May 2021 Sites in Review
This web resource complements the original research paper “Wisconsin school wellness policies after federal legislation change: Understanding key mechanisms of policy improvement” published in the May issue of the Journal. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - April 21, 2021 Category: Nutrition Tags: From the Academy Source Type: research

A Novel tp0548 Gene Type of Treponema pallidum Identified in Nanjing, China: Case Report and Review of Literature
Conclusion The novel tp0548 sequence type of T. pallidum not only expands the database up to 27 different sequence types but also indicates the substantial genetic diversity of the tp0548 gene sequence. (Source: Sexually Transmitted Diseases)
Source: Sexually Transmitted Diseases - April 21, 2021 Category: Sexual Medicine Tags: Original Studies Source Type: research

JAAD Game Changers: Comorbidity scores associated with limited life expectancy in the very elderly with nonmelanoma skin cancer
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Eden Lake Source Type: research

Using Sterile Adhesive Bandages to Maintain a Sterile Field during Dermatologic Surgery
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Paul Curtiss, Derek Davis, Divya Srivastava, Rajiv I. Nijhawan Source Type: research

Drug Survival of Systemic and Biologic Monotherapy Treatments for Pityriasis Rubra Pilaris: A Retrospective Observational Study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Caroline Kettering, Hasan Khosravi, Camila Ortiz, Joseph C. English Source Type: research

JAAD Game Changers: The role of wide local excision for the treatment of severe hidradenitis suppurativa (Hurley grade III): Retrospective analysis of 74 patients.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Andrew Thomas Patterson Source Type: research

JAAD Game Changers: Comparison of surgical margins for lentigo maligna versus melanoma in situ
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Jane Margaret Grant-Kels Source Type: research

JAAD Game Changers: Application of Mohs micrographic surgery appropriate-use criteria to skin cancers at a university health system
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Robert T. Brodell Source Type: research

IJERPH, Vol. 18, Pages 4405: Phase Angle Is Related to 10 m and 30 m Sprint Time and Repeated-Sprint Ability in Young Male Soccer Players
Conclusions: Our results suggest that young soccer players with higher PhA values, indicating better cell integrity and functionality, have better performance in typical anaerobic running activities, such as sprinting speed and RSA performance, adjusted to age and body composition characteristics. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - April 21, 2021 Category: Environmental Health Authors: Priscila Cust ódio Martins Anderson Santiago Teixeira Luiz Guilherme ANTONACCI Guglielmo Juliana Sabino Francisco Diego Augusto Santos Silva F ábio Yuzo Nakamura Luiz Rodrigo Augustemak de Lima Tags: Article Source Type: research

Correction
Shahriari N, Lin T-c, Litman HJ, Dube B, McLean RR, Shahriari M. Characterization of real-world psoriasis patients with and without a history of depression: The Corrona Psoriasis Registry. J Am Acad Dermatol. 2021;84(5):1444-1447. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Tags: Correction Source Type: research

Treatment of patients with atopic dermatitis with weekly dupilumab dosing: a single institutional retrospective medical record review and survey
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: David X. Gao, Jared S. Kahn, Stephanie R. Cohen, Kristin Fiumara, Anh Lam, Nicole Dumont, David Rosmarin Source Type: research

JAAD Game Changers: Comparative effectiveness of nonpurpuragenic 595-nm pulsed dye laser and microsecond 1064-nm neodymium:yttrium-aluminum-garnet laser for treatment of diffuse facial erythema: A double-blind randomized controlled trial
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Faramarz H. Samie Source Type: research

Costly Savings: An Ethical Analysis of Copay Assistance Programs in Dermatology
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Ameya Gangal, Benjamin Stoff Source Type: research

Ethical implications of senior authorship
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Jane M. Grant-Kels, Margot S. Peters Source Type: research

Platinum(II) N-heterocyclic carbene complexes arrest metastatic tumor growth [Chemistry]
Vimentin is a cytoskeletal intermediate filament protein that plays pivotal roles in tumor initiation, progression, and metastasis, and its overexpression in aggressive cancers predicted poor prognosis. Herein described is a highly effective antitumor and antimetastatic metal complex [PtII(C^N^N)(NHC2Bu)]PF6 (Pt1a; HC^N^N = 6-phenyl-2,2′-bipyridine; NHC= N-heterocyclic carbene) that engages vimentin via noncovalent... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Pui-Ki Wan, Ka-Chung Tong, Chun-Nam Lok, Chunlei Zhang, Xiao-Yong Chang, Kong-Hung Sze, Alice Sze Tsai Wong, Chi-Ming Che Tags: Chemistry Physical Sciences Source Type: research

