ERAPSO – Assessment of eating behavior, physical activity and prevalence of obesity in German psoriasis patients
Psoriasis is an inflammatory skin disease typically characterized by erythema, plaques and scaling. Proinflammatory cytokines including TNF- α, IL-23, and IL-17 are upregulated in psoriatic lesions and promote hyperproliferation of keratinocytes. Furthermore, psoriasis is seen as a systemic inflammatory disease associated with psoriatic arthritis, obesity and cardiometabolic comorbidities. Obesity negatively affects psoriasis disease se verity by producing proinflammatory adipokines by adipocytes and infiltrated immune cells and aggravates furthermore the cardiovascular risk in psoriasis patients. (Source: Journal of...
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

EUROSTAD prospective observational study: Baseline characteristics, atopic dermatitis severity, and patient-reported outcomes
Background: The European Prospective Observational Study in Patients Eligible for Systemic Immunosuppressive Therapy for Atopic Dermatitis (EUROSTAD) aims to describe characteristics of patients treated with systemic therapy for atopic dermatitis (AD) over time and their management in a real-world setting. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Evaluating dermatology curricula in US medical schools
Background: Dermatologic conditions place a large burden on primary care providers, necessitating vigorous training on the identification and treatment of commonly presenting conditions. Prior studies have demonstrated that errors in diagnosis of dermatologic conditions and failure to consult with board-certified dermatologists result in poorer patient outcomes. Thus, medical schools can play an important role in providing appropriate education and exposure in dermatology for future practitioners. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Evaluating the safety and efficacy of adhesive strips for epidermal reinforcement in lower extremity wounds created by Mohs surgery
Background: Closure of lower extremity wounds created during surgery is challenging due in part to complications. Factors contributing to complications include limited blood perfusion, venous stasis, fragility of the overlying skin and inadequate wound care. In carefully selected patients, efficient wound closure in lower extremities can be facilitated by the use of adhesive strips. To our knowledge, there have been no large studies investigating efficacy of suturing through adhesive strips in lower extremity Mohs surgery wound closures. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Evaluating the prevalence, risk factors, and potential areas of intervention for posttraumatic stress disorder (PTSD) from autoimmune bullous diseases
Background: Symptoms of posttraumatic stress disorder (PTSD) have been observed in patients with life-threatening health conditions, ranging from cancer to asthma. Autoimmune blistering diseases (AIBD) are chronic, relapsing diseases that significantly impair quality of life in affected patients. Growing evidence has indicated a high degree of psychological distress associated with AIBD. Indeed, even during disease remission, many patients with AIBD can experience nonspecific symptoms similar that elicit significant anxiety and fear of recurrence of their skin disease. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Evaluating the influence of baseline disease characteristics on efficacy of a selective oral TYK2 inhibitor, BMS-986165, in patients with moderate-to-severe plaque psoriasis in a phase 2 trial
Introduction: BMS-986165 is a potent, highly selective oral tyrosine kinase 2 (TYK2) inhibitor that activates cytokine signaling pathways involved in psoriasis (PsO) pathophysiology. A 12-week, placebo-controlled, Phase 2 trial (NCT02931838) investigated the efficacy and safety of BMS-986165 in patients (pts) with moderate-to-severe plaque PsO. BMS-986165 showed a favorable safety profile, and Psoriasis Area and Severity Index (PASI) 75 responses were the highest at doses ≥3 mg twice daily (BID; 67–75%) vs placebo (7%; P (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Evaluation of effectiveness and safety in two optimization strategies with secukinumab in the treatment of moderate severe psoriasis
Introduction: Secukinumab is a totally human monoclonal antibody that selectively binds to the IL-17A and blocks its interaction with the IL-17 receptor, inhibiting the release of several proinflammatory cytokines. The effectiveness and safety of this anti-Il17A drug has been amply demonstrated in randomized clinical trials and in real clinical practice series. In a complicated socioeconomic environment, the need to evaluate other strategies of therapeutic optimization with the use of secukinumab in moderate severe psoriasis is imposed. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Evaluation of a facial cream ’s ability in hydrating location-related facial skin hydration under dry environments
