Researcher finds dangerous levels of metals in liquor sold in Uganda
UCLA Extension ’s Ochan Otim is a chemist who specializes in developing methods for quantifying and assessing the health risk associated with organic and metal contaminants in the environment. For the last few years, Otim, who grew up in Uganda, has been driven to use his expertise to try to help solve a dangero us mystery in his country of birth.Why were so many people having health problems and even dying because of alcohol consumption?The two-decade civil war in Uganda beginning in the late 1980s ravaged the country with violence, abductions, concentration camps and starvation. The inhumane conditions and abject povery led to trauma and depression. Consequently, Otim said, many people were driven to drinking to alleviate their suffering.“It is a well-known phenomenon that when people are subjected to extreme stress, they seek relief, which in most cases involves abuse of recreational drugs, including alcohol,” he said. “Living conditions in the concentration camps eroded traditional social norms and ethics and destroyed the s ocial and cultural fabric of the communities and cut them adrift. When a culture is destroyed, the soul of a community is also destroyed.”Anecdotally, he added, there was talk of dangerous potency in the spirits available on the market in the city of Acoli. This was leading to a widespread culture of fear in the area and calls for a ban on alcohol. Otim wanted to determine what the actual cause was because with...
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00918K, Review ArticleNikhil Srivastava, LINGAMURTHY MACHA, Hyun-Joon Ha Among the large number of structurally diverse alkaloids, 2,6-disubstituted piperidine and its analogs have often been targeted when exploiting new synthetic techniques perhaps because of their strong pharmacological properties. This... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00826E, PaperSi-qin Luo, Wei Liu, Banfeng Ruan, Shilu Fan, Huixia Zhu, Wei Tao, Hua Xiao An expedient cyclopropanation of α-methylene-β-lactams with α-keto esters mediated by P(NMe2)3 has been developed. This reaction enables rapid access to a series of functionalized spirocyclopropyl β-lactams in good yields from... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00864H, CommunicationYoan Chevalier, Yvette Lock Toy Ki, Christian Herrero, Didier Le Nouen, Jean-Pierre Mahy, Jean-Philippe Goddard, Fr édéric Avenier The elusive flavin semiquinone intermediate found in flavoproteins such as cryptochromes has been obtained in aqueous solution by single electron reduction of the natural FMN cofactor using sodium ascorbate. This... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01053G, PaperFeng Li, Voker J äger A potent 20S proteasome inhibitor, 6-deoxy-omuralide was stereoselectively synthesized in 20 steps with 5.1% overall yield staring from a chiral boron agent and D-glyceraldehyde acetonide. The stereoselective alkylation of the... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00765J, CommunicationYingxian Li, CHENG CHENG, Lei Tang, YUAN-YONG YANG A highly enantioselective allylic alkylation of isoquinolinedione derivatives under palladium catalysis was developed in the preparation of quaternary carbon stereocenter. Under standard reaction conditions excellent yields and enantioselectivities were realized... The content of this RSS Feed (c) The Royal Society of Chemistry
ConclusionsUnlike [18F]FDG, [18F]BODIPY 1 showed prominent accumulation in BAT under both inactive and stimulated status. [18F]BODIPY 1 may serve as a valuable BAT PET agent to possibly assess BAT mitochondria density, thus BAT thermogenic capacity after further evaluation.
ConclusionsHypoxia modulation may play a role in nal-IRI ’s mechanism of action. Nal-IRI demonstrated greater anti-tumor activity in the more aggressive and hypoxic tumor model. Furthermore, hypoxia imaging provided early prediction of treatment response.
AbstractPurposeTo investigate and validate the potential role of a radiomics signature in predicting the side-specific probability of extracapsular extension (ECE) of prostate cancer (PCa).ProceduresThe preoperative magnetic resonance imaging data of 238 prostatic samples from 119 enrolled PCa patients were retrospectively assessed. The samples with were randomized in a two-to-one ratio into training (n = 74) and validation (n = 45) datasets. The radiomics features were derived from T2-weighted images (T2WIs). The optimal radiomics features were identified from the least absolute shrinkage and s...
ConclusionsIntegrated [68Ga]PSMA-11 PET/MRI provides a similarly high diagnostic performance for localization of recurrent PC as PET/CT. For the detection of local recurrences [68Ga]PSMA-11 PET/MRI is superior compared with [68Ga]PSMA-11 PET/CT.
Publication date: Available online 25 May 2020Source: Life SciencesAuthor(s): Serena L'Abbate, Ilaria Russo, Claudia Kusmic
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