Hazard from Himalayan glacier lake outburst floods [Environmental Sciences]
We present a robust probabilistic estimate of average GLOFs return periods in the... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Georg Veh, Oliver Korup, Ariane Walz Tags: Physical Sciences Source Type: research

Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome [Genetics]
Genetic and phenotypic heterogeneity and the lack of sufficiently large patient cohorts pose a significant challenge to understanding genetic associations in rare disease. Here we identify Bsnd (alias Barttin) as a genetic modifier of cystic kidney disease in Joubert syndrome, using a Cep290-deficient mouse model to recapitulate the phenotypic variability... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Simon A. Ramsbottom, Peter E. Thelwall, Katrina M. Wood, Gavin J. Clowry, Laura A. Devlin, Flora Silbermann, Helena L. Spiewak, Shirlee Shril, Elisa Molinari, Friedhelm Hildebrandt, Meral Gunay-Aygun, Sophie Saunier, Heather J. Cordell, John A. Sayer, Col Tags: Biological Sciences Source Type: research

CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas [Medical Sciences]
Immunotherapy directed at the PD-L1/PD-1 axis has produced treatment advances in various human cancers. Unfortunately, progress has not extended to glioblastoma (GBM), with phase III clinical trials assessing anti-PD-1 monotherapy failing to show efficacy in newly diagnosed and recurrent tumors. Myeloid-derived suppressor cells (MDSCs), a subset of immunosuppressive myeloid derived... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Joseph A. Flores-Toro, Defang Luo, Adithya Gopinath, Matthew R. Sarkisian, James J. Campbell, Israel F. Charo, Rajinder Singh, Thomas J. Schall, Meenal Datta, Rakesh K. Jain, Duane A. Mitchell, Jeffrey K. Harrison Tags: Biological Sciences Source Type: research

The circadian clock protein REVERB{alpha} inhibits pulmonary fibrosis development [Medical Sciences]
Pulmonary inflammatory responses lie under circadian control; however, the importance of circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we identify a striking change to these mechanisms resulting in a gain of amplitude and lack of synchrony within pulmonary fibrotic tissue. These changes result from an infiltration... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Peter S. Cunningham, Peter Meijer, Alicja Nazgiewicz, Simon G. Anderson, Lee A. Borthwick, James Bagnall, Gareth B. Kitchen, Monika Lodyga, Nicola Begley, Rajamiyer V. Venkateswaran, Rajesh Shah, Paul F. Mercer, Hannah J. Durrington, Neil C. Henderson, Ka Tags: Biological Sciences Source Type: research

Successive passaging of a plant-associated microbiome reveals robust habitat and host genotype-dependent selection [Microbiology]
There is increasing interest in the plant microbiome as it relates to both plant health and agricultural sustainability. One key unanswered question is whether we can select for a plant microbiome that is robust after colonization of target hosts. We used a successive passaging experiment to address this question by... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Norma M. Morella, Francis Cheng-Hsuan Weng, Pierre M. Joubert, C. Jessica E. Metcalf, Steven Lindow, Britt Koskella Tags: Biological Sciences Source Type: research

The Mycobacterium marinum ESX-1 system mediates phagosomal permeabilization and type I interferon production via separable mechanisms [Microbiology]
Following mycobacterial entry into macrophages the ESX-1 type VII secretion system promotes phagosomal permeabilization and type I IFN production, key features of tuberculosis pathogenesis. The current model states that the secreted substrate ESAT-6 is required for membrane permeabilization and that a subsequent passive leakage of extracellular bacterial DNA into the... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Julia Lienard, Esther Nobs, Victoria Lovins, Elin Movert, Christine Valfridsson, Fredric Carlsson Tags: Biological Sciences Source Type: research

Energy conservation involving 2 respiratory circuits [Microbiology]
Chemiosmosis and substrate-level phosphorylation are the 2 mechanisms employed to form the biological energy currency adenosine triphosphate (ATP). During chemiosmosis, a transmembrane electrochemical ion gradient is harnessed by a rotary ATP synthase to phosphorylate adenosine diphosphate to ATP. In microorganisms, this ion gradient is usually composed of H+, but it... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Marie Charlotte Schoelmerich, Alexander Katsyv, Judith Donig, Timothy J. Hackmann, Volker Muller Tags: Biological Sciences Source Type: research

