Epiretinal Membrane in Patients with Diabetic Macular Edema
PURPOSE: To compare anatomical and functional outcomes of pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peeling in diabetes retinopathy (DR) patients with and without diabetic macular edema (DME).
METHODS: A retrospective interventional case series of consecutive patients who underwent PPV with ERM peeling. Patients were divided into two groups: With and without preoperative DME. Visual acuity (VA) and optical coherence tomography (OCT) parameters were evaluated before surgery and during 12 months follow-up.
RESULTS: A total of 354 patients underwent PPV with ERM peeling, of which 51 met the inclusion criter...
Source: Ophthalmologica - April 27, 2022 Category: Opthalmology Source Type: research
Fluid control in neovascular age-related macular degeneration with brolucizumab: an analysis of the HAWK and HARRIER phase 3 trials
The objective of this analysis was to assess effects of brolucizumab versus aflibercept on retinal fluid resolution during two phase 3 trials (HAWK and HARRIER) in patients with nAMD. Anatomical assessments for intraretinal fluid (IRF) and subretinal fluid (SRF) were performed every 4 weeks by spectral domain optical coherence tomography. Sustained dryness was defined as a patient being fluid-free (SRF and IRF) on ≥3 consecutive visits. Time to sustained dryness was determined by Kaplan-Meier estimates.
Results: At week 96, fluid resolution (absence of IRF and SRF) was achieved by more brolucizumab- (6mg; 76.1%) versus a...
Source: Ophthalmologica - April 25, 2022 Category: Opthalmology Source Type: research
Incidence, Risk Factors, Treatment, and Outcome of Ocular Hypertension following Intravitreal Steroid Injections: A Comparative Study
Conclusion: Twenty-eight percent of TA and 17% of Dex administrations developed OHT. Early and severe IOP rises were more common in TA than among Dex administrations. Myopia is a risk for Dex-OHT.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - April 25, 2022 Category: Opthalmology Source Type: research
Incidence, risk factors, treatment and outcome of ocular hypertension following intravitreal steroid injections: A comparative study
Conclusion: 28% of TA and 17% of Dex administrations developed OHT. Early and severe IOP rise was more common in TA than among Dex administrations. Myopia is a risk for Dex-OHT. (Source: Ophthalmologica)
Source: Ophthalmologica - April 25, 2022 Category: Opthalmology Source Type: research
Brolucizumab 12- and 16-Week Fixed Dosing Potential in Neovascular AMD: A post hoc Evaluation of Data from the HAWK and HARRIER Trials
Conclusions: This analysis demonstrates the potential durability of action and effectiveness of brolucizumab. (Source: Ophthalmologica)
Source: Ophthalmologica - March 28, 2022 Category: Opthalmology Source Type: research
Brolucizumab 12- and 16-week fixed dosing potential in neovascular AMD: a post-hoc evaluation of data from the HAWK and HARRIER trials
Conclusions: This analysis demonstrates the potential durability of action and effectiveness of brolucizumab. (Source: Ophthalmologica)
Source: Ophthalmologica - March 28, 2022 Category: Opthalmology Source Type: research
Comparison of retinochoroidal vascular and structural changes after half-dose photodynamic therapy versus half-fluence photodynamic therapy based on optical coherence tomography angiography in eyes with chronic central serous chorioretinopathy
Purpose: To compare the efficacy of half-fluence photodynamic therapy (PDT) and half-dose PDT on the choroidal structure via perfusion of the retinal plexus and choriocapillaris in eyes with chronic central serous chorioretinopathy (cCSCR).
Materials and Methods: This retrospective study included 43 eyes in 43 patients with cCSCR. Patients in group 1 received half-fluence (verteporfin 6 mg m –2) PDT and those in group 2 received half-dose (verteporfin 3 mg m–2) PDT. Enhanced depth imaging optical coherence tomography (EDI-OCT) and optical coherence tomography angiography (OCTA) images were recorded 1 day before and 3 ...
