Ketoroloac tromethamine loaded nanodispersion incorporated into thermosensitive in situ gel for prolonged ocular delivery
Publication date: 15 June 2016 Source:International Journal of Pharmaceutics, Volume 506, Issues 1–2 Author(s): Nadia Morsi, Dalia Ghorab, Hanan Refai, Hoda Teba The present study was designed to improve the ocular availability of ketorolac tromethamine and to prolong its precorneal residence time for the treatment of postoperative ocular inflammation. Ketorolac tromethamine nanodispersions were successfully prepared by nanoprecipitation method using Eudragit® RL100. These nanodispersions were characterized in terms of particle size, zeta potential, entrapment efficiency and in vitro release. Consequently, t...
Source: International Journal of Pharmaceutics - April 26, 2016 Category: Drugs & Pharmacology Source Type: research
For Whom the Bell Tolls (and Nods): Spit-acular Saliva
Abstract
Having emerged during the early part of the Cretaceous period, ticks are an ancient group of hematophagous ectoparasites with significant veterinary and public health importance worldwide. The success of their life strategy can be attributed, in part, to saliva. As we enter into a scientific era where the collection of massive data sets and structures for biological application is possible, we suggest that understanding the molecular mechanisms that govern the life cycle of ticks is within grasp. With this in mind, we discuss what is currently known regarding the manipulation of Toll-like (TLR) a...
Source: Current Tropical Medicine Reports - April 4, 2016 Category: Tropical Medicine Source Type: research
LC and LC–MS study for simultaneous determination of tramadol hydrochloride and ketorolac tromethamine in bulk and formulation with their major degradation products
Publication date: Available online 22 February 2016 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Vrushali S. Tambe, M.N. Deodhar, Vijayalakshmi Prakya The present work was aimed to separate, identify and characterize the major degradation products of tramadol hydrochloride and ketorolac tromethamine. A rapid, specific and accurate stability indicating reversed phase liquid chromatographic method has been developed for simultaneous determination of tramadol hydrochloride and ketorolac tromethamine in bulk and formulation. The drugs were subjected to hydrolysis (acidic, alkaline and neutral),...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 23, 2016 Category: Drugs & Pharmacology Source Type: research
Formulation and corneal permeation of ketorolac tromethamine-loaded chitosan nanoparticles.
Authors: Fathalla ZM, Khaled KA, Hussein AK, Alany RG, Vangala A
Abstract
The aim of this work was to formulate chitosan (CS)-based nanoparticles (NPs) loaded with ketorolac tromethamine (KT) intended for topical ocular delivery. NPs were prepared using ionic gelation method incorporating tri-polyphosphate (TPP) as cross-linker. Following the preparation, the composition of the system was optimized in terms of their particle size, zeta potential, entrapment efficiency (EE) and morphology, as well as performing structural characterization studies using Fourier transform infrared spectroscopy (FT-IR) and dif...
Source: Drug Development and Industrial Pharmacy - February 16, 2016 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Validated spectrophotometric and chromatographic methods for simultaneous determination of ketorolac tromethamine and phenylephrine hydrochloride.
Abstract
This work describes five simple and reliable spectrophotometric and chromatographic methods for analysis of the binary mixture of ketorolac tromethamine (KTR) and phenylephrine hydrochloride (PHE). Method I is based on the use of conventional Amax and derivative spectrophotometry with the zero-crossing technique where KTR was determined using its Amax and (1)D amplitudes at 323 and 341nm respectively, while PHE was determined by measuring the (1)D amplitudes at 248.5nm. Method II involves the application of the ratio spectra derivative spectrophotometry. For KTR, 12μg/mL PHE was used as a divisor...
Source: Annales Pharmaceutiques Francaises - February 16, 2016 Category: Drugs & Pharmacology Authors: Belal TS, El-Kafrawy DS, Mahrous MS, Abdel-Khalek MM, Abo-Gharam AH Tags: Ann Pharm Fr Source Type: research
Patient-Reported Outcomes from A National, Prospective, Observational Study of Emergency Department Acute Pain Management with an Intranasal NSAID, Opioids or Both.
CONCLUSIONS: Automated telephonic follow-up of ED patients prescribed short-term analgesia is feasible. Ketorolac-based analgesia after an ED visit for many acute pain syndromes was associated with favorable patient outcomes and higher satisfaction than opioid-based therapy. SPRIX, an NSAID that is not available over-the-counter and has a novel delivery approach, may be useful for short-term post-ED outpatient analgesia. This article is protected by copyright. All rights reserved.
