Transsynaptic Fish-lips signaling prevents misconnections between nonsynaptic partner olfactory neurons [Neuroscience]
Our understanding of the mechanisms of neural circuit assembly is far from complete. Identification of wiring molecules with novel mechanisms of action will provide insights into how complex and heterogeneous neural circuits assemble during development. In the Drosophila olfactory system, 50 classes of olfactory receptor neurons (ORNs) make precise synaptic... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Qijing Xie, Bing Wu, Jiefu Li, Chuanyun Xu, Hongjie Li, David J. Luginbuhl, Xin Wang, Alex Ward, Liqun Luo Tags: Biological Sciences Source Type: research

Increased ER-mitochondria tethering promotes axon regeneration [Neuroscience]
Translocation of the endoplasmic reticulum (ER) and mitochondria to the site of axon injury has been shown to facilitate axonal regeneration; however, the existence and physiological importance of ER–mitochondria tethering in the injured axons are unknown. Here, we show that a protein linking ER to mitochondria, the glucose regulated protein... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Soyeon Lee, Wei Wang, Jinyeon Hwang, Uk Namgung, Kyung-Tai Min Tags: Biological Sciences Source Type: research

The neural circuit linking mushroom body parallel circuits induces memory consolidation in Drosophila [Neuroscience]
Memory consolidation is augmented by repeated learning following rest intervals, which is known as the spacing effect. Although the spacing effect has been associated with cumulative cellular responses in the neurons engaged in memory, here, we report the neural circuit-based mechanism for generating the spacing effect in the memory-related mushroom... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Hiroko Awata, Mai Takakura, Yoko Kimura, Ikuko Iwata, Tomoko Masuda, Yukinori Hirano Tags: Biological Sciences Source Type: research

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion [Physiology]
Membrane transporters and receptors are responsible for balancing nutrient and metabolite levels to aid body homeostasis. Here, we report that proximal tubule cells in kidneys sense elevated endogenous, gut microbiome-derived, metabolite levels through EGF receptors and downstream signaling to induce their secretion by up-regulating the organic anion transporter-1 (OAT1). Remote... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Jitske Jansen, Katȷa Jansen, Ellen Neven, Ruben Poesen, Amr Othman, Alain van Mil, Joost Sluiȷter, Javier Sastre Torano, Esther A. Zaal, Celia R. Berkers, Diederik Esser, Harry J. Wichers, Karin van Ede, Maȷorie van Duursen, Stephane Tags: Biological Sciences Source Type: research

The Rho-family GTPase OsRac1 controls rice grain size and yield by regulating cell division [Plant Biology]
Grain size is a key factor for determining grain yield in crops and is a target trait for both domestication and breeding, yet the mechanisms underlying the regulation of grain size are largely unclear. Here we show that the grain size and yield of rice (Oryza sativa) is positively regulated... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Ying Zhang, Yan Xiong, Renyi Liu, Hong-Wei Xue, Zhenbiao Yang Tags: Biological Sciences Source Type: research

Gain control of saccadic eye movements is probabilistic [Psychological and Cognitive Sciences]
Saccades are rapid eye movements that orient the visual axis toward objects of interest to allow their processing by the central, high-acuity retina. Our ability to collect visual information efficiently relies on saccadic accuracy, which is limited by a combination of uncertainty in the location of the target and motor... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Matteo Lisi, Joshua A. Solomon, Michael J. Morgan Tags: Biological Sciences Source Type: research

Credit assignment to state-independent task representations and its relationship with model-based decision making [Psychological and Cognitive Sciences]
Model-free learning enables an agent to make better decisions based on prior experience while representing only minimal knowledge about an environment’s structure. It is generally assumed that model-free state representations are based on outcome-relevant features of the environment. Here, we challenge this assumption by providing evidence that a putative model-free... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Nitzan Shahar, Rani Moran, Tobias U. Hauser, Rogier A. Kievit, Daniel McNamee, Michael Moutoussis, NSPN Consortium, Raymond J. Dolan Tags: Social Sciences Source Type: research

Officer characteristics and racial disparities in fatal officer-involved shootings [Psychological and Cognitive Sciences]
Despite extensive attention to racial disparities in police shootings, two problems have hindered progress on this issue. First, databases of fatal officer-involved shootings (FOIS) lack details about officers, making it difficult to test whether racial disparities vary by officer characteristics. Second, there are conflicting views on which benchmark should be... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: David J. Johnson, Trevor Tress, Nicole Burkel, Carley Taylor, Joseph Cesario Tags: Social Sciences Source Type: research