Pyridoxal-5'-phosphate-dependent bifunctional enzyme catalyzed biosynthesis of indolizidine alkaloids in fungi [Microbiology]
Indolizidine alkaloids such as anticancer drugs vinblastine and vincristine are exceptionally attractive due to their widespread occurrence, prominent bioactivity, complex structure, and sophisticated involvement in the chemical defense for the producing organisms. However, the versatility of the indolizidine alkaloid biosynthesis remains incompletely addressed since the knowledge about such biosynthetic machineries... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Guang Zhi Dai, Wen Bo Han, Ya Ning Mei, Kuang Xu, Rui Hua Jiao, Hui Ming Ge, Ren Xiang Tan Tags: Biological Sciences Source Type: research

Variable functional connectivity architecture of the preterm human brain: Impact of developmental cortical expansion and maturation [Neuroscience]
Functional connectivity (FC) is known to be individually unique and to reflect cognitive variability. Although FC can serve as a valuable correlate and potential predictor of (patho-) physiological nervous function in high-risk constellations, such as preterm birth, templates for individualized FC analysis are lacking, and knowledge about the capacity of... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Sophia Stoecklein, Anne Hilgendorff, Meiling Li, Kai Forster, Andreas W. Flemmer, Franziska Galie, Stephan Wunderlich, Danhong Wang, Sophie Stein, Harald Ehrhardt, Olaf Dietrich, Qihong Zou, Shuqin Zhou, Birgit Ertl–Wagner, Hesheng Liu Tags: Biological Sciences Source Type: research

Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance [Neuroscience]
Ankyrin-G (AnkG), a highly enriched scaffold protein in the axon initial segment (AIS) of neurons, functions to maintain axonal polarity and the integrity of the AIS. At the AIS, AnkG regulates selective intracellular cargo trafficking between soma and axons via interaction with the dynein regulator protein Ndel1, but the molecular... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Jin Ye, Jianchao Li, Fei Ye, Yan Zhang, Mingjie Zhang, Chao Wang Tags: Biological Sciences Source Type: research

Behavioral evidence for geomagnetic imprinting and transgenerational inheritance in fruit flies [Physiology]
Certain long-distance migratory animals, such as salmon and sea turtles, are thought to imprint on the magnetic field of their natal area and to use this information to help them return as adults. Despite a growing body of indirect support for such imprinting, direct experimental evidence thereof remains elusive. Here,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: In-Taek Oh, Hye-Jin Kwon, Soo-Chan Kim, Hyung-Jun Kim, Kenneth J. Lohmann, Kwon-Seok Chae Tags: Biological Sciences Source Type: research

Combinatorial interactions of the LEC1 transcription factor specify diverse developmental programs during soybean seed development [Plant Biology]
The LEAFY COTYLEDON1 (LEC1) transcription factor is a central regulator of seed development, because it controls diverse biological programs during seed development, such as embryo morphogenesis, photosynthesis, and seed maturation. To understand how LEC1 regulates different gene sets during development, we explored the possibility that LEC1 acts in combination with... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Leonardo Jo, Julie M. Pelletier, Ssu-Wei Hsu, Russell Baden, Robert B. Goldberg, John J. Harada Tags: Biological Sciences Source Type: research

Rhythmic swaying induced by sound in chimpanzees (Pan troglodytes) [Psychological and Cognitive Sciences]
In this study, we investigated if sound induced spontaneous rhythmic... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Yuko Hattori, Masaki Tomonaga Tags: Social Sciences Source Type: research

Sadness, but not all negative emotions, heightens addictive substance use [Psychological and Cognitive Sciences]
Do negative feelings in general trigger addictive behavior, or do specific emotions play a stronger role? Testing these alternative accounts of emotion and decision making, we drew on the Appraisal Tendency Framework to predict that sadness, specifically, rather than negative mood, generally, would 1) increase craving, impatience, and actual addictive... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Charles A. Dorison, Ke Wang, Vaughan W. Rees, Ichiro Kawachi, Keith M. M. Ericson, Jennifer S. Lerner Tags: Social Sciences Source Type: research

