, Bijoor M, Wallis SC, Roberts JA Tags: Anesth Analg Source Type: research

Sustained release of ketorolac tromethamine from poloxamer 407/cellulose nanofibrils graft nanocollagen based ophthalmic formulations.
Abstract There has been extensive utilization of poloxamer 407 (PM) for the delivery of various ophthalmic drugs aimed at efficient ophthalmic drug delivery approach for longer precorneal residence time along with acceptable bioavailability of drugs. We have studied the effect of nanocellulose grafted collagen (CGC) on the performance of in situ gels based on PM for the controlled in vitro release of Ketorolac Tromethamine (KT). CGC has shown great influence evident by the reduction in PM critical gelation concentration, increased gel strength, and prolonged the release of loaded drugs compared with the virgin PM ...
Source: International Journal of Biological Macromolecules - August 18, 2019 Category: Biochemistry Authors: Orasugh JT, Dutta S, Das D, Pal C, Zaman A, Das S, Dutta K, Banerjee R, Ghosh SK, Chattopadhyay D Tags: Int J Biol Macromol Source Type: research

[ASAP] CdS-Decorated MIL-53(Fe) Microrods with Enhanced Visible Light Photocatalytic Performance for the Degradation of Ketorolac Tromethamine and Mechanism Insight
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.9b04312 (Source: The Journal of Physical Chemistry C)
Source: The Journal of Physical Chemistry C - July 1, 2019 Category: Chemistry Authors: Garima Chaturvedi, Amandeep Kaur, and Sushil Kumar Kansal* Source Type: research

The effect of ketorolac buccal infiltration on postoperative endodontic pain: a prospective, double-blind, randomized, controlled clinical trial
Akhlaghi, Nahid / Azarshab, Mahsa / Akhoundi, Nasrin / Meraji, NaghmehPage 540 - 546Objectives: The aim of the present double-blind, randomized, controlled clinical trial was to evaluate the effect of ketorolac buccal infiltration of on postendodontic pain of patients with symptomatic irreversible pulpitis in mandibular first/second molars.Method and materials: Sixty patients meeting the inclusion criteria were evaluated. After receiving a standard inferior alveolar nerve block (IANB) followed by a buccal infiltration injection with lidocaine, half of the participants randomly received a supplemental buccal infiltration of...
Source: Quintessence International - June 11, 2019 Category: Dentistry Source Type: research

Observation of analgesic effect of dexmedetomidine combined with ketorolac tromethamine in laparoscopic surgery under ERAS.
Authors: Zhang Y, Sun X, Liang J, Wang X, Cao X Abstract PMID: 31146517 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - June 2, 2019 Category: General Medicine Tags: Panminerva Med Source Type: research

Current and emerging pharmaceutical interventions for myopia.
Abstract Myopia is a major cause of visual impairment. Its prevalence is growing steadily, especially in East Asia. Despite the immense disease and economic burden, there are currently no Food and Drug Administration-approved drugs for myopia. This review aims to summarise pharmaceutical interventions of myopia at clinical and preclinical stages in the last decade and discuss challenges for preclinical myopia drugs to progress to clinical trials. Atropine and oral 7-methylxanthine are shown to reduce myopia progression in human studies. The former has been extensively studied and is arguably the most successful me...
Source: The British Journal of Ophthalmology - May 15, 2019 Category: Opthalmology Authors: Vutipongsatorn K, Yokoi T, Ohno-Matsui K Tags: Br J Ophthalmol Source Type: research

Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants
The purpose of this study is to extend drug release from ACUVUE Oasys ® and ACUVUE TruEye® silicone hydrogel contact lenses by incorporation of vitamin E in conjunction with a cationic surfactant. In ACUVUE Oasys® and ACUVUE TruEye®, the release of ketorolac tromethamine and flurbiprofen sodium is extended from hours to several days for 11% and 21% vitamin E, (wei ght of vitamin E / weight of dry lens) but with a considerable reduction in the amount of drug released. Cetalkonium chloride and stearylamine increased the drug loading capacity which was otherwise compromised by the addition of vitamin E in the ...
Source: Contact Lens and Anterior Eye - May 10, 2019 Category: Opthalmology Authors: Cesar Torres-Luna, Naiping Hu, Tejaswi Tammareddy, Roman Domszy, Jeffrey Yang, Nam Sun Wang, Arthur Yang Source Type: research