Introduction: Dry skin can occur due to various environmental conditions especially when the humidity is low with little moisture in the air. The present studies were conducted to evaluate the effectiveness of a facial cream containing glacial glycoprotein and olive-derived squalane in hydrating facial skin, that is known to have location-related differences in the level of hydration, under high temperature and low humidity conditions. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Evaluation of the efficacy of autologous platelet-rich plasma in postoperative Mohs surgery patients: A prospective analysis
Introduction: Autologous plasma rich in platelets (PRP) is a derived blood product whose application and value in both clinical therapy and the cosmetics industry is still being assessed. Although the effectiveness of PRP as an antibacterial and regenerative agent in wound healing trajectories highlights its potential therapeutic value, more studies are still needed to understand this possible therapy ’s effectiveness, mechanism of action, and ideal dosing; especially in postoperative Mohs surgery patients. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Evaluation of the efficacy and tolerance of a facial treatment on subjects with self-perceived sensitive skin
Introduction: Sensitive skin is commonly associated with compromised skin barrier function and may be exacerbated by environmental, topical and internal factors. Further, it is often characterized by sensorial and visual signs such as discomfort and red, blotchy appearance. Studies have shown that sensitive skin is associated with higher transepidermal water loss (TEWL). The present studies were conducted to evaluate the efficacy and tolerance of a facial moisturizer with D-Panthenol and centella asiatica derived madecassoside on subjects with self-perceived sensitive skin. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Evaluation of the timeliness and accuracy of inpatient dermatology pathology reports at Saint Louis University Hospital
Background: An increased number of patients are being admitted to the hospital for dermatologic conditions. Studies have shown that dermatologic conditions are frequently misdiagnosed by nondermatologists. Dermatology consultations often result in changes in both the diagnosis and management of hospitalized patients, and thus play a critical role for the inpatient. The most common conditions seen by dermatology consult services are cutaneous infections, dermatitis, and drug eruptions. The majority of consult requests come from the internal medicine service. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Feedback in dermatology residency programs: A national survey
Background: Millennials —adults of ages 18-34 years—represent the largest share of the American workforce, and the average dermatology resident is considered a millennial. Recent surveys have demonstrated the value millennials place on receiving detailed and regular feedback and its positive influences. Many residency programs offer annual to semi-annual evaluation periods. However, more consistent and frequent feedback may improve resident satisfaction, performance, and patient care. Despite the known feedback preferences of millennials, no formal studies have thoroughly examined dermatology residency programs...
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Femoral artery ultrasound improves the screening of subclinical atherosclerosis in psoriasis. Analysis of its relationship with insulin resistance
Background: Psoriasis is associated with an increased risk of cardiovascular disease (CVD) at younger ages that is not identifiable by traditional risk factors. Screening for subclinical atherosclerosis with ultrasound has only been investigated in carotid arteries. The role of femoral arteries ultrasound remains to be elucidated for this purpose. The link between psoriasis and accelerated atherosclerosis in psoriasis has not yet been established. Our objective was to study the usefulness of femoral artery ultrasound for the detection of subclinical atherosclerosis in psoriasis. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Even mild hidradenitis suppurativa severely impairs patients ’ quality of life
Background: Hidradenitis suppurativa (HS) is a chronic debilitating dermatologic condition presenting with recurrent abscesses and interconnected sinus tracts. HS causes dramatic impairment of patients ’ quality of life. The purpose of this study is to better characterize this impairment by examining the relationship between HS and Dermatology Quality of Life Index (DLQI) score. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Ex vivo confocal microscopy of basal cell carcinoma on a 3-color scale
