Bystander training for faculty: A promising approach to tackling microaggressions in the academy
Publication date: December 2021Source: New Ideas in Psychology, Volume 63Author(s): Michelle C. Haynes-Baratz, Tugba Metinyurt, Yun Ling Li, Joseph Gonzales, Meg A. Bond (Source: New Ideas in Psychology)
Source: New Ideas in Psychology - June 12, 2021 Category: Psychiatry & Psychology Source Type: research

Diet Quality as Measured by the Healthy Eating Index 2015 and Oral and Pharyngeal Cancer Risk
Publication date: Available online 11 June 2021Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Valeria Edefonti, Matteo Di Maso, Laura Tomaino, Maria Parpinel, Werner Garavello, Diego Serraino, Monica Ferraroni, Anna Crispo, Carlo La Vecchia, Francesca Bravi (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - June 12, 2021 Category: Nutrition Source Type: research

Race-Related Stressors and Resources for Resilience: Associations With Emotional Health, Conduct Problems, and Academic Investment Among African American Early Adolescents
This study examined whether race-related stressors (awareness and experiences of racism) and resources for resilience (racial-ethnic connectedness and perceptions of embedded achievement) were associated with emotional health, conduct problems, and academic investment among African American early adolescents. Embedded achievement is the belief that achievement is a part of one ’s racial or ethnic group identity. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - June 12, 2021 Category: Psychiatry Authors: Jessie L. Austin, Elijah F. Jeffries, Willie Winston, Sonya S. Brady Tags: New Research Source Type: research

The memory for words: Armand Trousseau on aphasia
J Hist Neurosci. 2021 Jun 11:1-19. doi: 10.1080/0964704X.2021.1898909. Online ahead of print.ABSTRACTOf all the nineteenth-century physicians whose names still resonate today, Armand Trousseau is perhaps the one most familiar, for his description of carpal spasm as a sign of hypocalcemia (Trousseau's sign) and his description of the hypercoagulable state associated with cancer (Trousseau's syndrome). In the last three years of his life, Trousseau turned his attention to aphasia, which he included in his 1864 and 1865 lectures given at Hôtel-Dieu Hospital in Paris and which he discussed in an address to the Imperial A...
Source: Journal of the History of the Neurosciences - June 11, 2021 Category: Neuroscience Authors: Richard Leblanc Source Type: research

Recently Released Report by Major Scientific Academy Proposes Significant Changes in Understanding and Managing TMDs
A recent Consensus Study Report1 of The National Academies of Sciences, Engineering, and Medicine (NASEM) recommends that the field of temporomandibular disorders (TMDs) must be totally changed in terms of biomedical research, professional education/training, and patient care. Recent research demonstrates that TMDs are complex multi-system disorders, which points to the need for a different, patient-centered, interprofessional approach to TMD research and treatment. Therefore, traditional dental-centric approaches to research and treatment of TMDs must be modernized to align with insights gained from new scientific discove...
Source: Journal of Oral and Maxillofacial Surgery - June 11, 2021 Category: ENT & OMF Authors: Charles S. Greene, John W. Kusiak, Terrie Cowley, Allen W. Cowley Tags: ANNOUNCEMENT Source Type: research

Oral isotretinoin: 29  years of medical malpractice cases in the United States
Reviews of malpractice claims in the United States show trends of increasing payments with statistically higher payouts for more debilitating and permanent injuries. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 11, 2021 Category: Dermatology Authors: David W. Martell, Douglas S. Ruhl Tags: Original article Source Type: research

Staged Excisions for Extensive Acne Keloidalis
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 11, 2021 Category: Dermatology Authors: Paul Curtiss, Rajiv I. Nijhawan Source Type: research

Adverse Pregnancy and Maternal Outcomes in Women with Hidradenitis Suppurativa
Capsule summary: Information on pregnancy and maternal outcomes in hidradenitis suppurativa (HS) is sparse. HS is linked to a number of adverse pregnancy and maternal outcomes, some of which may be mitigated through early identification and control of comorbid conditions. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 11, 2021 Category: Dermatology Authors: Laura Fitzpatrick, Jennifer Hsiao, Rachel Tannenbaum, Andrew Strunk, Amit Garg Source Type: research