Prestimulus feedback connectivity biases the content of visual experiences [Psychological and Cognitive Sciences]
Ongoing fluctuations in neural excitability and in networkwide activity patterns before stimulus onset have been proposed to underlie variability in near-threshold stimulus detection paradigms—that is, whether or not an object is perceived. Here, we investigated the impact of prestimulus neural fluctuations on the content of perception—that is, whether one or... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Elie Rassi, Andreas Wutz, Nadia Muller–Voggel, Nathan Weisz Tags: Biological Sciences Source Type: research

Effects of policy-driven hypothetical air pollutant interventions on childhood asthma incidence in southern California [Social Sciences]
Childhood asthma is a major public health concern and has significant adverse impacts on the lives of the children and their families, and on society. There is an emerging link between air pollution, which is ubiquitous in our environment, particularly in urban centers, and incident childhood asthma. Here, using data... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Erika Garcia, Robert Urman, Kiros Berhane, Rob McConnell, Frank Gilliland Tags: Social Sciences Source Type: research

Reconciling modern machine-learning practice and the classical bias-variance trade-off [Statistics]
Breakthroughs in machine learning are rapidly changing science and society, yet our fundamental understanding of this technology has lagged far behind. Indeed, one of the central tenets of the field, the bias–variance trade-off, appears to be at odds with the observed behavior of methods used in modern machine-learning practice. The... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Mikhail Belkin, Daniel Hsu, Siyuan Ma, Soumik Mandal Tags: Physical Sciences Source Type: research

Membraneless polyester microdroplets as primordial compartments at the origins of life [Systems Biology]
Compartmentalization was likely essential for primitive chemical systems during the emergence of life, both for preventing leakage of important components, i.e., genetic materials, and for enhancing chemical reactions. Although life as we know it uses lipid bilayer-based compartments, the diversity of prebiotic chemistry may have enabled primitive living systems to... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 6, 2019 Category: Science Authors: Tony Z. Jia, Kuhan Chandru, Yayoi Hongo, Rehana Afrin, Tomohiro Usui, Kunihiro Myojo, H. James Cleaves II Tags: Physical Sciences Source Type: research

Molecular Testing for Advanced Non-Small Cell Lung Cancer in Malaysia: Consensus Statement from the College of Pathologists, Academy of Medicine Malaysia, the Malaysian Thoracic Society, and the Malaysian Oncological Society
Lung cancer is the second most common cancer globally. However, it is the most common cause of cancer death. In 2015, there were 2 million incident cases of lung cancer and 1.7 million deaths worldwide. [1] (Source: Lung Cancer)
Source: Lung Cancer - August 5, 2019 Category: Cancer & Oncology Authors: Pathmanathan Rajadurai, Phaik Leng Cheah, Soon Hin How, Chong Kin Liam, Muhammad Azrif Ahmad Annuar, Norhayati Omar, Noriah Othman, Nurhayati Mohd Marzuki, Yong Kek Pang, Ros Suzanna Ahmad Bustamam, Lye Mun Tho Tags: Review Source Type: research

A novel technique of using smartphones as Operating Microscope
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 5, 2019 Category: Dermatology Authors: Sanjeev Gupta, Kartikay Aggarwal, Ravi Shankar Jangra, Saurabh Swaroop Gupta Source Type: research

Efficacy and safety of methotrexate add-on therapy versus placebo for patients with chronic spontaneous urticaria resistant to H1-antihistamines: a randomized, controlled trial
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 5, 2019 Category: Dermatology Authors: S. Leducq, M. Samimi, C. Bernier, A. Soria, E. Amsler, D. Staumont-Sall é, G. Gabison, O. Chosidow, N. Beneton, C. Bara, A. Grange-Prunier, E. Wierzbicka-Hainaut, E. Brenaut, C. Droitcourt, N. Raison-Peyron, H. Bourgoin, H. Cornillier, L. Machet, B. Gira Source Type: research

Warren R. Heymann, MD
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 5, 2019 Category: Dermatology Authors: Warren Heymann Source Type: research