Introduction: Ex vivo confocal microscopy (CM) is a scanner laser microscope capable of visualizing freshly excised tissues in real-time with cellular resolution without ulterior sample processing. Depending on the laser wavelength, either reflectance (RCM) or fluorescence (FCM) can be collected from the tissue, obtaining thin digital images. It has been demonstrated that ex vivo CM is useful and reliable for fast evaluation of tumour margins during Mohs micrographic surgery (MMS). The use of dyes improved contrast, thus even small strands of BCC have been spotted in FCM mosaics. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Evidence for activity of GBR 830 (Anti-OX40) in extrinsic and intrinsic atopic dermatitis (AD): Post hoc analysis of a phase 2a study
Background: GBR 830 is a first-in-class, humanized, monoclonal immunoglobulin G1 antibody that selectively blocks the binding of OX40 to its OX40L ligand, thereby reducing the longevity and efficacy of effector and memory T cells. By blocking the OX40/OX40L pathway, GBR 830 has the potential to treat various T cell-mediated autoimmune diseases, including atopic dermatitis (AD). Topline results from a phase 2a study (NCT02683928) of adults with moderate-to-severe AD demonstrated that GBR 830 was safe and well tolerated. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Examining quality of life with apremilast in white and nonwhite patients with psoriasis: Analysis of the ESTEEM, PSOR-011, and UNVEIL trials
Background: Patients (pts) with psoriasis often report impaired quality of life (QOL). Apremilast demonstrated improved QOL in pts with moderate to severe psoriasis in the phase 2b PSOR-011 and phase 3 ESTEEM 1 and 2 (EST) studies and in pts with moderate psoriasis in the phase 4 UNVEIL study. We compared QOL findings in white and nonwhite pts in the pooled EST population and in PSOR-011 (nonwhite only) and UNVEIL. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Exosome for hair regeneration: From bench to bedside
Background: Exosome, a relatively recently founded 30- to 150-nm-sized extracellular vesicle, is secreted from most cells and acts as a communicator between them. We would like to explore whether exosomes from mesenchymal stem cells (MSCs) could be used as a novel therapeutic option for hair loss. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Exploratory study to examine the gene expression effects of retinol on aging-related molecular pathways in individuals of East Asian descent
Introduction: Retinol improves the appearance of photoaged skin while also minimizing the appearance of fine wrinkling in older individuals. However, it is unclear whether retinol merely reduces the appearance of skin aging features through structural changes or whether classic aging-related molecular pathways are also affected. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Experience with secukinumab in the treatment of palmoplantar pustular psoriasis: Analysis of 6 cases
Introduction and Objectives: Pustular palmoplantar psoriasis (PPPP) is a chronic inflammatory disease of the skin characterized by erythema, hyperkeratosis and crops of sterile pustules on palms and soles. Although it is considered a clinical variant of psoriasis vulgaris, the inflammatory molecular pathways involved have not been fully explained. Given the lack of approved pharmacologic agents for this indication and the frequent recalcitrant course of the disease, therapeutic options are limited. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Experience in patients with a history of malignancy through 3 years of continuous treatment with guselkumab in the VOYAGE 1 and 2 trials
Background: Malignancy is a potential safety concern for all immunosuppressive biologics. Guselkumab (GUS), a monoclonal antibody targeting interleukin 23, is approved for psoriasis. VOYAGE 1& 2 are randomized, double-blinded, placebo (PBO)/active comparator-controlled trials comparing GUS with PBO and adalimumab (ADA) in which patients (pts) with a history of malignancy with no evidence of recurrence for more than 5 years before screening were allowed to participate. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Exosomes promote skin wound healing
This study represents that the exosomes derived from ASCs (ASC-exo) play an important role in human dermal fibroblasts by stimulating its cell cycle. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Fear of negative evaluation correlates with worse quality of life in hidradenitis suppurativa patients
Background: Hidradenitis suppurativa (HS) is a chronic, debilitating dermatologic condition with extensive scarring and recurrent abscesses. The physical manifestations of the disease can create anxiety from fear of negative evaluation by others. The purpose is to determine the impact of fear of negative evaluation on the quality of life and mental well-being of patients with HS. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Factors that drive disparities in pruritus quality of life among Asian Americans: A qualitative study
