BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection [Immunology and Inflammation]
Neutrophils are vital for antimicrobial defense; however, their role during viral infection is less clear. Furthermore, the molecular regulation of neutrophil fate and function at the viral infected sites is largely elusive. Here we report that BCL6 deficiency in myeloid cells exhibited drastically enhanced host resistance to severe influenza A... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Bibo Zhu, Ruixuan Zhang, Chaofan Li, Li Jiang, Min Xiang, Zhenqing Ye, Hirohito Kita, Ari M. Melnick, Alexander L. Dent, Jie Sun Tags: Biological Sciences Source Type: research

Role of thyroid dysimmunity and thyroid hormones in endometriosis [Immunology and Inflammation]
Endometriosis is characterized by the presence of ectopic endometrial cells outside the uterine cavity. Thyroid autoimmunity has been associated with endometriosis. This work investigated the potential pathophysiological link between endometriosis and thyroid disorders. Transcripts and proteins involved in thyroid metabolism are dysregulated in eutopic and ectopic endometrium of endometriotic patients,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Marine Peyneau, Niloufar Kavian, Sandrine Chouzenoux, Carole Nicco, Mohamed Jelȷeli, Laurie Toullec, Jeanne Reboul–Marty, Camille Chenevier–Gobeaux, Fernando M. Reis, Pietro Santulli, Ludivine Doridot, Charles Chapron, Frederic Batteux Tags: Biological Sciences Source Type: research

Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b [Immunology and Inflammation]
We present cryoelectron tomography structures of IgM, C1, and C4b complexes formed on antigen-bearing lipid membranes by normal human serum at... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Thomas H. Sharp, Aimee L. Boyle, Christoph A. Diebolder, Alexander Kros, Abraham J. Koster, Piet Gros Tags: Biological Sciences Source Type: research

An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo [Medical Sciences]
We describe 18F-MAPP, an activatable MPO activity radioprobe for positron emission tomography (PET) imaging. The activated radioprobe binds to proteins and accumulates at... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Cuihua Wang, Edmund Keliher, Matthias W. G. Zeller, Gregory R. Wojtkiewicz, Aaron D. Aguirre, Leonard Buckbinder, Hye-Yeong Kim, Jianqing Chen, Kevin Maresca, Maaz S. Ahmed, Negin Jalali Motlagh, Matthias Nahrendorf, John W. Chen Tags: Biological Sciences Source Type: research

Perfluorocarbon nanoparticle-mediated platelet inhibition promotes intratumoral infiltration of T cells and boosts immunotherapy [Medical Sciences]
Cancer immunotherapy can stimulate and enhance the ability of the immune system to recognize, arrest, and eliminate tumor cells. Immune checkpoint therapies (e.g., PD-1/PD-L1) have shown an unprecedented and durable clinical response rate in patients among various cancer types. However, a large fraction of patients still does not respond to... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Zaigang Zhou, Baoli Zhang, Wenjing Zai, Lin Kang, Ahu Yuan, Yiqiao Hu, Jinhui Wu Tags: Biological Sciences Source Type: research

Photocontrollable mononegaviruses [Microbiology]
Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generated. The Magnet proteins were inserted into the flexible domain of viral polymerase, and... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Maino Tahara, Yuto Takishima, Shohei Miyamoto, Yuichiro Nakatsu, Kenji Someya, Moritoshi Sato, Kenzaburo Tani, Makoto Takeda Tags: Brief Reports Biological Sciences Source Type: research

Kinase pathway inhibition restores PSD95 induction in neurons lacking fragile X mental retardation protein [Neuroscience]
Fragile X syndrome (FXS) is the leading monogenic cause of autism and intellectual disability. FXS is caused by loss of expression of fragile X mental retardation protein (FMRP), an RNA-binding protein that regulates translation of numerous mRNA targets, some of which are present at synapses. While protein synthesis deficits have... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Ying Yang, Yang Geng, Dongyun Jiang, Lin Ning, Hyung Joon Kim, Noo Li Jeon, Anthony Lau, Lu Chen, Michael Z. Lin Tags: Biological Sciences Source Type: research

