Advocacy and Public Policy Efforts of the American Academy of Addiction Psychiatry.
PMID: 32902042 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - September 1, 2020 Category: Addiction Authors: Rosenthal RN, Welsh JW, Connery HS, Barnett BS, DeVido J, Hill K, Levin FR, Williams AR, Greenfield SF Tags: Am J Addict Source Type: research

Establishing the First Annual Meetings of the American Academy of Addiction Psychiatry.
Abstract This paper describes the initial meetings of the American Academy of Addiction Psychiatry, and it compares and contrasts these relatively small meetings with the much larger meetings today. The paper is centered on the organization's initial focus on establishing itself in the mainstream of medicine and psychiatry. (Am J Addict 2020;00:00-00). PMID: 32902043 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - September 1, 2020 Category: Addiction Authors: Weiss RD Tags: Am J Addict Source Type: research

Evolution of the Journal of the American Academy of Addiction Psychiatry: The American Journal on Addictions.
PMID: 32902044 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - September 1, 2020 Category: Addiction Authors: Kosten TR, Frances R, Domingo CB Tags: Am J Addict Source Type: research

A Celebration of the 35th Anniversary of the American Academy of Addiction Psychiatry.
PMID: 32902046 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - September 1, 2020 Category: Addiction Authors: Renner JA Tags: Am J Addict Source Type: research

The American Psychiatric Association Creates a Subspecialty: The Birth of Addiction Psychiatry, Early Years of the American Academy of Addiction Psychiatry.
PMID: 32902053 [PubMed - in process] (Source: American Journal on Addictions)
Source: American Journal on Addictions - September 1, 2020 Category: Addiction Authors: Frances R, Nace E, Khantzian E, Kaufman E Tags: Am J Addict Source Type: research

“Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth”: National Academies Report Calling for a Decade of Children and Youth
American Journal of Psychiatry,Volume 177, Issue 9, Page 808-810, September 01, 2020. (Source: American Journal of Psychiatry)
Source: American Journal of Psychiatry - September 1, 2020 Category: Psychiatry Authors: Ricardo F. Mu ñoz Myrna M. Weissman Source Type: research

The motley drivers of heat and cold exposure in 21st century US cities [Sustainability Science]
We use a suite of decadal-length regional climate simulations to quantify potential changes in population-weighted heat and cold exposure in 47 US metropolitan regions during the 21st century. Our results show that population-weighted exposure to locally defined extreme heat (i.e., “population heat exposure”) would increase by a factor of 12.7–29.5... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Ashley Mark Broadbent, Eric Scott Krayenhoff, Matei Georgescu Tags: Physical Sciences Source Type: research

News and Notes
International Academy of Gnathology - American Section (Source: Journal of Prosthetic Dentistry)
Source: Journal of Prosthetic Dentistry - September 1, 2020 Category: Dentistry Source Type: research

"Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth": National Academies Report Calling for a Decade of Children and Youth.
"Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth": National Academies Report Calling for a Decade of Children and Youth. Am J Psychiatry. 2020 Sep 01;177(9):808-810 Authors: Muñoz RF, Weissman MM PMID: 32867521 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2020 Category: Psychiatry Authors: Muñoz RF, Weissman MM Tags: Am J Psychiatry Source Type: research

Editorial: The Preschool Emotional Brain: Connections Matter
There is broad consensus that children ’s ability to regulate emotion, particularly negative affect, can have enormous implications for the cascading processes underlying social and emotional development. With the burgeoning autonomy of toddlerhood comes a rudimentary understanding of the varieties of emotional experience, and initial awareness that a child’s actions can augment or attenuate the intensity of those experiences. Successful forays into emotion regulation are crucial for healthy psychological development, allowing children to accommodate life’s difficulties by purposefully altering their emot...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - September 1, 2020 Category: Psychiatry Authors: Justin D. Russell, Ryan J. Herringa Tags: Editorial Source Type: research

Editorial: Sharpening Our Focus on Early Adversity, Development, and Resilience Through Cross-National Research
The impacts of the Adverse Childhood Experiences (ACEs) study continue to reverberate across medicine, influencing clinical practice, research, and public policy, prompting reexamination of the original ACEs research, and generating a range of new research questions that are critical for understanding health and development across the lifespan1,2. Within child and adolescent psychiatry, this explosion of interest in childhood trauma and its consequences is generating rich new areas of inquiry: how does adversity become biologically embedded in brain structure and functioning? What familial, environmental and genetic factor...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - September 1, 2020 Category: Psychiatry Authors: Matthew G. Biel, Erica E. Coates Tags: Editorial Source Type: research