News Feature: Voyager still breaking barriers decades after launch [Astronomy]
As Voyagers 1 and 2 continue their epic journeys through interstellar space, they're resolving past controversies and even helping to spark a new one: the true shape of the heliosphere. Launched more than four decades ago, the two Voyager spacecraft keep expanding our horizons. Having flown past the giant planets... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Ken Croswell Tags: News Features, Astronomy, Front Matter Source Type: research

Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs [Medical Sciences]
Cancer cells can survive chemotherapy-induced stress, but how they recover from it is not known. Using a temporal multiomics approach, we delineate the global mechanisms of proteotoxic stress resolution in multiple myeloma cells recovering from proteasome inhibition. Our observations define layered and protracted programs for stress resolution that encompass extensive... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Paula Saavedra–Garcia, Monica Roman–Trufero, Hibah A. Al–Sadah, Kevin Blighe, Elena Lopez–Jimenez, Marilena Christoforou, Lucy Penfold, Daria Capece, Xiaobei Xiong, Yirun Miao, Katarzyna Parzych, Valentina S. Caputo, Alexandros P. Tags: Medical Sciences Biological Sciences Source Type: research

Parallel evolution of UbiA superfamily proteins into aromatic O-prenyltransferases in plants [Plant Biology]
Plants produce ∼300 aromatic compounds enzymatically linked to prenyl side chains via C–O bonds. These O-prenylated aromatic compounds have been found in taxonomically distant plant taxa, with some of them being beneficial or detrimental to human health. Although their O-prenyl moieties often play crucial roles in the biological activities of... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Ryosuke Munakata, Alexandre Olry, Tomoya Takemura, Kanade Tatsumi, Takuȷi Ichino, Cloe Villard, Joȷi Kageyama, Tetsuya Kurata, Masaru Nakayasu, Florence Jacob, Takao Koeduka, Hirobumi Yamamoto, Eiko Moriyoshi, Tetsuya Matsukawa, Jeremy Gros& Tags: Plant Biology Biological Sciences Source Type: research

Incipient genome erosion and metabolic streamlining for antibiotic production in a defensive symbiont [Evolution]
Genome erosion is a frequently observed result of relaxed selection in insect nutritional symbionts, but it has rarely been studied in defensive mutualisms. Solitary beewolf wasps harbor an actinobacterial symbiont of the genus Streptomyces that provides protection to the developing offspring against pathogenic microorganisms. Here, we characterized the genomic architecture... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Taras Y. Nechitaylo, Mario Sandoval–Calderon, Tobias Engl, Natalie Wielsch, Diane M. Dunn, Alexander Goesmann, Erhard Strohm, Aleš Svatoš, Colin Dale, Robert B. Weiss, Martin Kaltenpoth Tags: Evolution Biological Sciences Source Type: research

Direct validation of dune instability theory [Earth, Atmospheric, and Planetary Sciences]
Modern dune fields are valuable sources of information for the large-scale analysis of terrestrial and planetary environments and atmospheres, but their study relies on understanding the small-scale dynamics that constantly generate new dunes and reshape older ones. Here, we designed a landscape-scale experiment at the edge of the Gobi desert,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Ping Lu, Clement Narteau, Zhibao Dong, Philippe Claudin, Sebastien Rodriguez, Zhishan An, Laura Fernandez–Cascales, Cyril Gadal, Sylvain Courrech du Pont Tags: Earth, Atmospheric, and Planetary Sciences Physical Sciences Source Type: research

Role of bacterial RNA polymerase gate opening dynamics in DNA loading and antibiotics inhibition elucidated by quasi-Markov State Model [Biophysics and Computational Biology]
To initiate transcription, the holoenzyme (RNA polymerase [RNAP] in complex with σ factor) loads the promoter DNA via the flexible loading gate created by the clamp and β-lobe, yet their roles in DNA loading have not been characterized. We used a quasi-Markov State Model (qMSM) built from extensive molecular dynamics... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Ilona Christy Unarta, Siqin Cao, Shintaroh Kubo, Wei Wang, Peter Pak-Hang Cheung, Xin Gao, Shoji Takada, Xuhui Huang Tags: Biophysics and Computational Biology Physical Sciences Source Type: research