Analysis of phototoxin taste closely correlates nucleophilicity to type 1 phototoxicity [Neuroscience]
Pigments often inflict tissue-damaging and proaging toxicity on light illumination by generating free radicals and reactive oxygen species (ROS). However, the molecular mechanism by which organisms sense phototoxic pigments is unknown. Here, we discover that Transient Receptor Potential Ankyrin 1-A isoform [TRPA1(A)], previously shown to serve as a receptor for... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Eun Jo Du, Tae Jung Ahn, Hwajin Sung, HyunJi Jo, Hyung-Wook Kim, Seong-Tae Kim, KyeongJin Kang Tags: Biological Sciences Source Type: research

High sensitivity and interindividual variability in the response of the human circadian system to evening light [Neuroscience]
Before the invention of electric lighting, humans were primarily exposed to intense (>300 lux) or dim ( (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Andrew J. K. Phillips, Parisa Vidafar, Angus C. Burns, Elise M. McGlashan, Clare Anderson, Shantha M. W. Rajaratnam, Steven W. Lockley, Sean W. Cain Tags: Biological Sciences Source Type: research

Variable G protein determinants of GPCR coupling selectivity [Pharmacology]
G protein-coupled receptors (GPCRs) activate four families of heterotrimeric G proteins, and individual receptors must select a subset of G proteins to produce appropriate cellular responses. Although the precise mechanisms of coupling selectivity are uncertain, the Gα subunit C terminus is widely believed to be the primary determinant recognized by... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Najeah Okashah, Qingwen Wan, Soumadwip Ghosh, Manbir Sandhu, Asuka Inoue, Nagarajan Vaidehi, Nevin A. Lambert Tags: Biological Sciences Source Type: research

Quantum phase-sensitive diffraction and imaging using entangled photons [Physics]
We propose a quantum diffraction imaging technique whereby one photon of an entangled pair is diffracted off a sample and detected in coincidence with its twin. The image is obtained by scanning the photon that did not interact with matter. We show that when a dynamical quantum system interacts with... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Shahaf Asban, Konstantin E. Dorfman, Shaul Mukamel Tags: Physical Sciences Source Type: research

External power amplification drives prey capture in a spider web [Physiology]
Power amplification allows animals to produce movements that exceed the physiological limits of muscle power and speed, such as the mantis shrimp’s ultrafast predatory strike and the flea’s jump. However, all known examples of nonhuman, muscle-driven power amplification involve anatomical structures that store energy from a single cycle of muscular... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: S. I. Han, H. C. Astley, D. D. Maksuta, T. A. Blackledge Tags: Biological Sciences Source Type: research

Direct visualization of cAMP signaling in primary cilia reveals up-regulation of ciliary GPCR activity following Hedgehog activation [Physiology]
The primary cilium permits compartmentalization of specific signaling pathways, including elements of the Hedgehog (Hh) pathway. Hh transcriptional activity is thought to be negatively regulated by constitutively high ciliary cAMP maintained by the Gα(s)-coupled GPCR, GPR161. However, cilia also sequester many other Gα(s)-coupled GPCRs with unknown potential to regulate Hh.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Jason Y. Jiang, Jeffrey L. Falcone, Silvana Curci, Aldebaran M. Hofer Tags: Biological Sciences Source Type: research

NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis [Plant Biology]
The 5′ end of a eukaryotic mRNA transcript generally has a 7-methylguanosine (m7G) cap that protects mRNA from degradation and mediates almost all other aspects of gene expression. Some RNAs in Escherichia coli, yeast, and mammals were recently found to contain an NAD+ cap. Here, we report the development of... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Hailei Zhang, Huan Zhong, Shoudong Zhang, Xiaojian Shao, Min Ni, Zongwei Cai, Xuemei Chen, Yiji Xia Tags: Biological Sciences Source Type: research

Genetic and molecular analysis of trichome development in Arabis alpina [Plant Biology]
The genetic and molecular analysis of trichome development in Arabidopsis thaliana has generated a detailed knowledge about the underlying regulatory genes and networks. However, how rapidly these mechanisms diverge during evolution is unknown. To address this problem, we used an unbiased forward genetic approach to identify most genes involved in... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Divykriti Chopra, Mona Mapar, Lisa Stephan, Maria C. Albani, Anna Deneer, George Coupland, Eva–Maria Willing, Swen Schellmann, Korbinian Schneeberger, Christian Fleck, Andrea Schrader, Martin Hulskamp Tags: Biological Sciences Source Type: research

