Transdermal therapeutic system: Study of cellulose nanocrystals influenced methylcellulose-chitosan bionanocomposites
Int J Biol Macromol. 2022 Jul 26;218:556-567. doi: 10.1016/j.ijbiomac.2022.07.166. Online ahead of print.ABSTRACTOver the past few years, there is a drive toward the fabrication and application of bio-based non-cytotoxic drug carriers. Cellulose nanocrystals (CNCs) have gotten immense research attention as a promising bioderived material in the biomedical field due to its remarkable properties. The delivery of analgesic and anti-inflammatory drug, ketorolac tromethamine (KT) by transdermal route is stipulated herewith to fabricate suitable transdermal therapeutic systems. We have synthesized CNCs from jute fibers and aim t...
Source: International Journal of Biological Macromolecules - July 29, 2022 Category: Biochemistry Authors: Mir Sahidul Ali Pritha Bhunia Arpita Priyadarshini Samanta Jonathan Tersur Orasugh Dipankar Chattopadhyay Source Type: research
Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization
Drug Deliv. 2022 Dec;29(1):2258-2268. doi: 10.1080/10717544.2022.2094500.ABSTRACTPulsatile drug delivery systems have drawn attention in contemporary research for designing chronotherapeutic systems. The current work aims to design pulsatile ketorolac tromethamine tablets using compression coating for delayed delivery with a lag time suitable for the treatment of morning stiffness in arthritis. Rapidly disintegrating core tablets of ketorolac tromethamine were formulated using super-disintegrants, and the optimized formulation was compression using PEO WSR coagulant and Eudragit RLPO for delaying the release. The central c...
Source: Drug Delivery - July 15, 2022 Category: Drugs & Pharmacology Authors: Hibah M Aldawsari N Raghavendra Naveen Nabil A Alhakamy Prakash S Goudanavar Gsn Koteswara Rao Roja Rani Budha Anroop B Nair Shaimaa M Badr-Eldin Source Type: research
Effect of ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative analgesia in patients undergoing laparoscopic hernia repair
Objective:
To observe the effect of Ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative sedation in patients undergoing laparoscopic hernia repair.
Methods:
100 male patients aged 60 to 80 years old, a line to elective laparoscopic inguinal hernia repair, were randomly divided into four groups: control group (Group A) and dezocine group (Group B), ketorolac tromethamine group (Group C), ketorolac tromethamine combined with dezocine group (Group D). Patients were administrated with 0.1 mg/kg dezocine in Group B, 0.5 mg/kg ketorolac in Group C, 0.1 mg/kg d...
Source: Medicine - May 20, 2022 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Ketorolac tromethamine alleviates IL-1 β-induced chondrocyte injury by inhibiting COX-2 expression
Exp Ther Med. 2022 May;23(5):337. doi: 10.3892/etm.2022.11267. Epub 2022 Mar 18.ABSTRACTOsteoarthritis (OA) is one of the most frequently diagnosed chronic diseases, and its prevalence is rising as life expectancy increases. The present study was designed to investigate the role of ketorolac tromethamine (KT) in OA by establishing an in vitro model in ATDC5 cells. The OA model was established through induction using 10 ng/ml IL-1β. KT was then used to treat the ATDC5 cells. An MTT assay was adopted to detect the viability of ATDC5 cells with or without IL-1β induction, and cyclo-oxygenase-2 (COX-2) expression in IL-1β-i...
Source: Experimental and Therapeutic Medicine - April 12, 2022 Category: General Medicine Authors: Chang Liu Yizhi Chen Source Type: research