The Completeness and Accuracy of DataDerm ™: The Database of The American Academy of Dermatology (AAD)
This report documents the validity of data elements within DataDerm, the clinical registry database of The American Academy of Dermatology (AAD).An external audit of DataDerm, performed by a third-party vendor, involved the manual review of 1,098 individual patient charts from calendar year 2018 from 8 different dermatology practices that utilized 4 different electronic health records (EHRs). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 11, 2021 Category: Dermatology Authors: Marta VanBeek, Robert A. Swerlick, Barbara Mathes, Margo J. Reeder, Toni Kaye, Arik Aninos, Matthew E. Fitzgerald, Caryn D. Etkin, Jeffrey P. Jacobs Source Type: research

Superelastic oxide micropillars enabled by surface tension-modulated 90{degrees} domain switching with excellent fatigue resistance [Applied Physical Sciences]
Superelastic materials capable of recovering large nonlinear strains are ideal for a variety of applications in morphing structures, reconfigurable systems, and robots. However, making oxide materials superelastic has been a long-standing challenge due to their intrinsic brittleness. Here, we fabricate ferroelectric BaTiO3 (BTO) micropillars that not only are superelastic but... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2021 Category: Science Authors: Yingwei Li, Kangjie Chu, Chang Liu, Peng Jiang, Ke Qu, Peng Gao, Jie Wang, Fuzeng Ren, Qingping Sun, Longqing Chen, Jiangyu Li Tags: Applied Physical Sciences Source Type: research

Hypertrophic cardiomyopathy {beta}-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state [Biochemistry]
Hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, associated with over 1,000 mutations, many in β-cardiac myosin (MYH7). Molecular studies of myosin with different HCM mutations have revealed a diversity of effects on ATPase and load-sensitive rate of detachment from actin. It has been difficult to... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2021 Category: Science Authors: Alison Schroer Vander Roest, Chao Liu, Makenna M. Morck, Kristina Bezold Kooiker, Gwanghyun Jung, Dan Song, Aminah Dawood, Arnav Jhingran, Gaspard Pardon, Sara Ranjbarvaziri, Giovanni Fajardo, Mingming Zhao, Kenneth S. Campbell, Beth L. Pruitt, James A. S Tags: Biochemistry Biological Sciences Source Type: research

Do crystallographic XFEL data support binding of a water molecule to the oxygen-evolving complex of photosystem II exposed to two flashes of light? [Physical Sciences]
X-ray free electron laser (XFEL) crystallography could revolutionize mechanistic studies of photosystem II (PSII) by providing three-dimensional structures of its reaction intermediates that cannot be obtained using traditional crystallographic techniques. However, care must be taken to ensure that the XFEL data are interpreted correctly. Here, we challenge the conclusion that... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2021 Category: Science Authors: Jimin Wang, William H. Armstrong, Victor S. Batista Tags: Biophysics and Computational Biology, Letters, Letters and Replies Source Type: research

Torsional fracture of viscoelastic liquid bridges [Engineering]
Short liquid bridges are stable under the action of surface tension. In applications like electronic packaging, food engineering, and additive manufacturing, this poses challenges to the clean and fast dispensing of viscoelastic fluids. Here, we investigate how viscoelastic liquid bridges can be destabilized by torsion. By combining high-speed imaging and... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2021 Category: Science Authors: San To Chan, Frank P. A. van Berlo, Hammad A. Faizi, Atsushi Matsumoto, Simon J. Haward, Patrick D. Anderson, Amy Q. Shen Tags: Engineering Physical Sciences Source Type: research

Starvation induces shrinkage of the bacterial cytoplasm [Microbiology]
Environmental fluctuations are a common challenge for single-celled organisms; enteric bacteria such as Escherichia coli experience dramatic changes in nutrient availability, pH, and temperature during their journey into and out of the host. While the effects of altered nutrient availability on gene expression and protein synthesis are well known, their... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2021 Category: Science Authors: Handuo Shi, Corey S. Westfall, Jesse Kao, Pascal D. Odermatt, Sarah E. Anderson, Spencer Cesar, Montana Sievert, Jeremy Moore, Carlos G. Gonzalez, Lichao Zhang, Joshua E. Elias, Fred Chang, Kerwyn Casey Huang, Petra Anne Levin Tags: Microbiology Biological Sciences Source Type: research