Inequalities in jail incarceration across the life course [Social Sciences]
The expansive and unequal reach of the criminal justice system is well documented. Annually in the United States, 62 million individuals experience police contact, and 10 million are arrested (1, 2). There are about 10.6 million jail admissions and about 600,000 state or federal prison admissions annually (3). These point... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Kristin Turney Tags: Social Sciences, Commentaries Commentary Source Type: research

To eat, or not to eat, that is the question: Neural stem cells escape phagocytosis in autism with macrocephaly [Neuroscience]
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder that is thought to emerge very early in development. Cerebral overgrowth, which is clinically referred to as macrocephaly, is frequently observed in children with ASD, and brain imaging studies have reported increases in both gray- and white-matter volume (1–6). Children... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Simon T. Schafer, Fred H. Gage Tags: Neuroscience, Commentaries Commentary Source Type: research

Electrical unfolding of cytochrome c during translocation through a nanopore constriction [Biophysics and Computational Biology]
Many small proteins move across cellular compartments through narrow pores. In order to thread a protein through a constriction, free energy must be overcome to either deform or completely unfold the protein. In principle, the diameter of the pore, along with the effective driving force for unfolding the protein, as... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Prabhat Tripathi, Abdelkrim Benabbas, Behzad Mehrafrooz, Hirohito Yamazaki, Aleksei Aksimentiev, Paul M. Champion, Meni Wanunu Tags: Biophysics and Computational Biology Biological Sciences Source Type: research

HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis [Genetics]
The position of recombination events established along chromosomes in early prophase I and the chromosome remodeling that takes place in late prophase I are intrinsically linked steps of meiosis that need to be tightly regulated to ensure accurate chromosome segregation and haploid gamete formation. Here, we show that RAD-51 foci,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Saravanapriah Nadaraȷan, Elisabeth Altendorfer, Takamune T. Saito, Marina Martinez–Garcia, Monica P. Colaiacovo Tags: Genetics Biological Sciences Source Type: research

Inequality in learning is a major concern after school closures [Social Sciences]
The COVID-19 pandemic has come with many nonpharmaceutical interventions to curb the spread of the virus. One of the most significant measures has been to close schools for in-school education, at the primary, secondary, and tertiary levels of schooling. While such interventions have been demonstrated to be effective in reducing... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Herman G. van de Werfhorst Tags: Social Sciences, Commentaries, Coronavirus Related Commentary Source Type: research

Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex [Biophysics and Computational Biology]
Backtracking, the reverse motion of the transcriptase enzyme on the nucleic acid template, is a universal regulatory feature of transcription in cellular organisms but its role in viruses is not established. Here we present evidence that backtracking extends into the viral realm, where backtracking by the severe acute respiratory syndrome... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Brandon Malone, James Chen, Qi Wang, Eliza Llewellyn, Young Joo Choi, Paul Dominic B. Olinares, Xinyun Cao, Carolina Hernandez, Edward T. Eng, Brian T. Chait, David E. Shaw, Robert Landick, Seth A. Darst, Elizabeth A. Campbell Tags: Biophysics and Computational Biology, Coronavirus (COVID-19) Biological Sciences Source Type: research

Engineering autoreactive T and B cell responses toward active immunotherapy for inflammatory diseases [Applied Biological Sciences]
Antiinflammatory therapeutics are commonly used to combat a vast array of chronic inflammatory and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, and Crohn’s disease (1). These chronic inflammatory diseases affect ∼5 to 7% of the population, creating a significant socioeconomic burden and impact on patients’ quality of life... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Jason Y. H. Chang, Darrell J. Irvine Tags: Applied Biological Sciences, Commentaries Commentary Source Type: research

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In the Clinical Perspectives article “One Size Does Not Fit All: Making Suicide Prevention and Interventions Equitable for Our Increasingly Diverse Communities,” published in the February 2021 issue of the Journal of the American Academy of Child and Adolescent Psychiatry (2021; 2:209-212),  Dr. Eraka Bath was not appropriately gi ven credit for her contributions to the conceptualization of the article. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - April 21, 2021 Category: Psychiatry Tags: Correction Source Type: research

