In vitro anti ‐LPS dose determination of ketorolac tromethamine and in vivo safety of repeated dosing in healthy horses
Flunixin meglumine (FM) is a commonly used Nonsteroidal anti‐inflammatory drug (NSAID) in horses, but clinical efficacy is often unsatisfactory. Ketorolac tromethamine (KT) demonstrates superior efficacy compared to other NSAIDs in humans, but its anti‐inflammatory effects have not been investigated in the horse. Safety of repeated dosing of KT has not been evaluated. The first objective was to conduct a dose determination study to verify that a previously described dosage of KT would inhibit Lipopolysaccharide (LPS)‐induced eicosanoid production in vitro, and to compare KT effects of this inhibition to those of FM. ...
Source: Journal of Veterinary Pharmacology and Therapeutics - June 1, 2017 Category: Veterinary Research Authors: A. W. Bianco, G. E. Moore, B. R. Cooper, S. D. Taylor Tags: ORIGINAL ARTICLE Source Type: research
Erratum
In the article, “Effects of topical ketorolac tromethamine 0.45% on intraoperative miosis and prostaglandin E2 release during femtosecond laser–assisted cataract surgery” (J Cataract Refract Surg 2017; 43:492–497), the last sentence in the Results section of the Abstract should read as follows: “The mean aqueous humor PGE2 concentrations were 893.60 pg/mL ± 843.10 (SD) in the conventional group, 1911.43 ± 1178.63 pg/mL in the femtosecond no-NSAID group, and 743.63 ± 927.46 pg/mL in the femtosecond NSAID group (P .05, conventional versus femtosecond NSAID). (Source: Journal of Cataract and Refractive Surgery)
Source: Journal of Cataract and Refractive Surgery - June 1, 2017 Category: Opthalmology Tags: Erratum Source Type: research
Randomized Controlled Trial Comparing the Effects of 2 Analgesic Drug Protocols in Patients who Received 5 Dental Implants
Conclusion: This study suggests that there is no difference in managing postoperative pain and swelling with betamethasone versus betamethasone and ketorolac. (Source: Implant Dentistry)
Source: Implant Dentistry - May 31, 2017 Category: Dentistry Tags: Basic and Clinical Research Source Type: research
Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels
ConclusionsKT-P407-HG was proposed as suitable formulation for anti-inflammatory local treatment without theoretical systemic side effect. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 24, 2017 Category: Drugs & Pharmacology Source Type: research
Body weight, gender and pregnancy affect enantiomer ‐specific ketorolac pharmacokinetics
ConclusionsBesides the anticipated impact of body weight on clearance, R‐ and S‐ketorolac clearance is increased in male subjects and in women at delivery. To reach an exposure equivalent to that in nonpregnant women, males should receive a 36% increased ketorolac dose and pregnant women a 55% increased dose, in addition to a dose adjustment by body weight. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - May 14, 2017 Category: Drugs & Pharmacology Authors: Pyry A. V älitalo, Heidi Kemppainen, Aida Kulo, Anne Smits, Kristel Calsteren, Klaus T. Olkkola, Jan Hoon, Catherijne A. J. Knibbe, Karel Allegaert Tags: PHARMACOKINETICS Source Type: research
Body weight, gender, and pregnancy affect enantiomer ‐specific ketorolac pharmacokinetics
ConclusionsBesides the anticipated impact of body weight on clearance, R‐ and S‐ketorolac clearance is increased in male subjects and women at delivery. To reach an exposure equivalent to non‐pregnant women, males should receive a 36% increased ketorolac dose and pregnant women should receive a 55% increased dose, in addition to dose adjustment by bodyweight. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - April 1, 2017 Category: Drugs & Pharmacology Authors: Pyry A. V älitalo, Heidi Kemppainen, Aida Kulo, Anne Smits, Kristel Calsteren, Klaus T. Olkkola, Jan Hoon, Catherijne A. J. Knibbe, Karel Allegaert Tags: PHARMACOKINETICS Source Type: research
Effects of topical ketorolac tromethamine 0.45% on intraoperative miosis and prostaglandin E2 release during femtosecond laser –assisted cataract surgery
To determine the effects of topical 0.45% ketorolac tromethamine on intraoperative miosis and prostaglandin E2 (PGE2) release during femtosecond laser–assisted cataract surgery. (Source: Journal of Cataract and Refractive Surgery)
Source: Journal of Cataract and Refractive Surgery - April 1, 2017 Category: Opthalmology Authors: Jong Hwa Jun, Young-Sik Yoo, Sung A. Lim, Choun-Ki Joo Tags: Article Source Type: research
(107) Vitamin B12 and Ketorolac on pain and inflammation in Long Evans rats
Effects of vitamin B12 on nociceptive pain, inflammatory pain were used in several experimental studies but comparison of these effect with ketorolac tromethamine (KT) and their combination has not been established. To assess the effects of vitamin B12 and KT against pain and inflammation after single administration in rat models and compare them with the combinations of vitamin B12 with KT. This experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2015 to February 2016. (Source: The Journal of Pain)
Source: The Journal of Pain - March 29, 2017 Category: Materials Science Authors: M. Rahman Source Type: research
Development and in vitro evaluation of potential electromodulated transdermal drug delivery systems based on carbon nanotube buckypapers
Publication date: 1 July 2017 Source:Materials Science and Engineering: C, Volume 76 Author(s): Alex Schwengber, Héctor J. Prado, Pablo R. Bonelli, Ana L. Cukierman Buckypapers based on different types of carbon nanotubes with and without the addition of four model drugs, two of basic nature (clonidine hydrochloride, selegiline hydrochloride) and the others of acidic character (flurbiprofen, ketorolac tromethamine) were prepared and characterized. The influence of the conditions employed in the preparation of the buckypapers (dispersion time and solvents used in the preparation, as well as the type of carbon nanotub...