Unifying deterministic and stochastic ecological dynamics via a landscape-flux approach [Ecology]
The frequency distributions can characterize the population-potential landscape related to the stability of ecological states. We illustrate the practical utility of this approach by analyzing a forest–savanna model. Savanna and forest states coexist under certain conditions, consistent with past theoretical work and empirical observations. However, a grassland state, unseen in... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2021 Category: Science Authors: Li Xu, Denis Patterson, Ann Carla Staver, Simon Asher Levin, Jin Wang Tags: Ecology Biological Sciences Source Type: research

Reply to Wang et al.: Clear evidence of binding of Ox to the oxygen-evolving complex of photosystem II is best observed in the omit map [Physical Sciences]
Wang et al. (1) performed their own analysis of our crystallographic data (2) and questioned our, and similar previous (3–5), results that a newly inserted water (Ox) in the catalytic center of photosystem II (PSII) can be uniquely identified in the room temperature crystal structures taken at various time points... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 11, 2021 Category: Science Authors: Mohamed Ibrahim, Nigel W. Moriarty, Jan Kern, James M. Holton, Aaron S. Brewster, Asmit Bhowmick, Uwe Bergmann, Athina Zouni, Johannes Messinger, Vittal K. Yachandra, Junko Yano, Holger Dobbek, Nicholas K. Sauter, Paul D. Adams Tags: Biophysics and Computational Biology, Letters, Letters and Replies Source Type: research

Management of inadequate response and adverse effects to dupilumab in atopic dermatitis
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritus, skin-pain, and sleep disturbances. Currently, dupilumab is the only U.S. FDA approved systemic therapy and biologic medication for moderate-to-severe AD in adults and children. There is a sparsity of literature available on determining treatment failure with dupilumab and the next steps healthcare providers can take to treat AD. Individual goals and quality of life, and not just body surface area should be considered when defining treatment failure. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 11, 2021 Category: Dermatology Authors: Shanthi Narla, Jonathan I. Silverberg, Eric L. Simpson Source Type: research

Experiences with and Perception of a Web-Based Mindfulness, Nutrition, and Fitness Platform Reported by First-Year University Students: A Qualitative Study
Publication date: Available online 10 June 2021Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Jessica R.L. Lieffers, Maira Quintanilha, Claire F. Trottier, Steven T. Johnson, João F. Mota, Carla M. Prado (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - June 10, 2021 Category: Nutrition Source Type: research

A bibliometric analysis and systematic literature review of tourism-environmental degradation nexus
This study aims to provide a comprehensive knowledge map of tourism and environmental degradation literature review based on scientific articles published between 1999 and 2020. The study provides an overview of research, influential authors, and journals. The PR China has maintained the lead in academic research with the most contribution in academic research in recent years. Sustainability, the Chinese Academy of Sciences, and Katircioglu are the most productive journal, academic institution, and author in the field of tourism and environmental degradation, respectively. The degree of research contribution among research...
Source: Environmental Science and Pollution Research International - June 10, 2021 Category: Environmental Health Authors: Muhammad Shahbaz Muhammad Farhan Bashir Muhammad Adnan Bashir Luqman Shahzad Source Type: research

A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis [Biochemistry]
Plants synthesize many diverse small molecules that affect function of the mammalian central nervous system, making them crucial sources of therapeutics for neurological disorders. A notable portion of neuroactive phytochemicals are lysine-derived alkaloids, but the mechanisms by which plants produce these compounds have remained largely unexplored. To better understand how... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 10, 2021 Category: Science Authors: Ryan S. Nett, Yaereen Dho, Yun-Yee Low, Elizabeth S. Sattely Tags: Biochemistry Biological Sciences Source Type: research

Cutaneous Langerhans cell histiocytosis in adults: a retrospective cohort study of adult patients presenting to a single academic cancer center between 2003-2017
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 10, 2021 Category: Dermatology Authors: Ai-Tram N. Bui, Cecilia Larocca, Anita Giobbie-Hurder, Eric D. Jacobsen, Nicole R. LeBoeuf Source Type: research

Authors’ Response
Publication date: Available online 9 June 2021Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Parke Wilde (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - June 9, 2021 Category: Nutrition Source Type: research