Comments on “Basal cell carcinoma: Contemporary approaches to diagnosis, treatment, and prevention”
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 5, 2019 Category: Dermatology Authors: Anirudh Sethi, Meagan Vogt, Jason Brocato, Lindsay Habeeb, Nicholas Squittieri Source Type: research

Spray sunscreen: characterizing application area density and implications for sun protection
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 5, 2019 Category: Dermatology Authors: Lindsey Broussard, Sarah Hirner, Robert P. Dellavalle, Cory A. Dunnick, Jeremy Hugh Source Type: research

Telangiectasia macularis eruptiva perstans (TMEP): A form of cutaneous mastocytosis with potential systemic involvement
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 5, 2019 Category: Dermatology Authors: Adam Friedman Source Type: research

Comparative effectiveness of biologic agents for the treatment of psoriasis in a real-world setting: Results from a large, prospective, observational study (Psoriasis Longitudinal Assessment and Registry [PSOLAR])
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 5, 2019 Category: Dermatology Authors: Adam Friedman Source Type: research

A systematic review of the safety and efficacy of systemic corticosteroids in atopic dermatitis
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 5, 2019 Category: Dermatology Authors: Eliot Mostow Source Type: research

Improved clinical outcome and biomarkers in adults with papulopustular rosacea treated with doxycycline modified-release capsules in a randomized trial
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 5, 2019 Category: Dermatology Authors: Adam Friedman Source Type: research

Cellulitis Recurrence Score: A tool for predicting recurrence of lower limb cellulitis
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 5, 2019 Category: Dermatology Authors: Eliot Mostow Source Type: research

Taste Exposure Increases Intake and Nutrition Education Increases Willingness to Try an Unfamiliar Vegetable in Preschool Children: A Cluster Randomized Trial
ConclusionsTaste exposures encouraged children to eat more of the unfamiliar vegetable, whereas nutrition education encouraged children who were noneaters to try the vegetable. Both approaches were effective and can be used to produce different outcomes. (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - August 2, 2019 Category: Nutrition Source Type: research

Increasing Intake of an Unfamiliar Vegetable in Preschool Children Through Learning Using Storybooks and Sensory Play: A Cluster Randomized Trial
ConclusionsCongruency between storybook and vegetable increased intake; sensory play with celeriac increased the likelihood of eating celeriac. Storybooks and sensory play are simple interventions to increase willingness to try an unfamiliar vegetable. (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - August 2, 2019 Category: Nutrition Source Type: research

Building capacity in Africa's national science academies
Publication date: 3–9 August 2019Source: The Lancet, Volume 394, Issue 10196Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - August 2, 2019 Category: General Medicine Source Type: research

Fellow Versus Resident: Graduate Medical Education and Patient Outcomes After Anterior Cervical Diskectomy and Fusion Surgery.
This study shows that patient health-related outcomes are similar in ACDF cases that were fellow-assisted versus resident-assisted. However, fellow-assisted ACDF cases were associated with more blood loss and longer surgery time. PMID: 31365356 [PubMed - as supplied by publisher] (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - August 2, 2019 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Access to Elective Orthopaedic Surgery After the Affordable Care Act Medicaid Expansion: The New York State Experience.
Authors: Williamson TR, Paoli AR, Hutzler L, Zuckerman J, Bosco J Abstract BACKGROUND: As part of the Patient Protection and Affordable Care Act, states were given the option of expanding Medicaid coverage to include adults younger than age 65 years with income at or below 138% of the federal poverty level. Although this expansion was intended to provide health care coverage to an estimated 20 million Americans, several studies have shown increased coverage does not equate to increased access to care by specialty providers. METHODS: We queried the New York Statewide Planning and Research Cooperative System data...
Source: The Journal of the American Academy of Orthopaedic Surgeons - August 2, 2019 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Behavior Modification Reduces Psychotropic Medication Use in Inpatient Children With Aggression: A Retrospective Cohort Study
In this study we examine changes in PRN (pro re nata, or ‘as needed’) psychotropic medication use to manage severe aggression on a children’s psychiatric inpatient unit, comparing rates before and after a behavior modification program (BMP) was discontinued. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - August 2, 2019 Category: Psychiatry Authors: Gabrielle A. Carlson, Jaclyn Chua, Katherine Pan, Tahsin Hasan, Adam Bied, Andr és Martin, Daniel N. Klein Tags: New Research Source Type: research