Individual differences in visual salience vary along semantic dimensions [Psychological and Cognitive Sciences]
What determines where we look? Theories of attentional guidance hold that image features and task demands govern fixation behavior, while differences between observers are interpreted as a “noise-ceiling” that strictly limits predictability of fixations. However, recent twin studies suggest a genetic basis of gaze-trace similarity for a given stimulus. This... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Benjamin de Haas, Alexios L. Iakovidis, D. Samuel Schwarzkopf, Karl R. Gegenfurtner Tags: Social Sciences Source Type: research

Music in premature infants enhances high-level cognitive brain networks [Psychological and Cognitive Sciences]
Neonatal intensive care units are willing to apply environmental enrichment via music for preterm newborns. However, no evidence of an effect of music on preterm brain development has been reported to date. Using resting-state fMRI, we characterized a circuitry of interest consisting of three network modules interconnected by the salience... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Lara Lordier, Dȷalel–Eddine Meskaldȷi, Frederic Grouiller, Marie P. Pittet, Andreas Vollenweider, Lana Vasung, Cristina Borradori–Tolsa, Francois Lazeyras, Didier Grandȷean, Dimitri Van De Ville, Petra S. Huppi Tags: Biological Sciences Source Type: research

Historical roots of implicit bias in slavery [Psychological and Cognitive Sciences]
Implicit racial bias remains widespread, even among individuals who explicitly reject prejudice. One reason for the persistence of implicit bias may be that it is maintained through structural and historical inequalities that change slowly. We investigated the historical persistence of implicit bias by comparing modern implicit bias with the proportion... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: B. Keith Payne, Heidi A. Vuletich, Jazmin L. Brown-Iannuzzi Tags: Social Sciences Source Type: research

A scarcity mindset alters neural processing underlying consumer decision making [Psychological and Cognitive Sciences]
Not having enough of what one needs has long been shown to have detrimental consequences for decision making. Recent work suggests that the experience of insufficient resources can create a “scarcity” mindset; increasing attention toward the scarce resource itself, but at the cost of attention for unrelated aspects. To investigate... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Authors: Inge Huijsmans, Ili Ma, Leticia Micheli, Claudia Civai, Mirre Stallen, Alan G. Sanfey Tags: Social Sciences Source Type: research

Correction for Rasmussen et al., Primitive Old World monkey from the earliest Miocene of Kenya and the evolution of cercopithecoid bilophodonty [Corrections]
ANTHROPOLOGY Correction for “Primitive Old World monkey from the earliest Miocene of Kenya and the evolution of cercopithecoid bilophodonty,” by D. Tab Rasmussen, Anthony R. Friscia, Mercedes Gutierrez, John Kappelman, Ellen R. Miller, Samuel Muteti, Dawn Reynoso, James B. Rossie, Terry L. Spell, Neil J. Tabor, Elizabeth Gierlowski-Kordesch, Bonnie F.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Tags: Correction Source Type: research

Correction for Colon-Gonzalez et al., Limiting global-mean temperature increase to 1.5-2 {degrees}C could reduce the incidence and spatial spread of dengue fever in Latin America [Corrections]
ENVIRONMENTAL SCIENCES, SUSTAINABILITY SCIENCE Correction for “Limiting global-mean temperature increase to 1.5–2 °C could reduce the incidence and spatial spread of dengue fever in Latin America,” by Felipe J. Colón-González, Ian Harris, Timothy J. Osborn, Christine Steiner São Bernardo, Carlos A. Peres, Paul R. Hunter, and Iain R. Lake, which... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Tags: Sustainability Science Correction Source Type: research

Correction for Beraki et al., Divergent kinase regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole [Correction]
MICROBIOLOGY Correction for “Divergent kinase regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole,” by Tsebaot Beraki, Xiaoyu Hu, Malgorzata Broncel, Joanna C. Young, William J. O’Shaughnessy, Dominika Borek, Moritz Treeck, and Michael L. Reese, which was first published March 8, 2019; 10.1073/pnas.1816161116 (Proc. Natl. Acad. Sci. U.S.A. 116, 6361–6370). The... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2019 Category: Science Tags: Corrections Source Type: research

