The Effect of Ketorolac Tromethamine, Methylprednisolone, and Platelet-Rich Plasma on Human Chondrocyte and Tenocyte Viability
Conclusions: Tendon and cartilage cells showed increased cell viability after an exposure to allogeneic PRP and ketorolac tromethamine. Exposure to methylprednisolone alone decreased cell viability, and addition of PRP could partially reverse this negative effect.Clinical Relevance: Intra-articular injections of pain-modifying or anti-inflammatory drugs are routinely given in orthopaedic practice. Among the many agents available for intra-articular injection, corticosteroids and local anesthetics are the most common in clinical practice. Potential detrimental side effects of intra-articular injections of corticosteroids an...
Source: Arthroscopy - June 30, 2013 Category: Surgery Authors: Knut Beitzel, Mary Beth McCarthy, Mark P. Cote, John Apostolakos, Ryan P. Russell, James Bradley, Neal S. ElAttrache, Antony A. Romeo, Robert A. Arciero, Augustus D. Mazzocca Tags: Original Articles Source Type: research
Rapid and Sensitive Reverse-phase High-performance Liquid Chromatography Method for Estimation of Ketorolac in Pharmaceuticals Using Weighted Regression
SK Dubey, S Duddelly, H Jangala, RN SahaIndian Journal of Pharmaceutical Sciences 2013 75(1):89-93A reliable, rapid and sensitive isocratic reverse phase high-performance liquid chromatography method has been developed and validated for assay of ketorolac tromethamine in tablets and ophthalmic dosage forms using diclofenac sodium as an internal standard. An isocratic separation of ketorolac tromethamine was achieved on Oyster BDS (150×4.6 mm i.d., 5 μm particle size) column using mobile phase of methanol:acetonitrile:sodium dihydrogen phosphate (20 mM; pH 5.5) (50:10:40, %v/v) at a flow rate ...
Source: Indian Journal of Pharmaceutical Sciences - June 17, 2013 Category: Drugs & Pharmacology Authors: SK DubeyS DuddellyH JangalaRN Saha Source Type: research
Pharmacokinetics and perioperative efficacy of intravenous ketorolac in dogs
Ketorolac (KET) is a nonsteroidal anti‐inflammatory drug approved for the use in humans that possesses a potent analgesic activity, comparable to morphine, and could represent a useful tool to control acute pain also in animals. The clinical efficacy and pharmacokinetic profile of intravenous (IV) ketorolac tromethamine (0.5 mg/kg) were studied in 15 dogs undergoing gonadectomy. Intra‐operative cardiorespiratory variables were monitored, and post‐operative pain was assessed using a subjective pain score (0–24) in all dogs, whereas the pharmacokinetic profile of the drug was determined in 10 animals. During surgery...
Source: Journal of Veterinary Pharmacology and Therapeutics - March 8, 2013 Category: Veterinary Research Authors: P. Cagnardi, A. Zonca, M. Gallo, R. Villa, S. Carli, M. Beccaglia, D. Fonda, G. Ravasio Tags: Scientific Paper Source Type: research
An In Vitro Evaluation of the Anti-Inflammatory Effects of Platelet-Rich Plasma, Ketorolac, and Methylprednisolone
Conclusions: Although PRP and ketorolac reduced cellular inflammation markers (E-selectin, vascular cell adhesion molecule, and human leukocyte antigen DR) compared with control, neither caused as great a reduction as methylprednisolone.Clinical Relevance: Although PRP and ketorolac did not produce as significant a reduction in cellular inflammation markers as methylprednisolone, they reduced cellular inflammation compared with the control. These agents may have clinical application as injectable anti-inflammatory medications. (Source: Arthroscopy)
Source: Arthroscopy - February 8, 2013 Category: Surgery Authors: Augustus D. Mazzocca, Mary Beth R. McCarthy, Jessica Intravia, Knut Beitzel, John Apostolakos, Mark P. Cote, James Bradley, Robert A. Arciero Tags: Original Articles Source Type: research
Intracranial hemorrhage requiring surgery in neurosurgical patients given ketorolac: a case-control study within a cohort (2001-2010).
CONCLUSION: Although the adjusted estimate for risk of symptomatic bleeding requiring surgery and ketorolac use is very close to the null effect, it may be not reproducible, and the width of the confidence interval is not conclusive evidence of the safety of ketorolac after elective neurosurgical procedures.
PMID: 23302965 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - January 31, 2013 Category: Anesthesiology Authors: Magni G, La Rosa I, Melillo G, Abeni D, Hernandez H, Rosa G Tags: Anesth Analg Source Type: research