Altruistic behaviors relieve physical pain [Psychological and Cognitive Sciences]
Engaging in altruistic behaviors is costly, but it contributes to the health and well-being of the performer of such behaviors. The present research offers a take on how this paradox can be understood. Across 2 pilot studies and 3 experiments, we showed a pain-relieving effect of performing altruistic behaviors. Acting... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Yilu Wang, Jianqiao Ge, Hanqi Zhang, Haixia Wang, Xiaofei Xie Tags: Social Sciences Source Type: research

Reward does not facilitate visual perceptual learning until sleep occurs [Psychological and Cognitive Sciences]
A growing body of evidence indicates that visual perceptual learning (VPL) is enhanced by reward provided during training. Another line of studies has shown that sleep following training also plays a role in facilitating VPL, an effect known as the offline performance gain of VPL. However, whether the effects of... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Authors: Masako Tamaki, Aaron V. Berard, Tyler Barnes-Diana, Jesse Siegel, Takeo Watanabe, Yuka Sasaki Tags: Social Sciences Source Type: research

Correction for Yu et al., Wildfire prevention through prophylactic treatment of high-risk landscapes using viscoelastic retardant fluids [Correction]
APPLIED PHYSICAL SCIENCES Correction for “Wildfire prevention through prophylactic treatment of high-risk landscapes using viscoelastic retardant fluids,” by Anthony C. Yu, Hector Lopez Hernandez, Andrew H. Kim, Lyndsay M. Stapleton, Ruben J. Brand, Eric T. Mellor, Cameron P. Bauer, Gregory D. McCurdy, Albert J. Wolff III, Doreen Chan, Craig S.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Tags: Corrections Source Type: research

Correction for Zhang et al., Elevated signature of a gene module coexpressed with CDC20 marks genomic instability in glioma [Correction]
MEDICAL SCIENCES Correction for “Elevated signature of a gene module coexpressed with CDC20 marks genomic instability in glioma,” by Yunqiu Zhang, Jiuyi Li, Kaikai Yi, Jing Feng, Zhengmin Cong, Zheng Wang, Yanfei Wei, Fan Wu, Wen Cheng, Ayaz Ali Samo, Paolo Salomoni, Qiong Yang, Yu Huang, Chunsheng Kang, Tao Jiang,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Tags: Corrections Source Type: research

Correction for Heeger and Mackey, Oscillatory recurrent gated neural integrator circuits (ORGaNICs), a unifying theoretical framework for neural dynamics [Correction]
NEUROSCIENCE, PSYCHOLOGICAL AND COGNITIVE SCIENCES Correction for “Oscillatory recurrent gated neural integrator circuits (ORGaNICs), a unifying theoretical framework for neural dynamics,” by David J. Heeger and Wayne E. Mackey, which was first published October 21, 2019; 10.1073/pnas.1911633116 (Proc. Natl. Acad. Sci. U.S.A. 116, 22783–22794). The authors note that, on page... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 14, 2020 Category: Science Tags: Corrections Source Type: research

Identifying Adolescents at Risk for Depression: A Prediction Score Performance in Cohorts Based in Three Different Continents
Prediction models have become frequent in the medical literature, but most published studies are conducted in a single setting. Heterogeneity between development and validation samples has been posited as a major obstacle for the generalization of models. We aimed to develop a multivariable prognostic model using sociodemographic variables easily obtainable from adolescents at age 15 to predict a depressive disorder diagnosis at age 18, and to evaluate its generalizability in two samples from diverse socioeconomic and cultural settings. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - January 14, 2020 Category: Psychiatry Authors: Thiago Botter-Maio Rocha, Helen L. Fisher, Arthur Caye, Luciana Anselmi, Louise Arseneault, Fernando C. Barros, Avshalom Caspi, Andrea Danese, Helen Gon çalves, HonaLee Harrington, Renate Houts, Ana M.B. Menezes, Terrie E. Moffitt, Valeria Mondelli, Rich Tags: New Research Source Type: research

Reply to: ‘‘Skin diseases of the breast and nipple: Benign and malignant tumors”
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 14, 2020 Category: Dermatology Authors: Edward Eid, Ossama Abbas Source Type: research