Topical application in burning mouth syndrome
Publication date: Available online 8 June 2019Source: Journal of Dental SciencesAuthor(s): Junad Khan, Moin Anwer, Noma Noboru, Davis Thomas, Mythilli KalladkaAbstractBackground/purposeIntraoral and perioral burning sensations may be sequelae of burning mouth syndrome (BMSD) or burning mouth symptoms (BMSP), which present a diagnostic challenge. The aims of the study were to evaluate the efficacy of a topical anesthetic as a diagnostic test to differentiate BMSD from BMSP and to assess the comorbidities and responses to various pharmacologic treatments in BMSD and BMSP patients.Materials and methodsA total of forty-four ch...
Source: Journal of Dental Sciences - June 10, 2019 Category: Dentistry Source Type: research

Using a transparent plastic cup over a nail clipper to facilitate nail sampling
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 10, 2019 Category: Dermatology Authors: Saad Altalhab, Mohammed I. AlJasser Source Type: research

Predicting Sepsis in Stevens-Johnson/Toxic Epidermal Necrolysis: Should Dermatologists be Pro-Procalcitonin?
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 10, 2019 Category: Dermatology Authors: Warren R. Heymann Source Type: research

Clinical Markers of Herpes Simplex Virus Infection in Patients with Pemphigus Vulgaris
Herpes simplex virus (HSV) is known to influence the course of pemphigus vulgaris. Relapse, exacerbation and treatment resistance in patients with pemphigus vulgaris can be due to HSV infection. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 10, 2019 Category: Dermatology Authors: Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa Source Type: research

Evaluation of a virtual basic dermatology curriculum for dermoscopy using the Triage Amalgamated Dermoscopic Algorithm (TADA) for novice dermoscopists
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 10, 2019 Category: Dermatology Authors: Jason R. Susong, Hadjh T. Ahrns, Andrew Daugherty, Ashfaq A. Marghoob, Elizabeth V. Seiverling Source Type: research

Risk Factors and Diagnostic Markers of Bacteraemia in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Cohort Study of 176 Patients
Sepsis is the main cause of death in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 10, 2019 Category: Dermatology Authors: Hui Kai Koh, Zi Teng Chai, Hui Wen Tay, Stephanie Fook-Chong, Karen JL. Choo, Choon Chiat Oh, Yi Wei Yeo, Hong Yi Koh, Shiu Ming Pang, Haur Yueh Lee Source Type: research

Publication Productivity of Authors of Psoriasis Clinical Practice Guidelines With and Without Ties to Industry
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 10, 2019 Category: Dermatology Authors: Sree S. Kolli, William W. Huang, Steven R. Feldman Source Type: research

Minding the gap in pediatric headache care: Can a focus on quality measures improve outcomes?
Background The American Academy of Neurology Headache Quality Measures seek to improve care delivery and outcomes by addressing gaps in care. Our practice identified underperformance in 3 of the 7 measures that apply to children and adolescents. We expected that improved performance on these measures would lead to a reduction in emergency department (ED) visits and improvement in the average disability grade of established patients. Methods An interdisciplinary workgroup used the Institute for Healthcare Improvement's Model for Improvement. Quality improvement (QI) interventions focused on the use of Pediatric Migraine Di...
Source: Neurology Clinical Practice - June 10, 2019 Category: Neurology Authors: Turner, S., Foss-Barratt, A., Malmberg, J., Disabato, J. Tags: Pediatric headache, Cost effectiveness/economic, Health systems Research Source Type: research

CDC's guideline on pediatric mild traumatic brain injury: Recommendations for neurologists
Purpose of review In September 2018, the Centers for Disease Control and Prevention (CDC) published an evidence-based guideline on the diagnosis and management of mild traumatic brain injury (mTBI) among children. Recent findings Based on a systematic review of the evidence that covers research published over a 25-year span (1990–2015), the CDC Pediatric mTBI Guideline strives to optimize the care of pediatric patients with mTBI. The guideline was developed using a rigorous methodology developed by the American Academy of Neurology. Summary Clinical practice recommendations in the CDC Pediatric mTBI Guideline can h...
Source: Neurology Clinical Practice - June 10, 2019 Category: Neurology Authors: Weissman, B., Joseph, M., Gronseth, G., Sarmiento, K., Giza, C. C. Tags: Pediatric headache, CT, Clinical neurology examination, Brain trauma Review Source Type: research

