Navigating the Treatment Landscape

Navigating the Treatment Landscape for Advanced-stage Kidney Cancer Mayer N. Fishman, MD, PhD For the patient with advanced-stage kidney cancer, deciding on a course of treatment presents diverse choices. The physician must weigh how quickly the cancer is spreading, the pattern of that spread, and relative risks from other medical conditions against the patient’s individual treatment goals and medical needs. In many cases of patients with advanced disease, there are therapies that can realistically be used to meet the goals of longer survival, longer time to disease progression, and tumor shrinkage. While choosing a kidney cancer treatment can be a complex process, it is one in which the patient can and should participate. Patient input may impact the disease in real and significant ways. Once the patient and physician decide to start medical therapy, there is an array of options. As shown in Table 1, such options include FDA-approved agents as well as investigational drugs, and can generally be divided into a just a few general categories: Immunotherapy such as interleukin-2 (IL-2) and interferon-alfa, which are cytokines Immunotherapy with checkpoint inhibitors, which are newer agents still only available in trials; examples are the drugs that are PD-1 inhibitors[1],[2],[3] Targeted therapies such as medicines that inhibit the vascular endothelial growth factor (VEGF) pathway; most of these agents are commonly known as VEGF receptor-tyrosine kinase ...
Source: Kidney Cancer Association - Category: Cancer & Oncology Source Type: news

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This study examined whether instrumented gait and balance could determine the magnitude of deterioration in motor-performance from chemotherapy-induced peripheral neuropathy (CIPN).MethodsWe recruited 84 adults with cancer (age = 71.1 ± 9.7 years old, BMI = 26.8 ± 6.2 kg/m2, gender = 56%female) and 57 age-matched non-cancer patients (age = 69.5 ± 9.8 years old, BMI = 27.1 ± 6.0 kg/m2, gender = 79%female). Based on clinical screening, the group with cancer was classified into two groups: participants with CIPN (CIPN+) and without CIPN (CIPN-). Gait ...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 19 January 2019Source: Antiviral ResearchAuthor(s): Anne Leske, Irke Waßmann, Kevin Schnepel, Kyle Shifflett, Julia Holzerland, Linus Bostedt, Patrick Bohn, Thomas C. Mettenleiter, Ana M. Briggiler, Julia Brignone, Delia Enria, Sandra M. Cordo, Thomas Hoenen, Allison GrosethAbstractArenaviruses cause several viral hemorrhagic fevers endemic to Africa and South America. The respective causative agents are classified as biosafety level (BSL) 4 pathogens. Unlike for most other BSL4 agents, for the New World arenavirus Junín virus (JUNV) both a highly effective vaccination (Candi...
Source: Antiviral Therapy - Category: Virology Source Type: research
Authors: Wang X, Zhu H, Xu D Abstract PMID: 30657285 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
CONCLUSIONS: Saffron administration may provide some experimental evidence for the inhibitory effect of saffron on the proliferation of QGY-7703 cells, suggesting that saffron may have potential utility for the treatment of liver cancer. PMID: 30657284 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Zhang Z, Hu C, Wang R, Lin J, Ruan Z Abstract BACKGROUND: To study the predictive factors for new-onset atrial fibrillation (AF) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). METHODS: A total of 934 ACS patients admitted into the Department of Cardiology from February 2015 to February 2017 were collected. All patients were treated with PCI after admission and followed up for 1 year. Data of patients, such as age, gender, past medical history, dyslipidemia, cardiogenic shock, heart failure, medication, culprit vessel, echocardiographic characteristics and...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
In conclusion, the findings reported here will help improve animal’s well-being during vaccine trials for CLA and consequently represent significant contribution to animal’s welfare.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 19 January 2019Source: The Veterinary JournalAuthor(s): K.C. Pinello, J. Niza-Ribeiro, L. Fonseca, A.J. de MatosAbstractLymphoma is one of the most common neoplasms in dogs and it is one of the top five causes of cancer-related deaths, similar to human lymphoma. Companion animal epidemiological studies define dogs as sentinels of potential risk factors for human health, mainly due to shared environments, shorter disease latencies, and spontaneous disease. The aims of this study were to describe human and canine epidemiologic features of non-Hodgkin’s lymphoma (NHL) and their similar...
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Publication date: Available online 19 January 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Mabrouka Doghman-Bouguerra, Enzo LalliAbstractER-mitochondria contact sites represent hubs for signaling that control mitochondrial biology related to several aspects of cellular survival, metabolism, cell death sensitivity and metastasis, which all contribute to tumorigenesis. Altered ER-mitochondria contacts can deregulate Ca2+ homeostasis, phospholipid metabolism, mitochondrial morphology and dynamics. MAM represent both a hot spot in cancer onset and progression and an Achilles' heel of canc...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Publication date: Available online 18 January 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Polly Zhang, Adam Schatz, Babatunde Adeyemi, David Kozminski, JoEllen Welsh, Martin Tenniswood, Wei-Lin Winnie WangAbstractVitamin D3 and its receptor are responsible for controlling energy expenditure in adipocytes and have direct roles in the transcriptional regulation of energy metabolic pathways. This phenomenon also has a significant impact on the etiology of prostate cancer (PCa). Using several in vitro models, the roles of vitamin D3 on energy metabolism and its implication in primary, early ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: 25 February 2019Source: Chemico-Biological Interactions, Volume 300Author(s): Dhanaraj Teekaraman, Sugantha Priya Elayapillai, Mangala Priya Viswanathan, Arunakaran JagadeesanAbstractOvarian cancer is the leading cause of gynaecology related cancer death worldwide. It is often diagnosed with an advanced stage. Apoptosis is a process of programmed cell death controlled by cell cycle machinery and several signaling pathways. Plant-derived compounds have received an increased interest in the treatment of cancer. Quercetin is a flavonoid present in fruits and vegetables which possess anticancer properties. Se...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
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