School Closures and Social Anxiety During the COVID-19 Pandemic
In their recent systematic review, Loades et al.1 reported on the effects that social isolation and loneliness may have on children and adolescents during the global coronavirus disease 2019 (COVID-19) pandemic, with their findings suggesting associations between social anxiety and loneliness/social isolation. While this is undoubtedly true for many individuals, it is also worth commenting upon the subset of children and youth with social phobia for whom a temporary lessening of distress may be observed while schools are closed due to a lack of exposure to anxiety-provoking situations in the school environment. (Source: Jo...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - September 1, 2020 Category: Psychiatry Authors: Matthew Morrissette Tags: Letter to the Editor Source Type: research

Dr. Loades and Prof. Reynolds Reply
: (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - September 1, 2020 Category: Psychiatry Authors: Maria Elizabeth Loades, Shirley Reynolds Tags: Letter to the Editor Source Type: research

“Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth”: National Academies Report Calling for a Decade of Children and Youth
American Journal of Psychiatry,Volume 177, Issue 9, Page 808-810, September 01, 2020. (Source: American Journal of Psychiatry)
Source: American Journal of Psychiatry - September 1, 2020 Category: Psychiatry Authors: Ricardo F. Mu ñoz Myrna M. Weissman Source Type: research

Aspirin after Acute Ischemic Stroke.
PMID: 32866353 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Conway J, Friedman BW Tags: Am Fam Physician Source Type: research

Treatment of Subclinical Hypothyroidism: BMJ Rapid Recommendation.
PMID: 32866354 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Pyzocha N Tags: Am Fam Physician Source Type: research

Cloudy Pleural Fluid on Thoracentesis.
PMID: 32866355 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Bailey J, Florence J Tags: Am Fam Physician Source Type: research

Corticosteroids for Hospitalized Patients with Community-Acquired Pneumonia.
PMID: 32866356 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Cayley WE Tags: Am Fam Physician Source Type: research

Esophageal Motility Disorders.
Abstract Esophageal motility disorders can cause chest pain, heartburn, or dysphagia. They are diagnosed based on specific patterns seen on esophageal manometry, ranging from the complete absence of contractility in patients with achalasia to unusually forceful or disordered contractions in those with hypercontractile motility disorders. Achalasia has objective diagnostic criteria, and effective treatments are available. Timely diagnosis results in better outcomes. Recent research suggests that hypercontractile motility disorders may be overdiagnosed, leading to unnecessary and irreversible interventions. Many sym...
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Wilkinson JM, Halland M Tags: Am Fam Physician Source Type: research

Health Equity in Preventive Services: The Role of Primary Care.
PMID: 32866358 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Teutsch S, Carey TS, Pignone M Tags: Am Fam Physician Source Type: research

Misoprostol Dosing for First-Trimester Abortion.
PMID: 32866359 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Do AC, Neher JO, Safranek S Tags: Am Fam Physician Source Type: research

Otitis Media, COVID-19 and Hydroxychloroquine, Postoperative Pulmonary Risk, Hidradenitis Suppurativa.
Authors: PMID: 32866360 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Tags: Am Fam Physician Source Type: research

Palliative Care During Public Health Emergencies: Examples from the COVID-19 Pandemic.
PMID: 32866361 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Gracey K, Martin S, Reidy J Tags: Am Fam Physician Source Type: research

Placental Alpha Macroglobulin-1 (PartoSure) Immunoassay to Assess the Risk of Spontaneous Preterm Birth.
PMID: 32866362 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Brown SR Tags: Am Fam Physician Source Type: research

Effectiveness of PPAR Gamma Agonists in Preventing Recurrent Stroke and Other Vascular Events.
PMID: 32866363 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Singh M, Grine K, Hays A Tags: Am Fam Physician Source Type: research

