An In Vitro Evaluation of the Anti-Inflammatory Effects of Platelet-Rich Plasma, Ketorolac, and Methylprednisolone

Conclusions: Although PRP and ketorolac reduced cellular inflammation markers (E-selectin, vascular cell adhesion molecule, and human leukocyte antigen DR) compared with control, neither caused as great a reduction as methylprednisolone.Clinical Relevance: Although PRP and ketorolac did not produce as significant a reduction in cellular inflammation markers as methylprednisolone, they reduced cellular inflammation compared with the control. These agents may have clinical application as injectable anti-inflammatory medications.

Source: Arthroscopy - February 8, 2013 Category: Surgery Authors: Augustus D. Mazzocca, Mary Beth R. McCarthy, Jessica Intravia, Knut Beitzel, John Apostolakos, Mark P. Cote, James Bradley, Robert A. Arciero Tags: Original Articles Source Type: research