Formulation and pharmacokinetics of colon-specific double-compression coated mini-tablets: Chronopharmaceutical delivery of ketorolac tromethamine
Publication date: 1 August 2015 Source:International Journal of Pharmaceutics, Volume 491, Issues 1–2 Author(s): Sateesh Kumar Vemula The present study is designed and significantly planned to study the effect of double-compression coating on core mini-tablets to attain the chronopharmaceutical delivery of ketorolac tromethamine to colon. Double-compression coated tablets were prepared based on time-controlled hydroxypropyl methylcellulose K100M inner compression coat and pH-sensitive Eudragit S100 outer compression coat. From the in vitro drug release studies, F6 tablets was considered as the optimized formulation,...
Source: International Journal of Pharmaceutics - June 18, 2015 Category: Drugs & Pharmacology Source Type: research
Nasal delivery of analgesic ketorolac tromethamine thermo- and ion-sensitive in situ hydrogels
In this study, a novel nasal thermo- and ion-sensitive ISG of KT was prepared with thermo-sensitive poloxamer 407 (P407) and ion-sensitive deacetylated gellan gum (DGG). The optimal formulation of the KT ISG consisted of 3% (w/v) DGG and 18% (w/v) P407 and its viscosity was up to 7.63 Pas at 37°C. Furthermore, penetration enhancers and bacterial inhibitors were added and their fractions in the ISG were optimized based on transmucosal efficiencies and toxicity on toad pili. Sulfobutyl ether-β-cyclodextrin of 2.5% (w/v) and chlorobutanol of 0.5% (w/v) were chosen as the penetration enhancer and the bacterial inhibitor, res...
Source: International Journal of Pharmaceutics - May 15, 2015 Category: Drugs & Pharmacology Source Type: research
Preclinical evaluation of dual action intranasal formulation intended for postoperative/cancer associated therapies.
Abstract
Granisetron hydrochloride is a potent antiemetic yet experiencing first pass metabolism. Ketorolac Tromethamine is a potent analgesic NSAID that is known to cause gastrointestinal complications. The purpose of this study is to prepare combined in situ nasal copolymer thermal gel combining both drugs for the management of postoperative and cancer associated nausea, vomiting and pain while avoiding the problems associated with their therapy. In situ gelling nasal formulations with/without different mucoadhesive polymers were prepared and evaluated. Viscosity of different formulations was measured an...
Source: European Journal of Pharmaceutical Sciences - April 24, 2015 Category: Drugs & Pharmacology Authors: El-Setouhy DA, Ahmed S, Badawi AA, El-Nabarawi MA, Sallam N Tags: Eur J Pharm Sci Source Type: research
Comparison of ketorolac 0.4% and nepafenac 0.1% for the prevention of cystoid macular oedema after phacoemulsification: prospective placebo-controlled randomised study
Conclusions
Used prophylactically after uneventful cataract surgery, non-steroidal anti-inflammatory drugs were not efficacious in preventing macular oedema compared with placebo.
Trial registration number
ClinicalTrials: NCT02084576. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - April 17, 2015 Category: Opthalmology Authors: Tzelikis, P. F., Vieira, M., Hida, W. T., Motta, A. F., Nakano, C. T., Nakano, E. M., Alves, M. R. Tags: Ophthalmologic surgical procedures, Lens and zonules, Retina, Editor's choice Original articles - Clinical science Source Type: research
Optimization Of Combinational Intranasal Drug Delivery System For The Management Of Migraine By Using Statistical Design.
This study uses Box-Behnken design for the first time to develop, optimize the TMISG and assess factors affecting the critical quality attributes. Histopathological study of the nasal mucosa suggested that the formulation was safe for nasal administration. The statistical difference in absolute bioavailability between oral and intranasal route suggested that intranasal route had almost 21% increases in bioavailability for ZT and for KT there was 16% increase over oral formulations. Optimized formulation would help mitigate migraine associated symptoms much better over the currently available formulations.
PMID: 256...
Source: European Journal of Pharmaceutical Sciences - February 9, 2015 Category: Drugs & Pharmacology Authors: Kumar A, Garg T, Sarma GS, Rath G, Goyal AK Tags: Eur J Pharm Sci Source Type: research
pH-sensitive interpenetrating polymer network microspheres of poly(vinyl alcohol) and carboxymethyl cellulose for controlled release of the nonsteroidal anti-inflammatory drug ketorolac tromethamine
Artificial Cells, Nanomedicine, and Biotechnology, Ahead of Print. (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - January 24, 2015 Category: Biotechnology Tags: article Source Type: research
Comparison of Topical Dorzolamide and Ketorolac Treatment for Cystoid Macular Edema in Retinitis Pigmentosa and Usher's Syndrome
Conclusions: Results suggest that dorzolamide and ketorolac might improve visual acuity and therefore be of interest in selected cases. No relationship between retinal thickness fluctuation and visual acuity was found. Sample size was a limitation to the study.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - November 26, 2014 Category: Opthalmology Source Type: research
Comparison of ketorolac 0.4% and nepafenac 0.1% for the prevention of cystoid macular oedema after phacoemulsification: prospective placebo-controlled randomised study.
CONCLUSIONS: Used prophylactically after uneventful cataract surgery, non-steroidal anti-inflammatory drugs were not efficacious in preventing macular oedema compared with placebo.