Thyroid Nodules: Advances in Evaluation and Management.
Abstract Thyroid nodules can be detected by ultrasonography in up to 68% of the general population. They are typically benign and are often discovered incidentally. The primary goal of thyroid nodule evaluation is to determine whether it is malignant. After thyroid ultrasonography has been performed, the next step is measurement of serum thyroid-stimulating hormone. If levels are low, a radionuclide thyroid uptake scan is indicated. Hyperfunctioning nodules are rarely malignant and do not require tissue sampling. Nonfunctioning nodules and nodules in a patient with a normal or high thyroid-stimulating hormone leve...
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Kant R, Davis A, Verma V Tags: Am Fam Physician Source Type: research

Urinary Tract Infections in Young Children and Infants: Common Questions and Answers.
Abstract Urinary tract infections (UTIs) are common in children and are associated with significant short- and long-term morbidity. They have a high recurrence rate and are associated with anatomic and functional abnormalities. The decision to test for UTI is based on risk factors and the child's age. Urinalysis is valuable to rule out UTI and to help decide when to start antibiotics; however, urine culture is needed for definitive diagnosis. Urine specimens collected via perineal bagging should not be used for culture because of high false-positive rates. Diagnosis of UTI requires pyuria and bacterial growth in t...
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Veauthier B, Miller MV Tags: Am Fam Physician Source Type: research

We're Listening and Taking Action on Racism and Health Inequities.
PMID: 32866366 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Authors: Sexton S Tags: Am Fam Physician Source Type: research

UTIs in Children: What to Expect.
Authors: PMID: 32866367 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - September 1, 2020 Category: Primary Care Tags: Am Fam Physician Source Type: research

Screening for HIV-Associated Neurocognitive Disorder (HAND) in Adults Aged 50 and Over Attending a Government HIV Clinic in Kilimanjaro, Tanzania. Comparison of the International HIV Dementia Scale (IHDS) and IDEA Six Item Dementia Screen
AbstractValidated screening tools for HIV-associated neurocognitive disorders (HAND) are lacking for the newly emergent ageing population of people living with HIV (PLWH) in sub-Saharan Africa (SSA). We aimed to validate and compare diagnostic accuracy of two cognitive screening tools, the International HIV dementia scale (IHDS), and the Identification and Interventions for Dementia in Elderly Africans (IDEA) screen, for identification of HAND in older PLWH in Tanzania. A systematic sample of 253 PLWH aged  ≥ 50 attending a Government clinic in Tanzania were screened with the IHDS and IDEA. HAND were diagn...
Source: AIDS and Behavior - September 1, 2020 Category: Infectious Diseases Source Type: research

JAAD Consultative Dermatology- relaunched.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - September 1, 2020 Category: Dermatology Authors: Lucia Seminario-Vidal, Lindy P. Fox, Jane M. Grant-Kels, Dirk Elston Source Type: research

“Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth”: National Academies Report Calling for a Decade of Children and Youth
American Journal of Psychiatry,Volume 177, Issue 9, Page 808-810, September 01, 2020. (Source: American Journal of Psychiatry)
Source: American Journal of Psychiatry - September 1, 2020 Category: Psychiatry Authors: Ricardo F. Mu ñoz Myrna M. Weissman Source Type: research

In This Issue [This Week in PNAS]
Arctic plants and snow cover Snow buttercup in a meadow. Arctic tundra faces some of the most rapid climate change, with corresponding consequences for ecosystems. Climate change alters the diversity and distribution of functional traits in ecosystems, but the role of snow cover in functional trait diversity has not been... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Tags: In This Issue This Week in PNAS Source Type: research

Are nitrogen-to-phosphorus ratios of Chinese lakes actually increasing? [Biological Sciences]
Tong et al. (1) demonstrate an increased mass ratio of total nitrogen to total phosphorus (TN:TP) and decreased TP concentration in many Chinese lakes in association with widespread construction of sewage collection and treatment plants during 2008 to 2017. We argue this conclusion is not true and likely leads to... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Boqiang Qin, Yunlin Zhang, Guangwei Zhu, Zhijun Gong, Jianming Deng, David P. Hamilton, Guang Gao, Kun Shi, Jian Zhou, Keqiang Shao, Mengyuan Zhu, Yongqiang Zhou, Xiangming Tang, Liang Li Tags: Letters Source Type: research

Reply to Qin et al.: Consistency of monitoring data is key to explain the long-term nationwide trend of nutrients in lakes [Biological Sciences]
We appreciate the response to our recent publication in PNAS (1). Qin et al. (2) state that they found a different total nitrogen/total phosphorus (TN/TP) trend over time by using a different dataset and argue that this difference was mainly caused by a difference in field sample pretreatment and biogeochemical... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Yan Lin, Xin Dong, Mengzhu Wang, Yindong Tong Tags: Letters Source Type: research