Natamycin niosomes as a promising ocular nanosized delivery system with Ketorolac Tromethamine for dual effects for Treatment of Rabbit Keratitis; In-vitro/In-vivo and histopathological studies.
CONCLUSIONS: This study showed that F8 has the best results from all pharmaceutical in-vitro evaluations and a better cure percent in experimental application and enhancing the prolonged delivery of NAT and penetrating the cornea tissues. PMID: 30744431 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 14, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Pain management after photorefractive keratectomy
To evaluate the effect of a bandage contact lens soaked in ketorolac ophthalmic 0.45% solution (Acuvail) on pain modulation in patients having transepithelial photorefractive keratectomy (PRK). (Source: Journal of Cataract and Refractive Surgery)
Source: Journal of Cataract and Refractive Surgery - February 1, 2019 Category: Opthalmology Authors: Rohit Shetty, Ritika Dalal, Archana Padmanabhan Nair, Pooja Khamar, Sharon D'Souza, Ravish Vaishnav Source Type: research

Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection and nonsteroidal anti-inflammatory drug use in total knee arthroplasty
Conclusion: Intraoperative periarticular injection with multimodal drugs significantly relieved pain after surgery and reduced the requirements for NSAIDs. This injection also improved patient satisfaction and the range of joint motion with no apparent risks following TKA. (Source: Nigerian Journal of Clinical Practice)
Source: Nigerian Journal of Clinical Practice - August 29, 2018 Category: Rural Health Authors: ZB Shi XQ Dang Source Type: research

Novel in-situ gel for intravesical administration of ketorolac
The objective of the present study was to optimize an in-situ gel formulation of poloxamer and chitosan for intravesical delivery of ketorolac tromethamine. The gelling temperature of the prepared combinations ranged from 20.67 to 25.8 °C. In-vitro release of KT was sustained for up to 7 h using a poloxamer concentration ranging from 17% to 19% and a chitosan concentration ranging from 1% to 2%. Design-Expert® 10 was used to select the optimized formulation (poloxamer/chitosan 17/1.589% w/w) which significantly (p 
Source: Saudi Pharmaceutical Journal - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with chlorphenirmaine maleate
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Marwa A.A. Ragab, Fawzy A. El Yazbi, Ekram M. Hassan, Essam F. Khamis, Mohamed M.A. HamdyAbstractKetorolac tromethamine, KTC and phenylephrine hydrochloride, PHE binary mixture is co-formulated as eye vial, while their ternary mixture with chlorpheniramine maleate is co-formulated as eye drops. The existing work utilizes different spectrophotometric methods which are considered to be simple and rapid for the determination of both mixtures. These methods include: zero-order (D0), first derivative (D1), derivati...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Novel in-situ gel for intravesical administration of ketorolac
The objective of the present study was to optimize an in-situ gel formulation of poloxamer and chitosan for intravesical delivery of ketorolac tromethamine. The gelling temperature of the prepared combinations ranged from 20.67 to 25.8 °C. In-vitro release of KT was sustained for up to 7 h using a poloxamer concentration ranging from 17% to 19% and a chitosan concentration ranging from 1% to 2%. Design-Expert® 10 was used to select the optimized formulation (poloxamer/chitosan 17/1.589% w/w) which significantly (p 
Source: Saudi Pharmaceutical Journal - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with chlorphenirmaine maleate
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Marwa A.A. Ragab, Fawzy A. El Yazbi, Ekram M. Hassan, Essam F. Khamis, Mohamed M.A. HamdyAbstractKetorolac tromethamine, KTC and phenylephrine hydrochloride, PHE binary mixture is co-formulated as eye vial, while their ternary mixture with chlorpheniramine maleate is co-formulated as eye drops. The existing work utilizes different spectrophotometric methods which are considered to be simple and rapid for the determination of both mixtures. These methods include: zero-order (D0), first derivative (D1), derivati...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Toradol following Breast Surgery: Is There an Increased Risk of Hematoma?
Conclusions: Recently, the high rates of prescribing postoperative narcotics have received increased attention. Aside from the risk of increased availability of narcotics in the community, the side effects can delay patient recovery. Ketorolac is controversial for postoperative pain control because of the potential risk of bleeding, but in the authors’ 3-year retrospective study, it was not associated with an increased risk of hematoma formation. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - May 24, 2018 Category: Cosmetic Surgery Tags: Breast: Special Topics Source Type: research

