Ketorolac tromethamine represses senescence in aging articular chondrocytes
Biosci Biotechnol Biochem. 2022 Apr 11:zbac047. doi: 10.1093/bbb/zbac047. Online ahead of print.ABSTRACTThe present study aims to explore the potential function of ketorolac tromethamine in treating osteoarthritis (OA) by examining its effects on interleukin-1β (IL-1β)-triggered cellular senescence in chondrocytes. More β-galactosidase (SA-β-Gal) positively stained cells, promoted cell fraction in the G0/G1 phase, increased release of matrix metalloproteinase (MMP)-3 and MMP-13, and upregulated cellular senescence-related genes (p21 and p53) were observed in IL-1β-challenged HC-A cells, all of which were significantly...
Source: Bioscience, Biotechnology, and Biochemistry - April 11, 2022 Category: Biochemistry Authors: Wei Zhang Rong Mei Shuxuan Wu Source Type: research
Ketorolac tromethamine represses senescence in aging articular chondrocytes
Biosci Biotechnol Biochem. 2022 Apr 11:zbac047. doi: 10.1093/bbb/zbac047. Online ahead of print.ABSTRACTThe present study aims to explore the potential function of ketorolac tromethamine in treating osteoarthritis (OA) by examining its effects on interleukin-1β (IL-1β)-triggered cellular senescence in chondrocytes. More β-galactosidase (SA-β-Gal) positively stained cells, promoted cell fraction in the G0/G1 phase, increased release of matrix metalloproteinase (MMP)-3 and MMP-13, and upregulated cellular senescence-related genes (p21 and p53) were observed in IL-1β-challenged HC-A cells, all of which were significantly...
Source: Bioscience, Biotechnology, and Biochemistry - April 11, 2022 Category: Biochemistry Authors: Wei Zhang Rong Mei Shuxuan Wu Source Type: research
In Situ Gelling System for Sustained Intraarticular Delivery of Bupivacaine and Ketorolac in Sheep
Eur J Pharm Biopharm. 2022 Mar 29:S0939-6411(22)00060-1. doi: 10.1016/j.ejpb.2022.03.012. Online ahead of print.ABSTRACTSuboptimal control of postoperative pain following knee arthroplasty can slow recovery and reduce patient satisfaction. Intraarticular (IA) administration of bupivacaine and ketorolac offers efficient pain control and minimizes opioid consumption. However, the clinical benefits of this approach are short lived due to rapid clearance of drugs from the joint cavity. Here, we describe a poloxamer based thermoresponsive in situ gelling system for the sustained IA delivery of bupivacaine hydrochloride (BH) and...
Source: Cancer Control - April 1, 2022 Category: Cancer & Oncology Authors: Hani Abdeltawab Scott M Bolam Jagdish K Jaiswal Sue R McGlashan Simon W Young Andrew Hill Darren Svirskis Manisha Sharma Source Type: research
In Situ Gelling System for Sustained Intraarticular Delivery of Bupivacaine and Ketorolac in Sheep
Eur J Pharm Biopharm. 2022 Mar 29:S0939-6411(22)00060-1. doi: 10.1016/j.ejpb.2022.03.012. Online ahead of print.ABSTRACTSuboptimal control of postoperative pain following knee arthroplasty can slow recovery and reduce patient satisfaction. Intraarticular (IA) administration of bupivacaine and ketorolac offers efficient pain control and minimizes opioid consumption. However, the clinical benefits of this approach are short lived due to rapid clearance of drugs from the joint cavity. Here, we describe a poloxamer based thermoresponsive in situ gelling system for the sustained IA delivery of bupivacaine hydrochloride (BH) and...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 1, 2022 Category: Drugs & Pharmacology Authors: Hani Abdeltawab Scott M Bolam Jagdish K Jaiswal Sue R McGlashan Simon W Young Andrew Hill Darren Svirskis Manisha Sharma Source Type: research
In Situ Gelling System for Sustained Intraarticular Delivery of Bupivacaine and Ketorolac in Sheep
Eur J Pharm Biopharm. 2022 Mar 29:S0939-6411(22)00060-1. doi: 10.1016/j.ejpb.2022.03.012. Online ahead of print.ABSTRACTSuboptimal control of postoperative pain following knee arthroplasty can slow recovery and reduce patient satisfaction. Intraarticular (IA) administration of bupivacaine and ketorolac offers efficient pain control and minimizes opioid consumption. However, the clinical benefits of this approach are short lived due to rapid clearance of drugs from the joint cavity. Here, we describe a poloxamer based thermoresponsive in situ gelling system for the sustained IA delivery of bupivacaine hydrochloride (BH) and...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 1, 2022 Category: Drugs & Pharmacology Authors: Hani Abdeltawab Scott M Bolam Jagdish K Jaiswal Sue R McGlashan Simon W Young Andrew Hill Darren Svirskis Manisha Sharma Source Type: research
Construction of multifunctional NH < sub > 2 < /sub > -UiO-66 metal organic framework: sensing and photocatalytic degradation of ketorolac tromethamine and tetracycline in aqueous medium
Environ Sci Pollut Res Int. 2022 Feb 8. doi: 10.1007/s11356-022-18629-w. Online ahead of print.ABSTRACTExistence of pharmaceutical residues in water has endangered environmental pollution worldwide, which makes it ineludible to develop prospective bifunctional materials which not only possess excellent fluorescence behaviour to monitor pharmaceuticals but also exhibit simultaneous photocatalytic removal efficiency. Strengthened by functionalized metal organic framework (MOF) materials, we present here an amine functionalized zirconium-based MOF NH2-UiO-66 which has been successfully synthesized using solvothermal approach....
Source: Environmental Science and Pollution Research International - February 8, 2022 Category: Environmental Health Authors: Manpreet Kaur Surinder Kumar Mehta Sushil Kumar Kansal Source Type: research
Cyclodextrin/Adamantane-Grafted Polyethylene Glycol-Based Self-assembling Constructs for Topical Delivery of Ketorolac Tromethamine: Formulation, Characterization, and In Vivo Studies
AAPS PharmSciTech. 2022 Jan 3;23(1):45. doi: 10.1208/s12249-021-02188-3.ABSTRACTTopical formulation of non-steroidal anti-inflammatory drugs (NSAIDs) exhibits many advantages over the oral administration route, such as avoiding the direct effect on GIT and avoiding the poor oral bioavailability of such drugs. Our study aims to develop a new self-assembling construct based on the hydrophobic interaction between adamantane terminated poly (ethylene glycol) polymers and polymerized β-cyclodextrin. The viscous constructs were developed from direct mixing of host and guest polymer solutions, indicating spontaneous formation wi...
Source: AAPS PharmSciTech - January 4, 2022 Category: Drugs & Pharmacology Authors: Ahmed A H Abdellatif Ahmed M Mohammed Gamal Zayed Saleh Abd El-Rasoul Saud Almawash Mohamed A Safwat Shaaban K Osman Source Type: research