Acetabular Bone Marrow Aspiration During Total Hip Arthroplasty
J Am Acad Orthop Surg. 2021 Jun 9. doi: 10.5435/JAAOS-D-21-00085. Online ahead of print.ABSTRACTBiologically augmented surgical treatments of orthopaedic conditions are increasingly popular. Bone marrow aspirate concentrate is a key orthobiologic tissue source, and the field is moving from the standard iliac crest marrow aspiration toward local aspirations of marrow depots that are accessible during the standard-of-care procedures in an attempt to reduce morbidity, surgery time, and cost. Here, we present the aspiration of the standard iliac marrow depot, but through a novel acetabular approach during total hip arthroplast...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 9, 2021 Category: Orthopaedics Authors: Severin Ruoss Scott T Ball Shanelle N Dorn Jesal N Parekh Alexander J Whitehead Adam J Engler Samuel R Ward Source Type: research

Patient Goal-directed Care in an Orthopaedic Spine Specialty Clinic
J Am Acad Orthop Surg. 2021 Jun 9. doi: 10.5435/JAAOS-D-20-01105. Online ahead of print.ABSTRACTINTRODUCTION: Using health-related goals to direct care could improve quality and reduce cost of medical care; however, the effect of these goals for patients with spinal pathologies is not well understood. The purpose of this study was to describe patient-reported goals by provider type and to evaluate the effect of patient-provider goal awareness on patient satisfaction and treatment pathway.METHODS: A pilot program was instituted in which all new or existing patients scheduled with either a single spine surgeon or a nonsurgic...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 9, 2021 Category: Orthopaedics Authors: Justin Turcotte McKayla Kelly Kerry Lynch Karen Pipkin Chad Patton Source Type: research

Popliteal Artery Entrapment Syndrome: A Diagnostic and Treatment Enigma for Orthopaedic Surgeons
J Am Acad Orthop Surg. 2021 Jun 9. doi: 10.5435/JAAOS-D-21-00151. Online ahead of print.ABSTRACTPopliteal artery entrapment syndrome (PAES) is an uncommon condition that causes recurrent posterior leg pain and foot paresthesia in running athletes. This condition occurs most commonly due to an accessory or abnormal implant of the medial head of the gastrocnemius muscle. It may mimic or coincide with other chronic conditions of the lower extremity including chronic exertional compartment syndrome but is most consistent with vascular claudication. Clinical features that distinguish PAES from other causes of leg pain include a...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 9, 2021 Category: Orthopaedics Authors: Timothy L Miller Rose Backs Patrick S Vaccaro Source Type: research

Patient Goal-directed Care in an Orthopaedic Spine Specialty Clinic
J Am Acad Orthop Surg. 2021 Jun 9. doi: 10.5435/JAAOS-D-20-01105. Online ahead of print.ABSTRACTINTRODUCTION: Using health-related goals to direct care could improve quality and reduce cost of medical care; however, the effect of these goals for patients with spinal pathologies is not well understood. The purpose of this study was to describe patient-reported goals by provider type and to evaluate the effect of patient-provider goal awareness on patient satisfaction and treatment pathway.METHODS: A pilot program was instituted in which all new or existing patients scheduled with either a single spine surgeon or a nonsurgic...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 9, 2021 Category: Orthopaedics Authors: Justin Turcotte McKayla Kelly Kerry Lynch Karen Pipkin Chad Patton Source Type: research

Acetabular Bone Marrow Aspiration During Total Hip Arthroplasty
J Am Acad Orthop Surg. 2021 Jun 9. doi: 10.5435/JAAOS-D-21-00085. Online ahead of print.ABSTRACTBiologically augmented surgical treatments of orthopaedic conditions are increasingly popular. Bone marrow aspirate concentrate is a key orthobiologic tissue source, and the field is moving from the standard iliac crest marrow aspiration toward local aspirations of marrow depots that are accessible during the standard-of-care procedures in an attempt to reduce morbidity, surgery time, and cost. Here, we present the aspiration of the standard iliac marrow depot, but through a novel acetabular approach during total hip arthroplast...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 9, 2021 Category: Orthopaedics Authors: Severin Ruoss Scott T Ball Shanelle N Dorn Jesal N Parekh Alexander J Whitehead Adam J Engler Samuel R Ward Source Type: research