TRIAL REGISTRATION NUMBER: ClinicalTrials: NCT02084576.
PMID: 25385061 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - November 10, 2014 Category: Opthalmology Authors: Tzelikis PF, Vieira M, Hida WT, Motta AF, Nakano CT, Nakano EM, Alves MR Tags: Br J Ophthalmol Source Type: research
Ketorolac tromethamine floating beads for oral application: Characterization and in vitro/in vivo evaluation
Publication date: September 2014 Source:Saudi Pharmaceutical Journal, Volume 22, Issue 4 Author(s): Amal El Sayeh F. Abou el Ela , Maha A. Hassan , Dalia A. El- Maraghy The floating beads have been employed to make a sustained release of the drug in the stomach and to decrease the dose of the drug and hence overcome its side effects. The common benefits of the floating beads were it is easy preparation, without the need of a high temperature, and high percentage of the drug entrapment. In the present work, the Ketorolac tromethamine (KT) floating beads were prepared by extrusion congealing method utilizing calcium c...
Source: Saudi Pharmaceutical Journal - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Effect of methyl cellulose on gelation behavior and drug release from poloxamer based ophthalmic formulations.
Abstract
The effect of weight average molecular weight (Mw) of methyl cellulose (MC) on the gelation behavior of Poloxamer 407 (PM) and in vitro release of Ketorolac Tromethamine (KT) from different ophthalmic formulations based on PM is examined. A drop of gelation temperature of PM is observed using MC of various Mw by test tube tilting method, UV-vis spectroscopy, viscometry and rheometry. It is also observed that the viscosity and gel strength of all the formulations are increased with the increase in Mw of MC. PM with highest Mw of MC provides best drug release property among all the formulations. It ...
Source: International Journal of Biological Macromolecules - September 22, 2014 Category: Biochemistry Authors: Dewan M, Bhowmick B, Sarkar G, Rana D, Bain MK, Bhowmik M, Chattopadhyay D Tags: Int J Biol Macromol Source Type: research
Novel Stereoselective High-Performance Liquid Chromatographic Method for Simultaneous Determination of Guaifenesin and Ketorolac Enantiomers in Human Plasma.
Abstract
A novel method was developed for the simultaneous determination of guaifenesin (GUA) and ketorolac tromethamine (KET) enantiomers in plasma samples. Since GUA probably increases the absorption of coadministered drugs (e.g., KET), it would be extremely important to monitor KET plasma levels for the purpose of dose adjustment with a subsequent decrease in the side effects. Enantiomeric resolution was achieved on a polysaccharide-based chiral stationary phase, amylose-2, as a chiral selector under the normal phase (NP) mode and using ornidazole (ORN) as internal standard. This innovative method has t...
Source: Chirality - July 8, 2014 Category: Molecular Biology Authors: Maher HM, Al-Taweel SM, Alshehri MM, Alzoman NZ Tags: Chirality Source Type: research
Ketorolac Tromethamine – Routes and Clinical Implications
Abstract
Opioids have long been used for analgesic purposes for a wide range of procedures. However, the binding of these drugs to opiate receptors has created various challenges to the clinician due to unfavorable side effect profiles and the potential for tolerance and abuse. In 1989, ketorolac became an approved nonsteroidal inflammatory drug (NSAID) for injectable use as an analgesic. Over the last 20 years, numerous studies have been conducted involving ketorolac. These studies have provided additional information about various routes of administration and their effect on the efficacy and the side effect profile of k...
Source: Pain Practice - April 16, 2014 Category: Anesthesiology Authors: Nalini Vadivelu, Anusha M. Gowda, Richard D. Urman, Suneil Jolly, Vijay Kodumudi, Monisa Maria, Robert Taylor, Joseph V. Pergolizzi Tags: Review Article Source Type: research
Prophylactic Use of Ketorolac Tromethamine in Cataract Surgery: A Randomized Trial
Journal of Ocular Pharmacology and Therapeutics , Vol. 0, No. 0. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - April 15, 2014 Category: Opthalmology Tags: article Source Type: research
Aqueous Humor Penetration of Ketorolac Formulated in DuraSite or DuraSite 2 Delivery Systems Compared to Acular LS in Rabbits
Journal of Ocular Pharmacology and Therapeutics , Vol. 0, No. 0. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - September 1, 2013 Category: Opthalmology Tags: article Source Type: research
Validated stability-indicating reverse-phase ultra-performance liquid chromatography method for simultaneous determination of sodium methylparaben, sodium propylparaben and ketorolac tromethamine in topical dosage forms
C Roy, J Chakrabarty, PB ModIndian Journal of Pharmaceutical Sciences 2013 75(2):197-204A sensitive, fast, and stability-indicating isocratic reverse-phase ultra-performance liquid chromatography method was developed and validated for quantitative simultaneous determination of sodium methylparaben, sodium propylparaben and ketorolac tromethamine in topical dosage forms. Separation of all peaks was achieved by using acquity ethylene bridged hybrid C18 (50×2.1 mm, 1.7 μ) as stationary phase, mobile phase used was triethylamine buffer (pH 2.5):tetrahydrofuran:methanol (665:35:300, v/v/v) with isocratic...
Source: Indian Journal of Pharmaceutical Sciences - July 23, 2013 Category: Drugs & Pharmacology Authors: C RoyJ ChakrabartyPB Mod Source Type: research
