Choriocapillaris Flow Signal Impairment in Sorsby Fundus Dystrophy
ABSTRACT Purpose To quantify choriocapillaris flow alterations in early Sorsby Fundus Dystrophy (SFD) and to investigate the relationship of the choriocapillaris flow deficits with the choroidal and outer retinal microstructure. Methods In this prospective case-control study, 18 eyes of 11 patients with early SFD and 31 eyes of 31 controls without ocular pathology underwent multimodal imaging, including spectral-domain optical coherence tomography (OCT), followed by deep-learning-based layer segmentation. OCT Angiography (OCTA) was performed to quantify choriocapillaris flow signal deficits (FDs). Differences in chori...
Source: Ophthalmologica - November 29, 2021 Category: Opthalmology Source Type: research

The effect of intravitreal bevacizumab dose on retinal vascular progression in retinopathy of prematurity.
Conclusion: The ratio of FD to DD decreased significantly with increasing age. The additional treatment rate and progression of retinal vascularization by unit of FD were similar between the gro ups. The difference of LTRV by unit of DD was higher in the low dose group. The usage of different formulas and methods may affect the evaluation of the progression of retinal vascularization. (Source: Ophthalmologica)
Source: Ophthalmologica - November 29, 2021 Category: Opthalmology Source Type: research

Structural and vascular changes of the choroid in polypoidal choroidal vasculopathy after intravitreal anti-VEGF therapy
Introduction: To identify the changes in vessel density (VD) of choriocapillaris (CC) and in subfoveal choroidal thickness (SFCT) and to evaluate their correlation with functional response after three monthly intravitreal injections of Ranibizumab (loading phase) in patients affected by Polypoidal Choroidal Vasculopathy (PCV). Methods: A total of 30 eyes of 30 PCV patients and 30 eyes of 30 healthy subjects as control group were enrolled in this prospective study. The best corrected visual acuity (BCVA) was measured at baseline and after one month from third intravitreal injections in each patient. The VD of CC was evalua...
Source: Ophthalmologica - November 29, 2021 Category: Opthalmology Source Type: research

Erratum
Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - November 25, 2021 Category: Opthalmology Source Type: research

Progression of macular atrophy in patients receiving long-term anti-VEGF therapy for age-related macular degeneration; Real Life Data
Conclusion In this real-life setting, half of neovascular AMD patients under anti-VEGF treatment, without MA at thera py initiation, developed MA over a period of at least 6 years. In this work, the number of injections did not seem to have a significant association with MA progression. (Source: Ophthalmologica)
Source: Ophthalmologica - November 24, 2021 Category: Opthalmology Source Type: research

Preliminary Pages
Ophthalmologica 2021;244(suppl 1):I –II (Source: Ophthalmologica)
Source: Ophthalmologica - November 23, 2021 Category: Opthalmology Source Type: research

Abstracts
Ophthalmologica 2021;244:1 –1087 (Source: Ophthalmologica)
Source: Ophthalmologica - November 23, 2021 Category: Opthalmology Source Type: research

Optical Coherence Tomography Prognostic Factors in AMD Patients with Peripapillary Choroidal Neovascularization
Purpose: To investigate the correlation between optical coherence tomography (OCT) findings and visual acuity outcomes after treatment with intravitreal bevacizumab (IVB) injections for age related macular degeneration (AMD) patients with peripapillary choroidal neovascularization (PPCNV). METHODS: A retrospective case series of consecutive patients diagnosed with PPCNV secondary to AMD. All patients were treated with IVB injections with a follow-up time of one year. Data collected included best corrected visual acuity (BCVA), automated and manually measured OCT parameters. RESULTS: A total of 68 eyes were diagnosed with...
Source: Ophthalmologica - November 22, 2021 Category: Opthalmology Source Type: research