Popliteal Artery Entrapment Syndrome: A Diagnostic and Treatment Enigma for Orthopaedic Surgeons
J Am Acad Orthop Surg. 2021 Jun 9. doi: 10.5435/JAAOS-D-21-00151. Online ahead of print.ABSTRACTPopliteal artery entrapment syndrome (PAES) is an uncommon condition that causes recurrent posterior leg pain and foot paresthesia in running athletes. This condition occurs most commonly due to an accessory or abnormal implant of the medial head of the gastrocnemius muscle. It may mimic or coincide with other chronic conditions of the lower extremity including chronic exertional compartment syndrome but is most consistent with vascular claudication. Clinical features that distinguish PAES from other causes of leg pain include a...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 9, 2021 Category: Orthopaedics Authors: Timothy L Miller Rose Backs Patrick S Vaccaro Source Type: research

Patient Goal-directed Care in an Orthopaedic Spine Specialty Clinic
J Am Acad Orthop Surg. 2021 Jun 9. doi: 10.5435/JAAOS-D-20-01105. Online ahead of print.ABSTRACTINTRODUCTION: Using health-related goals to direct care could improve quality and reduce cost of medical care; however, the effect of these goals for patients with spinal pathologies is not well understood. The purpose of this study was to describe patient-reported goals by provider type and to evaluate the effect of patient-provider goal awareness on patient satisfaction and treatment pathway.METHODS: A pilot program was instituted in which all new or existing patients scheduled with either a single spine surgeon or a nonsurgic...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 9, 2021 Category: Orthopaedics Authors: Justin Turcotte McKayla Kelly Kerry Lynch Karen Pipkin Chad Patton Source Type: research

Acetabular Bone Marrow Aspiration During Total Hip Arthroplasty
J Am Acad Orthop Surg. 2021 Jun 9. doi: 10.5435/JAAOS-D-21-00085. Online ahead of print.ABSTRACTBiologically augmented surgical treatments of orthopaedic conditions are increasingly popular. Bone marrow aspirate concentrate is a key orthobiologic tissue source, and the field is moving from the standard iliac crest marrow aspiration toward local aspirations of marrow depots that are accessible during the standard-of-care procedures in an attempt to reduce morbidity, surgery time, and cost. Here, we present the aspiration of the standard iliac marrow depot, but through a novel acetabular approach during total hip arthroplast...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 9, 2021 Category: Orthopaedics Authors: Severin Ruoss Scott T Ball Shanelle N Dorn Jesal N Parekh Alexander J Whitehead Adam J Engler Samuel R Ward Source Type: research

August Book Forum: We Hear You
In June and July of last year, JAACAP Senior Editors recruited researchers and clinicians across the globe to complete an open-ended online questionnaire about their perceptions of the pandemic ’s effects on children and adolescents and which of these issues deserved immediate attention in future research. In May, JAACAP published the survey results.1 In keeping with these findings, the Book Forum has turned its focus to reviewing resources specific to the concerns raised by these partic ipants. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - June 9, 2021 Category: Psychiatry Authors: Julie A. Chilton Source Type: research

The Transition of Academic Mental Health Clinics to Telehealth During the COVID-19 Pandemic
A consortium of eight academic child and adolescent psychiatry programs in the United States and Canada examined their pivot from in-person, clinic-based services to home-based telehealth during the COVID-19 pandemic. The aims were to document the transition across diverse sites and present recommendations for future telehealth service planning. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - June 9, 2021 Category: Psychiatry Authors: Johanna B. Folk, Marissa A. Schiel, Rachel Oblath, Vera Feuer, Aditi Sharma, Shabana Khan, Bridget Doan, Chetana Kulkarni, Ujjwal Ramtekkar, Jessica Hawks, Victor Fornari, Lisa R. Fortuna, Kathleen Myers Tags: New Research Source Type: research

Opinion: How to ensure regulations don’t stymie much-needed COVID-19 point-of-care testing [Chemistry]
The coronavirus disease 2019 (COVID-19) pandemic has raged for more than a year in the United States, upending life as we knew it. Nevertheless, we have seen incredibly rapid advances in vaccines, therapeutics, and diagnostic testing technology. There is tremendous need and economic interest in reopening our businesses and schools... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 9, 2021 Category: Science Authors: Clare Rock, Jonathan Zenilman Tags: Opinions, Chemistry, Medical Sciences, Front Matter, Coronavirus Related Source Type: research