Empowering the Next Generation to End Stigma By Starting the Conversation: Bring Change to Mind and the College Toolbox Project
To examine outcomes in a four-year college pilot program built on stigma change research. U Bring Change to Mind (UBC2M) was developed and launched at Indiana University (IU) in 2014 as an institutionally-supported, student-led organization to make campuses “safe and stigma-free zones.” The accompanying College Toolbox Project (CTP) assessed change in student prejudice and discriminatory predispositions as well as perceptions and behaviors at follow-up. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - August 2, 2019 Category: Psychiatry Authors: Bernice A. Pescosolido, Brea L. Perry, Anne C. Krendl Tags: New Research Source Type: research

27. effectiveness of delivering difficult news training: improved skills and self-efficacy of pediatric trainees
Publication date: August 2019Source: Academic Pediatrics, Volume 19, Issue 6Author(s): Tanya D. Murtha, Emily Pinto Taylor, Joana Tala, Andrea Asnes, Janet Hafler, Stephanie Massaro, Sarah KandilBackgroundDelivering difficult news to patients and families is an essential but challenging communication skill. Pediatric trainees report limited training, competence, or comfort in this skill, and when tested, perform poorly.ObjectiveTo assess the effectiveness of a modified American Academy of Pediatrics (AAP) Resiliency Curriculum (Part B) to improve skills and self-efficacy of pediatric trainees in delivering bad news.Methods...
Source: Academic Pediatrics - August 1, 2019 Category: Pediatrics Source Type: research

83. the carolinas collaborative: how a pediatric residency training program collaborative improved community health and advocacy curricula
ConclusionInvolvement in a multi-institutional Residency Training Collaborative can improve the quality and depth of Community Health and Advocacy education for residents. Both the breadth and depth of curricula improved, but the changes in level of learning, as defined by Miller's Pyramid, were the most significant. (Source: Academic Pediatrics)
Source: Academic Pediatrics - August 1, 2019 Category: Pediatrics Source Type: research

101. resident-led qi initiative to improve assessment and care of patients with early childhood caries
Conclusions and Next StepsImplementation of this QI project showed our patient population was at high-risk for ECC, which had previously been unknown, and decreased with our interventions. Creation of an electronic screening tool facilitated screening. Family education and providing a referral list of community dentists were the most successful interventions. Next steps include creating an electronic dental referral system and partnering with community dentists to enhance ECC-related family and patient education. (Source: Academic Pediatrics)
Source: Academic Pediatrics - August 1, 2019 Category: Pediatrics Source Type: research

A Seat at the Table: Strategic Engagement in Service Activities for Early-Career Faculty From Underrepresented Groups in the Academy
Many academic institutions strive to promote more diverse and inclusive campuses for faculty, staff, and students. As part of this effort, these institutions seek to include individuals from historically underrepresented groups (URGs)—such as women, people from racial/ethnic minority populations, persons with disabilities—on committees and in other service activities. However, given the low number of faculty members from URGs at many institutions, these faculty members tend to receive more requests to provide service to the institution or department (e.g., serving on committees, mentoring) than their counterpar...
Source: Academic Medicine - August 1, 2019 Category: Universities & Medical Training Tags: Invited Commentaries Source Type: research

A National Patient Safety Curriculum in Pediatric Emergency Medicine
Conclusions An online centralized curriculum is an effective platform for teaching content in quality and safety to a national group of physicians. Local oversight by program directors may improve compliance with curriculum completion. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - August 1, 2019 Category: Emergency Medicine Tags: Original Articles Source Type: research

A Survey Assessment of Perceived Importance and Methods of Maintenance of Critical Procedural Skills in Pediatric Emergency Medicine
Conclusions Critical procedural skills are perceived by emergency providers who care for children as extremely important to maintain. Direct care of pediatric patients likely does not provide sufficient opportunity to maintain these skills. There are widespread deficiencies relating to mandatory maintenance of critical procedural skill training. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - August 1, 2019 Category: Emergency Medicine Tags: Original Articles Source Type: research