PMID: 26782787 [PubMed - as supplied by publisher] (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - January 19, 2016 Category: Emergency Medicine Authors: Pollack CV, Dierck DB, Thomas SH, Shapiro NI, Fanikos J, Mace SE, Rafique Z, Todd KH Tags: Acad Emerg Med Source Type: research
Patient‐Reported Outcomes from A National, Prospective, Observational Study of Emergency Department Acute Pain Management with an Intranasal NSAID, Opioids or Both
ConclusionsAutomated telephonic follow‐up of ED patients prescribed short‐term analgesia is feasible. Ketorolac‐based analgesia after an ED visit for many acute pain syndromes was associated with favorable patient outcomes and higher satisfaction than opioid‐based therapy. SPRIX, an NSAID that is not available over‐the‐counter and has a novel delivery approach, may be useful for short‐term post‐ED outpatient analgesia.This article is protected by copyright. All rights reserved. (Source: Academic Emergency Medicine)
Source: Academic Emergency Medicine - January 1, 2016 Category: Emergency Medicine Authors: Charles V. Pollack, Deborah B. Dierck, Stephen H. Thomas, Nathan I. Shapiro, John Fanikos, Sharon E. Mace, Zubaid Rafique, Knox H. Todd Tags: Original Contribution Source Type: research
Sublingual desmopressin is efficient and safe in the therapy of lithiasic renal colic
Conclusions
Sublingual desmopressin is at least as potent as NSAID in the treatment of lithiasic renal colic. The combination of sublingual desmopressin and NSAID has additive analgesic effects. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 16, 2015 Category: Urology & Nephrology Source Type: research
Effect Size Comparison of Ketorolac Nasal Spray and Commonly Prescribed Oral Combination Opioids for Pain Relief After Third Molar Extraction Surgery.
CONCLUSIONS: The treatment effect sizes of ketorolac nasal spray were similar to or higher than the opioid comparators after third molar surgery, a well-accepted pain model. These results support ketorolac nasal spray as an effective treatment for moderate to moderately severe short-term pain.
PMID: 26616001 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - December 1, 2015 Category: Internal Medicine Tags: Postgrad Med Source Type: research
Comparison of the anti-inflammatory effect of dexamethasone and ketorolac in the extractions of third molars
Abstract
This double-blind, split-mouth, and randomized study was aimed to compare the efficacy of dexamethasone and ketorolac tromethamine, through the evaluation of pain, edema, and limitation of mouth opening. Thirty-four individuals aged 18–26 years, having bilateral mandibular third molars, in a similar position, were selected. Two different surgical procedures were performed on the same individual by the single surgeon. For an extraction, the individual received 1 capsule of 10 mg ketorolac tromethamine 1 h before surgery and every 8 h for 2 days. For the extraction of the contralateral side,...
Source: Oral and Maxillofacial Surgery - November 16, 2015 Category: ENT & OMF Source Type: research
Development and Evaluation of Sustained Oral Ketorolac Tromethamine Particulate Matrix via Bioadhesive Chitosan Based Freeze-Dried Solid Dispersions.
CONCLUSIONS: Results suggested freeze-dried chitosan based SDPM (1:7) as a potential candidate for sustained oral administration of KT.
PMID: 26456210 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 12, 2015 Category: Drugs & Pharmacology Authors: Rasool BK, Aziz US, Abu-Gharbieh E, Khan SA Tags: Curr Drug Deliv Source Type: research
Effect of topical ketorolac 0.4%, nepafenac 0.1%, and bromfenac 0.09% on postoperative inflammation using laser flare photometry in patients having phacoemulsification
To study the effect of topical ketorolac 0.4% (Acular LS), bromfenac 0.09% (Megabrom), and nepafenac 0.1% (Nevanac) on postoperative inflammation using laser flare photometry in patients having phacoemulsification with posterior chamber intraocular lens (PC IOL) implantation. (Source: Journal of Cataract and Refractive Surgery)
Source: Journal of Cataract and Refractive Surgery - October 1, 2015 Category: Opthalmology Authors: Sabin Sahu, Jagat Ram, Reema Bansal, Surinder S. Pandav, Amod Gupta Tags: Article Source Type: research
Pharmacokinetics of ketorolac tromethamine in horses after intravenous, intramuscular, and oral single‐dose administration
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are an integral component of equine analgesia, yet currently available NSAIDs are both limited in their analgesic efficacy and have adverse effects. The NSAID ketorolac tromethamine (KT) is widely used in humans as a potent morphine‐sparing analgesic drug but has not been fully evaluated in horses. The purpose of this study was to determine the pharmacokinetic profile of KT in horses after intravenous (i.v.), intramuscular (i.m.), and oral (p.o.) administration. Nine healthy adult horses received a single 0.5‐mg/kg dose of KT via each route of administration. Plasma was c...
Source: Journal of Veterinary Pharmacology and Therapeutics - September 30, 2015 Category: Veterinary Research Authors: A. W. Bianco, P. D. Constable, B. R. Cooper, S. D. Taylor Tags: Original Article Source Type: research
A simplified way for the urgent treatment of somatic pain in patients admitted to the emergency room: the SUPER algorithm
Abstract
Somatic pain is one of the most frequent symptoms reported by patients presenting to the emergency department (ED), but, in spite of this, it is very often underestimated and under-treated. Moreover, pain-killers prescriptions are usually related to the medical examination, leading to a delay in its administration, thus worsening the patient’s quality of life. With our study, we want to define and validate a systematic and homogeneous approach to analgesic drugs administration, testing a new therapeutic algorithm in terms of earliness, safety, and efficacy. 442 consecutive patients who accessed...
Source: Internal and Emergency Medicine - September 4, 2015 Category: Emergency Medicine Source Type: research
Prospective, Randomized Study Comparing the Effect of 0.1% Nepafenac and 0.4% Ketorolac Tromethamine on Macular Thickness in Cataract Surgery Patients With Low Risk for Cystoid Macular Edema
Conclusions: Postoperative macular thickening after cataract surgery in eyes with low CME risk is similar with nepafenac and ketorolac. A larger population of diabetic patients should be studied to verify any beneficial effect of nepafenac on this subgroup. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2015 Category: Opthalmology Tags: Original Clinical Study Source Type: research