Reply to: ‘‘Skin diseases of the breast and nipple”
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 14, 2020 Category: Dermatology Authors: E. Eid, O. Abbas Source Type: research

TEMPORARY REMOVAL: Identifying Adolescents at Risk for Depression: A Prediction Score Performance in Cohorts Based in Three Different Continents
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found athttps://www.elsevier.com/about/our-business/policies/article-withdrawal. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - January 14, 2020 Category: Psychiatry Authors: Thiago Botter-Maio Rocha, Helen L. Fisher, Arthur Caye, Luciana Anselmi, Louise Arseneault, Fernando C. Barros, Avshalom Caspi, Andrea Danese, Helen Gon çalves, HonaLee Harrington, Renate Houts, Ana M.B. Menezes, Terrie E. Moffitt, Valeria Mondelli, Rich Source Type: research

Shortened CBT Program May Help Youth With Anxiety Problems
Youth with anxiety problems can benefit from as few as five sessions of cognitive-behavioral therapy (CBT) delivered at school, suggests astudy published in theJournal of the American Academy of Child& Adolescent Psychiatry.Studies in multiple countries including the United States have shown that school-based CBT programs that identify and treat youth considered at risk of disorders like depression or anxiety can be effective. A typical course of CBT involves eight to 12 sessions, which can be difficult to implement in a school setting, wrote Bente Storm Mowatt Haugland, Ph.D., of the University of Bergen in Norway and...
Source: Psychiatr News - January 13, 2020 Category: Psychiatry Tags: anxiety brief CBT child and adolescent psychiatry cognitive behavioral therapy Journal of the American Academy of Child & school-based intervention targeted intervention Source Type: research

Removing Race From Guidelines for Urinary Tract Infection in Infants and Children
This Viewpoint presents arguments in favor of removing race from the American Academy of Pediatrics clinical practice guideline on urinary tract infections in infants and young children with fever. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - January 13, 2020 Category: Pediatrics Source Type: research

Deep brain stimulation for Tourette ’s syndrome
AbstractTourette syndrome (TS) is a childhood-onset neuropsychiatric disorder characterized by the presence of multiple motor and vocal tics. TS usually co-occurs with one or multiple psychiatric disorders. Although behavioral and pharmacological treatments for TS are available, some patients do not respond to the available treatments. For these patients, TS is a severe, chronic, and disabling disorder. In recent years, deep brain stimulation (DBS) of basal ganglia-thalamocortical networks has emerged as a promising intervention for refractory TS with or without psychiatric comorbidities. Three major challenges need to be ...
Source: Translational Neurodegeneration - January 13, 2020 Category: Neurology Source Type: research

Systematic Review and Meta-Analysis: Mental Health in Children With Neurogenetic Disorders Associated With Intellectual Disability
The objectives of this systematic review and meta-analysis were to systematically review the prevalence of psychiatric disorders and symptoms in children and adolescents with these disorders and compare phenotypic signatures between syndromes. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - January 13, 2020 Category: Psychiatry Authors: Emma J. Glasson, Nicholas Buckley, Wai Chen, Helen Leonard, Amy Epstein, Rachel Skoss, Peter Jacoby, A. Marie Blackmore, Jenny Bourke, Jenny Downs Tags: Review Source Type: research

A Qualitative Study Assessing Information on the Internet Compared With AAOS Guidelines for the Treatment of Distal Radius Fractures.
Abstract The goal of this study was to compare information available on the Internet about the treatment of distal radius fractures with the guidelines established by the American Academy of Orthopaedic Surgeons (AAOS) in a qualitative observational study. A scoring system was used to compare the top 20 websites, excluding advertisements, from Google, Bing, and Yahoo with the AAOS guidelines. In addition, the results of the advertising content and the social media content were discussed. Of the 32 unique websites included in the study, 22 (68.75%) suggested operative fixation for fractures with unacceptable postre...
Source: Orthopedics - January 13, 2020 Category: Orthopaedics Authors: Lamont SM, Steffensmeier AM, Harman TW, Martineau DW Tags: Orthopedics Source Type: research