Source: Ophthalmologica - March 4, 2022 Category: Opthalmology Source Type: research
Globe ruptures: outcomes and prognostic analysis of severe ocular trauma
Conclusion: In this large, retrospective study on globe ruptures we identified male gender, short wound length, and the absence of vitreous hemorrhage or retinal detachment as predictors of improved functional outcome. We found a correlation between the presenting and final visual acuities and the Ocular Trauma Score. Our determination to reconstruct the traumatized eyes as early and as completely as possible was justified by the functional results: despite the severity of the injuries , one out of four eyes reached a final visual acuity greater than 20/200. (Source: Ophthalmologica)
Source: Ophthalmologica - February 23, 2022 Category: Opthalmology Source Type: research
Association between neurodegeneration and macular perfusion in the progression of diabetic retinopathy. A 3-year longitudinal study
Objective and purpose: To explore the relation between retinal neurodegenerative changes and vessel closure (VC) in individuals with non-proliferative diabetic retinopathy (NPDR) in a follow-up period of 3 years.
Design: 3-year prospective longitudinal study with four annual visits.
Participants: 74 individuals with type 2 diabetes, NPDR and ETDRS grades from 10 to 47, one eye/person. An age-matched healthy control population of 84 eyes was used as control group.
Methods: Participants were annually examined by color fundus photography (CFP), spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA...
Source: Ophthalmologica - February 14, 2022 Category: Opthalmology Source Type: research
Optical Coherence Tomography Angiography In Central Retinal Vein Occlusion: Macular Changes And Their Correlation With Peripheral Nonperfusion At Ultra-Widefield Fluorescein Angiography
Conclusion: OCT-A macular parameters (namely, FAZ area and PD of SCP and DCP) significantly correlated with ISI, a quantitative way to assess peripheral retinal nonperfusion on UWF FA. Macular OCT-A analysis may help in assessing the need for additional UWF FA testing in eyes affected by CRVO. (Source: Ophthalmologica)
Source: Ophthalmologica - February 10, 2022 Category: Opthalmology Source Type: research
Efficacy of Combined Vitrectomy with Intravitreal Corticosteroid Injection for Idiopathic Epiretinal Membrane Removal on Anatomical and Functional Outcomes: A Meta-analysis
Conclusion: Combined treatment with vitrectomy and intravitreal corticosteroid injection may accelerate CMT reduction 3 months after ERM surgery. However, it did not result in a significant change in CMT and BCVA compared with vitrectomy alone at the end of follow-up. (Source: Ophthalmologica)
Source: Ophthalmologica - February 9, 2022 Category: Opthalmology Source Type: research
Additive value of a face-to-face visit to virtual remote decision in patients with neovascular age-related macular degeneration
Conclusions: Virtual evaluation results in similar treatment decisions for nvAMD patients compared to st andard face-to-face clinical examination. (Source: Ophthalmologica)
Source: Ophthalmologica - February 3, 2022 Category: Opthalmology Source Type: research
Controlled subretinal injection pressure prevents damage in pigs
Conclusion
This study indicates that an injection pressure at approximately 24 PSI might be safe for subretinal delievery. Retinal damage at low injection pressures may be explained by mechanical damage to the RPE due to prolonged needle time in the subretinal space, whilst retinal damage at high pressures can be related to high flow in the injection cannula. Controlled subretinal injection pressure of 24 PSI showed minimum mechanical and flow-related damage to the porcine retina. (Source: Ophthalmologica)
Source: Ophthalmologica - January 24, 2022 Category: Opthalmology Source Type: research
Elevated risk of mood disorders after the occurrence of recurrent retinal detachment: a population-based cohort study
Conclusion: Patients with recurrent RD and multiple surgeries and females with RD who needed surgical treatment were at greater risk for developing MDD. (Source: Ophthalmologica)
Source: Ophthalmologica - January 13, 2022 Category: Opthalmology Source Type: research
Full-Field Electroretinography Changes Associated with Age-Related Macular Degeneration: A Systematic Review with Meta-Analyses
Background: The aim of this study was to systematically review the literature and to perform meta-analyses on full-field electroretinography (ffERG) between healthy controls and age-related macular degeneration (AMD) to map the extent of retinal dysfunction.Summary: We systematically searched 11 databases on 3 March 2021. Eligible studies had to measure retinal function using ffERG in eyes with AMD and in healthy controls. We extracted data on a-wave and b-wave function in dark- and light-adapted ffERG and calculated summary estimates on differences between eyes with AMD and controls using weighted mean differences (WMD). ...
Source: Ophthalmologica - January 11, 2022 Category: Opthalmology Source Type: research