QnAs with Sharad Goel and Allison Koenecke [QnAs]
Sharad Goel works at the interface of computer science, statistics, and the social sciences. An assistant professor of management science and engineering at Stanford University, Goel has applied computational and statistical techniques to study a variety of socially relevant, policy-related topics, including voter fraud and political polarization. Goel and a... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Sandeep Ravindran Tags: QnAs Source Type: research

Profile of Edward H. Egelman [Profiles]
Edward H. Egelman has had a long and distinguished career as a biophysicist, but he took a fairly circuitous path into science. Egelman graduated high school in 1968, a particularly tumultuous year for the United States. “This was the peak of the Vietnam war and my main interests at that... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Sandeep Ravindran Tags: PNAS Profiles Source Type: research

A panorama of transcription-coupled repair in yeast chromatin [Genetics]
Cyclobutane pyrimidine dimers (CPDs) are predominant ultraviolet (UV) light-induced DNA lesions that can result in mutations and lead to skin cancers (1). CPD lesions are primarily repaired by nucleotide excision repair (NER), a highly conserved repair pathway (2). NER consists of two subpathways: transcription-coupled NER (TC-NER) and global genome NER... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Dong Wang Tags: Commentaries Source Type: research

An endosymbiont’s ȷourney through metamorphosis of its insect host [Evolution]
Symbiotic microorganisms are essential for the lives of many multicellular eukaryotes (1). In insects, decades of symbiosis and—more recently—microbiome research have shown that microbial symbionts can supplement limiting nutrients, aid in digestion or detoxification, and defend their host against antagonists, thereby expanding the ecological and evolutionary potential of their hosts... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Martin Kaltenpoth Tags: Commentaries Source Type: research

Ediacaran sponges, animal biomineralization, and skeletal reefs [Earth, Atmospheric, and Planetary Sciences]
With an estimated 15,000 living species (1), the animal phylum Porifera (colloquially known as sponges) is not a biodiversity heavyweight as are arthropods, mollusks, and chordates. Unassuming in character, sponges barely move in their adult lifetime of up to several thousand years, and they passively strain food particles from water... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Shuhai Xiao Tags: Commentaries Source Type: research

Root angle modifications by the DRO1 homolog improve rice yields in saline paddy fields [Agricultural Sciences]
The root system architecture (RSA) of crops can affect their production, particularly in abiotic stress conditions, such as with drought, waterlogging, and salinity. Salinity is a growing problem worldwide that negatively impacts on crop productivity, and it is believed that yields could be improved if RSAs that enabled plants to... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Yuka Kitomi, Eiko Hanzawa, Noriyuki Kuya, Haruhiko Inoue, Naho Hara, Sawako Kawai, Noriko Kanno, Masaki Endo, Kazuhiko Sugimoto, Toshimasa Yamazaki, Shingo Sakamoto, Naoki Sentoku, Jianzhong Wu, Hitoshi Kanno, Nobutaka Mitsuda, Kinya Toriyama, Tadashi Sat Tags: Biological Sciences Source Type: research

Extended dilation of the radiocarbon time scale between 40,000 and 48,000 y BP and the overlap between Neanderthals and Homo sapiens [Anthropology]
The new radiocarbon calibration curve (IntCal20) allows us to calculate the gradient of the relationship between 14C age and calendar age over the past 55 millennia before the present (55 ka BP). The new gradient curve exhibits a prolonged and prominent maximum between 48 and 40 ka BP during which... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Edouard Bard, Timothy J. Heaton, Sahra Talamo, Bernd Kromer, Ron W. Reimer, Paula J. Reimer Tags: Brief Reports Physical Sciences Source Type: research

Covariation of fetal skull and maternal pelvis during the perinatal period in rhesus macaques and evolution of childbirth in primates [Anthropology]
A large brain combined with an upright posture in humans has resulted in a high cephalopelvic proportion and frequently obstructed labor. Fischer and Mitteroecker [B. Fischer, P. Mitteroecker, Proc. Natl. Acad. Sci. U.S.A. 112, 5655−5660 (2015)] proposed that the morphological covariations between the skull and pelvis could have evolved to... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Mikaze Kawada, Masato Nakatsukasa, Takeshi Nishimura, Akihisa Kaneko, Naoki Morimoto Tags: Biological Sciences Source Type: research