Intense Pulsed Light Therapy with Meibomian Gland Expression for Dry Eye Disease.
CONCLUSIONS: The results suggested a significant increase in TBUT and a nonsignificant increase in SPEED and Schirmer's test values at all follow-up periods post-treatment. Ultimately, IPL with MGX appears to be a promising therapy for MGD. PMID: 31941589 [PubMed - as supplied by publisher] (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - January 13, 2020 Category: Opthalmology Authors: Sambhi RS, Sambhi GDS, Mather R, Malvankar-Mehta MS Tags: Can J Ophthalmol Source Type: research

Positive predictive value and screening performance of GoCheck Kids in a primary care university clinic
Publication date: Available online 12 January 2020Source: Journal of American Association for Pediatric Ophthalmology and StrabismusAuthor(s): Megan X. Law, Mariana Flores Pimentel, Catherine E. Oldenburg, Alejandra G. de Alba CampomanesAbstractPurposeTo determine the positive predictive value (PPV) of GoCheck Kids, a smartphone-based photoscreener, to detect refractive amblyopia risk factors (ARFs) in children 3-48 months of age.MethodsThe medical records of all children ≤48 months of age who failed GoCheck Kids photoscreening at a University of California, San Francisco, pediatric clinic between February 2017 and Augu...
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - January 12, 2020 Category: Opthalmology Source Type: research

Effects of Diabetes Mellitus on Functional Outcomes and Complications After Torsional Ankle Fracture.
Authors: Schmidt T, Simske NM, Audet MA, Benedick A, Kim CY, Vallier HA Abstract INTRODUCTION: It is well known that patients with diabetes mellitus experience higher complication rates after torsional ankle fracture; however, the functional consequences remain less clear. The goal of this study was to determine the effects of diabetes on complications, secondary operations, and functional outcomes after torsional ankle fracture. METHODS: Nine hundred seventy-nine adult patients treated surgically for a torsional ankle injury (Orthopaedic Trauma Association 44B, 44C) over 13 years were retrospectively reviewed....
Source: The Journal of the American Academy of Orthopaedic Surgeons - January 12, 2020 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Conversion to Positive Latent Tuberculosis Infection Status is Low in Hidradenitis Suppurativa Patients Taking Biologic Medications
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 12, 2020 Category: Dermatology Authors: Ariana Ellis, Urmi Khanna, AbdulAziz Galadari, Anthony P. Fernandez Source Type: research

Association between Uremic Pruritus and Long-Term Outcomes in Patients Undergoing Dialysis
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 12, 2020 Category: Dermatology Authors: Sze-Wen Ting, Pei-Chun Fan, Yu-Sheng Lin, Ming-Shyan Lin, Cheng-Chia Lee, George Kuo, Chih-Hsiang Chang Source Type: research

Principal Components Analysis as a Tool to Identify Lesional Skin Patterns in Cutaneous Lupus Erythematosus
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 12, 2020 Category: Dermatology Authors: Smriti Prasad, Justin Raman, Motolani E. Ogunsanya, Benjamin F. Chong Source Type: research

Efficacies and merits of the Cotton Swab technique to diagnose Tinea Capitis in the Pediatric Population
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 12, 2020 Category: Dermatology Authors: Michelle Le, Sofianne Gabrielli, Feras M. Ghazawi, Rayan Alkhodair, Donald C. Sheppard, Fatemeh Jafarian Source Type: research

67. Training for Pediatric Residents on Pregnancy Options Counseling
The purpose of this study was to evaluate the effectiveness of a roleplay-based training on pregnancy options counseling (POC) skills for first-year pediatric residents. The American Academy of Pediatrics recommends that pediatricians should be prepared to provide comprehensive POC to pregnant adolescents. There have been no previous published studies evaluating the efficacy of a roleplay-based training on POC among pediatric residents. (Source: Journal of Adolescent Health)
Source: Journal of Adolescent Health - January 11, 2020 Category: Child Development Authors: Laura Kirkpatrick, Susan Wiener, Lauren Bell, Nicholas Szoko, Benjamin Hazen, Amy Collins, Tahniat Syed Tags: Research Poster Symposia: Reproductive Health Source Type: research