Supplemental scleral buckle for the management of rhegmatogenous retinal detachment by pars plana vitrectomy: A meta-analysis of randomized controlled trials
Conclusion: Low-certainty evidence from RCTs did not demonstrate a benefit in placement of a supplemental scleral buckle during vitrectomy for management of RRD in the current analysis. Additional high-quality trials are needed to provide more precise estimates of effect. (Source: Ophthalmologica)
Source: Ophthalmologica - November 3, 2021 Category: Opthalmology Source Type: research

Subject Index
Ophthalmologica 2021;244:484 (Source: Ophthalmologica)
Source: Ophthalmologica - November 2, 2021 Category: Opthalmology Source Type: research

Author Index
Ophthalmologica 2021;244:483 (Source: Ophthalmologica)
Source: Ophthalmologica - November 2, 2021 Category: Opthalmology Source Type: research

Prelims
Ophthalmologica 2021;244:361 –364 (Source: Ophthalmologica)
Source: Ophthalmologica - November 2, 2021 Category: Opthalmology Source Type: research

The Development of Macular Atrophy in Patients with Wet Age-Related Macular Degeneration Receiving Anti-VEGF Treatment
Age-related macular degeneration (AMD) is a leading cause of blindness. Late AMD can be classified into exudative (commonly known as wet AMD [wAMD]) or dry AMD, both of which may progress to macular atrophy (MA). MA causes irreversible vision loss and currently has no approved pharmacological treatment. The standard of care for wAMD is treatment with anti-vascular endothelial growth factors (VEGF). However, recent evidence suggests that anti-VEGF treatment may play a role in the development of MA. Therefore, it is important to identify risk factors for the development of MA in patients with wAMD. For example, excessive blo...
Source: Ophthalmologica - October 25, 2021 Category: Opthalmology Source Type: research

The effect of supervision and out-of-hours surgery on the outcomes of primary macula-on retinal detachments operated by vitreoretinal fellows: A review of 435 surgeries
(Source: Ophthalmologica)
Source: Ophthalmologica - October 25, 2021 Category: Opthalmology Source Type: research

Clinical/demographic, functional testing and multimodal imaging differences between genetically solved and unsolved retinitis pigmentosa
INTRODUCTION The purpose of this study was to compare clinical/demographic, functional testing and multimodal imaging features between genetically solved and genetically unsolved non-syndromic retinitis pigmentosa (nsRP) patients. METHODS Cross sectional study conducted at an inherited retinal dystrophies reference center. Consecutive patients with nsRP and available genetic testing results performed between 2018 and 2020 were included. Genetic testing was clinically-oriented and variants were classified according to the Am erican College of Medical Genetics and Genomics. Only class IV or V variants were considered dise...
Source: Ophthalmologica - October 25, 2021 Category: Opthalmology Source Type: research

The impact of COVID-19 pandemic on surgical primary retinal detachments
This study enrolled four hundred and forty-nine eyes of 443 patients: 272 in the pre-COVID group and 177 in the COVID one. Of the patients, 63.6% were male and the mean±SD age was 63.0±13.2y (range 13 to 92y). Of the eyes, 55.5% (n = 151) presented with macular detachment in the pre-COVID group compared with 66.9% ( n = 119) in the COVID group (odds ratio [OR] 1.62; 95% confidence interval [CI], 1.09-3.86; p=0.016). The time from symptoms onset to hospital admission (p=0.021) and from admission to surgery (p (Source: Ophthalmologica)
Source: Ophthalmologica - October 21, 2021 Category: Opthalmology Source Type: research

The effect of selective retina therapy for bevacizumab-resistant chronic central serous chorioretinopathy
Purpose: To evaluate the efficacy of selective retina therapy (SRT), used in conjunction with real-time feedback dosimetry (RFD), in the treatment of bevacizumab-resistant chronic central serous chorioretinopathy (CSC). Patients and Methods: In this retrospective cohort study, 22 eyes of 22 patients with anti-VEGF-resistant chronic CSC, showing focal or diffuse foveal leakages on fundus fluorescein angiography (FFA), were included. After evaluation of the test spots at temporal arcades, SRT (wavelength, 527 nm; pulse repetition rate, 100 Hz; ramping over maximal 15 micropulses; and spot diameter, 200 µm) using RFD w...
Source: Ophthalmologica - October 14, 2021 Category: Opthalmology Source Type: research

