Novel in-situ gel for intravesical administration of ketorolac
The objective of the present study was to optimize an in-situ gel formulation of poloxamer and chitosan for intravesical delivery of ketorolac tromethamine. The gelling temperature of the prepared combinations ranged from 20.67 to 25.8 °C. In-vitro release of KT was sustained for up to 7 h using a poloxamer concentration ranging from 17% to 19% and a chitosan concentration ranging from 1% to 2%. Design-Expert® 10 was used to select the optimized formulation (poloxamer/chitosan 17/1.589% w/w) which significantly (p < 0.05) extended the drug release more than each polymer alone. An ex-vivo study showed the abil...
Source: Saudi Pharmaceutical Journal - July 5, 2018 Category: Drugs & Pharmacology Source Type: research
Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with chlorphenirmaine maleate
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Marwa A.A. Ragab, Fawzy A. El Yazbi, Ekram M. Hassan, Essam F. Khamis, Mohamed M.A. HamdyAbstractKetorolac tromethamine, KTC and phenylephrine hydrochloride, PHE binary mixture is co-formulated as eye vial, while their ternary mixture with chlorpheniramine maleate is co-formulated as eye drops. The existing work utilizes different spectrophotometric methods which are considered to be simple and rapid for the determination of both mixtures. These methods include: zero-order (D0), first derivative (D1), derivati...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research
Toradol following Breast Surgery: Is There an Increased Risk of Hematoma?
Conclusions:
Recently, the high rates of prescribing postoperative narcotics have received increased attention. Aside from the risk of increased availability of narcotics in the community, the side effects can delay patient recovery. Ketorolac is controversial for postoperative pain control because of the potential risk of bleeding, but in the authors’ 3-year retrospective study, it was not associated with an increased risk of hematoma formation.
CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - May 24, 2018 Category: Cosmetic Surgery Tags: Breast: Special Topics Source Type: research
Efficacy of Mesoglycan in Pain Control after Excisional Hemorrhoidectomy: A Pilot Comparative Prospective Multicenter Study.
Conclusions: The administration of mesoglycan after an open diathermy excisional hemorrhoidectomy can reduce postoperative thrombosis and pain at 7-10 days after surgery, permitting a faster return to normal activities.
PMID: 29743886 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - May 11, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Ketorolac and Hematoma Incidence in Postmastectomy Implant-Based Breast Reconstruction
Conclusions
Review of our breast reconstruction database did not find a trend toward an elevated incidence of hematoma associated with intraoperative Toradol use in implant-based postmastectomy reconstruction. (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - April 11, 2018 Category: Cosmetic Surgery Tags: Breast Surgery Source Type: research
Comparative cost evaluation of brand name and generic ophthalmology medications in Ontario.
Abstract
Medication cost for the same indication can vary considerably and can affect patient compliance. In this comparative cost analysis of commonly prescribed ophthalmology medications, the differences in cost between generic and brand name medications as well as different medications within an individual drug class were evaluated. Eye preparations from the Ontario Drug Benefit Formulary were identified, and further agents commonly prescribed by ophthalmologists were included. The standardized prescription drug cost, which includes the cost of the medication, mark-up, and dispensing cost, was provided ...
Source: Canadian Journal of Ophthalmology - April 1, 2018 Category: Opthalmology Authors: Popovic M, Chan C, Lattanzio N, El-Defrawy S, Schlenker MB Tags: Can J Ophthalmol Source Type: research
Novel in-situ gel for intravesical administration of Ketorolac
The objective of the present study was to optimize an in-situ gel formulation of poloxamer and chitosan for intravesical delivery of ketorolac tromethamine. The gelling temperature of the prepared combinations ranged from 20.67 to 25.8 °C. In-vitro release of KT was sustained for up to 7 hours using a poloxamer concentration ranging from 17% to 19% and a chitosan concentration ranging from 1% to 2%. Design-Expert® 10 was used to select the optimized formulation (poloxamer/chitosan 17/1.589% w/w) which significantly (p <0.05) extended the drug release more than each polymer alone. An ex-vivo study showed the abilit...
Source: Saudi Pharmaceutical Journal - March 28, 2018 Category: Drugs & Pharmacology Source Type: research
Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with chlorphenirmaine maleate
Publication date: Available online 21 March 2018 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Marwa A.A. Ragab, Fawzy A. El Yazbi, Ekram M. Hassan, Essam F. Khamis, Mohamed M.A. Hamdy Ketorolac tromethamine, KTC and phenylephrine hydrochloride, PHE binary mixture is co-formulated as eye vial, while their ternary mixture with chlorpheniramine maleate is co-formulated as eye drops. The existing work utilizes different spectrophotometric methods which are considered to be simple and rapid for the determination of both mixtures. These methods include: zero-order (D0), first derivative (D1), deriva...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 21, 2018 Category: Drugs & Pharmacology Source Type: research
Synthesis of methylcellulose/cellulose nano-crystals nanocomposites: Material properties and study of sustained release of ketorolac tromethamine
Publication date: 15 May 2018 Source:Carbohydrate Polymers, Volume 188 Author(s): Jonathan Tersur Orasugh, Nayan Ranjan Saha, Gunjan Sarkar, Dipak Rana, Roshnara Mishra, Dibyendu Mondal, Swapan Kumar Ghosh, Dipankar Chattopadhyay Non-toxic nanocomposites based bio-films obtained from methylcellulose (MC) can reduce environmental problems associated with synthetic polymers. A new facile route for the isolation of cellulose nano-crystals (CNC) from jute waste is successfully utilized here. The fabrication of CNC reinforced MC nanocomposites by film casting technique and the studies of the effect of CNC on the prope...