Beyond Burnout: Talking about Physician Suicide in Dermatology
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Michelle S. Lee, Vinod E. Nambudiri Source Type: research

Propranolol for the treatment of ulcerated infantile hemangiomas: a prospective study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 21, 2021 Category: Dermatology Authors: Yi Ji, Kaiying Yang, Jiangyuan Zhou, Xuepeng Zhang, Bo Xiang, Xian Jiang, Xuewen Xu, Tong Qiu, Shiyi Dai, Feiteng Kong, Guoyan Lu, Qingxia Qiu, Yongbo Zhang, Siyuan Chen Source Type: research

Meniscal Salvage: Where We Are Today
J Am Acad Orthop Surg. 2021 Apr 16. doi: 10.5435/JAAOS-D-20-00915. Online ahead of print.ABSTRACTThe menisci are fibrocartilaginous semilunar structures in the knee that provide load support. Injury to the meniscus alters its load sharing and biomechanical profile. Knee arthroscopy with meniscus débridement is the most common orthopaedic surgical procedure done in the United States. The current goals of meniscal surgery are to preserve native meniscal tissue and maintain structural integrity. Meniscal preservation is critical to maintain the normal mechanics and homeostasis of the knee; however, it is not always fea...
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 20, 2021 Category: Orthopaedics Authors: Ashley B Anderson Joel Gaston Lance E LeClere Jonathan F Dickens Source Type: research

Principles of Amputation Surgery, Prosthetics, and Rehabilitation in Children
J Am Acad Orthop Surg. 2021 Apr 20. doi: 10.5435/JAAOS-D-20-01283. Online ahead of print.ABSTRACTPediatric patients may benefit from extremity amputations with potential prosthetic fitting when addressing limb deficiencies, trauma, infection, limb ischemia, or other pathologies. The performance of a quality amputation is a fundamental skill to an orthopaedic surgeon, yet avoidance of pitfalls can be elusive in children. The need for surgical precision and sound decision-making is amplified in pediatric amputations, where the skeleton is dynamic and growing, anatomy can be miniscule and (in the case of congenital anomalies)...
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 20, 2021 Category: Orthopaedics Authors: Craig Ray Louer Phoebe Scott-Wyard Rebecca Hernandez Anna Dimitriovna Vergun Source Type: research

Telehealth Utilization in Response to the COVID-19 Pandemic in Pediatric Orthopaedic Surgery
This study demonstrates the rapid response measures instituted by pediatric orthopaedic institutions to meet the fundamental needs of the pediatric population during this unprecedented pandemic.PMID:33878081 | DOI:10.5435/JAAOS-D-20-00694 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 20, 2021 Category: Orthopaedics Authors: Robert L Parisien Max Shin David P Trofa Aman Prasad Xinning Li William N Levine John M Flynn Theodore J Ganley Source Type: research

American Academy of Orthopaedic Surgeons Clinical Practice Guideline Summary for Limb Salvage or Early Amputation
J Am Acad Orthop Surg. 2021 Apr 16. doi: 10.5435/JAAOS-D-20-00188. Online ahead of print.ABSTRACTClinical Practice Guideline for Limb Salvage or Early Amputation is based on a systematic review of current scientific and clinical research. The purpose of this clinical practice guideline is to address treatment for severe lower limb trauma below the distal femur by either amputation or limb salvage by providing evidence-based recommendations for key decisions that affect the management of patients with lower extremity trauma. This guideline contains 11 recommendations to evaluate the decision factors important for limb salva...
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 20, 2021 Category: Orthopaedics Authors: Colonel B K Potter Michael J Bosse Source Type: research

State Medicaid Authorities' Policy Communications With Providers on Individualized Pediatric Dental Care
CONCLUSION: Updating Medicaid agency administrative documents-including dental provider manuals and periodicity and fee schedules-holds promise to promote individualized dental care as ensured by EPSDT.PMID:33874788 | DOI:10.1177/00333549211008452 (Source: Public Health Reports)
Source: Public Health Reports - April 20, 2021 Category: International Medicine & Public Health Authors: Chelsea Fosse Burton L Edelstein Source Type: research