Long-term follow-up of Outer retinal layers in patients with Epiretinal Membranes
(Source: Ophthalmologica)
Source: Ophthalmologica - October 11, 2021 Category: Opthalmology Source Type: research

Intravitreal dexamethasone in diabetic macular edema: a way of enhancing the response to anti VEGF in non or poor responders?
(Source: Ophthalmologica)
Source: Ophthalmologica - September 29, 2021 Category: Opthalmology Source Type: research

Occurrence of macular neovascularization after RPE-choroid translocation surgery to treat complicated AMD: incidence, management and outcome.
(Source: Ophthalmologica)
Source: Ophthalmologica - September 16, 2021 Category: Opthalmology Source Type: research

Complications associated with worse visual outcomes in patients with exudative neovascular age-related macular degeneration
(Source: Ophthalmologica)
Source: Ophthalmologica - September 13, 2021 Category: Opthalmology Source Type: research

Central serous chorioretinopathy: Morphological and functional outcome after subthreshold thermal laser coagulation with a frequency-doubled Nd:YAG continuous wave laser
(Source: Ophthalmologica)
Source: Ophthalmologica - September 13, 2021 Category: Opthalmology Source Type: research

Optical Coherence Tomography Biomarkers Predicting Visual Acuity Change after Intravitreal Bevacizumab Injections for Macular Edema Secondary to Branch Retinal Vein Occlusion
(Source: Ophthalmologica)
Source: Ophthalmologica - September 10, 2021 Category: Opthalmology Source Type: research

Quantitative optical coherence tomography angiography biomarkers for Alport syndrome
(Source: Ophthalmologica)
Source: Ophthalmologica - September 1, 2021 Category: Opthalmology Source Type: research

OCT-angiography for detection of choroidal neovascularization: a retrospective real-life study
(Source: Ophthalmologica)
Source: Ophthalmologica - July 30, 2021 Category: Opthalmology Source Type: research

Macular retinal sensitivity and microvasculature changes before and after vitrectomy in idiopathic macular epiretinal membrane with classification
(Source: Ophthalmologica)
Source: Ophthalmologica - July 23, 2021 Category: Opthalmology Source Type: research

The Effect of Syringe Filling Technique on the Risk for Endophthalmitis after Intravitreal Injection of Anti-VEGF Agents
(Source: Ophthalmologica)
Source: Ophthalmologica - July 23, 2021 Category: Opthalmology Source Type: research

Endpoints: The beginning of a new treatment?
(Source: Ophthalmologica)
Source: Ophthalmologica - July 19, 2021 Category: Opthalmology Source Type: research

Erratum
Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - July 13, 2021 Category: Opthalmology Source Type: research

Efficacy and safety of Intravitreal Aflibercept Vs Verteporfin Photodynamic Therapy in a Caucasian Population with Polypoidal Choroidal Vasculopathy: A Randomized Clinical Trial.
(Source: Ophthalmologica)
Source: Ophthalmologica - July 13, 2021 Category: Opthalmology Source Type: research

Microscope-assisted episcleral surgery with encircling buckles and chandelier endoillumination for primary rhegmatogenous retinal detachment in phakic and pseudophakic patients: a 12-months comparative study
(Source: Ophthalmologica)
Source: Ophthalmologica - July 1, 2021 Category: Opthalmology Source Type: research

Closure of Full-Thickness Macular Holes Associated with Macular Edema with Medical Therapy
(Source: Ophthalmologica)
Source: Ophthalmologica - June 28, 2021 Category: Opthalmology Source Type: research