Background: Racial disparities in the quality of life (QoL) impact of chronic pruritus (CP) have been reported. Specifically, Asian and Pacific Islanders (API) appear to be more commonly and severely impacted by CP. The factors underlying this disparity are unclear and likely multifactorial, including biological and sociocultural influences. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Facial Sweet syndrome resulting in Bell ’s palsy
Introduction: Sweet syndrome (SS) is a rare syndrome presenting with painful, erythematous plaques or nodules and fevers. Subtypes of SS include malignancy-associated SS, commonly linked to acute myelogenous leukemia (AML), and medication-associated SS, associated with granulocyte colony-stimulating factor (G-CSF). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Exploring the association between rosacea and gastrointestinal disease
Introduction: Rosacea is a common inflammatory skin disease characterized by flares of centrofacial flushing, erythema, and varying presence of papules, pustules, and telangiectasias. Establishing the validity of gastrointestinal (GI) bacterial associations with rosacea is important to test the hypothesis of rosacea presenting as a cutaneous manifestation of a more systemic inflammatory disease. As a systemic inflammatory disease, overgrowth of GI bacterial populations and/or their products may contribute to rosacea symptoms, driving disease flares. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Federal Adverse Event Reporting System (FAERS) postmarketing reports of injection site reactions with biologics approved to treat moderate-to-severe psoriasis
Introduction and Objectives: Injection-site reactions (ISRs) are localized skin reactions after an injection, typically characterized by erythema, edema and/or pain. Biologics used to treat moderate-to-severe plaque psoriasis (Ps) may cause ISRs. ISR frequency is often included in product labels. The United States (US) Food and Drug Administration collects spontaneous postmarketing reports of adverse events (AE) from drugs/biologics; these are included in the Federal Adverse Event Reporting System (FAERS) where they are coded by Medical Dictionary for Regulatory Activities preferred terms. (Source: Journal of the American ...
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Fears and misconceptions of women with chronic inflammatory diseases on their journey to motherhood
Introduction: Psoriasis (PSO) and psoriatic arthritis (PsA) often affect women of childbearing age; but it is unclear if these women ( ♀) feel able to make informed treatment decisions around pregnancy and breastfeeding. This survey gained insight on disease management and pregnancy, to assess if they feel adequately supported. Methods: Women (18–45 years) with chronic inflammatory diseases from the US, Japan, and Germany, Fran ce, UK, Italy and Spain (EU5) participated in a 20-min online survey (Jul–Oct 2017; InSites Consulting). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

First report of a phase IV study of electronic brachytherapy (EBx) in nonmelanoma skin cancer patients
Surgery, Doylestown, PA (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Frequency of depression in dermatologist-managed patients who have acne, isotretinoin-exposure vs no isotretinoin exposure: Pharmacovigilance analysis of a large Midwestern US population from the RADAR (Research on Adverse Drug events And Reports) program
Background: Prior studies have reported on both the occurrence or nonoccurrence of depression subsequent to isotretinoin exposure. The aim of this retrospective real-world study was to compare the frequency of depression occurring in dermatologist-managed patients diagnosed with acne and exposed to isotretinoin vs all other dermatology patients in the same practice setting who were diagnosed with acne, but not exposed to isotretinoin. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Frequency of the types of alopecia at 22 specialist hair clinics: A multicenter study
The objective of this study was to analyze the frequency of the different types of alopecia in patients evaluated at SHC across the globe and to analyze the possible differences in frequencies between geographic areas, gender, and age. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Fungal superinfection with herpes zoster of the tongue