Characterizing public perceptions of social and cultural impacts in policy decisions [Psychological and Cognitive Sciences]
Social scientists and community advocates have expressed concerns that many social and cultural impacts important to citizens are given insufficient weight by decision makers in public policy decision-making. In two large cross-sectional surveys, we examined public perceptions of a range of social, cultural, health, economic, and environmental impacts. Findings suggest... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 9, 2021 Category: Science Authors: Nathan F. Dieckmann, Robin Gregory, Terre Satterfield, Marcus Mayorga, Paul Slovic Tags: Psychological and Cognitive Sciences Social Sciences Source Type: research

The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes [Genetics]
DNA replication is dramatically slowed down under replication stress. The regulation of replication speed is a conserved response in eukaryotes and, in fission yeast, requires the checkpoint kinases Rad3ATR and Cds1Chk2. However, the underlying mechanism of this checkpoint regulation remains unresolved. Here, we report that the Rad3ATR-Cds1Chk2 checkpoint directly targets... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 9, 2021 Category: Science Authors: Yang Liu, Lu Wang, Xin Xu, Yue Yuan, Bo Zhang, Zeyang Li, Yuchen Xie, Rui Yan, Zeqi Zheng, Jianguo Ji, Johanne M. Murray, Antony M. Carr, Daochun Kong Tags: Genetics Biological Sciences Source Type: research

Fifty million years of beetle evolution along the Antarctic Polar Front [Evolution]
Global cooling and glacial–interglacial cycles since Antarctica’s isolation have been responsible for the diversification of the region’s marine fauna. By contrast, these same Earth system processes are thought to have played little role terrestrially, other than driving widespread extinctions. Here, we show that on islands along the Antarctic Polar Front,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 9, 2021 Category: Science Authors: Helena P. Baird, Seunggwan Shin, Rolf G. Oberprieler, Maurice Hulle, Philippe Vernon, Katherine L. Moon, Richard H. Adams, Duane D. McKenna, Steven L. Chown Tags: Evolution Biological Sciences Source Type: research

Involvement of Scratch2 in GalR1-mediated depression-like behaviors in the rat ventral periaqueductal gray [Neuroscience]
Galanin receptor1 (GalR1) transcript levels are elevated in the rat ventral periaqueductal gray (vPAG) after chronic mild stress (CMS) and are related to depression-like behavior. To explore the mechanisms underlying the elevated GalR1 expression, we carried out molecular biological experiments in vitro and in animal behavioral experiments in vivo. It... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 9, 2021 Category: Science Authors: Yutao Yang, Yueting Li, Bo Liu, Chenchen Li, Ziȷin Liu, Jiahui Deng, Hanȷiang Luo, Xiaoxiao Li, Jinȷin Wu, Hui Li, Chuan–Yue Wang, Ming Zhao, Haohao Wu, Francois Lallemend, Per Svenningsson, Tomas G. M. Hokfelt, Zhi–Qing D Tags: Neuroscience Biological Sciences Source Type: research

Designing antimalarials that break into cells to lock down parasites [Biochemistry]
A once in a century new viral outbreak, COVID-19, has caused unfathomable numbers of deaths, toward 4 million. Yet an ancient disease, malaria, endemic to the residents of more than half of Earth, is even more devastating than this pandemic over time: It caused about 12 million deaths in the... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 9, 2021 Category: Science Authors: Svetlana Glushakova, Joshua Zimmerberg Tags: Biochemistry, Commentaries Commentary Source Type: research

HIF-1{alpha} is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes [Immunology and Inflammation]
Patients with severe COVID-19 infection exhibit a low level of oxygen in affected tissue and blood. To understand the pathophysiology of COVID-19 infection, it is therefore necessary to understand cell function during hypoxia. We investigated aspects of human monocyte activation under hypoxic conditions. HMGB1 is an alarmin released by stressed... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 9, 2021 Category: Science Authors: Travis Peng, Shin-Yi Du, Myoungsun Son, Betty Diamond Tags: Immunology and Inflammation, Coronavirus (COVID-19) Biological Sciences Source Type: research