The ESVS Academy is Growing …
One of the goals of the European Society for Vascular Surgery (ESVS) is to provide educational opportunities with the aim of promoting optimal care for patients with vascular disease. Three years ago, the educational ambitions in connection with the annual meeting were revised, and the ESVS Academy was founded. One of its main objectives was to replace the long training courses including traditional lectures during the annual meeting with dedicated hands on workshops or interactive case discussions with clear learning objectives. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - June 10, 2019 Category: Surgery Authors: Jonas Peter Eiberg, Ramon Vila, Isabelle Van Herzeele, ESVS Academy Tags: Editorial Source Type: research

The ESVS Academy is Growing ….
The ESVS Academy is Growing…. Eur J Vasc Endovasc Surg. 2019 Jun 10;: Authors: Eiberg JP, Vila R, Van Herzeele I, ESVS Academy PMID: 31196593 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - June 10, 2019 Category: Surgery Authors: Eiberg JP, Vila R, Van Herzeele I, ESVS Academy Tags: Eur J Vasc Endovasc Surg Source Type: research

Risk factors and diagnostic markers of bacteremia in Stevens-Johnson syndrome and toxic epidermal necrolysis: A cohort study of 176 patients
Sepsis is the main cause of death in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 10, 2019 Category: Dermatology Authors: Hui Kai Koh, Zi Teng Chai, Hui Wen Tay, Stephanie Fook-Chong, Karen J.L. Choo, Choon Chiat Oh, Yi Wei Yeo, Hong Yi Koh, Shiu Ming Pang, Haur Yueh Lee Tags: Original article Source Type: research

Advances in pathological diagnosis of mesothelioma: what pulmonologists should know
Purpose of review Malignant pleural mesothelioma (MPM) is a universally fatal illness with a rising incidence, particularly in developing countries. The diagnosis can be challenging and require repeated investigations with implications for the patient and healthcare system. Recent findings Distinguishing between benign/reactive and malignant mesothelial proliferations can be challenging. Cytological diagnosis of MPM from pleural fluid is as reliable as histological analysis of tissue biopsies in epithelioid MPM – an approach endorsed by the International Academy of Cytology. Identification of BRCA1-associated pr...
Source: Current Opinion in Pulmonary Medicine - June 8, 2019 Category: Respiratory Medicine Tags: DISEASES OF THE PLEURA: Edited by Richard Light Source Type: research

"Sons of the West" Leadership Academy: Examining Impact on Community Connectedness, Leadership and Self-efficacy.
CONCLUSION: This study indicates that a men's health program can not only engage and improve the health of men, but also help them develop skills and enhance their own strengths, so they can improve the health and wellbeing of others. So what? The development of leadership pathways and capacity-building, embedded within health promotion programs, is an important aspect of improving health and well-being. PMID: 31168884 [PubMed - as supplied by publisher] (Source: Health Promotion Journal of Australia)
Source: Health Promotion Journal of Australia - June 8, 2019 Category: International Medicine & Public Health Tags: Health Promot J Austr Source Type: research

Fracture of a Carbon Fiber Reinforced Intramedullary Femoral Nail.
We present the case of a failure of a carbon fiber reinforced intramedullary femoral nail used in a closed distal femur fracture. PMID: 31170099 [PubMed - in process] (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 8, 2019 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Proximal Interphalangeal Joint Arthroplasty in Young Patients.
CONCLUSIONS: Younger age leads higher revision rates after PIP arthroplasty, particularly in the posttraumatic setting. LEVEL OF EVIDENCE: Therapeutic, level III. PMID: 31170098 [PubMed - in process] (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 8, 2019 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Cervical Spine Deformity: Indications, Considerations, and Surgical Outcomes.
Authors: Cho SK, Safir S, Lombardi JM, Kim JS Abstract Cervical spinal deformity (CSD) in adult patients is a relatively uncommon yet debilitating condition with diverse etiologies and clinical manifestations. Similar to thoracolumbar deformity, CSD can be broadly divided into scoliosis and kyphosis. Severe forms of CSD can lead to pain; neurologic deterioration, including myelopathy; and cervical spine-specific symptoms such as difficulty with horizontal gaze, dysphagia, and dyspnea. Recently, an increased interest is shown in systematically studying CSD with introduction of classification schemes and treatment al...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 8, 2019 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Revision Reverse Shoulder Arthroplasty.
Authors: Chalmers PN, Boileau P, Romeo AA, Tashjian RZ Abstract As shoulder arthroplasty becomes increasingly common, the burden of revision shoulder arthroplasty is also increasing. Revision reverse shoulder arthroplasty requires an understanding of the causes of failure and the evaluation of these causes and their sequelae, including infection, instability, component loosening, humeral bone loss, and glenoid bone loss. Revision reverse shoulder arthroplasty is technically complex. On the humeral side, corticotomy may be required for component removal, and bone grafting may be necessary to achieve rotational stabi...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 8, 2019 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