Herpes zoster is a dermatologic condition characterized by multiple painful vesicles and ulceration along a dermatome innervated by a dorsal root or sensory ganglion. It is caused by reactivation of the varicella zoster virus (VZV) in the setting of stress, infection, illness or an immunosuppressed state. Common complications of herpes zoster include postherpetic neuralgia and bacterial superinfection. If cranial nerves are involved, patients may suffer from ophthalmologic sequelae or meningoencephalitis. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Generalized lichen nitidus: Response to systemic steroids and stabilization on cyclosporine in an adult patient
Introduction: Generalized lichen nitidus is a rare presentation of lichen nitidus with variable response to treatment and few reported cases in adult patients. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Geographic variation of industry funding and scholarly impact in academic dermatology
Background: Industry funding has repeatedly been shown to be associated with academic productivity in various medical specialties. As headquarters of various pharmaceutical and medical device companies vary in location, geography may play a role in acquiring industry funding. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Group clinic for chemoprevention of squamous cell carcinoma —A pilot study
Background: Shared medical appointments (SMAs) enhance adherence to medical recommendations. Despite their documented advantages in other specialties, SMAs have rarely appeared in the dermatology literature. Topical 5-fluorouracil (5-FU) for actinic keratosis (AKs), which relies on patient behavior for effectiveness, presents a therapeutic challenge that could benefit from the group clinic format. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Hair aging in a Caucasian population: Clinical and instrumental characterization
In this study, we tried to identify solely aging effects, on a Caucasian population, with clinical and biometrological descriptors. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Halobetasol 0.01%/tazarotene 0.045% lotion in the treatment of moderate-to-severe plaque psoriasis: Maintenance of therapeutic effect after cessation of therapy
Background: Psoriasis is a chronic, immune-mediated disease that varies widely in its clinical expression. Topical corticosteroids (TCS) are the mainstay of treatment. Long-term safety remains a concern, limiting use, and posttreatment flare common. Tazarotene has also been shown to be effective in psoriasis, with efficacy maintained several weeks posttreatment. Fixed combination therapy with TCS may improve psoriasis signs and may maintain a therapeutic effect while minimizing posttreatment flare or rebound (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Health insurance status as a predictor of default to follow-up care in psoriasis patients
Background: Many patients with psoriasis are not receiving treatment. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Health outcomes of uninsured patients with malignant melanoma: A free-clinic case series
This study assessed follow-up care of uninsured patients with a history of malignant melanoma in order to improve and ensure the highest quality long-term care. Demographics and chronic disease diagnoses were extracted from 4,804 patients managed at eight free-clinics from the Tampa Bay Area during 2016. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Health care service utilization by 116,816 patients with atopic dermatitis in Israel
Defining the epidemiology and health care service utilization in relation to atopic dermatitis is warranted. For that purpose, we designed a cross-sectional study based on a group of patients with atopic dermatitis and a matched comparison group of enrollees without atopic dermatitis using the large medical database. Health care service utilization usage were extracted and compared between the groups. The study included 116,816 patients with atopic dermatitis and 116,812 controls. Atopic dermatitis was associated with an increased burden of health care utilization across the entire spectrum compared with the general popula...
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Hereditary leiomyomatosis and renal cell cancer: A case series from southeast Spain
Hereditary leiomyomatosis and renal cell cancer (HLRCC, OMIM 150800) is an autosomal dominant syndrome characterized by cutaneous leiomyiomas (CLM), benign tumors arising from the erector pili muscle, uterine leiomyomas in female patients and renal cell cancer (RCC) specially the aggressive type 2 papillary form. It is caused by mutations in the fumarate hydratase gene (FH) which codifies the enzyme fumarate hydratase, involved in the Krebs cycle catalyzing the conversion of fumarate to malate. FH loss secondary to germline mutations leads to an aberrant accumulation of fumarate which acts as an oncogenic metabolite. (Sour...
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Hidradenitis and sexual health: How should health providers ask about genital disease and impact on sexual health?