Delgocitinib ointment in pediatric patients with atopic dermatitis: a phase 3, randomized, double-blind, vehicle-controlled study and a subsequent open-label, long-term study
Capsule Summary ● Delgocitinib ointment, a topical Janus kinase inhibitor, was effective and well tolerated when applied to Japanese pediatric patients with atopic dermatitis for up to 56 weeks.● Delgocitinib ointment is a promising therapeutic option for atopic dermatitis in children as well as in adults. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 9, 2021 Category: Dermatology Authors: Hidemi Nakagawa, Osamu Nemoto, Atsuyuki Igarashi, Hidehisa Saeki, Kenji Kabashima, Manabu Oda, Takeshi Nagata Source Type: research

Risk of psoriasis according to body mass index: a retrospective cohort analysis
There is limited data on the incidence of psoriasis according to BMI. This analysis may support counseling and weigh management strategies for patients at risk for psoriasis, such as those with family history. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 9, 2021 Category: Dermatology Authors: Alexandra Norden, Sergey Rekhtman, Andrew Strunk, Amit Garg Source Type: research

Interpretation of genomic sequence variants in genetic skin diseases: A primer for clinicians
Over 1,000 heritable disorders have cutaneous manifestations, some of them being syndromic in association with extracutaneous manifestations, while others being limited to the skin. The genetic basis of many of these conditions has been deciphered, and mutation analysis by next-generation sequencing approaches, including whole-exome sequencing, whole-genome sequencing, and whole-transcriptome analysis, are now increasingly part of the diagnostic process. Besides confirming the diagnosis, information on the specific mutations can be used for sub-classification with prognostication and identification of carriers leading to a...
Source: Journal of the American Academy of Dermatology - June 9, 2021 Category: Dermatology Authors: Jouni Uitto, Amir H. Saedian, Leila Youssefian, Hassan Vahidnezhad Source Type: research

Sensors, Vol. 21, Pages 3979: Ocean-Bottom Seismographs Based on Broadband MET Sensors: Architecture and Deployment Case Study in the Arctic
lexander V. Neeshpapa Grigory O. Velichko Leopold I. Lobkovsky Igor P. Medvedev Igor P. Semiletov The Arctic seas are now of particular interest due to their prospects in terms of hydrocarbon extraction, development of marine transport routes, etc. Thus, various geohazards, including those related to seismicity, require detailed studies, especially by instrumental methods. This paper is devoted to the ocean-bottom seismographs (OBS) based on broadband molecular–electronic transfer (MET) sensors and a deployment case study in the Laptev Sea. The purpose of the study is to introduce the architecture of seve...
Source: Sensors - June 9, 2021 Category: Biotechnology Authors: Artem A. Krylov Ivan V. Egorov Sergey A. Kovachev Dmitry A. Ilinskiy Oleg Yu. Ganzha Georgy K. Timashkevich Konstantin A. Roginskiy Mikhail E. Kulikov Mikhail A. Novikov Vladimir N. Ivanov Elena A. Radiuk Daria D. Rukavishnikova Alexander V. Neeshpapa Gri Tags: Article Source Type: research

Journal Based CME Instructions and Information
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 8, 2021 Category: Dermatology Source Type: research

July 2021: Lisinopril for delayed inflammatory responses to hyaluronic acid fillers after COVID-19 vaccinations
In the April 2021 edition of JAAD Case Reports, Munavalli et  al1 reported a case series of 4 patients in whom delayed inflammatory responses to dermal hyaluronic acid filler developed following COVID-19 vaccination. All the patients had the facial filler placed for>8  months prior to the vaccination and significant edema developed at the sites of the filler 24-48 hours after receiving the COVID-19 messenger RNA vaccination. Through a proposed novel mechanism of action, the authors reported a rapid improvement with lisinopril via the inhibition of angiotensin-c onverting enzyme. (Source: Journal of the Am...
Source: Journal of the American Academy of Dermatology - June 8, 2021 Category: Dermatology Authors: Brett Sloan Tags: This month in Source Type: research

June iotaderma (#328)
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 8, 2021 Category: Dermatology Authors: Robert I. Rudolph Tags: JAAD Online Source Type: research

July iotaderma (#329)
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 8, 2021 Category: Dermatology Authors: Robert I. Rudolph Tags: JAAD Online Source Type: research

CME examination
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 8, 2021 Category: Dermatology Tags: Continuing medical education Source Type: research

Answers to CME examination
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 8, 2021 Category: Dermatology Tags: Continuing medical education Source Type: research