Conversion from Intermediate Age-Related Macular Degeneration to Geographic Atrophy in a Proxima B Subcohort Using a Multimodal Approach
(Source: Ophthalmologica)
Source: Ophthalmologica - June 25, 2021 Category: Opthalmology Source Type: research

Microstructural macular changes after pars plana vitrectomy for primary rhegmatogenous retinal detachment.
(Source: Ophthalmologica)
Source: Ophthalmologica - June 24, 2021 Category: Opthalmology Source Type: research

Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives
(Source: Ophthalmologica)
Source: Ophthalmologica - June 15, 2021 Category: Opthalmology Source Type: research

The Difference Between Approval Processes for Drugs and Medical Devices in Europe
(Source: Ophthalmologica)
Source: Ophthalmologica - May 31, 2021 Category: Opthalmology Source Type: research

Structural Endpoints and Outcome Measures in Uveitis
(Source: Ophthalmologica)
Source: Ophthalmologica - May 31, 2021 Category: Opthalmology Source Type: research

Prediction of Post-operative Visual Outcome in Patients with Idiopathic Epiretinal Membrane
(Source: Ophthalmologica)
Source: Ophthalmologica - May 31, 2021 Category: Opthalmology Source Type: research

Routine use of air tamponade in pars plana vitrectomy for primary rhegmatogenous retinal detachment repair
(Source: Ophthalmologica)
Source: Ophthalmologica - May 26, 2021 Category: Opthalmology Source Type: research

Ocular and systemic complement activation during anti-VEGF treatment and AREDS2 dietary supplementation in neovascular age-related macular degeneration
(Source: Ophthalmologica)
Source: Ophthalmologica - May 24, 2021 Category: Opthalmology Source Type: research

New insights in resistant diabetic macular edema
(Source: Ophthalmologica)
Source: Ophthalmologica - May 20, 2021 Category: Opthalmology Source Type: research

Efficacy of a disease management program of a tertiary center and ophthalmologic practitioners for the treatment of neovascular age related macular degeneration
(Source: Ophthalmologica)
Source: Ophthalmologica - May 20, 2021 Category: Opthalmology Source Type: research

Improvements of retinal sensitivity after intravitreal injection of aflibercept in eyes with neovascular age-related macular degeneration with or without polypoidal choroidal vasculopathy
(Source: Ophthalmologica)
Source: Ophthalmologica - May 19, 2021 Category: Opthalmology Source Type: research

Visual Impact of Early Hydroxychloroquine-related Retinal Structural Changes in Patients with Systemic Lupus Erythematosus
(Source: Ophthalmologica)
Source: Ophthalmologica - May 19, 2021 Category: Opthalmology Source Type: research

Evaluation of acute central serous chorioretinopathy using enhanced depth imaging OCT and multifocal electroretinography
(Source: Ophthalmologica)
Source: Ophthalmologica - May 5, 2021 Category: Opthalmology Source Type: research

Spontaneous closure of full-thickness macular holes
(Source: Ophthalmologica)
Source: Ophthalmologica - April 28, 2021 Category: Opthalmology Source Type: research

Evolution of macular Bruch Membrane Defects (BMD) of Patchy Chorioretinal Atrophy in Pathologic Myopia based on a recent classification system (ATN).
(Source: Ophthalmologica)
Source: Ophthalmologica - April 28, 2021 Category: Opthalmology Source Type: research

Comparison of perfluorodecalin and silicone oil as initial tamponade for giant retinal tear-associated retinal detachment
(Source: Ophthalmologica)
Source: Ophthalmologica - April 28, 2021 Category: Opthalmology Source Type: research

Optical coherence tomography angiography findings in proliferative diabetic retinopathy
(Source: Ophthalmologica)
Source: Ophthalmologica - April 25, 2021 Category: Opthalmology Source Type: research

Imaging Biomarkers and Their Impact on Therapeutic Decision Making in the Management of Neovascular Age-related Macular Degeneration
(Source: Ophthalmologica)
Source: Ophthalmologica - April 5, 2021 Category: Opthalmology Source Type: research