Ultraflexible organic light-emitting diodes for optogenetic nerve stimulation [Applied Biological Sciences]
Organic electronic devices implemented on flexible thin films are attracting increased attention for biomedical applications because they possess extraordinary conformity to curved surfaces. A neuronal device equipped with an organic light-emitting diode (OLED), used in combination with animals that are genetically engineered to include a light-gated ion channel, would enable... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Dongmin Kim, Tomoyuki Yokota, Toshiki Suzuki, Sunghoon Lee, Taeseong Woo, Wakako Yukita, Mari Koizumi, Yutaro Tachibana, Hiromu Yawo, Hiroshi Onodera, Masaki Sekino, Takao Someya Tags: Physical Sciences Source Type: research

Massively parallel classical logic via coherent dynamics of an ensemble of quantum systems with dispersion in size [Applied Physical Sciences]
Quantum parallelism can be implemented on a classical ensemble of discrete level quantum systems. The nanosystems are not quite identical, and the ensemble represents their individual variability. An underlying Lie algebraic theory is developed using the closure of the algebra to demonstrate the parallel information processing at the level of... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Hugo Gattuso, R. D. Levine, F. Remacle Tags: Physical Sciences Source Type: research

Supernova triggers for end-Devonian extinctions [Astronomy]
The Late Devonian was a protracted period of low speciation resulting in biodiversity decline, culminating in extinction events near the Devonian–Carboniferous boundary. Recent evidence indicates that the final extinction event may have coincided with a dramatic drop in stratospheric ozone, possibly due to a global temperature rise. Here we study... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Brian D. Fields, Adrian L. Melott, John Ellis, Adrienne F. Ertel, Brian J. Fry, Bruce S. Lieberman, Zhenghai Liu, Jesse A. Miller, Brian C. Thomas Tags: Brief Reports Physical Sciences Source Type: research

Quantifying the information impact of future searches for exoplanetary biosignatures [Astronomy]
One of the major goals for astronomy in the next decades is the remote search for biosignatures (i.e., the spectroscopic evidence of biological activity) in exoplanets. Here we adopt a Bayesian statistical framework to discuss the implications of such future searches, both in the case when life is detected and... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Amedeo Balbi, Claudio Grimaldi Tags: Physical Sciences Source Type: research

How a B family DNA polymerase has been evolved to copy RNA [Biochemistry]
We report here crystal structures of a reverse transcriptase RTX, which was evolved in vitro from the B family polymerase KOD, in complex with either a DNA duplex or an RNA–DNA hybrid. Compared with the apo, binary, and ternary complex structures of the original KOD polymerase, the 16 substitutions that... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Woo Suk Choi, Peng He, Arti Pothukuchy, Jimmy Gollihar, Andrew D. Ellington, Wei Yang Tags: Biological Sciences Source Type: research

Structural basis for amino acid exchange by a human heteromeric amino acid transporter [Biochemistry]
Heteromeric amino acid transporters (HATs) comprise a group of membrane proteins that belong to the solute carrier (SLC) superfamily. They are formed by two different protein components: a light chain subunit from an SLC7 family member and a heavy chain subunit from the SLC3 family. The light chain constitutes the... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Di Wu, Tamara N. Grund, Sonja Welsch, Deryck J. Mills, Max Michel, Schara Safarian, Hartmut Michel Tags: Biological Sciences Source Type: research

Selenoprotein N is an endoplasmic reticulum calcium sensor that links luminal calcium levels to a redox activity [Biochemistry]
The endoplasmic reticulum (ER) is the reservoir for calcium in cells. Luminal calcium levels are determined by calcium-sensing proteins that trigger calcium dynamics in response to calcium fluctuations. Here we report that Selenoprotein N (SEPN1) is a type II transmembrane protein that senses ER calcium fluctuations by binding this ion... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 1, 2020 Category: Science Authors: Alexander Chernorudskiy, Ersilia Varone, Sara Francesca Colombo, Stefano Fumagalli, Alfredo Cagnotto, Angela Cattaneo, Mickael Briens, Mireille Baltzinger, Lauriane Kuhn, Angela Bachi, Andrea Berardi, Mario Salmona, Giovanna Musco, Nica Borgese, Alain Les Tags: Biological Sciences Source Type: research