Source: Carbohydrate Polymers - February 21, 2018 Category: Biomedical Science Source Type: research
Nanocuboidal-shaped zirconium based metal organic framework for the enhanced adsorptive removal of nonsteroidal anti-inflammatory drug, ketorolac tromethamine, from aqueous phase
New J. Chem., 2018, Advance Article DOI: 10.1039/C7NJ03851H, PaperSukhjinder Singh, Shelja Sharma, Ahmad Umar, Menaka Jha, Surinder Kumar Mehta, Sushil Kumar Kansal Nanocuboidal-shaped zirconium based metal organic framework (UiO-66) was synthesized and used for enhanced adsorptive removal (729.92 mg g-1) of ketorolac tromethamine drug. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - January 11, 2018 Category: Chemistry Authors: Sukhjinder Singh Source Type: research
Nanocuboidal-shaped zirconium based metal organic framework (UiO-66) for the enhanced adsorptive removal of nonsteroidal anti-inflammatory drug, ketorolac tromethamine, from aqueous phase
New J. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7NJ03851H, PaperSukhjinder Singh, Shelja Sharma, Ahmad Umar, Menaka Jha, S. K. Mehta, Sushil Kumar Kansal This paper reports the successful, eco-friendly and cost-effective synthesis of nanocuboidal shaped zirconium based metal-organic framework (MOF), i.e. UiO-66 from poly(ethylene) terephthalate (PET) derived from 1,4-Benzenedicarboxylic acid (BDC). The BDC... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - December 15, 2017 Category: Chemistry Authors: Sukhjinder Singh Source Type: research
Cellulose nanofibrils/chitosan based transdermal drug delivery vehicle for controlled release of ketorolac tromethamine
New J. Chem., 2017, Advance Article DOI: 10.1039/C7NJ02539D, PaperGunjan Sarkar, Jonathan T. Orasugh, Nayan R. Saha, Indranil Roy, Amartya Bhattacharyya, Atis K. Chattopadhyay, Dipak Rana, Dipankar Chattopadhyay Cellulose nanofibrils (CNFs) have attracted attention as a promising material in the biomedical field because of their outstanding properties such as hydrophilicity, biocompatibility, biodegradability, and high surface area. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - November 20, 2017 Category: Chemistry Authors: Gunjan Sarkar Source Type: research
Sublingual Buprenorphine Efficacy in Renal Colic Pain Relief: A Randomized Placebo-Controlled Clinical Trial
ConclusionsWe found no difference between SL buprenorphine and intravenous ketorolac in renal colic pain relief but more adverse effects in the buprenorphine group.Trial Registration Iranian Registry of Clinical trials identifier, IRCT2015041421773N1. (Source: Pain and Therapy)
Source: Pain and Therapy - October 20, 2017 Category: Anesthesiology Source Type: research
Volumetric, acoustic and viscometric studies of l-histidine in aqueous solutions of non-steroid anti-inflammatory drug ketorolac tromethamine at different temperatures
Publication date: October 2017 Source:Journal of Molecular Liquids, Volume 243 Author(s): Mukesh Kumar, Neha Sawhney, Amit K. Sharma, Meena Sharma In this investigation density, speed of sound and viscosity of l-histidine (0.015–0.135) molkg−1 in aqueous ketorolac tromethamine solutions (0.1–0.7) molkg−1 at various temperatures (293.15, 298.15, 303.15, 308.15 and 308.15) K and at atmospheric pressure were studied. These data were further used to calculate apparent molar volume, V Φ , limiting apparent molar volume, V° Φ , limiting apparent molar volume of transfer, V° Φ,tr , apparent molar isentropic com...
Source: Journal of Molecular Liquids - August 11, 2017 Category: Molecular Biology Source Type: research
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial
Conclusion Ketorolac has similar analgesic efficacy at intravenous doses of 10, 15, and 30 mg, showing that intravenous ketorolac administered at the analgesic ceiling dose (10 mg) provided effective pain relief to ED patients with moderate to severe pain without increased adverse effects. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - July 21, 2017 Category: Emergency Medicine Source Type: research