Source: Materials Science and Engineering: C - March 19, 2017 Category: Materials Science Source Type: research
Poloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations: Design, characterisation, toxicity and transcorneal permeation studies.
This study was aimed at preparing, characterising and evaluating in situ gel formulations based on a blend of two hydrophilic polymers i.e. poloxamer 407 (P407) and poloxamer 188 (P188) for a sustained ocular delivery of ketorolac tromethamine (KT). Drug-polymer interaction studies were performed using DSC and FT-IR. The gelation temperature (Tsol-gel), gelation time, rheological behaviour, mucoadhesive characteristics of these gels, transcorneal permeation and ocular irritation as well as toxicity was investigated. DSC and FT-IR studies revealed that there may be electrostatic interactions between the drug and the polymer...
Source: European Journal of Pharmaceutics and Biopharmaceutics - January 22, 2017 Category: Drugs & Pharmacology Authors: Fathalla ZM, Vangala A, Longman M, Khaled KA, Hussein AK, El-Garhy OH, Alany RG Tags: Eur J Pharm Biopharm Source Type: research
Ketorolac Tromethamine Spray Prevents Postendotracheal-Intubation-Induced Sore Throat after General Anesthesia.
Conclusions. This study demonstrated that preanesthesia 5% ketorolac tromethamine spray could effectively decrease postendotracheal-intubation-induced sore throat in patients undergoing general anesthesia.
PMID: 28025646 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 28, 2016 Category: Research Authors: Yang HL, Liu FC, Tsai SC, Tsay PK, Lin HT, Liu HE Tags: Biomed Res Int Source Type: research
Enantiomer-specific ketorolac pharmacokinetics in young women, including pregnancy and postpartum period.
In conclusion, pregnancy affects S-, R-, and S/R-ketorolac disposition. This is of clinical relevance since S-ketorolac (analgesia) CL is even more increased compared to R-ketorolac CL, and S/R-ketorolac CL ratio is higher following delivery compared to postpartum period or to healthy female volunteers.
PMID: 27968707 [PubMed - as supplied by publisher] (Source: Bosnian Journal of Basic Medical Sciences)
Source: Bosnian Journal of Basic Medical Sciences - December 16, 2016 Category: Journals (General) Tags: Bosn J Basic Med Sci Source Type: research
Analgesic Effects of Ultrasound-Guided Serratus-Intercostal Plane Block and Ultrasound-Guided Intermediate Cervical Plexus Block After Single-Incision Transaxillary Robotic Thyroidectomy: A Prospective, Randomized, Controlled Trial
Conclusions: After START, a serratus-intercostal plane block performed at the level of the third rib was an effective analgesic technique for axillary pain; however, the clinical effectiveness of intermediate CPB for neck pain may be limited. (Source: Regional Anesthesia and Pain Medicine)
Source: Regional Anesthesia and Pain Medicine - August 25, 2016 Category: Anesthesiology Tags: Regional Anesthesia and Acute Pain: Original Articles Source Type: research
LC and LC –MS study for simultaneous determination of tramadol hydrochloride and ketorolac tromethamine in bulk and formulation with their major degradation products
Publication date: June 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 54, Issue 1 Author(s): Vrushali S. Tambe, M.N. Deodhar, Vijayalakshmi Prakya The present work was aimed to separate, identify and characterize the major degradation products of tramadol hydrochloride and ketorolac tromethamine. A rapid, specific and accurate stability indicating reversed phase liquid chromatographic method has been developed for simultaneous determination of tramadol hydrochloride and ketorolac tromethamine in bulk and formulation. The drugs were subjected to hydrolysis (acidic, alkaline and neutral), oxi...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 20, 2016 Category: Drugs & Pharmacology Source Type: research
Pharmacologic synergism of ocular ketorolac and systemic caffeine citrate in rat oxygen-induced retinopathy.
CONCLUSION: Caff or Keto given individually reduced retinal neovascularization, but the two drugs given together prevented severe OIR.Pediatric Research (2016); doi:10.1038/pr.2016.105.
PMID: 27438224 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - July 19, 2016 Category: Pediatrics Authors: Aranda JV, Cai CL, Ahmad T, Bronshtein V, Sadeh J, Valencia GB, Lazzaro DR, Beharry KD Tags: Pediatr Res Source Type: research