Introduction: Hidradenitis suppurativa (HS) has been shown to have a negative impact on quality of life, even more so than psoriasis, acne and eczema. Research has only recently focused on the impact HS has on sexual health. HS patients may experience sexual decline due to pain, physical appearance, and diminished sexual desire. Dermatologists who treat this chronic condition are in a unique position to screen these patients for sexual health concerns and provide counseling or specialized referral (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Hidradenitis suppurativa and diabetes mellitus: Updated systematic review and multivariate-adjusted metaanalysis
Introduction: Hidradenitis suppurativa (HS) is a debilitating and distressing chronic inflammatory skin disease. It is characterized by recurrent, painful, deep-seated skin nodules which can be complicated by abscesses formation, sinus tracks, fistulae and scarring. There is also evolving evidence supporting the association between HS and cardiovascular risk factors, including smoking, obesity, hyperlipidaemia, and metabolic syndrome. Notably, these are clinical features and risk factors that are closely associated with type 2 diabetes mellitus (DM). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Hidradenitis suppurativa and metabolic syndrome —Systematic review and multivariate-adjusted metaanalysis
Background: Hidradenitis suppurativa (HS) is a debilitating and distressing chronic inflammatory skin disease. Other chronic inflammatory diseases have been linked with metabolic syndrome. However, it is unclear whether this association is independent or driven by underlying risk factors and comorbidities in common, such as obesity, dyslipidemia, hyperglycemia and hypertension. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Hidradenitis suppurativa and polycystic ovarian syndrome: Systematic review and metaanalysis
Background: Hidradenitis suppurativa (HS) has been associated with various endocrine and autoimmune disorders. Although signs of hyperandrogenism are commonly observed amongst HS patients, few formal studies have assessed the relationship between HS and polycystic ovarian syndrome (PCOS). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Hidradenitis suppurativa has an enormous impact on patients ’ lives
Background: Hidradenitis suppurativa (HS) is a chronic, debilitating dermatological conditions with recurrent abscesses and fistulas. HS has a severe effect on overall health and well-being. The purpose of this study is to measure the health-related quality of life in a population of HS patients. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Hidradenitis suppurativa in adult patients. A Spanish Multicenter study of 604 patients
Introduction: Hidradenitis suppurativa (HS) is a chronic, systemic, inflammatory and immune-mediated disease of the hair follicle affecting around 1% of the population. There are few data regarding its real implications in Spanish population. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

High frequency ultrasound in cutaneous lymphomas
Introduction: High frequency ultrasound is becoming a common tool in dermatology ´s office. Several studies support this technique for demarking surgical edges before removal nonmelanoma skin cancer, classifying basal cell carcinomas in high risk vs low risk, and showing infiltrative components after incisional biopsy of superficial basal cell carcinomas. Only few studies descr ibe the sonographic findings of skin lymphomas and its applications in the clinical practice. We expose ultrasound features of patients with skin lymphoma. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

High rates of cutaneous infections in injection drug users with wounds
Wounds and soft tissue skin infections, including abscesses and cellulitis represent substantial cause of morbidity for people who inject drugs (PWID) and are the main reason that PWID visit the emergency department. However, wounds in PWID have been understudied. The purpose of this study is to determine the prevalence of both acute and chronic wounds within a community-based population of PWID frequenting the Infectious Disease Elimination Act (IDEA) needle exchange program. We conducted a cross-sectional investigation of IDEA clients (ie, PWID) ≥18 years old with either acute or chronic wounds who completed an in-per...
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

High-sensitivity C-reactive protein levels in a pooled plaque psoriasis study population
Psoriasis is associated with inflammatory, metabolic and cardiovascular comorbidity. Psoriasis patients show various signs of low-grade systemic inflammation, which may contribute to the development of peripheral insulin resistance, type 2 diabetes and atherosclerosis. High-sensitivity C-reactive protein (hs-CRP) is regarded as a marker that is able to detect low-grade inflammatory processes. In this context, the correlation of certain psoriatic comorbidities and metabolic parameters with hs-CRP at baseline was examined. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research