The Effects of Exercise During a 10-Week Basic Military Training Program on the Physical Fitness and the Body Composition of the Greek Naval Cadets
Mil Med. 2021 Apr 20:usab146. doi: 10.1093/milmed/usab146. Online ahead of print.ABSTRACTINTRODUCTION: The period of basic military training (BMT) is a sudden change in the individual habits of the trainees and is characterized by significant improvements in body composition such as the percentage of body fat (%BF) and lean body mass (BM). Research has shown that physical activity during the period of BMT lasting 7-10 weeks has positive effects on the physical condition and BM of cadets. The purpose of this study was to examine the effects of training combining cardiovascular conditioning, circuit strength training, swimmi...
Source: Military Medicine - April 20, 2021 Category: International Medicine & Public Health Authors: Antonios Vantarakis Nikolaos Vezos Konstantinos Karakatsanis Gerasimos Grivas Theodosia Oikonomou Anna D Argyratou Sotirios A Vantarakis Stamatis Kalligeros Source Type: research

Meniscal Salvage: Where We Are Today
J Am Acad Orthop Surg. 2021 Apr 16. doi: 10.5435/JAAOS-D-20-00915. Online ahead of print.ABSTRACTThe menisci are fibrocartilaginous semilunar structures in the knee that provide load support. Injury to the meniscus alters its load sharing and biomechanical profile. Knee arthroscopy with meniscus débridement is the most common orthopaedic surgical procedure done in the United States. The current goals of meniscal surgery are to preserve native meniscal tissue and maintain structural integrity. Meniscal preservation is critical to maintain the normal mechanics and homeostasis of the knee; however, it is not always fea...
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 20, 2021 Category: Orthopaedics Authors: Ashley B Anderson Joel Gaston Lance E LeClere Jonathan F Dickens Source Type: research

American Academy of Orthopaedic Surgeons Clinical Practice Guideline Summary for Limb Salvage or Early Amputation
J Am Acad Orthop Surg. 2021 Apr 16. doi: 10.5435/JAAOS-D-20-00188. Online ahead of print.ABSTRACTClinical Practice Guideline for Limb Salvage or Early Amputation is based on a systematic review of current scientific and clinical research. The purpose of this clinical practice guideline is to address treatment for severe lower limb trauma below the distal femur by either amputation or limb salvage by providing evidence-based recommendations for key decisions that affect the management of patients with lower extremity trauma. This guideline contains 11 recommendations to evaluate the decision factors important for limb salva...
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 20, 2021 Category: Orthopaedics Authors: Colonel B K Potter Michael J Bosse Source Type: research

Principles of Amputation Surgery, Prosthetics, and Rehabilitation in Children
J Am Acad Orthop Surg. 2021 Apr 20. doi: 10.5435/JAAOS-D-20-01283. Online ahead of print.ABSTRACTPediatric patients may benefit from extremity amputations with potential prosthetic fitting when addressing limb deficiencies, trauma, infection, limb ischemia, or other pathologies. The performance of a quality amputation is a fundamental skill to an orthopaedic surgeon, yet avoidance of pitfalls can be elusive in children. The need for surgical precision and sound decision-making is amplified in pediatric amputations, where the skeleton is dynamic and growing, anatomy can be miniscule and (in the case of congenital anomalies)...
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 20, 2021 Category: Orthopaedics Authors: Craig Ray Louer Phoebe Scott-Wyard Rebecca Hernandez Anna Dimitriovna Vergun Source Type: research

Telehealth Utilization in Response to the COVID-19 Pandemic in Pediatric Orthopaedic Surgery
This study demonstrates the rapid response measures instituted by pediatric orthopaedic institutions to meet the fundamental needs of the pediatric population during this unprecedented pandemic.PMID:33878081 | DOI:10.5435/JAAOS-D-20-00694 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 20, 2021 Category: Orthopaedics Authors: Robert L Parisien Max Shin David P Trofa Aman Prasad Xinning Li William N Levine John M Flynn Theodore J Ganley Source Type: research

State Medicaid Authorities' Policy Communications With Providers on Individualized Pediatric Dental Care
CONCLUSION: Updating Medicaid agency administrative documents-including dental provider manuals and periodicity and fee schedules-holds promise to promote individualized dental care as ensured by EPSDT.PMID:33874788 | DOI:10.1177/00333549211008452 (Source: Public Health Reports)
Source: Public Health Reports - April 20, 2021 Category: International Medicine & Public Health Authors: Chelsea Fosse Burton L Edelstein Source Type: research