Efficacy of Mesoglycan in Pain Control after Excisional Hemorrhoidectomy: A Pilot Comparative Prospective Multicenter Study.
Authors: Gallo G, Mistrangelo M, Passera R, Testa V, Pozzo M, Perinotti R, Lanati I, Lazzari I, Tonello P, Ugliono E, De Luca E, Realis Luc A, Clerico G, Trompetto M Abstract Introduction: Various pain management strategies for patients undergoing open excisional hemorrhoidectomy have been proposed, yet postoperative pain remains a frequent complaint. Objective: To determine whether mesoglycan (30 mg two vials i.m. once/day for the first 5 days postoperative, followed by 50 mg 1 oral tablet twice/day for 30 days) would reduce the edema of the mucocutaneous bridges and thus improve postoperative pa...
Source: Gastroenterology Research and Practice - May 11, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Ketorolac and Hematoma Incidence in Postmastectomy Implant-Based Breast Reconstruction
Conclusions Review of our breast reconstruction database did not find a trend toward an elevated incidence of hematoma associated with intraoperative Toradol use in implant-based postmastectomy reconstruction. (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - April 11, 2018 Category: Cosmetic Surgery Tags: Breast Surgery Source Type: research

Comparative cost evaluation of brand name and generic ophthalmology medications in Ontario.
Abstract Medication cost for the same indication can vary considerably and can affect patient compliance. In this comparative cost analysis of commonly prescribed ophthalmology medications, the differences in cost between generic and brand name medications as well as different medications within an individual drug class were evaluated. Eye preparations from the Ontario Drug Benefit Formulary were identified, and further agents commonly prescribed by ophthalmologists were included. The standardized prescription drug cost, which includes the cost of the medication, mark-up, and dispensing cost, was provided by Ontar...
Source: Canadian Journal of Ophthalmology - April 1, 2018 Category: Opthalmology Authors: Popovic M, Chan C, Lattanzio N, El-Defrawy S, Schlenker MB Tags: Can J Ophthalmol Source Type: research

Novel in-situ gel for intravesical administration of Ketorolac
The objective of the present study was to optimize an in-situ gel formulation of poloxamer and chitosan for intravesical delivery of ketorolac tromethamine. The gelling temperature of the prepared combinations ranged from 20.67 to 25.8 °C. In-vitro release of KT was sustained for up to 7 hours using a poloxamer concentration ranging from 17% to 19% and a chitosan concentration ranging from 1% to 2%. Design-Expert® 10 was used to select the optimized formulation (poloxamer/chitosan 17/1.589% w/w) which significantly (p <0.05) extended the drug release more than each polymer alone. An ex-vivo study showed the ...
Source: Saudi Pharmaceutical Journal - March 28, 2018 Category: Drugs & Pharmacology Source Type: research

Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with chlorphenirmaine maleate
Publication date: Available online 21 March 2018 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Marwa A.A. Ragab, Fawzy A. El Yazbi, Ekram M. Hassan, Essam F. Khamis, Mohamed M.A. Hamdy Ketorolac tromethamine, KTC and phenylephrine hydrochloride, PHE binary mixture is co-formulated as eye vial, while their ternary mixture with chlorpheniramine maleate is co-formulated as eye drops. The existing work utilizes different spectrophotometric methods which are considered to be simple and rapid for the determination of both mixtures. These methods include: zero-order (D0), first derivative (D1), derivative (...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 21, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis of methylcellulose/cellulose nano-crystals nanocomposites: Material properties and study of sustained release of ketorolac tromethamine
Publication date: 15 May 2018 Source:Carbohydrate Polymers, Volume 188 Author(s): Jonathan Tersur Orasugh, Nayan Ranjan Saha, Gunjan Sarkar, Dipak Rana, Roshnara Mishra, Dibyendu Mondal, Swapan Kumar Ghosh, Dipankar Chattopadhyay Non-toxic nanocomposites based bio-films obtained from methylcellulose (MC) can reduce environmental problems associated with synthetic polymers. A new facile route for the isolation of cellulose nano-crystals (CNC) from jute waste is successfully utilized here. The fabrication of CNC reinforced MC nanocomposites by film casting technique and the studies of the effect of CNC on the properties of ...
Source: Carbohydrate Polymers - February 21, 2018 Category: Biomedical Science Source Type: research