Safety of Shujinjianyao pill in clinical real world: A prospective, observational, multicenter, large-sample study Protocol
This study will obtain the safety results of SJJYP in clinical real world, which will offer a scientific basis for clinicians in the treatment of low back pain, and also provide a methodological basis for the safety study of other medicines. Trial registration: ClinicalTrial.gov registration number is NCT03598153. This study was approved by the ethics committee of Wangjing hospital, China Academy of Chinese Medical Sciences (WJEC-KT-2018-012-P002). (Source: Medicine)
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Gender Expression and Sexual Orientation Differences in Diet Quality and Eating Habits from Adolescence to Young Adulthood
Publication date: Available online 30 July 2019Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Nicole A. VanKim, Heather L. Corliss, Hee-Jin Jun, Jerel P. Calzo, Manar AlAwadhi, S. Bryn AustinAbstractBackgroundDiet and eating habits during youth have implications on diet and eating habits during adulthood, however, little longitudinal research has examined sexual orientation and gender expression differences in diet.ObjectiveOur aim was to examine sexual orientation and gender expression differences in diet quality and eating habits from adolescence to young adulthood.DesignData across multiple time poi...
Source: Journal of the Academy of Nutrition and Dietetics - August 1, 2019 Category: Nutrition Source Type: research

More Evidence Against Antibiotics for Acute Asthma Exacerbations.
PMID: 31361096 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Shrikant Kulkarni N Tags: Am Fam Physician Source Type: research

Infantile Hemangioma: AAP Releases Guideline for Management.
PMID: 31361095 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Hoover L Tags: Am Fam Physician Source Type: research

Asthma, PAD and Cardiovascular Disease, Persons Who Inject Drugs, Crohn's Disease, Insulin Analogs.
Authors: PMID: 31361097 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - August 1, 2019 Category: Primary Care Tags: Am Fam Physician Source Type: research

Hematologic Abnormality in a Young Soldier.
PMID: 31361098 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Howes AB Tags: Am Fam Physician Source Type: research

Chronic Neck Pain: Nonpharmacologic Treatment.
PMID: 31361100 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Barreto TW, Svec JH Tags: Am Fam Physician Source Type: research

Skin-to-Skin Contact for Improved Duration of Breastfeeding.
PMID: 31361099 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Kusko M, Benko R Tags: Am Fam Physician Source Type: research

Ingrown Toenails.
Authors: PMID: 31361109 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - August 1, 2019 Category: Primary Care Tags: Am Fam Physician Source Type: research

Should Adults with Prediabetes Be Prescribed Metformin to Prevent Diabetes Mellitus? Yes: High-Quality Evidence Supports Metformin Use in Persons at High Risk.
PMID: 31361108 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Moin T Tags: Am Fam Physician Source Type: research

Should Adults with Prediabetes Be Prescribed Metformin to Prevent Diabetes Mellitus? No: Evidence Does Not Show Improvements in Patient-Oriented Outcomes.
PMID: 31361107 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Brown SR Tags: Am Fam Physician Source Type: research

Ingrown Toenail Management.
Abstract Ingrown toenails account for approximately 20% of foot problems in primary care. The great toe is most often affected. Ingrown toenails occur most commonly in young men, and nail care habits and footwear are most often contributory factors. No consensus has been reached for the best treatment approach, but ingrown nails may be nonsurgically or surgically treated. Nonsurgical treatments are typically used for mild to moderate ingrown nails, whereas surgical approaches are used in moderate and severe cases. Simple nonsurgical palliative measures include correcting inappropriate footwear, managing hyperhidro...
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Mayeaux EJ, Carter C, Murphy TE Tags: Am Fam Physician Source Type: research

Hirsutism in Women.
Abstract Hirsutism is the excessive growth of terminal hair in a typical male pattern in a female. It is often a sign of excessive androgen levels. Although many conditions can lead to hirsutism, polycystic ovary syndrome and idiopathic hyperandrogenism account for more than 85% of cases. Less common causes include idiopathic hirsutism, nonclassic congenital adrenal hyperplasia, androgen-secreting tumors, medications, hyperprolactinemia, thyroid disorders, and Cushing syndrome. Women with an abnormal hirsutism score based on the Ferriman-Gallwey scoring system should be evaluated for elevated androgen levels. Wome...
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Matheson E, Bain J Tags: Am Fam Physician Source Type: research

Dapagliflozin in High-Risk Type 2 Diabetes Reduces Hospitalization for Heart Failure But Does Not Reduce Death, Myocardial Infarction, or Stroke.
PMID: 31361104 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Ebell MH Tags: Am Fam Physician Source Type: research