Treatment of Macular Degeneration with Sildenafil: Results of a Two-Year Trial
Conclusions: Our research supports sildenafil as a safe treatment for age-related and vitelliform macular degenerations. Thickened Bruch ’s membrane reduces the beneficial effect of perfusion increase, but all eyes appear to benefit from PDE6. Notably, maintenance or improvement in the photoreceptor layer may be the most significant result of sildenafil and is consistent with PDE6 inhibition. Thus, sildenafil treatment of macular degeneration offers significant potential for vision retention and recovery.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - April 25, 2018 Category: Opthalmology Source Type: research
Reliability of Vessel Density Measurements in the Peripapillary Retina and Correlation with Retinal Nerve Fiber Layer Thickness in Healthy Subjects Using Optical Coherence Tomography Angiography
Conclusion: Vessel density measurements showed good repeatability and reproducibility by OCT-A in the peripapillary retina, the vessel density was positively related to RNFL thickness and negatively related to optic disc area and rim area.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - April 25, 2018 Category: Opthalmology Source Type: research
Management of Subfoveal Perfluorocarbon Liquid: A Review
Perfluorocarbon liquid (PFCL) has been widely used in vitreoretinal surgeries, especially in retinal detachment treatment. A prominent complication of intraoperative PFCL application is inadvertent subretinal PFCL retention. Subfoveal PFCL, even in small amounts, receives much attention due to its potential side effect on the macular structure and function. Whether to observe with follow-up or to deal with surgery is often an intractable problem in the management of subfoveal PFCL. Safety and necessity are the 2 key issues in considering surgical treatment, that is, can we avoid surgically induced macular injury and will s...
Source: Ophthalmologica - April 18, 2018 Category: Opthalmology Source Type: research
Dexamethasone Intravitreal Implant for Early Treatment and Retreatment of Macular Edema Related to Branch Retinal Vein Occlusion: The Multicenter COBALT Study
Conclusions: Intravitreal dexamethasone treatment with an interval of ≥4 months provides rapid and significantly better improvement in BCVA and CRT in patients with BRVO-associated ME.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - April 11, 2018 Category: Opthalmology Source Type: research
Prophylactic Chorioretinectomy in Open Ocular Trauma: A Series of 36 Eyes
Conclusion: Prophylactic chorioretinectomy is a surgical procedure that may decrease posttraumatic PVR, thus improving final visual acuity and increasing globe survival rates.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - April 10, 2018 Category: Opthalmology Source Type: research
New Innovative Approaches for Difficult Retained Intraocular Foreign Bodies
Conclusion: Each case of RIOFB is unique and challenging. Here, innovative techniques are helpful to rescue these difficult RIOFB situations, which can result in excellent outcomes.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - April 10, 2018 Category: Opthalmology Source Type: research
Short-Term Results of Intravitreal Triamcinolone Acetonide Combined with Cataract Surgery for Diabetic Macular Edema in Japan: In the Era of Anti-Vascular Endothelial Growth Factor Therapy
Conclusions: IVTA combined with cataract surgery is effective for successful treatment of eyes with DME refractive to anti-VEGF therapy.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - April 5, 2018 Category: Opthalmology Source Type: research
Clinical Decision-Making when Treating Diabetic Macular Edema Patients with Dexamethasone Intravitreal Implants
Diabetes mellitus (DM) is a metabolic disease frequently associated with comorbidities that include diabetic macular edema (DME). The current medical approach to treating DME involves intravitreal injections with either anti-vascular endothelial growth factors or steroids. However, the burden associated with intravitreal injections and DM-derived complications is high, underlining the need to find optimal treatment regimens. In this article we describe the considerations we apply when treating DME patients with dexamethasone intravitreal implants (Ozurdex ®), particularly those that influence the clinical decision-making ...
Source: Ophthalmologica - April 4, 2018 Category: Opthalmology Source Type: research
Thrombin Generation in Vitreous and Subretinal Fluid of Patients with Retinal Detachment
Conclusion: The analysis of F1+2 and TAT confirmed significant thrombin generation in both vitreous and SRF of patients with RRD. An imbalance between the thrombin regulation mechanisms TAT and α2-macroglobulin possibly explains the difference from our previous findings.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - April 4, 2018 Category: Opthalmology Source Type: research
Epiretinal Proliferations Associated with Lamellar Macular Holes: Clinical and Surgical Implications
Conclusions: LHEP was correlated with the anatomical conformation of the LMH, yielding thinner floors and larger external diameters. However, it did not correlate with the anatomical or functional results, both in the patients who underwent surgery and in those managed conservatively.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - March 28, 2018 Category: Opthalmology Source Type: research
Angiographic and Tomographic Prognostic Factors of Chronic Central Serous Chorioretinopathy Treated with Half-Dose Photodynamic Therapy
Conclusion: A poor baseline BCVA, diffuse hyperfluorescence ICGA pattern, shallow irregular PED, and disruption of the ellipsoid zone indicate poor prognosis.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - March 23, 2018 Category: Opthalmology Source Type: research
Long-Term Results of Vitrectomy for Macular Holes after Failure of Vitreolysis
Conclusion: Vitrectomy with internal limiting membrane peeling leads to closure of macular holes even in cases of prior failure to close them by ocriplasmin injection.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - March 22, 2018 Category: Opthalmology Source Type: research
Activation of the ERK1/2-MAPK Signaling Pathway by Complement Serum in UV-POS-Pretreated ARPE-19 Cells
Conclusions: Our data imply that ERK1/2 activation in ARPE-19 cells may represent a response mechanism to cellular and oxidative stress, associated with apoptosis-regulating factors such as Bax and Bcl-2, which might play a role in AMD, while ERK1/2 seems not to represent the crucial signaling pathway mediating the functional changes in RPE cells in response to complement stimulation.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - February 27, 2018 Category: Opthalmology Source Type: research
Sutureless Belt Loops versus Sutured Buckle Technique in Combination with Vitrectomy for Retinal Detachment Repair: A Comparative Analysis
Conclusion: SBs installed using a belt loops sutureless technique appear to be as safe and effective as those applied using conventional suturing for repair of retinal detachment, with similar anatomic and functional outcomes.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - February 21, 2018 Category: Opthalmology Source Type: research
Posterior Hyaloid Dissection: Let ’s Make It Easy with Blue
Conclusions: A more controlled and easy dissection of posterior hyaloid during vitrectomy is accomplished with this simple technique without adding any extra cost.Message of the paper: An easy technique that allows a much easier dissection of the posterior hyaloid during vitrectomy improving visualization and decreasing risks. No extra cost, nor time is needed.Ophthalmologica (Source: Ophthalmologica)
Source: Ophthalmologica - February 13, 2018 Category: Opthalmology Source Type: research