114. Improving Sexually Transmitted Infection Screening Rate in Inpatient Pediatric Patients
Sexually transmitted infections (STIs) are a group of infectious diseases that can cause acute illness and life-long health effects. Nearly half of all diagnosed cases occur in adolescents and young adults, ages 15-24. The American Academy of Pediatrics and Centers for Disease Control provide guidelines for routine STI screening for all sexually active adolescents. Despite these recommendations, screening rates in adolescents admitted to our hospital are low. The purpose of this study is to use quality improvement methodology to improve screening for HIV, gonorrhea, chlamydia, and syphilis in adolescent patients in an inpa...
Source: Journal of Adolescent Health - January 11, 2020 Category: Child Development Authors: Mary Katherine Hood, Madeline Michalopulos, Michelle Bowden Source Type: research

107. No Missed Opportunities: A Trainee-Driven Long Acting Reversible Contraceptive Workshop for Pediatric Primary Care Clinicians
The American Academy of Pediatrics (AAP) recommends long-acting reversible contraceptives (LARCs), including intrauterine devices (IUDs) and etonogestrel implants, as first-line contraceptive methods for adolescents, yet fewer than 5% of adolescents ages 15-19 use these methods. Though pediatric providers are well positioned to provide LARCs, barriers include provider knowledge, attitude and experience, leading to missed opportunities to prevent teen pregnancy. An initial needs assessment identified that the majority of community pediatric providers were not providing LARCs. (Source: Journal of Adolescent Health)
Source: Journal of Adolescent Health - January 11, 2020 Category: Child Development Authors: Taylor A. Argo, Janna R. Gewirtz O ’Brien, Kathleen K. Miller, Alex L. Prince, Tori Bahr, Christy Boraas, Nicole Chaisson, Emily C. Borman-Shoap Source Type: research

105. Training Providers at School-Based Health Centers in Intrauterine Devices and Implants: The Effect of an Evidence-Based Program on Provider Knowledge, Attitudes, and Practices
Providing adolescents with access to the full range of contraceptive methods, including long-acting reversible contraceptives (LARC), is important to enable adolescents to prevent pregnancy if they wish to. Intra-uterine devices (IUDs) and implants have been shown to be safe and acceptable among adolescents. The American College of Obstetricians and Gynecologists and the American Academy of Pediatrics both recommend that providers include LARC in counseling adolescents, alongside other reversible methods. (Source: Journal of Adolescent Health)
Source: Journal of Adolescent Health - January 11, 2020 Category: Child Development Authors: Alison Comfort, Lavanya Rao, Suzan Goodman, Rosalyn Schroeder, Charles McCulloch, Cynthia Harper Source Type: research

225. Baby Town: A Role-Playing Board Game and Curriculum to Highlight the Challenges of Teenage Parenthood in a Destigmatizing Manner
Hexacago Health Academy is a summer program in which youth explore the social ecology of public health issues using game design and gameplay. In the game design segment on teenage pregnancy, young people noted that strategies to reduce teenage pregnancy may unintentionally promote stigmatization of teenage parents. This project describes the design and subsequent testing of a role-playing board game designed by youth about the daily challenges of teenage parenthood delivered with a curriculum developed by teachers. (Source: Journal of Adolescent Health)
Source: Journal of Adolescent Health - January 11, 2020 Category: Child Development Authors: Ellen McCammon, Amy Moore, Crystal P. Tyler, Mason Arrington, Patrick Jagoda, Ashlyn Sparrow, Melissa Gilliam Source Type: research

205. Telling the Truth: Adolescent and Young Adults' Honesty During a Sexual History and Association with Receipt Of Services
The American Academy of Pediatrics recommends that providers elicit a patient ’s sexual history during clinic visits to ensure patients receive appropriate sexual and reproductive health services and risk reduction counseling. However, little is known about patient truthfulness during a sexual history, which may be particularly relevant for adolescent and young adult (AYA) patients with heightened confidentiality concerns. Our purpose is to : 1) describe whether AYA patients truthfully disclose sexual activity to providers during a sexual history; 2) explore patient-provider relationship and demographic associations ...
Source: Journal of Adolescent Health - January 11, 2020 Category: Child Development Authors: Nicole Liddon, Sanjana Pampati, Riley J. Steiner, Devon J. Hensel, Tsung-chieh Fu, Jonathon Beckmeyer, Debby Herbenick Source Type: research