The French Academy of Sciences and the systems of units: A long history!
Publication date: January–February 2019Source: Comptes Rendus Physique, Volume 20, Issues 1–2Author(s): Christophe Salomon, Christian Bordé, Pierre Fayet (Source: Comptes Rendus Physique)
Source: Comptes Rendus Physique - June 8, 2019 Category: Physics Source Type: research

Factors Influencing Sleep Difficulty and Sleep Quantity in the Citizen Pscientist Psoriatic Cohort
ConclusionThese results are potentially meaningful in several aspects. We identify an important distinction between sleep difficulty and sleep quantity in psoriatic disease, whereby having psoriatic arthritis and being female are each associated with sleep difficulty despite no association with low sleep quantity. Furthermore, there is conflicting evidence from prior studies as to whether psoriasis severity is associated with sleep difficulty, but this well-powered, large study revealed a strong, graded relationship between psoriasis severity and both sleep difficulty and low sleep quantity. Overall, our results show that ...
Source: Dermatology and Therapy - June 8, 2019 Category: Dermatology Source Type: research

Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare
Sarcoidosis and granuloma annulare (GA) are cutaneous granulomatous disorders that can be difficult to treat. There is evidence of underlying JAK-STAT pathway activation in sarcoidosis, suggesting JAK inhibition might be effective. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 8, 2019 Category: Dermatology Authors: William Damsky, Durga Thakral, Meaghan K. McGeary, Jonathan Leventhal, Anjela Galan, Brett King Source Type: research

Vascular endothelial growth factor gene polymorphisms in patients with rosacea: A case-control study
Rosacea is a chronic disease that is characterized by facial skin inflammation and vascular abnormality. Vascular endothelial growth factor (VEGF) is a potent mediator of vascular permeability and inflammation that might play a role in the pathogenesis of rosacea. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 7, 2019 Category: Dermatology Authors: Y ıldız Hayran, Incilay Lay, Mehmet Cem Mocan, Tuba Bozduman, Sibel Ersoy-Evans Tags: Original article Source Type: research

Stigma and Acceptance of Sierra Leone's Child Soldiers: A Prospective Longitudinal Study of Adult Mental Health and Social Functioning
To investigate the associations of war and post-conflict factors with mental health among Sierra Leone ’s former child soldiers as adults. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - June 6, 2019 Category: Psychiatry Authors: Theresa S. Betancourt, Dana L. Thomson, Robert T. Brennan, Cara M. Antonaccio, Stephen E. Gilman, Tyler J. VanderWeele Tags: New Research Source Type: research

Frequency of dramatic price increases for topical medications, 2014-2018
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 6, 2019 Category: Dermatology Authors: Partik Singh, John Barbieri Source Type: research

Clinically Significant Incidental Findings Among Teledermatology Patients with History of Skin Cancer
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 6, 2019 Category: Dermatology Authors: Marissa L.H. Baranowski, Salma de la Feld, Howa Yeung, Suephy C. Chen Source Type: research

A Cross-sectional Survey of Knowledge, Attitude, and Practice in Prescription of Isotretinoin for Transgender Patients amongst Academic Dermatologists
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 6, 2019 Category: Dermatology Authors: Courtney J. Ensslin, Keshav Khanijow, Gayane Yenokyan, Manisha Loss Source Type: research

Psoriasis Prevalence In the United States In A Commercial Insurance Claims Database: 2011-2017
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 6, 2019 Category: Dermatology Authors: Jeffrey M. Cohen, Priscilla W. Wong, David E. Cohen, Randie H. Kim Source Type: research

Increased risk of alopecia areata for people with hidradenitis suppurativa in a cross-sectional study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 6, 2019 Category: Dermatology Authors: Mikael Horissian, Steven Maczuga, Joslyn S. Kirby, Amanda Nelson Source Type: research