Nanocuboidal-shaped zirconium based metal organic framework for the enhanced adsorptive removal of nonsteroidal anti-inflammatory drug, ketorolac tromethamine, from aqueous phase
New J. Chem., 2018, Advance Article DOI: 10.1039/C7NJ03851H, PaperSukhjinder Singh, Shelja Sharma, Ahmad Umar, Menaka Jha, Surinder Kumar Mehta, Sushil Kumar Kansal Nanocuboidal-shaped zirconium based metal organic framework (UiO-66) was synthesized and used for enhanced adsorptive removal (729.92 mg g-1) of ketorolac tromethamine drug. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - January 11, 2018 Category: Chemistry Authors: Sukhjinder Singh Source Type: research

Nanocuboidal-shaped zirconium based metal organic framework (UiO-66) for the enhanced adsorptive removal of nonsteroidal anti-inflammatory drug, ketorolac tromethamine, from aqueous phase
New J. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7NJ03851H, PaperSukhjinder Singh, Shelja Sharma, Ahmad Umar, Menaka Jha, S. K. Mehta, Sushil Kumar Kansal This paper reports the successful, eco-friendly and cost-effective synthesis of nanocuboidal shaped zirconium based metal-organic framework (MOF), i.e. UiO-66 from poly(ethylene) terephthalate (PET) derived from 1,4-Benzenedicarboxylic acid (BDC). The BDC... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - December 15, 2017 Category: Chemistry Authors: Sukhjinder Singh Source Type: research

Cellulose nanofibrils/chitosan based transdermal drug delivery vehicle for controlled release of ketorolac tromethamine
New J. Chem., 2017, Advance Article DOI: 10.1039/C7NJ02539D, PaperGunjan Sarkar, Jonathan T. Orasugh, Nayan R. Saha, Indranil Roy, Amartya Bhattacharyya, Atis K. Chattopadhyay, Dipak Rana, Dipankar Chattopadhyay Cellulose nanofibrils (CNFs) have attracted attention as a promising material in the biomedical field because of their outstanding properties such as hydrophilicity, biocompatibility, biodegradability, and high surface area. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - November 20, 2017 Category: Chemistry Authors: Gunjan Sarkar Source Type: research

Sublingual Buprenorphine Efficacy in Renal Colic Pain Relief: A Randomized Placebo-Controlled Clinical Trial
ConclusionsWe found no difference between SL buprenorphine and intravenous ketorolac in renal colic pain relief but more adverse effects in the buprenorphine group.Trial Registration Iranian Registry of Clinical trials identifier, IRCT2015041421773N1. (Source: Pain and Therapy)
Source: Pain and Therapy - October 20, 2017 Category: Anesthesiology Source Type: research

Volumetric, acoustic and viscometric studies of l-histidine in aqueous solutions of non-steroid anti-inflammatory drug ketorolac tromethamine at different temperatures
Publication date: October 2017 Source:Journal of Molecular Liquids, Volume 243 Author(s): Mukesh Kumar, Neha Sawhney, Amit K. Sharma, Meena Sharma In this investigation density, speed of sound and viscosity of l-histidine (0.015–0.135) molkg−1 in aqueous ketorolac tromethamine solutions (0.1–0.7) molkg−1 at various temperatures (293.15, 298.15, 303.15, 308.15 and 308.15) K and at atmospheric pressure were studied. These data were further used to calculate apparent molar volume, V Φ , limiting apparent molar volume, V° Φ , limiting apparent molar volume of transfer, V° Φ,tr , app...
Source: Journal of Molecular Liquids - August 11, 2017 Category: Molecular Biology Source Type: research

Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial
Conclusion Ketorolac has similar analgesic efficacy at intravenous doses of 10, 15, and 30 mg, showing that intravenous ketorolac administered at the analgesic ceiling dose (10 mg) provided effective pain relief to ED patients with moderate to severe pain without increased adverse effects. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - July 21, 2017 Category: Emergency Medicine Source Type: research

Erratum
In the article, “Effects of topical ketorolac tromethamine 0.45% on intraoperative miosis and prostaglandin E2 release during femtosecond laser–assisted cataract surgery” (J Cataract Refract Surg 2017; 43:492–497), the last sentence in the Results section of the Abstract should read as follows: “The mean aqueous humor PGE2 concentrations were 893.60 pg/mL ± 843.10 (SD) in the conventional group, 1911.43 ± 1178.63 pg/mL in the femtosecond no-NSAID group, and 743.63 ± 927.46 pg/mL in the femtosecond NSAID group (P .05, conventional versus femtosecond NSAID). (Source: Jo...
Source: Journal of Cataract and Refractive Surgery - June 1, 2017 Category: Opthalmology Tags: Erratum Source Type: research

In vitro anti ‐LPS dose determination of ketorolac tromethamine and in vivo safety of repeated dosing in healthy horses
Flunixin meglumine (FM) is a commonly used Nonsteroidal anti‐inflammatory drug (NSAID) in horses, but clinical efficacy is often unsatisfactory. Ketorolac tromethamine (KT) demonstrates superior efficacy compared to other NSAIDs in humans, but its anti‐inflammatory effects have not been investigated in the horse. Safety of repeated dosing of KT has not been evaluated. The first objective was to conduct a dose determination study to verify that a previously described dosage of KT would inhibit Lipopolysaccharide (LPS)‐induced eicosanoid production in vitro, and to compare KT effects of this inhibition to those of FM. ...
Source: Journal of Veterinary Pharmacology and Therapeutics - June 1, 2017 Category: Veterinary Research Authors: A. W. Bianco, G. E. Moore, B. R. Cooper, S. D. Taylor Tags: ORIGINAL ARTICLE Source Type: research

Randomized Controlled Trial Comparing the Effects of 2 Analgesic Drug Protocols in Patients who Received 5 Dental Implants
Conclusion: This study suggests that there is no difference in managing postoperative pain and swelling with betamethasone versus betamethasone and ketorolac. (Source: Implant Dentistry)
Source: Implant Dentistry - May 31, 2017 Category: Dentistry Tags: Basic and Clinical Research Source Type: research

Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels
ConclusionsKT-P407-HG was proposed as suitable formulation for anti-inflammatory local treatment without theoretical systemic side effect. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 24, 2017 Category: Drugs & Pharmacology Source Type: research

Body weight, gender and pregnancy affect enantiomer ‐specific ketorolac pharmacokinetics
ConclusionsBesides the anticipated impact of body weight on clearance, R‐ and S‐ketorolac clearance is increased in male subjects and in women at delivery. To reach an exposure equivalent to that in nonpregnant women, males should receive a 36% increased ketorolac dose and pregnant women a 55% increased dose, in addition to a dose adjustment by body weight. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - May 14, 2017 Category: Drugs & Pharmacology Authors: Pyry A. V älitalo, Heidi Kemppainen, Aida Kulo, Anne Smits, Kristel Calsteren, Klaus T. Olkkola, Jan Hoon, Catherijne A. J. Knibbe, Karel Allegaert Tags: PHARMACOKINETICS Source Type: research

Effects of topical ketorolac tromethamine 0.45% on intraoperative miosis and prostaglandin E2 release during femtosecond laser –assisted cataract surgery
To determine the effects of topical 0.45% ketorolac tromethamine  on intraoperative miosis and prostaglandin E2 (PGE2) release during femtosecond laser–assisted cataract surgery. (Source: Journal of Cataract and Refractive Surgery)
Source: Journal of Cataract and Refractive Surgery - April 1, 2017 Category: Opthalmology Authors: Jong Hwa Jun, Young-Sik Yoo, Sung A. Lim, Choun-Ki Joo Tags: Article Source Type: research