241. Quality Improvement for Universal Screening of Gonorrhea and Chlamydia for all Adolescents in a Resident Primary Care Clinic
The American Academy of Pediatrics recommends annual screening for gonorrhea and chlamydia (GC/CT) for sexually active females ≤ 25 years old; however, data suggest that adolescents may not report sexual activity to their health care providers, and GC/CT testing appearing on explanations of benefits limits adolescent confidentiality. Additionally, in 2017, the prevalence of GC/CT in North Carolina for 15- to 19-year-olds was higher than the national average, and 15- to 29-year-olds comprised 71% of gonorrhea and 85% of chlamydia cases in North Carolina. (Source: Journal of Adolescent Health)
Source: Journal of Adolescent Health - January 11, 2020 Category: Child Development Authors: Bianca A. Allison, Martha F. Perry Source Type: research

238. Is There an Ideal Age to Disclose HIV-Status to Youth Who are Unaware that They are Living With HIV to Maximize the Likelihood of Ongoing Viral Load Suppression?
Globally, there are 1.8 million children under 15 living with HIV. Recent estimates indicate over 70 new cases of pediatric HIV are identified annually, and nearly 2,000 children are living with HIV in the United States. The WHO recommends disclosure of HIV-status between 6-12 years, and the American Academy of Pediatrics recommends youth are informed at “school age.” Neither institution suggests an optimal age when children should learn of their infection. Considering the criticality of viral load suppression we preliminarily assessed the relationship between the age of HIV-status disclosure and longitudinal v...
Source: Journal of Adolescent Health - January 11, 2020 Category: Child Development Authors: Lori Mills, Lauren EB. Marefka, Sequoya A. Eady, Dayna Cook, Tina Simpson, Henna Budhwani Source Type: research

Educational Video Improves Dermatology Residents ’ Understanding of Mohs Micrographic Surgery: A Survey-Based Matched Cohort Study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 11, 2020 Category: Dermatology Authors: Evan McNeil, Hilary Reich, Elisabeth Hurliman Source Type: research

Response to letter to the editor titled 5-mm lateral margins are appropriate in the treatment of melanoma in situ
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 11, 2020 Category: Dermatology Authors: Joy H. Kunishige, David G. Brodland, John A. Zitelli Source Type: research

Five-millimeter lateral margins are appropriate in the treatment of melanoma in situ
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 11, 2020 Category: Dermatology Authors: Paola Valencia, Luisa Chaparro, Paloma Rico, Lina G ómez, Maximiliano Aragües, Pedro Rodríguez-Jiménez Source Type: research

Bridging neighboring civilizations at academic grounds: a story of Zygmunt Albert - Rector illustrissimus ac magnificus Academiae Medicae Wratislaviensis - a pathologist who visualized gamma-glutamyl transpeptidase.
Authors: Wincewicz A, Woltanowski P, Jeleń M Abstract The life stories can constitute more than simple biographies to remain great lessons of honesty, grit and steadfastness in keeping standards of medical science within a strong moral fiber and flexible wiseness in hard terms like in case of Zygmunt Albert (1908-2001). This eminent pathologist histochemically visualized tissue distribution of gamma-glutamyl transpeptidase in liver and other organs under various conditions. He was also deeply involved in experimental pathology of liver, particularly in his comprehensive studies on chrysoidin-induced hepatoma that ...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Establishing a Regional Trauma Preventable/Potentially Preventable Death Rate
Objective: To establish a trauma preventable/potentially preventable death rate (PPPDR) within a heavily populated county in Texas. Summary: The National Academies of Sciences estimated the trauma preventable death rate in the United States to be 20%, issued a call for zero preventable deaths, while acknowledging that an accurate preventable death rate was lacking. In this absence, effective strategies to improve quality of care across trauma systems will remain difficult. Methods: A retrospective review of death-related records that occurred during 2014 in Harris County, TX, a diverse population of 4.4 million. Pa...
Source: Annals of Surgery - January 10, 2020 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Dermatology Calendar
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 10, 2020 Category: Dermatology Source Type: research

Journal Based CME Instructions and Information
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 10, 2020 Category: Dermatology Source Type: research