Relationships Among the Physical and Social Home Food Environments, Dietary Intake, and Diet Quality in Mothers and Children
Publication date: Available online 20 April 2021Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Samantha M. Rex, Amanda Kopetsky, Barry Bodt, Shannon M. Robson (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - April 20, 2021 Category: Nutrition Source Type: research

A Mixed-Methods Evaluation of a School Wellness Initiative: An Examination of Longer Lunch Periods and More Physical Activity Opportunities
Publication date: Available online 20 April 2021Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Juliana F.W. Cohen, Michael Scott, Melanie Sutton, Katie Cueva, Eleanor T. Shonkoff, Roberta E. Goldman, Deborah N. Margolis, Ann E. Potempa, Karol Fink, Sarah Gustus, Mark Stock (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - April 20, 2021 Category: Nutrition Source Type: research

Deep carious lesions management in children and adolescents: a questionnaire survey among dentists practicing paediatric dentistry in France
AbstractIntroductionWhile many questionnaire surveys have been undertaken worldwide to investigate practices toward deep carious lesion (DCL) management in adults, very few are related to children and adolescents. The present cross-sectional study aimed to assess DCL management in children and adolescents among dentists practicing paediatric dentistry in France (Fr-DPPDs). The secondary objective was to compare practices between Fr-DPPDs and dentists registered in the European Academy of Paediatric Dentistry (EAPD).MethodsA questionnaire was electronically administrated to members of the CEOP (Coll ège des Enseignan...
Source: European Archives of Paediatric Dentistry - April 20, 2021 Category: Dentistry Source Type: research

Characteristic CD86 stain for organisms in cutaneous lesions of Talaromyces marneffei infection
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 20, 2021 Category: Dermatology Authors: Donghua Liu, Rifeng Chen Source Type: research

A balancing act between primate lentiviruses and their receptor [Microbiology]
The receptor for primate lentiviruses, including HIV-1, is the CD4 glycoprotein found on myeloid and T helper cells. CD4 also plays a critical role in mediating adaptive immune responses and in immune cell differentiation by coordinating interactions between T cell receptors and major histocompatibility complex (MHC) proteins (1). This sets... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 20, 2021 Category: Science Authors: Molly Ohainle, Harmit S. Malik Tags: Microbiology, Commentaries Commentary Source Type: research

The effect of information about climate risk on property values [Sustainability Science]
Floods and other climate hazards pose a widespread and growing threat to housing and infrastructure around the world. By reflecting climate risk in prices, markets can discourage excessive development in hazardous areas. However, the extent to which markets price these risks remains poorly understood. Here we measure the effect of... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 20, 2021 Category: Science Authors: Miyuki Hino, Marshall Burke Tags: Sustainability Science, Sustainability Science Social Sciences Source Type: research

{beta}-arrestin-dependent PI(4,5)P2 synthesis boosts GPCR endocytosis [Cell Biology]
β-arrestins regulate many cellular functions including intracellular signaling and desensitization of G protein–coupled receptors (GPCRs). Previous studies show that β-arrestin signaling and receptor endocytosis are modulated by the plasma membrane phosphoinositide lipid phosphatidylinositol-(4, 5)-bisphosphate (PI(4,5)P2). We found that β-arrestin also helped promote synthesis of PI(4,5)P2 and up-regulated GPCR endocytosis. We... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 20, 2021 Category: Science Authors: Seung-Ryoung Jung, Yifei Jiang, Jong Bae Seo, Daniel T. Chiu, Bertil Hille, Duk-Su Koh Tags: Cell Biology Biological Sciences Source Type: research

Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology [Immunology and Inflammation]
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system (CNS). Small non-coding RNAs (sncRNAs) and, in particular, microRNAs (miRNAs) have frequently been associated with MS. Here, we performed a comprehensive analysis of all classes of sncRNAs in matching samples of peripheral blood mononuclear cells (PBMCs),... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 20, 2021 Category: Science Authors: Galina Yurevna Zheleznyakova, Eliane Piket, Maria Needhamsen, Michael Hagemann-Jensen, Diana Ekman, Yanan Han, Tojo James, Mohsen Khademi, Faiez Al Nimer, Patrick Scicluna, Jesse Huang, Ingrid Kockum, Omid R. Faridani, Tomas Olsson, Fredrik Piehl, Maja Ja Tags: Immunology and Inflammation Biological Sciences Source Type: research